Hydroxypylththththththylcelllose (hpmc)A na-ejikarị polymer mmiri na-ejikarị ya eme ihe n'ọtụtụ ebe na-eme ọgwụ, nri, ihe eji eme ihe, ihe ịchọ mma na ubi ndị ọzọ. HPMC nwere ezigbo soniblity na njirimara viscosics ma nwee ike ịmalite ngwọta carfụl, ya mere, ọ na-arụ ọrụ dị mkpa n'ọtụtụ ngwa. Iji nye egwuregwu zuru oke na arụmọrụ HPMC, ezigbo usoro mgbasa dị ezigbo mkpa.
1. Usoro mmiri ozuzo nkịtị
Enwere ike ịgbasa hpmc na mmiri oyi, mana ọ na-abụkarị ụfọdụ nkà dị mkpa iji zere agglomeration. Iji meziwanye nsonaazụ, usoro ndị a nwere ike iji:
Kwụpụ 1: Tinye hpmc na mmiri
Na ụlọ okpomọkụ, buru ụzọ fesaa hpmc n'uzo mmiri iji zere ịwụpụ nnukwu ego nke Hpmc n'ime mmiri n'otu oge. N'ihi na HPMC bụ ogige polymer, na-agbakwunye nnukwu hpmc ga-eme ka ọ banye na mmiri ma daa ngwa ngwa.
Kwụpụ 2: Na-akpali
Mgbe ị gbakwunye Hpmc, na-eme ka a na-eme ka ọ dị. N'ihi na HPMC nwere ezigbo ihe, ọ ga-aza mmiri na-atọgbọ elu iji mepụta ihe dị ka ya. Na-akpali akpali na-egbochi HPMC site na agglomerating na clumps.
Kwụpụ 3: Guzo ma Ọzọkwa Bick
Ọ bụrụ na a naghị edozi HPMC kpamkpam, enwere ike ịhapụ ihe ngwọta ya ka ọ guzoro otu oge wee nọgide na-akpali. A ga-etisasị ya n'ime awa ole na ole.
Usoro a dị mma maka oge adịghị achọ ọkụ, mana ọ na-ewe ogologo oge iji hụ na a na-agbaze na HPMC kpamkpam.
2. Usoro Mgbasa Mmiri Na-ekpo ọkụ
HPMC na-agbasa ngwa ngwa na mmiri ọkụ, yabụ kpoo mmiri mmiri nwere ike ime ngwa ngwa usoro. Ihe a na-ejikarị okpomoku na-ejikarị 50-70 ℃, mana oke okpomọkụ (dị ka ihe karịrị 80 ℃) nwere ike ibute hpmc iji chịkwaa, yabụ na ọnọdụ okpomọkụ kwesịrị ịchịkwa.
Kwụpụ 1: Mmiri na-ekpo ọkụ
Ikpo mmiri dị ka 50 ℃ ma na-eme ka ọ na-aga n'ihu.
Kwụpụ 2: Tinye HPMC
Wụsa hpmc ji nwayọọ nwayọọ banye na mmiri ọkụ. N'ihi nnukwu mmiri mmiri, Hpmc ga-agbazekwuo mfe, na-ebelata agglomeration.
Kwụpụ 3: Na-akpali
Mgbe ịgbakwunye HPMC, gaa n'ihu na-akpali usoro ihe. Njikọ nke kpo oku na akpali akpali nwere ike ịkwalite mgbasa ngwa ngwa HPMC.
Kwụpụ 4: Nọgide na-enwe okpomọkụ ma gaa n'ihu na-akpali
Nwere ike ịnọgide na-enwe ụfọdụ okpomọkụ ma gaa n'ihu n'ihu ruo mgbe HPMC zuru oke.
3. Usoro mmanya na-egbu egbu
Enwere ike ịgbasa hpmc ọ bụghị naanị na mmiri, kamakwa na ụfọdụ mmanya na-egbu mmanya (dịka ethanol). Isi uru nke ịgbasa mmanya na-egbu egbu bụ na ọ nwere ike melite solubality nke HPMC, ọkachasị maka sistemụ mmiri dị elu.
Kwụpụ 1: Họrọ onye na-a alcoholụ mmanya kwesịrị ekwesị
A na-ejikarị ihe mgbaze ndị na-egbu egbu dịka etropropania na-abụkarị iji igbari hpmc. N'ikwu okwu, 70-90% Ethanol ngwọta nwere mmetụta dị mma na ịdọrọ Hpmc.
Kwụpụ 2: mgbasa
Jiri nwayọ wụsa mmanya na-egbu egbu, na-akpali akpali mgbe ị na-agbakwunye na HPMC nke ọma.
