Ọgwụ ọgwụ na-emepụta ọgwụ bụ ihe na-enweghị atụ na njikwa nke eji emepụta ọgwụ na ịkọpụta ọgwụ, ma dịkwa mkpa nke ọgwụ na-emepụta ọgwụ. Dị ka polymer sitere na mkpụrụ ndụ polyment nwere njirimara nke biodegrapyythythythythythythythythythythylythymthylthylthyl methyl methyl cellulose, hydroxyryl cellose,Eversgbọala CellugulDị ka hydroxyethythyth cellulose na etyl cellulose nwere uru dị mkpa na ọgwụ na-emepụta ọgwụ. Ka ọ dị ugbu a, a na-ejikarị ngwaahịa ndị kachasị elu na-ebugharị na etiti na nke dị ala nke ụlọ ọrụ, yana ọnụahịa ahụ adịghị elu. Industrylọ ọrụ ahụ kwesịrị ịgbanwe ma nweta nkwalite ma melite ngwa dị elu nke ngwaahịa.
Ọgwụ gbasara ọgwụ na-arụ ọrụ dị mkpa na mmepe na mmepụta nke usoro. Dịka ọmụmaatụ, na nhazi nke na-akwado nke polymer dị ka ọgwụ cellugul, usoro ọgwụgwọ dị iche iche, na-ejikwa ọgwụ ọjọọ na-emegharị emegharị. A na-ejikwa nkwadebe na nhazi mmiri nke a na-akwado ya. Na usoro ihe a, a na-eji polymers dịka ndị na-eme ka ndị na-ebu ọgwụ ọjọọ na-achịkwa ọnụego ọgwụ, ya bụ, a chọrọ ka ha wepụta ya na otu oge iji nweta ebumnuche nke ọgwụgwọ dị irè.
Dabere na ọnụ ọgụgụ nke nyocha na Ngalaba nyocha, enwere ihe dị ka ụdị 500 nke ndị dị na United States na European Union (karịa ụdị 3000), enwere nnukwu ọdịiche, na ụdị dị obere. Ọgwụ m nke obodo m nwere ike ịmepụta mmepe nke ahịa buru nnukwu. A na-aghota na oke ọgwụ na-eme ọgwụ na ọkwa nke obodo m bụ ọgwụ GELATIGES Gelatin, PVP, ihe nkiri glycollth (hpmc), na microcrystal eriri. Onye anaghị eri anụ, HPC, lactose.
"Mkpụrụ osisi eke" sitere n'okike nke usoro ihe omume celdrose na - eme ihe na - eme ihe dị iche iche na - eme ihe na - eme ihe. Ubi, ngwaahịa ọgwụ dị n'etiti na mpaghara dị elu nke ụlọ ọrụ na-eme ka ọ dị elu na-anọchi anya ya. Mpaghara matrik matrik, ihe eji eme ihe eji eme ihe, na-egbochi ihe eji eme ihe nkiri, na-ejikọ ihe nkiri ọgwụ na-eme ọgwụ, wdg.
Sodium Boelloxythythythythythythythythythythythylythylythylythythythythythythythythythythythythythythythythythythyth cellulose (cellulose na-enwe mmepụta na oriri na oriri na mba ọzọ. Ọ bụ ionic cellulose nke ether nke sitere na akwa na osisi site na alkalization na Ether na Elification na chloroacetic acid. CMC-na - egbu ọgwụ na - eji ọgwụ eme ihe. A na-ejikarị ya dị ka ihe mgbochi maka nkwadebe siri ike na dị ka nke na-eme mkpọtụ, na-emekwa ma na-egbochi onye nnọchi anya mmiri. Enwere ike iji ya dị ka mmiri matrik na ihe nkiri. A na-ejikarị ya dị ka ihe nkiri ọgwụ na-eme ọgwụ ma na-elekọta matrik matrik ma ọ bụ na-achịkwa ya.
Na mgbakwunye na sodium calloxythythythythythythythythythythythythythythythythythythythythythythythythy nwere ike ọgwụ, enwere ike iji sodium sodium dị ka ọgwụ na-emepụta ọgwụ. Sornoxythyythythythyythythylyyythymythylyyythylyyythylyym celloxyyl nke cell na-eme ihe na celloxym celludose na-emeghachi omume na ụfọdụ okpomọkụ (40-80 Celsilose na-emegharị na ụfọdụ okpomọkụ (40-80 ° C) n'okpuru ọrụ nke Inorganic acid na-eme ka ọ dị ọcha. Onye na-achọsi ike nwere ike ịbụ proslene glycold, suppric Arehydride, Anhydride, Adipic Ashydride, na ihe ndị yiri ya. A na-eji sodium sodium dị ka ihe na-enweghị atụ maka mbadamba, capsules na granules na nkwadebe onu. Ọ na - adabere na capillary na nsonaazụ ọzịza iji nweta nkụda mmụọ. Ọ nwere ezigbo ihe nzuzo na nkewa siri ike. Studies have shown that the swelling degree of croscarmellose sodium in water is greater than that of common disintegrants such as low-substituted sodium carboxymethyl cellulose and hydrated microcrystalline cellulose.
