Na ụlọ ọrụ ọgwụ, hypromelloseHPMC, METHOCEL ™) enwere ike iji dị ka ihe ndochi, ihe nkedo, mkpuchi mbadamba nkume polymer na ihe enyemaka igodo iji chịkwaa ntọhapụ ọgwụ. A na-eji Hypromellose mee ihe na mbadamba ihe karịrị afọ 60 ma bụrụ isi ihe dị mkpa nke ejiri mee ihe na mbadamba hydrophilic gel matrix.
Ọtụtụ ụlọ ọrụ na-emepụta ọgwụ na-eji hypromellose maka mwepụta ọgwụ a na-achịkwa, karịsịa na usoro mbadamba nkume gel matrix hydrophilic. A bịa n'ihe gbasara ngwaahịa hypromellose, ị nwere ike ịnọ na-eche ka ị ga-esi mee nhọrọ - ọkachasị ma ọ bụrụ na ị na-achọ ihe nwere-enyi na enyi ma na-adigide ahịa maka ndị ahịa gị. N'ime ntuziaka a, anyị ga-ekwu maka isi ihe ịchọrọ ịma gbasara hypromellose.
Kedu ihe bụ hypromellose?
Hypromellose, nke a makwaara dị kahydroxypropyl methylcellulose (HPMC), bụ polymer eji dị ka ọgwụ excipient iji chịkwaa ntọhapụ nke ọgwụ na ọnụ hydrophilic gel matrix mbadamba.
Hypromellose bụ ihe na-emepụta ihe na-emepụta ihe na-esi na cellulose pụta, polymer kasị ukwuu na okike. Ụfọdụ ihe ejikọtara ya gụnyere:
. soluble na mmiri oyi
. mmiri ọkụ na-esighị ike
. Nonionic
. Nhọrọ soluble na organic solvents
. Ntughari, ihe na-ekpo ọkụ gel
. Hydration na viscosity na-adabere na pH
. Surfactant
. adịghị egbu egbu
. Ire na isi dị nro
. Enzyme eguzogide
. pH (2-13) kwụsie ike
. Enwere ike iji ya dị ka thickener, emulsifier, binder, rate regulator, film mbụ
Gịnị bụ Hydrophilic Gel Matrix Tablet?
Mbadamba ụrọ hydrophilic gel matrix bụ ụdị usoro onunu ogwu nke nwere ike ijikwa mwepụta ọgwụ na mbadamba ihe ogologo oge.
Hydrophilic gel matrix mbadamba nkwadebe:
. dịtụ mfe
. Na-achọ naanị ngwa mkpakọ mbadamba nkume ọkọlọtọ
. Gbochie mkpofu ọgwụ ọgwụ
. Ike mbadamba nkume adịghị emetụta ya ma ọ bụ ike mkpakọ
. Enwere ike ịhazi ntọhapụ ọgwụ dịka ọnụọgụ nke ihe ndị na-emepụta ihe na polymer si dị
Ojiji nke hypromellose na mbadamba hydrophilic gel-matrix enwetawo nkwado nchịkwa dị ukwuu, na hypromellose dị mma iji mee ihe ma nwee ndekọ nchekwa dị mma, nke gosipụtara site n'ọtụtụ ọmụmụ. Hypromellose abụrụla nhọrọ kacha mma maka ụlọ ọrụ na-emepụta ọgwụ iji mepụta na imepụta mbadamba ihe na-adịgide adịgide.
Ihe na-emetụta mwepụta ọgwụ na mbadamba Matrix:
Mgbe ị na-emepụta mbadamba ihe agbatịpụrụ agbatị, enwere isi ihe abụọ ị ga-atụle: nhazi na nhazi. Enwekwara ihe ndị dị n'okpuru ihe ị ga-atụle mgbe ị na-achọpụta nhazi na ntọhapụ nke ngwaahịa ọgwụ ikpeazụ.
Usoro:
Isi ihe ndị a ga-atụle maka mmepe mmalite:
1. Polymer (ụdị nnọchi, viscosity, ego na urughuru nha)
2. ọgwụ ọjọọ (nha uru na solubility)
3. Bulking agents (slubility na onunu ogwu)
4. Ndị ọzọ excipients (stabilizers na buffers)
Nkà:
Ihe ndị a metụtara ka esi arụpụta ọgwụ:
1. Ụzọ mmepụta
2. Mbadamba ụrọ na Ụdị
3. Mbadamba ụrọ ike
4. gburugburu pH
5. Ihe mkpuchi ihe nkiri
Ka skeleton chips si arụ ọrụ:
Hydrophilic gel matrix mbadamba nwere ike ijikwa ntọhapụ nke ọgwụ ọjọọ site na gel oyi akwa, gụnyere usoro abụọ nke mgbasa (soluble na-arụ ọrụ ihe na-arụ ọrụ) na ozize (adịghị ike na-arụ ọrụ na-arụ ọrụ), ya mere viscosity nke polymer nwere mmetụta dị ukwuu na profaịlụ ntọhapụ. N'iji hypromellose, ụlọ ọrụ ọgwụ nwere ike iji teknụzụ mbadamba hydrophilic gel matrix iji dozie profaịlụ ntọhapụ nke ọgwụ ahụ, na-enye usoro ọgwụgwọ dị irè karị na nnabata ndị ọrịa ka mma, si otú ahụ belata ibu ọgwụ na ndị ọrịa. Ụzọ nke ịṅụ ọgwụ otu ugboro n'ụbọchị bụ n'ezie mma karịa ahụmahụ nke ịṅụ ọtụtụ mbadamba ọtụtụ ugboro n'ụbọchị.
Oge nzipu: Eprel-25-2024