Hydroxypropyl methylcellulose (HPMC) bụ ihe a na-ejikarị mmiri eme ihe, nke a na-ejikarị eme ihe na ọgwụ, ihe ịchọ mma, nri na ubi mmepụta ihe, karịsịa na nkwadebe nke gels. Njirimara anụ ahụ ya na omume mgbasa ozi nwere mmetụta dị ukwuu na arụmọrụ dị na ngwa dị iche iche. The gelation okpomọkụ nke HPMC gel bụ otu n'ime ya isi anụ ahụ Njirimara, nke kpọmkwem na-emetụta ya arụmọrụ na dị iche iche nkwadebe, dị ka achịkwa ntọhapụ, ihe nkiri guzobe, kwụsie ike, wdg.
1. Ọdịdị na Njirimara nke HPMC
HPMC bụ polymer soluble mmiri nke enwetara site na iwebata ihe nnọchi abụọ, hydroxypropyl na methyl, n'ime ọkpụkpụ molekụla cellulose. Ọdịdị molekụla ya nwere ụdị ihe nnọchi anya abụọ: hydroxypropyl (-CH2CHOHCH3) na methyl (-CH3). Ihe ndị dị ka ọdịnaya hydroxypropyl dị iche iche, ogo methylation, na ogo nke polymerization ga-enwe mmetụta dị mkpa na solubility, omume gelling, na nrụzi nke HPMC.
Na ngwọta mmiri, AnxinCel®HPMC na-emepụta ngwọta colloidal kwụsiri ike site n'ịme njikọ hydrogen na ụmụ irighiri mmiri na imekọrịta skeleton dabeere cellulose. Mgbe ọnọdụ mpụga (dị ka okpomọkụ, ike ionic, wdg) gbanwere, mmekọrịta dị n'etiti ụmụ irighiri ihe HPMC ga-agbanwe, na-ebute gelation.
2. Nkọwa na ihe na-emetụta ọnọdụ okpomọkụ gelation
Gelation okpomọkụ (Gelation Temperature, T_gel) na-ezo aka na okpomọkụ nke HPMC ngwọta na-amalite na-esi na mmiri mmiri na-esi ike mgbe ngwọta okpomọkụ na-ebili n'ókè ụfọdụ. N'oge okpomọkụ a, a ga-amachibido mmegharị nke agbụ molecular HPMC, na-eme usoro netwọk akụkụ atọ, na-ebute ihe dị ka gel.
Igwe ọkụ gelation nke HPMC na-emetụta ọtụtụ ihe, otu n'ime ihe kachasị mkpa bụ ọdịnaya hydroxypropyl. Na mgbakwunye na ọdịnaya hydroxypropyl, ihe ndị ọzọ na-emetụta okpomọkụ gel gụnyere ịdị arọ molecular, ntinye ngwọta, uru pH, ụdị mgbaze, ike ionic, wdg.
3. Mmetụta nke ọdịnaya hydroxypropyl na HPMC gel okpomọkụ
3.1 Mmụba nke ọdịnaya hydroxypropyl na-eduga na mmụba nke okpomọkụ gel
Okpomọkụ gelation nke HPMC nwere njikọ chiri anya na ogo nke nnọchi hydroxypropyl na molekul ya. Ka ọdịnaya hydroxypropyl na-abawanye, ọnụọgụ nke ihe nnọchi hydrophilic na yinye molekụla HPMC na-abawanye, na-ebute nkwalite mmekọrịta dị n'etiti molekul na mmiri. Mmekọrịta a na-eme ka agbụ molekụla gbatịkwuo n'ihu, si otú a na-ebelata ike nke mmekọrịta dị n'etiti ụdọ molekụla. N'ime usoro ịta ahụhụ ụfọdụ, ịba ụba ọdịnaya hydroxypropyl na-enyere aka ịkwalite ogo hydration ma na-akwalite nhazi ọnụ nke ụdọ molekụla, nke mere na enwere ike ịmepụta usoro netwọk na okpomọkụ dị elu. Ya mere, gelation okpomọkụ na-emekarị na-abawanye na hydroxypropyl na-ebili na ụba ọdịnaya.
