Hydroxypylththththththylcelllose (hpmc) A na-ejikarị polymer mmiri na-ejikarị ya eme ihe n'ọtụtụ ebe, eji ọgwụ, ihe ịchọ mma, nri na ubi, ọkachasị na nkwadebe nke gels. Njirimara anụ ahụ na esemokwu ya nwere mmetụta dị ukwuu na arụmọrụ dị iche iche. Ọnọdụ ikuku nke HPMC GEL bụ otu n'ime ihe anụ ahụ ya nwere ike, nke na-emetụta arụmọrụ ya na nkwadebe dị iche iche, dị ka mwepụta na-achịkwa, guzobe, nkwụsi ike, wdg.
1. Ọdịdị na Njirimara nke HPMC
HPMC bụ polymer na-agbanye mmiri site na iwebata ihe abụọ, hydroxylyl na methyl, n'ime akwara akwara mkpụrụ osisi cellular. Ihe owuwu ya nwere ụdị abụọ dị iche iche: hydroxypyl (-ch2chohch3) na methyl (chh3). Ihe ndị dị ka ọdịnaya hydroxyl dị iche iche, ogo nke polymerization ga-enwe mmetụta dị mkpa na slubality, ihe eji arụ ọrụ nke HPMC.
Na ngwọta osisi, na-eche nche na-edozi ahụ counch na nsị nke colroidal site na ịkpụkọ hydrogen na molecules mmiri na iso sọọsọ ya. Mgbe gburugburu ebe obibi (dị ka okpomọkụ, wdg ionic, wdg) mgbanwe, mmekọrịta dị n'etiti ụmụ irighiri Hpmc ga-agbanwe, na-ebute gelecules ga-agbanwe, na-ebute gelecules ga-agbanwe, na-ebute gelecules ga-agbanwe, na-ebute gelecules ga-agbanwe, na-ebute gelecules ga-agbanwe, na-ebute gelecules ga-agbanwe.
2. Nkọwapụta na ime ihe na-emetụta ọnọdụ ikuku
Ọnọdụ ndụ okpomọkụ (okpomọkụ okpomọkụ, t_Gel) na-ezo aka na ọnọdụ okpomọkụ nke HPMC Ngwọta na-amalite ntụgharị site na mmiri mmiri na-ebili ruo otu ọkwa. Na a okpomọkụ, mmegharị nke ụgbụ hpmc a ga-egbochi ihe owuwu netwọkụ atọ, nke na-ebute ihe dị ka ihe dị mma.
Ọtụtụ ihe, otu ihe dị mkpa bụ ihe kachasị mkpa bụ ọdịnaya Hydroxyl. Na mgbakwunye na ọdịnaya hydroxyl, ihe ndị ọzọ na-emetụta oke okpomọkụ gụnyere oke molecular, ịta uru, ụdị ihe mgbaasị, wdg.
3. Mmetụta nke ọdịnaya Hydypyl na HPMC GEL
3.1 Mmụba na ihe na-enye ihe na-eduga na mmụba na ogo gel
Ọnọdụ okpomọkụ nke Hpmc nwere njikọ chiri anya na ogo hydroxyppyl nnọchi anya ya. Ka ọdịnaya hydroxypyl na-abawanye, ọnụ ọgụgụ nke ndị na-eme ihe hydrophilic na ọdụ HPMC na-abawanye, na-ebute mmekọrịta dị n'etiti molekule na mmiri. Nchịkọta a na - eme ka agbụ ụdọ iji na - agbatị, si otú a belata ike nke mmekọrịta dị n'etiti agwọ. N'ime oke ịta, na-amụba ihe na-enye hydropyl na-enyere aka ịkwalite ogo hydration ma na-akwalite nhazi nke eriri abụọ, nke mere na enwere ike guzobere nhazi networ na okpomọkụ dị elu. Ya mere, okpomoku Geletion na-abawanye na hydropyyl na-aba ụba.
HPMC nwere ọdịnaya hydropospyl dị elu (dịka HPMC K15M) na-egosipụta oke ikuku dị elu karịa ka ị na-enwe na ọdịnaya dị ala (dịka HPDCOPPROPSL (dịka HPMC K4M). Nke a bụ maka ọdịnaya dị elu na-eme ka ọ sie ike maka na-eme ka ọ dịkwuo nkọ ma nweekwa ọnọdụ dị ala iji merie ihe owuwu network atọ. .
3.2 Mmekọrịta dị n'etiti ihe na-eme ihe na-enye ihe na ntinye uche
Ntinye uche bụkwa ihe dị mkpa na-emetụta ọnọdụ okpomọkụ nke Hpmc. Ngwọta HPMC nke dị elu, mmekọrịta nke mmekọrịta dị ike, yabụ ọnọdụ ikuku nwere ike ịdị elu ọbụlagodi ma ọ bụrụ na ọdịnaya mmiri hydroxyl dị ala. Na ala dị ala, mmekọrịta dị n'etiti ụmụ irighiri akwara hpmc adịghị ike, ọ ga-adịrị ya ike na gel na obere okpomọkụ.
Mgbe ọdịnaya hydroxypyl na-abawanye, ọ bụ ezie na hydrophilicity na-abawanye, ka dị elu ka dị elu iji mepụta gel. Karịsịa n'okpuru ọnọdụ ịta ala dị ala, okpomọkụ gelera na-abawanye nke ukwuu. Nke a bụ maka na HPMC nwere ọdịnaya Hydroxyl siri ike karị na-eme ka mmekọrịta dị n'etiti ọnọdụ ikuku, yana usoro mgbaze chọrọ ike ikuku iji merie mmetụta hydration.
3.3 Mmetụta nke Grodypyl na usoro geleration
N'ime ụdị ọdịnaya hydroxyyl, usoro geletion na-achịkwa site na mmekọrịta dị n'etiti hydration na ụyọkọ mmiri. Mgbe ihe na-eme ihe na-adịghị ala na HPMC Molekule dị ala, hydration adịghị ike, mmekọrịta dị n'etiti Molecules siri ike, na ọnọdụ okpomọkụ nwere ike ịkwalite nguzobe nke gel. Mgbe ọdịnaya hydroxypyl dị elu, hydration na-akawanye njọ, mmekọrịta dị n'etiti eluciar dị ike, ọnọdụ okpomọkụ na-abawanye.
Ọdịnaya Hydroxyl nwere ike iduga na mmụba na viscosity nke viscosity nke HPMC Ngwọta, mgbanwe na-abawanye okpomoku mgbe ụfọdụ.
Ihe ndị na-eme ihe na-eme ka ọ dịkwuo eluHpmc. Dị ka ọdịnaya hydroporpyl na-abawanye, hydrophilicy nke hpmc na-abawanye na mmekọrịta dị n'etiti elureculad dị na-esighi ike. Enwere ike ịkọwa ihe a na usoro mmekọrịta n'etiti obi ụtọ na ụyọkọ moleclar. Site na idozi ọdịnaya hydropyl nke HPMC, nke zuru oke nke ọnọdụ ikuku nke geleration, na-ebuli arụmọrụ nke HPMC na Ngwa ogwu, nri na ngwa ndị ọzọ.
Oge post: Jan-04-2025