(1) Okwu mmalite nke HPMC
Hydroxypropyl Methylcellulose (HPMC) bụ ihe dị mkpa nonionic cellulose ether nke a na-ejikarị eme ihe na ncha, ihe ụlọ, nri, ọgwụ na mpaghara ndị ọzọ. Na nchacha akwa, a na-eji HPMC eme ihe dị ka ihe nkwụsi ike iji nye nkwụsi ike nkwusioru na solubility dị mma, na-eme ka adhesion na ịsacha mmetụta nke ncha akwa. Agbanyeghị, iji nweta viscosity kacha mma nke HPMC na ncha akwa, ọ dị mkpa ka atụle ọtụtụ ihe, gụnyere ụdị, usoro onunu ogwu, ọnọdụ mgbasa, usoro mgbakwunye, wdg nke HPMC.
(2) Ihe ndị na-emetụta viscosity HPMC
1. Ụdị na ụdị nke HPMC
Arọ molekụla na ogo nke nnọchi (methoxy na hydroxypropyl nnọchi) nke HPMC na-emetụta viscosity ya na njirimara solubility ozugbo. Ụdị HPMC dị iche iche nwere ọkwa viscosity dị iche iche. Ịhọrọ ụdị HPMC dabara nke ọma maka imepụta ihe ncha akwa gị bụ isi. N'ikwu okwu n'ozuzu, HPMC dị arọ dị elu na-enye viscosities dị elu, ebe HPMC dị arọ na-enye viscosities dị ala.
2. Usoro onunu ogwu nke HPMC
Ọnụ ego nke HPMC nwere mmetụta dị ukwuu na viscosity. Dịka, a na-agbakwunye HPMC na nha n'etiti 0.5% na 2% n'ihe ncha akwa. Usoro onunu ogwu nke dị oke ala agaghị enweta mmetụta dị oke mkpa achọrọ, ebe usoro onunu ogwu nke dị oke elu nwere ike ibute nsogbu dị ka ihe isi ike na mgbasa na ngwakọta na-enweghị isi. Ya mere, usoro onunu ogwu nke HPMC kwesịrị ka edozi ya dabere na mkpa akọwapụtara na nsonaazụ nnwale iji nweta viscosity kacha mma.
3. Ọnọdụ mgbasa
Ọnọdụ mgbasa nke HPMC (okpomọkụ, uru pH, ọsọ na-akpali akpali, wdg) nwere mmetụta dị mkpa na viscosity ya:
Okpomọkụ: HPMC na-agbaze nwayọ nwayọ na obere okpomọkụ mana ọ nwere ike inye viscosities dị elu. Na-agbaze ngwa ngwa na oke okpomọkụ mana ọ nwere obere viscosity. A na-atụ aro ka igbari HPMC n'etiti 20-40 Celsius C iji hụ na nkwụsi ike ya na viscosity ya.
pH: HPMC na-arụ ọrụ kacha mma n'okpuru ọnọdụ na-anọpụ iche. Oke pH ụkpụrụ (oke acidic ma ọ bụ oke alkaline) nwere ike ibibi ihe owuwu nke HPMC ma belata viscosity ya. Ya mere, ịchịkwa uru pH nke usoro nchacha akwa n'etiti 6-8 na-enyere aka ịnọgide na-enwe nkwụsi ike na viscosity nke HPMC.
Ọsọ mkpali: Ọsọ mkpali kwesịrị ekwesị nwere ike ịkwalite mgbasa nke HPMC, mana oke mkpali nwere ike iwebata egosipụta ma na-emetụta ịdị n'otu nke ngwọta ahụ. A na-atụ aro ka iji ngwa ngwa na ọbụna na-akpalite ọsọ iji gbazee HPMC nke ọma.
4. Tinye usoro
HPMC na-etolite ngwa ngwa agglomerates na ngwọta, na-emetụta mgbasa ya na arụmọrụ viscosity. Ya mere, usoro agbakwunyere HPMC dị oke egwu:
Ịgwakọta mbụ: Gwakọta HPMC na ntụ ntụ ndị ọzọ akọrọ, wee jiri nwayọọ nwayọọ tinye ha na mmiri, nke nwere ike igbochi ịmepụta clumps ma nyere aka igbari nke ọma.
