HPMC (hydroxypropyl methylcellulose) bụ ihe a na-eji mmiri eme ihe na-eme ka mmiri sie ike n'ihe owuwu, ọgwụ, nri na kemịkalụ kwa ụbọchị. Ọ nwere ezigbo ndim, emulsification, imepụta ihe nkiri, colloid nchebe na ihe ndị ọzọ. Na usoro emulsion, HPMC nwere ike ijikwa viscosity nke emulsion n'ụzọ dịgasị iche iche.
1. Ọdịdị molekụla nke HPMC
A na-emetụta viscosity nke HPMC tumadi site na ibu molekụla ya na ogo nke nnọchi ya. Ibu ibu nke molekụla, nke dị elu nke viscosity nke ngwọta; na ogo nke nnọchi (ya bụ, ogo nke nnọchi nke hydroxypropyl na methoxy otu) na-emetụta solubility na viscosity Njirimara nke HPMC. Kpọmkwem, ka ogo nke nnọchi dị elu, ka mma mmiri solubility nke HPMC, na viscosity na-abawanye ya. Ndị na-emepụta ihe na-enyekarị ngwaahịa HPMC nwere nha molekụla dị iche iche na ogo nke nnọchi iji gboo mkpa nke ngwa dị iche iche.
2. Jiri uche mee ihe
Ntinye nke HPMC na ngwọta mmiri bụ otu n'ime isi ihe na-emetụta viscosity. N'ikwu okwu n'ozuzu, ka mkpokọta HPMC dị elu, ka viscosity nke ngwọta na-abawanye. Agbanyeghị, viscosity nke ụdị HPMC dị iche iche n'otu itinye uche nwere ike ịdị iche iche. Ya mere, n'ime ngwa bara uru, ọ dị mkpa ịhọrọ ntinye kwesịrị ekwesị nke ngwọta HPMC dị ka ihe chọrọ viscosity kpọmkwem. Dịka ọmụmaatụ, na ngwa ihe owuwu, a na-achịkwa ịta ahụhụ nke HPMC n'etiti 0.1% na 1% iji nye viscosity na-arụ ọrụ kwesịrị ekwesị na ịrụ ọrụ ihe owuwu.
3. Usoro mgbasa
Usoro mgbasa nke HPMC nwekwara mmetụta dị mkpa na viscosity ikpeazụ. HPMC dị mfe ịgbasa na mmiri oyi, mana ọnụego mgbasa na-adị ngwa; ọ na-agbaze ngwa ngwa na mmiri ọkụ, ma ọ dị mfe agglomerate. Iji zere agglomeration, enwere ike iji usoro mgbakwunye nwayọọ nwayọọ mee ihe, ya bụ, buru ụzọ jiri nwayọọ nwayọọ tinye HPMC na mmiri oyi iji gbasaa, wee kpoo ọkụ ma mee ka ọ gbazee kpamkpam. Na mgbakwunye, HPMC nwekwara ike ịbụ premixed ndị ọzọ akọrọ powders wee tinye na mmiri igbari ka mma mgbasa arụmọrụ na viscosity kwụsie ike.
4. Okpomọkụ
Okpomọkụ nwere mmetụta dị ukwuu na viscosity nke ngwọta HPMC. N'ozuzu, viscosity nke HPMC ngwọta na-ebelata ka okpomọkụ na-abawanye. Nke a bụ n'ihi na ịrị elu okpomọkụ ga-ebelata njikọ hydrogen n'etiti ụmụ irighiri ihe, na-eme ka HPMC molecular chain slide dị mfe karị, si otú ahụ na-ebelata viscosity nke ngwọta. Ya mere, na ngwa chọrọ elu viscosity, HPMC ngwọta na-ejikarị na ala okpomọkụ. Dịka ọmụmaatụ, na ngwa ọgwụ, a na-ejikarị ngwọta HPMC eme ihe na ụlọ okpomọkụ iji hụ na nkwụsi ike na ịdị irè nke ọgwụ ahụ.
5. pH uru
The viscosity nke HPMC ngwọta na-emetụtakwa uru pH. HPMC nwere viscosity kachasị elu n'okpuru ọnọdụ acid na-anọpụ iche na nke na-adịghị ike, ebe viscosity ga-ebelata nke ukwuu n'okpuru ọnọdụ acidic ma ọ bụ alkaline siri ike. Nke a bụ n'ihi na ụkpụrụ pH dị oke egwu ga-emebi usoro ihe omimi nke HPMC ma mee ka mmetụta ya sie ike. Ya mere, n'ime ngwa bara uru, uru pH nke ngwọta kwesịrị ịchịkwa ma debe ya n'ime ebe siri ike nke HPMC (na-emekarị pH 3-11) iji hụ na mmetụta ya siri ike. Dịka ọmụmaatụ, na ngwa nri, a na-ejikarị HPMC eme ihe na nri acidic dị ka yogọt na ihe ọṅụṅụ, enwere ike nweta ezigbo viscosity site n'ịgbanwe uru pH.
6. Ihe mgbakwunye ndị ọzọ
Na emulsion usoro, na viscosity nke HPMC nwekwara ike gbanwee site na-agbakwụnye ọzọ thickeners ma ọ bụ ihe mgbaze. Dịka ọmụmaatụ, ịgbakwunye nnu inorganic kwesịrị ekwesị (dị ka sodium chloride) nwere ike ime ka viscosity nke ngwọta HPMC dịkwuo elu; mgbe ị na-agbakwụnye ihe mgbaze organic dị ka ethanol nwere ike ibelata viscosity ya. Tụkwasị na nke ahụ, mgbe ejiri ya na ihe ndị ọzọ dị arọ (dị ka xanthan gum, carbomer, wdg), a pụkwara imeziwanye viscosity na nkwụsi ike nke emulsion. Ya mere, na nhazi usoro n'ezie, enwere ike ịhọrọ ihe mgbakwunye kwesịrị ekwesị dị ka ọ dị mkpa iji bulie viscosity na arụmọrụ nke emulsion.
HPMC nwere ike nweta njikwa ziri ezi nke emulsion viscosity site na usoro ihe omimi ya, itinye uche ojiji, usoro mgbasa, okpomọkụ, uru pH na mgbakwunye. N'ime ngwa bara uru, ekwesịrị ịtụle ihe ndị a n'ụzọ zuru oke iji họrọ ụdị HPMC kwesịrị ekwesị na ọnọdụ ojiji iji nweta nsonaazụ dị mma. Site n'ichepụta usoro sayensị na njikwa usoro, HPMC nwere ike ịrụ ọrụ dị mkpa n'ọhịa nke owuwu, ọgwụ, nri na kemịkalụ kwa ụbọchị, na-enye ọmarịcha arụmọrụ na ahụmịhe onye ọrụ.
Oge nzipu: Jul-17-2024