N'ebe a na-emepụta ọgwụ, sodium carboxymethylcellulose (CMC) na hydroxypropyl methylcellulose (HPMC) bụ ihe mgbakwunye ọgwụ abụọ a na-ejikarị eme ihe nwere njirimara na ọrụ dị iche iche.
Ọdịdị chemical na Njirimara
CMC bụ mkpụrụ ndụ cellulose na-agbaze mmiri nke enwetara site n'ịgbanwe akụkụ nke hydroxyl otu cellulose n'ime otu carboxymethyl. Mmiri solubility na viscosity nke CMC na-adabere n'ókè nke nnọchi ya na ịdị arọ molecular, ọ na-emekarị ka ọ bụrụ ezigbo onye na-ekpo ọkụ na onye nkwụsịtụ.
A na-enweta HPMC site na iji otu methyl na hydroxypropyl dochie akụkụ nke hydroxyl otu cellulose. Tụnyere CMC, HPMC nwere solubility ka ukwuu, enwere ike ịgbaze na mmiri oyi na mmiri ọkụ, ma gosipụta viscosity kwụsiri ike na ụkpụrụ pH dị iche iche. A na-ejikarị HPMC eme ihe dị ka ihe nkiri bụbu, nrapado, thickener na onye na-achịkwa ntọhapụ na ọgwụ.
Mpaghara ngwa
Mbadamba ụrọ
N'imepụta mbadamba nkume, a na-ejikarị CMC eme ihe dị ka ihe nkwụsị na nrapado. Dị ka onye na-agbaji, CMC nwere ike ịmịnye mmiri ma zaa, si otú ahụ na-akwalite mgbasa nke mbadamba nkume ma na-abawanye ọnụego ntọhapụ nke ọgwụ. Dị ka ihe nkedo, CMC nwere ike welie ike n'ibu nke mbadamba.
A na-eji HPMC eme ihe dị ka ihe nkiri bụbu onye ntọhapụ na-achịkwa na mbadamba. Ihe nkiri a na-emepụta nke HPMC nwere ike ịrụ ọrụ dị mma ma na-eyi nguzogide, nke nwere ike ichebe ọgwụ ahụ site na mmetụta nke gburugburu ebe obibi. N'otu oge ahụ, a pụkwara iji ihe ndị na-emepụta ihe nkiri nke HPMC iji chịkwaa ọnụego ntọhapụ nke ọgwụ ahụ. Site n'ịgbanwe ụdị na usoro onunu ogwu nke HPMC, enwere ike nweta ntọhapụ na-adịgide adịgide ma ọ bụ mmetụta ntọhapụ a na-achịkwa.
Capsules
Na nkwadebe capsule, CMC anaghị eji ya eme ihe, ebe a na-ejikarị HPMC eme ihe, ọkachasị na mmepụta capsules anaghị eri anụ. A na-ejikarị gelatin eme ihe mkpuchi capsule ọdịnala, mana n'ihi nsogbu nke isi anụmanụ, HPMC aghọwo ihe ọzọ dị mma. The capsule shei mere nke HPMC bụghị nanị na-enwe ezi biocompatibility, ma na-egbo mkpa nke anaghị eri anụ.
Nkwadebe mmiri mmiri
N'ihi ọmarịcha nkwusioru na nkwusioru ya, a na-eji CMC eme ihe n'ọtụtụ ebe na nkwadebe mmiri dị ka ngwọta ọnụ, ọdịda anya na nkwadebe. CMC nwere ike ịbawanye viscosity nke nkwadebe mmiri mmiri, si otú a na-eme ka nkwusioru na nkwụsi ike nke ọgwụ na-egbochi ọgwụ sedimentation.
Ngwa nke HPMC n'ime nkwadebe mmiri na-etinyekarị na thickeners na emulsifiers. HPMC nwere ike ịnọgidesi ike n'ọtụtụ pH ma nwee ike dakọtara na ọgwụ dị iche iche na-emetụtaghị ịdị mma nke ọgwụ ahụ. Tụkwasị na nke ahụ, a na-ejikwa ihe ndị na-emepụta ihe nkiri nke HPMC na-eme ihe na nkwadebe n'elu, dị ka ihe nchebe na-emepụta ihe nkiri na anya mmiri.
Nkwadebe ntọhapụ a na-achịkwa
Na nkwadebe ntọhapụ a na-achịkwa, ngwa nke HPMC bụ nke a ma ama. HPMC na-enwe ike ịmepụta netwọk gel, na ọnụego ntọhapụ nke ọgwụ ahụ nwere ike ịchịkwa site na ịhazi nhazi na nhazi nke HPMC. A na-eji akụrụngwa a mee ihe n'ọtụtụ ebe n'ime mbadamba ụrọ na-ahapụ ya na ntinye. N'ụzọ dị iche, CMC anaghị eji ya eme ihe na nhazi mwepụta a na-achịkwa, tumadi n'ihi na usoro gel ọ na-eme adịghị eguzosi ike ka HPMC.
Nkwụsi ike na ndakọrịta
CMC nwere nkwụsi ike na-adịghị mma na ụkpụrụ pH dị iche iche na gburugburu acid-base na-emetụta ya ngwa ngwa. Na mgbakwunye, CMC enweghị ndakọrịta nke ọma na ụfọdụ ihe eji eme ọgwụ, nke nwere ike ibute oke mmiri ọgwụ ma ọ bụ ọdịda.
HPMC na-egosi nkwụsi ike dị mma n'ofe pH sara mbara, acid-base adịghị emetụta ya ngwa ngwa, ma nwee ezigbo ndakọrịta. HPMC nwere ike dakọtara na ọtụtụ ngwa ọgwụ na-enweghị emetụta nkwụsi ike na ịdị mma nke ọgwụ ahụ.
Nchekwa na ụkpụrụ
A na-ahụta ma CMC na HPMC dị ka ihe enyemaka ọgwụ dị mma ma akwadoro ya maka iji ya na nkwadebe ọgwụ site na pharmacopoeias na ụlọ ọrụ nchịkwa na mba dị iche iche. Agbanyeghị, n'oge eji, CMC nwere ike ibute mmeghachi ahụ nfụkasị ahụ ma ọ bụ ahụ erughị ala afọ, ebe HPMC anaghị ebutekarị mmeghachi omume ọjọọ.
CMC na HPMC nwere uru nke ha na ngwa ọgwụ. CMC nọ n'ọnọdụ dị mkpa na nkwadebe mmiri n'ihi ọmarịcha nkwusioru na nkwusioru ya, ebe HPMC ejirila ya mee ihe na mbadamba mbadamba, capsules na nkwadebe ntọhapụ n'ihi imepụta ihe nkiri na njikwa njikwa ya. Nhọrọ nke nkwadebe ọgwụ kwesịrị ịdabere na njirimara ọgwụ dị iche iche na ihe nkwadebe chọrọ, n'ụzọ zuru ezu na-atụle uru na ọghọm nke abụọ ahụ, na ịhọrọ ihe kacha mma.
Oge nzipu: Jul-19-2024