Hydroxypropyl methylcellulose (HPMC) bụ polymer vasatail nke a na-ejikarị eme ihe na usoro ọgwụ dị ka ihe nkedo, n'etiti ọrụ ndị ọzọ. Ndị na-ekekọta ihe na-arụ ọrụ dị oke mkpa n'ichepụta mbadamba ọgwụ, na-ahụ na njikọta nke ntụ ntụ n'oge mkpakọ n'ụdị usoro onunu ogwu siri ike.
1. Usoro ejikọtara:
HPMC nwere ma hydrophilic na hydrophobic Njirimara n'ihi nhazi kemịkalụ ya, nke mejupụtara methyl na hydroxypropyl otu jikọtara na cellulose azụ. N'oge mkpakọ mbadamba nkume, HPMC na-emepụta ihe nkiri na-egbuke egbuke, na-agbanwe agbanwe mgbe ekpughere ya na mmiri ma ọ bụ ihe ngwọta mmiri, si otú ahụ na-ejikọta ihe ndị ahụ ekpokọtara ọnụ. Ụdị nrapado a na-esite na ikike njikọ hydrogen nke otu hydroxyl dị na HPMC, na-eme ka mmekọrịta ya na ụmụ irighiri ihe ndị ọzọ.
2. Agglomeration urughuru:
HPMC na-enyere aka n'ichebe agglomerates site n'ịmepụta àkwà mmiri n'etiti ihe ndị dị n'otu n'otu. Dị ka mbadamba nkume granules na-abịakọrọ, HPMC ụmụ irighiri na-agbatị na interpenetrate n'etiti irighiri ihe, na-akwalite urughuru-na-irighiri ihe nrapado. Agglomeration a na-eme ka ike arụ ọrụ na iguzosi ike n'ezi ihe nke mbadamba ihe.
3. Njikwa ọnụego mgbasa:
Viscosity nke ngwọta HPMC na-emetụta ọnụego mbadamba nkume na mwepụta ọgwụ. Site n'ịhọrọ ọkwa kwesịrị ekwesị na itinye uche nke HPMC, ndị na-emepụta ihe nwere ike ịhazi profaịlụ mgbasa nke mbadamba nkume ahụ iji nweta kinetics ntọhapụ ọgwụ achọrọ. Ogo viscosity dị elu nke HPMC na-ebutekarị nhụsianya nke nta nke nta n'ihi mmụba n'ichepụta gel.
4. Nkesa Uniform:
HPMC na-enyere aka n'usoro nkesa nke ngwa ọgwụ na-arụ ọrụ (API) na ihe ndị na-enye ihe n'ime matriks mbadamba. Site n'omume njide ya, HPMC na-enyere aka igbochi ikewapụta ihe, na-ahụta nkesa otu na ọdịnaya ọgwụ na-agbanwe agbanwe na mbadamba ọ bụla.
5. Ndakọrịta na ihe ndị na-arụ ọrụ:
HPMC bụ kemịkalụ na-adịghị agwụ agwụ yana dakọtara na ụdị ọgwụ dị iche iche na-arụ ọrụ, na-eme ka ọ dabara maka ịmepụta ngwaahịa ọgwụ dị iche iche. Ọ naghị emeghachi omume na ma ọ bụ mebie ọtụtụ ọgwụ, na-echekwa nkwụsi ike na ịdị irè ya n'oge ndụ nchekwa nke mbadamba nkume ahụ.
6. Mbelata Uzuzu:
N'oge mkpakọ mbadamba, HPMC nwere ike rụọ ọrụ dị ka ihe na-egbochi uzuzu, na-ebelata ọgbọ nke irighiri ikuku. Ngwongwo a na-akwalite nchekwa onye ọrụ ma na-edobe ebe nrụpụta dị ọcha.
7. Ọzịza dabere pH:
HPMC na-egosipụta omume ọzịza na-adabere pH, ebe ntinye mmiri ya na njirimara nhazi gel dị iche na pH. Njirimara a nwere ike ịba uru maka ịmepụta ụdị usoro ọgwụgwọ a na-achịkwa nke emebere iji hapụ ọgwụ ahụ na saịtị ụfọdụ n'akụkụ eriri afọ.
8. Nnabata usoro iwu:
Ụlọ ọrụ na-achịkwa HPMC na-anabata nke ọma dị ka US Food and Drug Administration (FDA) na Ụlọ Ọrụ Ọgwụ na Europe (EMA) maka iji ọgwụ. Edepụtara ya n'ụdị pharmacopeias dị iche iche ma na-agbaso ụkpụrụ ịdị mma siri ike, na-ahụ maka nchekwa ngwaahịa na ịdị mma.
9. Mgbanwe na nhazi:
HPMC na-enye mgbanwe nhazi, n'ihi na enwere ike iji ya naanị ya ma ọ bụ jikọtara ya na ndị ọzọ na-ekekọta, ihe ndochi, na disintegrants iji nweta akụrụngwa mbadamba ihe achọrọ. Ọdịiche a na-enye ndị na-emepụta ihe aka ịhazi usoro iji gboo mkpa ịnye ọgwụ.
10. Biocompatibility na nchekwa:
HPMC bụ ihe dakọtara, anaghị egbu egbu, na anaghị egbu egbu, na-eme ka ọ dabara maka ụdị usoro onunu. Ọ na-enweta mgbasa ngwa ngwa na eriri afọ na-enweghị ịkpata iwe ma ọ bụ mmetụta ọjọọ, na-enye aka na profaịlụ nchekwa zuru oke nke mbadamba ọgwụ.
Hydroxypropyl methylcellulose na-arụ ọrụ dị ka onye na-ekekọta ọgwụ na-emepụta ọgwụ site n'ịkwalite nchikota urughuru, na-achịkwa ọnụego mgbasa, hụ na nkesa otu ihe, na inye mgbanwe nhazi, niile mgbe ị na-ejigide nchekwa na nrube isi nke usoro iwu. Ngwongwo ya pụrụ iche na-eme ka ọ bụrụ ihe dị mkpa na mmepe nke mbadamba nkume dị elu maka nnyefe ọnụ.
Oge nzipu: Mee-25-2024