Ịgbasa Hydroxypropyl Methylcellulose (HPMC) n'ime mmiri bụ ihe a na-emekarị na ụlọ ọrụ dị iche iche, gụnyere ọgwụ, nri, ihe ịchọ mma, na ihe owuwu. HPMC bụ ihe nrụpụta cellulose nke na-etolite ihe ngwọta na-enweghị ntụpọ, enweghị agba na viscous mgbe agwakọtara ya na mmiri. Ihe ngwọta a na-egosipụta ihe pụrụ iche dị ka ịgba, njide, imepụta ihe nkiri, na ịkwado ntọhapụ nke ihe ndị na-arụ ọrụ. The mgbasa usoro nke HPMC na mmiri na-agụnye kpọmkwem nzọụkwụ iji hụ na kwesịrị ekwesị dispersion na uniformity.
Okwu mmalite nke HPMC:
Hydroxypropyl Methylcellulose (HPMC) bụ ether cellulose na-abụghị ionic nke sitere na polymer cellulose eke. A na-emepụta ya site n'ịgwọ cellulose na propylene oxide na methyl chloride. A na-eji HPMC eme ihe n'ọtụtụ ụlọ ọrụ dị iche iche n'ihi na ọ na-emepụta ihe nkiri dị mma, na-eme ka ọ dịkwuo mma, na-eme ka ọ dịkwuo mma, na-ejidekwa mmiri. Ngwa izizi nke HPMC gụnyere:
Ọgwụ: Ejiri ya dị ka ihe nchikota, ihe nkiri mbụ, ihe ngbanwe viscosity, yana ihe ntọhapụ na-achịkwa na mbadamba, capsules, ointments, na nkwusioru.
Ụlọ ọrụ nri: A na-eji ya dị ka ihe na-agbapụta, stabilizer, emulsifier, na onye na-ejigide mmiri na ngwaahịa nri dị ka sauces, mmiri ara ehi, na ngwa esi nri.
Ihe owuwu: Na-arụ ọrụ dị ka ihe na-ejigide mmiri, nrapado, na ihe na-esi ísì ụtọ na ihe ndị dabeere na ciment, plasta nke gypsum, na ihe ntanye tile.
Nchọcha mma: Ọrụ dị ka ihe na-ekpu mmiri, ihe nkiri mbụ, na emulsion stabilizer na lotions, creams, shampoos, na ngwaahịa nlekọta onwe onye.
Usoro mgbasa nke HPMC n'ime mmiri:
Ịgbasa HPMC n'ime mmiri gụnyere ọtụtụ usoro dị mkpa iji nweta otu edozi na ngwọta kwụsiri ike:
Nhọrọ nke ọkwa HPMC: Họrọ ọkwa kwesịrị ekwesị nke HPMC dabere na viscosity achọrọ, nha urughuru na ọkwa nnọchi. Ọkwa dị iche iche na-enye ogo dị iche iche nke viscosity na njirimara solubility.
Nkwadebe nke Mmiri: Jiri mmiri dị ọcha ma ọ bụ distilled mee ihe iji dozie ngwọta. Ogo mmiri nwere ike imetụta usoro mgbasa na njirimara nke ngwọta ikpeazụ. Zere iji mmiri siri ike ma ọ bụ mmiri nwere adịghị ọcha nwere ike igbochi mgbasa.
Ị̀tụ̀tụ̀ nha na nha: Tụọ nke ọma ọnụ ọgụgụ HPMC achọrọ site na iji itule dijitalụ. Ntinye uche nke HPMC na mmiri dị iche iche dabere na ngwa ezubere. Na mkpokọta, mkpokọta sitere na 0.1% ruo 5% w / w bụ ihe a na-ahụkarị maka ọtụtụ ngwa.