Moisturizing: Tupu ịtinye HPMC na nchacha akwa akwa, ị nwere ike ibu ụzọ mee ya na mmiri oyi dị ntakịrị, wee tinye mmiri ọkụ ka ọ gbazee. Nke a nwere ike melite mgbasa arụmọrụ na viscosity nke HPMC.
(3) Nzọụkwụ iji kwalite viscosity HPMC
1. Ụdị nhazi
Họrọ ụdị HPMC kwesịrị ekwesị na usoro onunu dabere na njedebe ojiji na ihe achọrọ nke ncha akwa. Akwa-arụmọrụ ihicha akwa akwa nwere ike ịchọ HPMC viscosity dị elu, ebe ngwaahịa nhicha izugbe nwere ike họrọ HPMC nke ọkara na obere viscosity.
2. Nnwale nnwale
Mee obere ule n'ime ụlọ nyocha iji hụ mmetụta ya na viscosity nke ncha akwa akwa site n'ịgbanwe usoro onunu ogwu, ọnọdụ mgbasa, usoro mgbakwunye, wdg nke HPMC. Dekọọ paramita na nsonaazụ nnwale ọ bụla iji chọpụta nchikota kacha mma.
3. Nhazi nhazi
Tinye usoro ntụziaka kachasị mma nke ụlọ nyocha na ọnọdụ nhazi na usoro mmepụta ma dozie ha maka mmepụta nnukwu. Gbaa mbọ hụ na nkesa na mgbasa otu nke HPMC n'oge usoro mmepụta iji zere nsogbu dị ka mkpọmkpọ na mgbasa na-adịghị mma.
4. njikwa mma
Site na usoro nnwale dị mma, dị ka nlele viscometer, nyocha nha nha, wdg, a na-enyocha arụmọrụ HPMC na ncha akwa iji hụ na ọ nwetara viscosity a tụrụ anya ya na mmetụta ojiji. Na-eme nyocha nke ọma mgbe niile ma gbanwee usoro na usoro ngwa ngwa ma ọ bụrụ na achọpụtara nsogbu.
(4) Ajụjụ a na-ajụkarị na azịza ya
1. Mgbasa na-adịghị mma nke HPMC
Ihe kpatara ya: okpomọkụ mgbasa na-ekwesịghị ekwesị, oke ọsọ ọsọ ma ọ bụ ngwa ngwa na-akpalite ọsọ ọsọ, usoro mgbakwunye na-ekwesịghị ekwesị, wdg.
Ngwọta: Gbanwee okpomoku mgbasa ka ọ bụrụ 20-40C, jiri nwayọ na ọbụna ịkpali ọsọ, wee bulie usoro mgbakwunye.
2. HPMC viscosity erughi ọkọlọtọ
Ihe kpatara ya: Ụdị HPMC ezighi ezi, usoro ọgwụgwọ ezughị oke, uru pH dị oke elu ma ọ bụ dị ala, wdg.
Ngwọta: Họrọ ụdị HPMC kwesịrị ekwesị na usoro onunu, ma jikwaa uru pH nke sistemu ịsa akwa n'etiti 6-8.
3. HPMC clump guzobere
Ihe kpatara ya: Agbakwunyere HPMC ozugbo na ngwọta, ọnọdụ mgbasa na-ezighị ezi, wdg.
Ngwọta: Jiri usoro tupu agwakọta, buru ụzọ gwakọta HPMC na ntụ nkụ ndị ọzọ, wee jiri nwayọọ nwayọọ tinye ya na mmiri ka ọ gbazee.
Iji nweta viscosity kacha mma nke HPMC na ncha akwa, ihe ndị dị ka ụdị, usoro onunu ogwu, ọnọdụ mgbasa, na usoro mgbakwunye nke HPMC kwesịrị ka echebara echiche nke ọma. Site n'ichepụta usoro sayensị, nnwale nnwale na nhazi usoro, enwere ike ịkwalite arụmọrụ viscosity nke HPMC nke ọma, si otú ahụ kwalite mmetụta ojiji yana asọmpi ahịa nke ncha akwa.
Oge nzipu: Jul-08-2024