Hydroxypropyl methylcellulose (HPMC)bụ ihe a na-ejikarị mmiri na-agbaze mmiri, nke a na-ejikarị eme ihe na ọgwụ, nri, ihe ụlọ, ihe ịchọ mma na ubi ndị ọzọ. HPMC nwere ezigbo solubility na viscosity e ji mara ma nwee ike ịmepụta ngwọta colloidal kwụsiri ike, yabụ na ọ na-arụ ọrụ dị mkpa n'ọtụtụ ngwa. Iji nye egwuregwu zuru oke na arụmọrụ nke HPMC, usoro mgbasa ozi ziri ezi dị mkpa karịsịa.
1. Usoro mgbasa mmiri okpomọkụ nkịtị
Enwere ike ịgbaze HPMC na mmiri oyi, mana ọ na-adịkarị ụfọdụ nkà iji zere mkparị ya. Iji meziwanye mmetụta mgbasa, enwere ike iji usoro ndị a:
Nzọụkwụ 1: Tinye HPMC na mmiri
Mgbe okpomọkụ dị n'ime ụlọ, buru ụzọ fesa HPMC nke ọma n'elu mmiri ka ị ghara ịwụsa nnukwu HPMC n'ime mmiri n'otu oge. N'ihi na HPMC bụ ngwakọta polymer, na-agbakwunye nnukwu ego HPMC ozugbo ga-eme ka ọ na-amịkọrọ mmiri ma zaa ngwa ngwa n'ime mmiri iji mepụta ihe dị ka gel.
Nzọụkwụ 2: ịkpali
Mgbe ịgbakwunye HPMC, na-akpali akpali ọbụna. N'ihi na HPMC nwere ezigbo irighiri ihe, ọ ga-aza mgbe ọ na-amịkọrọ mmiri iji mepụta ihe dị ka gel. Ịkpalite na-enyere aka igbochi HPMC ka ọ ghara ịba ụba n'ime mkpọmkpọ.
Nzọụkwụ 3: Guzo ma kpalie ọzọ
Ọ bụrụ na HPMC adịghị agbaze kpamkpam, enwere ike ịhapụ ngwọta ahụ ka ọ guzoro ruo oge ma gaa n'ihu na-akpali akpali. A ga-agbazekarị ya kpamkpam n'ime awa ole na ole.
Usoro a dabara adaba maka oge okpomọkụ anaghị achọ, mana ọ na-ewe ogologo oge iji hụ na agbazere HPMC kpamkpam.
2. Usoro mgbasa mmiri ọkụ
HPMC na-agbaze ngwa ngwa na mmiri ọkụ, yabụ ikpo ọkụ mmiri nwere ike ime ka usoro mgbasa ahụ dịkwuo ngwa ngwa. Mmiri okpomọkụ a na-ejikarị eme ihe bụ 50-70 ℃, mana oke okpomọkụ (dị ka ihe karịrị 80 ℃) nwere ike ime ka HPMC mebie, ya mere ọ dị mkpa ka a na-achịkwa okpomọkụ.
Nzọụkwụ 1: Na-ekpo ọkụ mmiri
Kpoo mmiri ahụ ruo ihe dịka 50 ℃ ma na-edebe ya mgbe niile.
Nzọụkwụ 2: Tinye HPMC
Wụsa HPMC nwayọọ nwayọọ n'ime mmiri ọkụ. N'ihi oke okpomọkụ nke mmiri, HPMC ga-agbaze ngwa ngwa, na-ebelata agglomeration.
Nzọụkwụ 3: ịkpali
Mgbe ịgbakwunye HPMC, gaa n'ihu na-akpalite ngwọta mmiri. Nchikota kpo oku na mkpali nwere ike kwalite mgbasa ngwa ngwa nke HPMC.
Nzọụkwụ 4: Jikwaa okpomọkụ ma nọgide na-akpali
Ị nwere ike ịnọgide na-enwe ụfọdụ okpomọkụ ma nọgide na-akpali ruo mgbe HPMC na-agbaze kpamkpam.
3. Ụzọ mgbasa mmanya
Enwere ike ịgbaze HPMC ọ bụghị naanị na mmiri, kamakwa na ụfọdụ ihe mgbaze mmanya (dị ka ethanol). Isi uru nke usoro mgbasa mmanya na-aba n'anya bụ na ọ nwere ike melite solubility na dispersibility nke HPMC, karịsịa maka usoro nwere nnukwu mmiri.
Nzọụkwụ 1: Họrọ ihe mgbaze mmanya kwesịrị ekwesị
A na-ejikarị ihe mgbaze mmanya dị ka ethanol na isopropanol na-agbari HPMC. N'ikwu okwu n'ozuzu, 70-90% ethanol ngwọta nwere mmetụta dị mma na igbari HPMC.
Nzọụkwụ 2: Mgbasa
Jiri nwayọ fesa HPMC n'ime ihe mgbaze mmanya na-aba n'anya, na-akpali akpali mgbe ị na-agbakwunye iji hụ na agbasasịla HPMC nke ọma.