Ọkpụkpụ hydration: Wụsa HPMC ahụ a tụrụ nwayọọ nwayọọ na nke ọma n'elu mmiri ahụ ka ị na-akpalite mgbe niile. Zere ịgbakwunye HPMC na nnukwu clumps iji gbochie guzobe lumps ma ọ bụ agglomerates. Hapụ HPMC ka ọ gbasa mmiri wee fesaa nke nta nke nta n'ime mmiri.
Ngwakọta na mgbakasị: Jiri ngwa agwakọta kwesịrị ekwesị dị ka magnetik stirrer, propeller igwekota, ma ọ bụ elu shiee igwekota iji kwado otu dispersion nke HPMC ahụ na mmiri. Nọgide na-enwe mkpasu iwe iji gbochie oke ụfụfụ ma ọ bụ ọnyà ikuku.
Njikwa okpomọkụ: Nyochaa ma jikwaa ọnọdụ okpomọkụ n'oge usoro mgbasa. N'ọtụtụ ọnọdụ, okpomọkụ ụlọ (20-25 Celsius) zuru ezu maka igbari HPMC. Agbanyeghị, maka mgbasa ngwa ngwa ma ọ bụ usoro akọwapụtara, enwere ike ịchọ okpomọkụ dị elu. Zere ikpo ọkụ, n'ihi na ọ nwere ike imebi polymer ma na-emetụta ihe ngwọta.
Oge mgbasa: Mgbasa zuru oke nke HPMC nwere ike were ọtụtụ awa, dabere na ọkwa, nha urughuru na oke mkpasu iwe. Gaa n'ihu na-akpalite ruo mgbe ngwọta ahụ ga-edo anya, doo anya, na enweghị ike ịhụ ahụ ma ọ bụ agglomerates.
Ndozi pH (ọ bụrụ na ọ dị mkpa): N'ụdị ụfọdụ, ngbanwe pH nwere ike ịdị mkpa iji bulie nkwụsi ike na arụmọrụ nke ngwọta HPMC. Jiri ihe nkpuchi kwesịrị ekwesị ma ọ bụ dozie pH site na iji acid ma ọ bụ ntọala dịka ihe achọrọ.
Nzacha (ọ bụrụ na achọrọ): Mgbe mgbasa zuru oke, kpochaa ngwọta HPMC site na mma ntupu ma ọ bụ akwụkwọ nzacha iji wepụ ihe ọ bụla na-agbasaghị ma ọ bụ adịghị. Nke a nzọụkwụ na-eme ka o doo anya na homogeneity nke ngwọta.
Nchekwa na nkwụsi ike: Chekwaa ngwọta HPMC akwadoro n'ime akpa dị ọcha, ikuku adịghị ahapụ ìhè anyanwụ kpọmkwem na oke okpomọkụ. Ihe ngwọta echekwara nke ọma na-adịgide ruo ogologo oge na-enweghị nnukwu mgbanwe na viscosity ma ọ bụ ihe ndị ọzọ.
Ihe na-emetụta mgbasa nke HPMC:
Ọtụtụ ihe nwere ike imetụta usoro mgbasa na njirimara nke ngwọta HPMC:
Oke urughuru na ọkwa: Finely powdered akara ule nke HPMC igbari ngwa ngwa karịa uru irighiri uru n'ihi ụba elu ebe na ngwa ngwa hydration kinetics.
Okpomọkụ: Okpomọkụ dị elu na-eme ka ọnụego mgbasa nke HPMC dịkwuo ngwa mana ọ nwekwara ike bute viscosity mfu ma ọ bụ mmebi n'ọnọdụ dị oke egwu.
Ọsọ mkpasu iwe: mkpasu iwe kwesịrị ekwesị na-eme ka a hụ mgbasa nke irighiri ihe HPMC ma na-akwalite mgbasa ngwa ngwa. Oke mkpasu iwe nwere ike iwebata afụ ikuku ma ọ bụ ụfụfụ n'ime ngwọta.