Methyl cellulose (mc) bụ ihe na-abụghị ionic moonose mere si owu na osisi site na alkalization na methyl chloride nke methy. Methyl cellulose nwere ezigbo mmiri solubality ma kwụsie ike na plọs nke 2.0 ruo 13.0. A na-ejikarị ya na ọgwụ na-eme ọgwụ, a na-ejikwa ya na mbadamba ọgwụ, ma na-eji intramuscular, nsị onu, mbadamba ọnụ na ntinye aka. Na mgbakwunye, na nhazi nke Mbụ, Mc Enwere ike iji Matrik Gel Matriks nke ọma, ihe eji eme ihe eji eme ihe nkiri, na-ejikwa ihe nkiri microtoped nke emechara, wdg.
Hydroxypyl Methylcelllose (HPMC) bụ agwakọta cellulose agwakọta nke akwa na osisi site na alkalization oxidene na methyl chloride. Ọ bụ pucalless, enweghị uto, na-enweghị ihe na-egbu egbu, soluble na mmiri oyi, na gels na mmiri ọkụ. Hydroxypyl Methylcellose bụ cellulose agwakọta dịgasị iche iche na-abawanye ngwa ngwa na mmepụta, oriri na mma n'ime afọ 15 gara aga. Ọ bụkwa otu n'ime ụlọ ọrụ ọgwụ kachasị ukwuu nke eji eme ihe n'ụlọ na mba ofesi. Ejirila ya dị ka ọgwụ na-emepụta ọgwụ ihe fọrọ nke nta ka ọ bụrụ afọ iri ise. Afọ nke akụkọ ihe mere eme. Ugbu a, a na-egosipụta ngwa nke HPMC na akụkụ ise ndị a:
Otu dị ka ihe mgbochi na ibelata. HPMC dị ka ihe mgbochi nwere ike ime ka ọgwụ dị mfe mmiri, ọ nwere ike ịgbasa ọtụtụ narị oge mgbe ọ ga - eme ka mgbasa ma ọ bụ wepụta mbadamba. HPMC nwere viscosity siri ike, ma nwee ike ịkwalite urughuru visot ma melite ihe ngosi nke akụrụngwa na crisp ma ọ bụ udidi. HPMC na obere viscosity nwere ike iji dị ka ihe mgbochi na ibe ya, na HPMC na HPMC nwere enwere ike iji ya dị ka ihe mkpuchi.
Nke abuo, a na-eji ya eme ihe ma na-achịkwa ya maka nkwadebe onu. HPMC bụ ihe eji eme ihe eji eme ihe na-akwado ya na nkwadebe. Enwere ike iji HPMC nke ogo viscosity (5 ~ 50MPaS) nwere ike iji ya dị ka ihe mgbochi ma na-egbochi matrix matrik maka capsules na mbadamba Gel Matriks. HPMC bụ soluble na gastrinestinal mmiri, nwere uru dị mma na-egosipụta, ezigbo mmiri, ikike ọgwụ ike na-emetụta pH nke PH. Ọ bụ ihe eji eme ihe eji eme ihe eji eme ihe na usoro nkwadebe matrik na-ejikarị njikere na-akwado-matrik na-eme ka ihe a na-eme ka ọ bụrụ nke a na-eme ka ihe a na-eme ememme.
Nke atọ bụ dịka onye na-edebe ihe nkiri na-eme ihe nkiri.Hpmcnwere ezigbo ihe ngụkọta ihe nkiri. Ihe nkiri ahụ guzobere na ya bụ otu edo edo, ma sie ike, ọ dịghịkwa mfe ịgbaso n'oge mmepụta. Karịsịa maka ọgwụ ndị dị mfe ịnabata mmiri ma na-akwụghị ụgwọ, na-eji ya dị ka oyi akwa nwere ike ime ka ihe nkiri na-agbanwe agba. HPMC nwere nkọwa dịgasị iche iche. Ọ bụrụ na ahọpụtara nke ọma, ọdịdị na ọdịdị nke mbadamba nkume dị mma karịa ihe ndị ọzọ, na ịta ya bụ 2% ruo 10%.