Nzọụkwụ 3: Iguzo na edemede
Usoro nke ihe mgbaze mmanya na-agbari HPMC dị ngwa ngwa, ọ na-ewekarị nkeji ole na ole iji nweta mgbasa zuru oke.
A na-ejikarị usoro mgbasa mmanya na-aba n'anya eme ihe n'ọnọdụ ngwa nke chọrọ mgbasa ngwa ngwa na iwetu mmiri dị ala.
4. Usoro mgbaze-mmiri agwakọta
Mgbe ụfọdụ, HPMC na-agbaze na ngwakọta nke mmiri na ihe mgbaze. Usoro a dabara adaba maka ọnọdụ ebe enwere ike idozi viscosity nke ngwọta ma ọ bụ ọnụego mgbasa. Ihe mgbaze nkịtị gụnyere acetone, ethanol, wdg.
Nzọụkwụ 1: Kwadebe ihe ngwọta
Họrọ nha kwesịrị ekwesị nke ihe mgbaze na mmiri (dịka 50% mmiri, 50% mgbaze) na ikpo ọkụ na okpomọkụ kwesịrị ekwesị.
Nzọụkwụ 2: Tinye HPMC
Ka ị na-akpali, jiri nwayọọ nwayọọ tinye HPMC iji hụ na mgbasa otu.
Nzọụkwụ 3: Ngbanwe ọzọ
Dị ka ọ dị mkpa, enwere ike ịbawanye oke mmiri ma ọ bụ ihe mgbaze iji dozie solubility na viscosity nke HPMC.
Usoro a dabara adaba maka oge ebe a na-agbakwunye ihe ndị na-emepụta ihe na-emepụta ihe na-emepụta ihe na-edozi ahụ na ngwọta mmiri iji meziwanye ọnụego mgbasa ma ọ bụ gbanwee ihe onwunwe nke ngwọta ahụ.
5. Ultrasonic-enyere aka mgbasa mgbasa
N'iji mmetụta oscillation dị elu nke ultrasound, usoro mgbasa ozi na-enyere aka ultrasonic nwere ike mee ka usoro mgbasa nke HPMC dịkwuo elu. Usoro a dabara adaba maka nnukwu HPMC dị mkpa ka agbaze ngwa ngwa, ma nwee ike ibelata nsogbu agglomeration nke nwere ike ime n'oge mkpali ọdịnala.
Nzọụkwụ 1: Kwadebe ihe ngwọta
Tinye HPMC na mmiri kwesịrị ekwesị ma ọ bụ ihe ngwọta agwakọtara mmiri.
Nzọụkwụ 2: Ultrasonic ọgwụgwọ
Jiri ultrasonic Cleaner ma ọ bụ ultrasonic dissolver na-emeso ya dị ka ike na oge atọrọ. The oscillation mmetụta nke ultrasound nwere ike budata mee ngwangwa mgbasa mgbasa nke HPMC.
Nzọụkwụ 3: Lelee mmetụta mgbasa
Mgbe ọgwụgwọ ultrasonic gasịrị, lelee ma ihe ngwọta agbazere kpamkpam. Ọ bụrụ na enwere akụkụ a na-agbazeghị, enwere ike ịme ọgwụgwọ ultrasonic ọzọ.
Usoro a dabara adaba maka ngwa ndị chọrọ mgbasa nke ọma na ngwa ngwa.
6. Pretreatment tupu mgbasa
Iji zereHPMCagglomeration ma ọ bụ ihe isi ike na igbari, ụfọdụ pretreatment ụzọ nwere ike iji, dị ka ịgwakọta HPMC na obere ego nke ọzọ ihe mgbaze (dị ka glycerol), ihicha ya mbụ, ma ọ bụ wetting HPMC tupu agbakwunye mgbaze. Ndị a pretreatment nzọụkwụ nwere ike n'ụzọ dị irè melite solubility nke HPMC.
E nwere ọtụtụ ụzọ igbari HPMC. Ịhọrọ usoro mgbasa ozi kwesịrị ekwesị nwere ike imeziwanye nrụpụta mgbasa na ogo ngwaahịa. Usoro mgbaze nke ime ụlọ dị mma maka ebe dị nro, usoro ịgbasa mmiri ọkụ nwere ike ime ka usoro mgbasa ozi dị ngwa ngwa, na usoro mgbaze mmanya na ihe mgbaze-mmiri na-ekpo ọkụ na-adaba adaba na mkpa pụrụ iche. Usoro mgbasa ozi ultrasonic na-enyere aka bụ ụzọ dị irè iji dozie mgbasa ngwa ngwa nke nnukwu ego nke HPMC. Dị ka ụfọdụ ngwa chọrọ, mgbanwe nhọrọ nke kwesịrị ekwesị mgbasa usoro nwere ike hụ na kasị mma arụmọrụ nke HPMC dị iche iche ubi.
Oge nzipu: Dec-19-2024