Ogo mmiri: Ogo mmiri ejiri maka mgbasa na-emetụta idoanya, nkwụsi ike, na viscosity nke ngwọta HPMC. A na-ahọrọ mmiri dị ọcha ma ọ bụ kpochapuru iji belata adịghị ọcha na ion nke nwere ike igbochi mgbasa.
pH: pH nke ngwọta nwere ike imetụta solubility na nkwụsi ike nke HPMC. Ịgbanwe pH n'ime oke kachasị maka ọkwa HPMC akọwapụtara nwere ike ịkwalite mgbasa na arụmọrụ.
Ike Ionic: Njupụta nke nnu ma ọ bụ ion dị elu na ngwọta nwere ike igbochi mgbasa HPMC ma ọ bụ mee ka ọkpụkpụ. Jiri mmiri deionized ma ọ bụ dozie ntinye nnu dị ka ọ dị mkpa.
Ndị agha Shear: Ịgwakọta ma ọ bụ nhazi ọkwa dị elu nwere ike imetụta njirimara rheological na arụmọrụ nke ngwọta HPMC, karịsịa na ngwa mmepụta ihe.
Ndụmọdụ nchọpụta nsogbu:
Ọ bụrụ na ị na-ezute ihe isi ike n'ịgbasa HPMC ma ọ bụ nwee nsogbu na ịdịmma nke ngwọta, tụlee ndụmọdụ nchọpụta nsogbu ndị a:
Mmụba mkpasu iwe: welie ngwakọta ike ma ọ bụ jiri akụrụngwa agwakọta pụrụ iche iji kwalite mgbasawanye na mgbasa nke ụmụ irighiri ihe HPMC.
Gbanwee okpomọkụ: welie ọnọdụ okpomọkụ n'ime oke akwadoro iji kwado mgbasa ngwa ngwa na-emebighị nkwụsi ike polymer.
Mbelata nha urughuru: Jiri akara kacha mma nke HPMC ma ọ bụ were usoro mbelata nha dị ka igwe igwe ma ọ bụ micronization iji melite nsonye kinetics.
Ndozi pH: Lelee pH nke ngwọta ma gbanwee dị ka ọ dị mkpa iji nọgide na-enwe ọnọdụ kachasị mma maka nkwụsi ike na nkwụsi ike HPMC.
Ogo mmiri: Gbaa mbọ hụ na ịdị ọcha na ịdị mma nke mmiri ejiri maka mgbaze site na iji nzacha ma ọ bụ ụzọ nchacha kwesịrị ekwesị.
Nnwale ndakọrịta: Mee ọmụmụ ihe ndakọrịta na ihe nhazi ndị ọzọ iji chọpụta mmekọrịta ọ bụla ma ọ bụ enweghị ndakọrịta nwere ike imetụta mgbasa.
Nyochaa ntuziaka ndị nrụpụta: Rụtụ aka na ndụmọdụ na ntuziaka onye nrụpụta maka akara ule HPMC akọwapụtara gbasara ọnọdụ mgbasa, oke ịta ahụhụ, na ndụmọdụ nsogbu.
Mgbasa Hydroxypropyl Methylcellulose (HPMC) n'ime mmiri bụ nzọụkwụ dị oke mkpa na usoro mmepụta ihe dị iche iche, gụnyere ọgwụ, nri, ihe owuwu na ihe ịchọ mma. Site n'ịgbaso usoro akwadoro ma na-atụle isi ihe dị ka urughuru size, okpomọkụ, agitation, na mmiri mma, ị nwere ike nweta a edo na kwụsiri ike HPMC ngwọta na chọrọ rheological Njirimara. Na mgbakwunye, usoro nchọpụta nsogbu na atụmatụ njikarịcha nwere ike inye aka imeri ihe ịma aka ma hụ na mgbasa nke HPMC na-aga nke ọma maka ngwa dị iche iche. Ịghọta usoro mgbasa na ya
Oge nzipu: Mar-09-2024