A na-eji anọ dị ka ihe mkpuchi. N'afọ ndị na-adịbeghị anya, ya na ntiwapụ nke anụmanụ na-efe efe nke ọma, ma e jiri ya tụnyere okpu Gelatin, osisi capsules abụrụla ihe ọhụrụ nke ọgwụ na nri ọgwụ. Pfizer enwewo hpmc nke ọma site na osisi sitere n'okike ma kwadebere versules nri. E jiri ya tụnyere ọdịnala gelatin ọdịnala, akwukwo nri nwere uru dị ukwuu nke ime mgbanwe, enweghị ihe ize ndụ nke mmeghachi omume na-enweghị isi, na nkwụsi ike dị elu. Ọnụego ntọhapụ ọgwụ dịtụ mma, yana nke ọ bụla dị obere. Mgbe ị na-enweghị ahụ ike mmadụ, ọ naghị etinye aka na ọ ga-eme ya. Excreted si ahu. N'ihe banyere ọnọdụ nchekwa, mgbe ọtụtụ ule, ọ fọrọ nke nta ka ọ ghara ịdabere n'okpuru ọnọdụ iru mmiri, yana akụrụngwa nke capsules ọdịdị dị n'okpuru ọnọdụ nchekwa dị njọ. Site na nghọta ndị mmadụ banyere capsules osisi na mgbanwe nke echiche ọgwụ ọha n'ụlọ na mba ofesi, achọrọ maka mkpụrụ osisi ga-eto ngwa ngwa.
Nke ise dị ka onye na-anọchi anya. Nkwadebe mmiri na-eme ka mmiri mmiri na-ejikarị ụdị usoro ọgwụgwọ nke na-ejikọkarị nke ọma nke ọgwụ ọjọọ nke na-akụzi ọgwụ siri ike na-agbasa. Nkwụsi ike nke usoro ahụ na-ekpebi ogo nke nkwadebe mmiri. Ngwọta HPMC nwere ike belata esemokwu nke mmiri siri ike, belata ike na-enweghị ike nke ihe ndị siri ike, ma dozie usoro mgbasa ozi nke heteoogenous. Ọ bụ onye na-ahụ maka ịnọchi anya. A na-eji HPMC dị ka nke na-agbada maka anya mmiri, yana ọdịnaya nke 0.45% ruo 1.0%.
Hydroxypropy Cellulose (HPC) bụ ihe na-abụghị nke Ionic modeute nke emere site na owu na nkụ site na alkalization oxigification. HPC na-abụkarị nke mmiri dị n'okpuru 40 ° C na nnukwu ego nke polar, na arụmọrụ ya metụtara ọdịnaya nke hydropyyl na ogo polymerizationl. HPC nwere ike dakọtara na ọgwụ dị iche iche ma nwee ezigbo ibu.
Odide Hydroposed dị ala(L-hpc)na-ejikarị dị ka mbadamba mbadamba na ihe mkpuchi. Njirimara ya bụ: Dị mfe pịa na ụdị, ntinye ike siri ike karị, na mbadamba ụrọ, tinye l -hy na-emebi emebi na mbadamba ihe ahụ, ma melite mmetụta dị iche iche.
Enwere ike iji Hydroposed Celdrosed (H-HPC) dị ka onye na-eme mkpọtụ maka mbadamba maka mbadamba, granules na ezigbo nkọcha na mpaghara ọgwụ. H-HPC nwere ezigbo ihe nkiri na-akpụ akpụ, na ihe nkiri siri ike siri ike ma sie ike iji fọdụrụnụ. Site na ịgwakọta ndị ọzọ na-egbochi ndị ọzọ, a ga-eme ka arụmọrụ nke fim ahụ ka mma, a na-ejikarị ya mee ihe nkiri maka mbadamba ihe nkiri. Enwere ike iji H-HPC mee ihe dị ka ihe matrix iji dozie mbadamba matrik, kwagide na mbadamba okpukpu abụọ okpukpu abụọ.
Hydroxyethythythythythythythythythythythythythythythythythythythy bụ na-abụghị nke cellulose moonose mere site na owu na osisi site na alkalization na ethlene oxilification. A na-ejikarị HEC mee ihe dị ka Triverner, onye na-echebe onwe gị, nrapado, ndị na-agbasa, na-egbochi onye nnọchi anya, na-ese ihe nkiri na-ewepụta ngwa ngwa na mpaghara ahụike. Enwere ike itinye ya na emulsions, mmanu mmanu, na anya ida maka ọgwụ. Mpaghara mmiri, mbadamba siri ike, capsules na ụdị onunu ogwu. Hydroxyethythythythythythythyethythythsose etinyela na US Phallopoeia / US Phaicalary na European Promacopoea.