Kwụpụ 3: iguzo ma na-akpali akpali
Usoro nke mmanya na-egbu egbu na-agbaze hpmc dịtụ ngwa ngwa, ọ na-ewekwa obere oge iji nweta mgbasa zuru oke.
A na-ejikarị usoro a na-egbu egbu na-egbu egbu na ọnọdụ ngwa na-achọ mgbasa ngwa ngwa na ala mmiri.
4.
Mgbe ụfọdụ, a na-agbaze hpmc na ngwakọta nke mmiri ụfọdụ na-agba mbọ. Usoro a kachasị mma maka ọnọdụ ebe viscosity nke ihe ngwọta ma ọ bụ usoro mgbasa dị mkpa idozigharị. Sọ ọrụ ndị na-ahụkarị gụnyere acetone, ethanol, wdg.
Kwụpụ 1: Kwadebe ihe ngwọta
Họrọ ruru ihe ruru eru na mmiri (dịka mmiri 50%, sava 50%) na okpomọkụ nye okpomọkụ kwesịrị ekwesị.
Kwụpụ 2: Tinye HPMC
Ọ bụ ezie na ị na-akpali, jiri nwayọ tinye HPMC iji hụ na mgbasa nke edo edo.
Kwụpụ 3: Mgbanwe ọzọ
Dị ka ọ dị mkpa, enwere ike ịbawanye mmiri ma ọ bụ ihe mgbaze nwere ike ịbawanye iji dozie solib na viscosity nke HPMC.
Methodzọ a dị mma maka oge a na-agbakwunye ihe mgbaze na usoro ihe ngwọta iji meziwanye ọnụego ya ma ọ bụ dozie Njirimara nke ihe ngwọta.
5
Iji mmetụta ndị dị elu nke ultrasound nke ultrasonic - na-enyere aka na usoro ultrasonic-enyere aka mee ngwa ngwa nke ịchụpụ HPMC. Usoro a kachasị mma maka nnukwu hpmc nke kwesịrị ka etisasị ngwa ngwa, ma nwee ike belata nsogbu agglomed nke nwere ike ime n'oge ọdịnala ọdịnala.
Kwụpụ 1: Kwadebe ihe ngwọta
Tinye HPMC ka mmiri siri ike ma ọ bụ mmiri mmiri gwakọtara agwakọta.
Kwụpụ 2: Ọgwụ Ultrasonic
Jiri nhicha nhicha ma ọ bụ ultrasonic ma na-emeso ya dabere na ike na oge. Mmetụta nke oscillation nke ultrasound nwere ike ime ngwa ngwa nke ngbasa nke HPMC.
Kwụpụ 3: Lelee nsonaazụ
Mgbe ọgwụgwọ ultrasovic, lelee ma ọ bụrụ na a na-asachapụ ya kpamkpam. Ọ bụrụ na enwere akụkụ doro anya akụkụ, a ga-eme ọgwụgwọ ultrasonic ọzọ.
Methodzọ a dị mma maka ngwa ndị chọrọ nke ọma na ngwa ngwa.
6. Playinment tupu mgbasa
Iji zereHpmcAgglomeration ma ọ bụ ihe isi ike jupụta, enwere ike iji ụzọ ụfọdụ eme ihe, dịka ịgwakọta hpmc na obere solvents ndị ọzọ (dị ka Glycel), na-ebu ụzọ mee ya, ma ọ bụ iwepụ HPMC tupu ịgbakwunye ihe mgbatị ahụ. Nzọụkwụ ndị a na-enweghị atụ nwere ike ime ka mbọ nke HPMC.
Enwere ọtụtụ ụzọ iji gbazee hpmc. Chohọrọ ụzọ mgbasa kwesịrị ekwesị nwere ike imeziwanye arụmọrụ na ogo ngwaahịa. Okpomoku nke ime ulo di nma maka gburugburu ebe a na-eme ihe, uzo mmiri a na-ekpo ọkụ nwere ike ime ka usoro a na-apụ apụ na usoro a na-egbu egbu na-agbasa dị mma maka mgbasa. Akụkụ nke ultrasonic-enyere aka na ụzọ dị irè iji dozie ngwa ngwa nke nnukwu ego HPMC. Dabere na ngwa ndị chọrọ, nhọrọ mgbanwe nke usoro ndọrọ agbanwe kwesịrị ekwesị nwere ike ịgba mbọ hụ na arụmọrụ kachasị mma nke HPMC na mpaghara dị iche iche.
Oge Post: Dec-19-2024