HPMC nwere ọdịnaya hydroxypropyl dị elu (dị ka HPMC K15M) na-achọ igosipụta okpomọkụ gelation dị elu n'otu ntinye uche karịa AnxinCel®HPMC nwere ọdịnaya hydroxypropyl dị ala (dị ka HPMC K4M). Nke a bụ n'ihi na ọdịnaya hydroxypropyl dị elu na-eme ka o sie ike ka ụmụ irighiri ihe na-emekọrịta ihe na ịmepụta netwọk na obere okpomọkụ, na-achọ okpomọkụ dị elu iji merie hydration a ma kwalite mmekọrịta intermolecular iji mepụta usoro netwọk nke akụkụ atọ. .
3.2 Mmekọrịta dị n'etiti ọdịnaya hydroxypropyl na ntinye ngwọta
Ntinye uche nke ngwọta bụkwa ihe dị mkpa na-emetụta okpomọkụ gelation nke HPMC. N'ihe ngwọta HPMC dị elu, mmekọrịta intermolecular na-esiwanye ike, ya mere okpomọkụ gelation nwere ike ịdị elu ọbụna ma ọ bụrụ na ọdịnaya hydroxypropyl dị ala. N'ebe dị ala, mmekọrịta dị n'etiti ụmụ irighiri ihe HPMC adịghị ike, ihe ngwọta ya nwekwara ike ịla na okpomọkụ dị ala.
Mgbe ọdịnaya hydroxypropyl na-abawanye, ọ bụ ezie na hydrophilicity na-abawanye, a ka chọrọ okpomọkụ dị elu iji mepụta gel. Karịsịa n'okpuru ọnọdụ ntinye uche dị ala, okpomọkụ gelation na-abawanye nke ukwuu. Nke a bụ n'ihi na HPMC nwere ọdịnaya hydroxypropyl dị elu na-esikwu ike ịmalite mmekọrịta n'etiti ụdọ molekụla site na mgbanwe okpomọkụ, na usoro gelation chọrọ ume ọkụ ọzọ iji merie mmetụta hydration.
3.3 Mmetụta nke ọdịnaya hydroxypropyl na usoro gelation
N'ime akụkụ ụfọdụ nke ọdịnaya hydroxypropyl, usoro gelation na-achịkwa site na mmekọrịta dị n'etiti hydration na agbụ molecular. Mgbe ọdịnaya hydroxypropyl dị na molekul HPMC dị ala, hydration adịghị ike, mmekọrịta dị n'etiti ụmụ irighiri ihe dị ike, na obere okpomọkụ nwere ike ịkwalite nhazi nke gel. Mgbe ọdịnaya hydroxypropyl dị elu, hydration na-abawanye nke ọma, mmekọrịta dị n'etiti ụdọ molekụla na-esiwanye ike, okpomọkụ gelation na-abawanye.
Ọdịnaya hydroxypropyl dị elu nwekwara ike ibute mmụba na viscosity nke ngwọta HPMC, mgbanwe nke na-abawanye mgbe ụfọdụ okpomọkụ mmalite nke gelation.
Ọdịnaya Hydroxypropyl nwere mmetụta dị ukwuu na okpomọkụ gelation nkeHPMC. Ka ọdịnaya hydroxypropyl na-abawanye, hydrophilicity nke HPMC na-abawanye na mmekọrịta dị n'etiti ụdọ molekụla na-ebelata, ya mere okpomọkụ gelation ya na-abawanye. Enwere ike ịkọwa ihe omume a site na usoro mmekọrịta dị n'etiti hydration na agbụ molecular. Site n'ịgbanwe ọdịnaya hydroxypropyl nke HPMC, enwere ike nweta njikwa ziri ezi nke okpomọkụ gelation, si otú ahụ na-ebuli arụmọrụ nke HPMC na ọgwụ, nri na ngwa ụlọ ọrụ ndị ọzọ.
Oge nzipu: Jan-04-2025