Ethyl Cellulose (ec) bụ otu n'ime mmiri mmiri na-ejikarị mkpụrụ osisi cellivase. EC bụ ihe na-adịghị egbu egbu, kwụsie ike, na-enweghị ntụpọ na mmiri, acid ma ọ bụ ihe ngwọta, na soruble na sọks organic dị ka ethanol na methanol na methanol na methanol na methanol. Ihe mgbaze a na-ejikarị bụ ihe mgbaze nke toluene / ethanol 4/1 (ibu). A na-ejikwa ọtụtụ ndị na-eme ihe na-akwado ya, ma na-ejikwa ndị na-ebu ihe nkiri, wdg. Ndozigharị nke a na-akwado ya ma na-akwado pellets, dị ka ihe eji achọ mma iji dozie microtoses ma ọ bụrụ na microtoses; A na-ejikwa ya ebe niile dị ka ihe na-ebu ya iji kwadebe mgbasa ozi siri ike; Enwere ike iji ya na teknụzụ ọgwụ dị ka ihe nkiri na-emepụta ihe na mkpuchi mkpuchi, na ya nwekwara ike iji ya dị ka ihe mkpuchi na fild. Dị ka mkpuchi mkpuchi maka mbadamba, ọ nwere ike belata ezi uche nke mbadamba nkume ndị ahụ na iru mmiri ma gbochie ọgwụ ọjọọ ịghọ ihe na-emebi emebi ma na-emebi emebi ma na-emebi emebi ma na-emebi emebi ma na-emebi emebi ma na-akawanye njọ site na mmiri. Ọ nwekwara ike imepụta oyi gluu na-enweghị nwayọ na microcicatelarị na polymen iji wepụta mmetụta ọgwụ ahụ.
Na nchịkọta, ọnya mmiri sodinose, methyth cellulose, hydroxyyl cellulose, hydroxyyl cellulose na mmanụ na-eme ka ọ bụrụ ihe na-adịghị mma maka ihe ndị na-emepụta ọgwụ Maka nkwadebe onu, iji ihe ndi mmadu na - eme ihe nkiri, ihe okpu na ihe ndi ozo. Na-ele ụwa anya, ọtụtụ ụlọ ọrụ mba ofesi (Shin-ospa Japan, Dow Wolff na Ashland na China n'ọdịnihu, ma mụbara ọnụ ahịa ma ọ bụ na-abawanye, ha amụbawo ọnụnọ ha n'ọhịa a. Itinye ego n'ime ngwa ahụ. Dow Wolff mara ọkwa na ọ ga-abawanye na ọ ga-abawanye na usoro ọgwụgwọ, ihe ndị na-eme ka nke ọgwụ nkwadebe na-emepụta ọgwụ China, na nyocha ya ga-agbasi mbọ ike ịbịaru nso n'ahịa. The wolf Cellulose nkewa kemịkalụ na agba agba nke United States ehiwela onwe ya na nchịkwa ma na-achịkwa nkwadebe na-achịkwa ụwa niile. O nwere ndị ọrụ 1,200 na obodo iri na iteghete, 15 bara uru na ụlọ ọrụ 6 GMP. Atinyere ndị na-eme nchọpụta nyocha ọrụ na-enye ndị ahịa ọrụ ihe dị ka mba 160. Ashland nwere ntọala mmepụta na Beijing, Tianjin, Shanghai, Nanj, na Jiangmen, etinyela ego na ụlọ ọrụ nyocha teknụzụ atọ na Shanghai na Nanj.
Dabere na Statistics si websaịtị China, na 2017, mmepụta ụlọ nke cellulose ether 373,000 tọn na olu ndị ahịa bụ puku atọ. N'afọ 2017, olu ire ahịa nke IonicKmcA na-eme ka ụbọchị 234,000 dị afọ iri abụọ na puku 12.61% na afọ, na ọnụ ahịa ahịa cmc dị 126,000, mmụba nke 8.2% afọ. Na mgbakwunye na HPMC (na-ewu ụlọ) ngwaahịa na-abụghị Ionic,Hpmc(Uzo nke ọgwụ), HPMC (ọkwa ọgwụ), HPMC, HPC, MC, MC, wdg, wdg. Eutric celloucose eyer na-eto ngwa ngwa ruo ihe karịrị afọ iri, na mmepụta abụrụla nke mbụ n'ụwa. Agbanyeghị, ọtụtụ ụlọ ọrụ Ihuulose Ether Cellulose na-ejikarị n'etiti ụlọ ọrụ, yana ọnụahịa ahụ adịghị elu.
Ugbu a, ọtụtụ n'ime ụlọ ọrụ na-arịa ụlọ nke ụlọ na-agagharị na-agbanwe agbanwe na ndozigharị. Ha kwesịrị ịdị na-eme ka nyocha ngwaahịa na mgbalị iche iche, na-eme ka etolite China, na-abawanye ụba nke China, na-abawanye ike iji zụlite ahịa ndị ọzọ. Mezue mgbanwe na nkwalite, tinye etiti elu nke ụlọ ọrụ, ma nweta oke na mmepe mmepe.
Oge post: Apr-25-2024