HPMC (hydroxpyythlthylthylthylthylthylthyllllose) bụ ihe dị iche iche na eriri na-ejikarị ya na akụrụngwa, mkpuchi, ọgwụ na nri na nri. HPMC 15 CPS pụtara na visse ya bụ CentSise 15, nke bụ ọkwa dị ala.
1. Mmụba hpmc
Wayzọ kachasị dị egwu ma dị mma iji bulie viscosict nke HPMC bụ iwelie itinye uche ya na ihe ngwọta ya. Mgbe obere nkebi nke Hpmc na-abawanye, viscosity nke ihe ngwọta ga-aba ụba. Isi nke usoro a bụ hpmc na-abawanye viscosity nke ihe ngwọta site na ịmebe usoro netwọkụ atọ. Dị ka ọnụ ọgụgụ nke Molecules Hpmc na ngwọta na-abawanye, njupụta na ike nke ihe owuwu network ga-abawanye, si otú a na-abawanye victose nke ihe ngwọta. Agbanyeghị, enwere oke iji mee ka ịta ahụ sie ike. Oke dị elu nke hpmc ga-eme ka mmiri belata, ma nwee ike imetụta arụmọrụ ya n'otu ngwa, dị ka iwu na arụ ọrụ.
2. Njikwa okpomọkụ nke ihe ngwọta
Ọnọdụ okpomọkụ nwere mmetụta dị ukwuu na solubality na vissity nke HPMC. Na obere okpomọkụ, viscosity HPMC Ngwọta dị elu; Ọ bụ ezie na oge dị elu, viscosity HPMC ga-ebelata. Ya mere, belata ọnọdụ okpomọkụ nke ihe ngwọta kwesịrị ekwesị n'oge ihe nwere ike ime ka viscosity nke HPMC. Ọ kwesịrị iburu n'uche na ngbanwe nke HPMC na ngwọta dị iche na ọnọdụ dị iche iche. Ọ na-adịkarị mfe ịgbasa mmiri oyi, mana ọ na-ewe oge ụfọdụ iji gbazee. Ọ na-akụda ngwa ngwa na mmiri ọkụ, mana viscosity dị ala.
3. Gbanwee uru nke ihe mgbaze
Viscosity nke HPMC na-enwekwa mmetụta na uru plọ uru nke ihe ngwọta. N'okpuru ọnọdụ na-anọpụ iche ma ọ bụ nke dị nso, viscosity nke HPMC Ngwọta bụ nke kachasị elu. Ọ bụrụ n 'uru ph uru nke ihe ngwọta na-emebi site na nnọpụiche, vissity nwere ike ibelata. Ya mere, viscosity nke HPMC nwere ike ịbawanye site na ịhazigharị uru nke ph uru nke ihe ngwọta (dịka ọmụmaatụ, site na ịgbakwunye ihe ndozi ma ọ bụ ịgbakwunye acorfitor ma ọ bụ acid-bas-bages). Agbanyeghị, na ịrụ ọrụ n'ezie, mgbanwe nke uru nke PH kwesịrị ịkpachara anya, n'ihi na mgbanwe dị ukwuu nwere ike ibute nrụrụ nke HPMC ma ọ bụ mmebi arụmọrụ HPMC.
4. Họrọ ihe kwesiri ekwesi
Ngalaba na viscosity nke HPMC na sistemu dị iche iche dị iche. Ọ bụ ezie na a na-ejikarị HPMC na-ejikarị ya na ngwọta, mgbakwunye nke ụfọdụ ihe mgbazinye ihe dị iche iche (dịka ethorophan, wdg) ma ọ bụ nnu dị iche iche nwere ike ịgbanwe n 'modecule nke HPMC, si otú ahụ na-emetụta viscositity. Iji maa atụ, obere ego nke ihe mgbaze organic nwere ike belata nnyonye mmiri nke molecules mmiri na HPMC, si na-abawanye victose nke ihe ngwọta. N'ime ọrụ ụfọdụ, ọ dị mkpa ịhọrọ sonye soonic osisi dị ka ngwa ahụ n'ezie.
5. Jiri oria AIDS
N'ọnọdụ ụfọdụ, enwere ike ịgbakwunye ọrịa AIDS ndị ọzọ na hpmc iji nweta mmetụta nke ịba ụba viscosity. A na-ejikarị ọrịa AIDS na-ewu ewu nke Xanthan, Guarshan chịngọm, carbomer, wdg. Dịka ọmụmaatụ, Xanthan chịm bụ polysiccharide nwere mmetụta siri ike. Mgbe ejiri HPMC, ha abụọ nwere ike itolite mmetụta siynergistic ma bulie viscosity nke usoro ahụ.
6. Gbanwee ogo nke hpmc
Ọrịa viscity HPMC nwekwara njikọ na ogo nke nhichapụ nke otu methoxy ya na ìgwè ndị otu. Ogo nke dochie anya ya na viscosity nke ngwọta. Site na ịhọrọ HPMC site na ogo dị iche iche nke ihe nnọchi, enwere ike idozigharị ihe ngwọta, enwere ike idozigharị viscosise ahụ. If a higher viscosity HPMC is required, a product with a higher methoxy content can be selected, because the higher the methoxy content, the stronger the hydrophobicity of HPMC, and the viscosity after dissolution is relatively high.
7. Gbasaa oge a na-agbasa
Oge ahụ nke HPMC agbachi ekwenye ga-emetụtakwa viocosity. Ọ bụrụ na a naghị edozi Hpmc kpamkpam, viscosity nke ihe ngwọta agaghị erute ezigbo ọnọdụ. Ya mere, n'ụzọ dabara adaba na-agbasa n'oge Hpmc na mmiri iji hụ na a na-eji mmiri hydrated kpamkpam nwere ike iwepụta viscosity viscosity nke ihe ngwọta ya. Karịsịa mgbe ị na-agbanye na okpomọkụ okpomọkụ, usoro HPMC nwere ike ịdị nwayọ, ma na-agbatị oge dị mkpa.
8. Gbanwee ọnọdụ Shire
A na-etinye viscosity nke Hpmc na a na-edobe ya n'oge eji ya. N'okpuru ọnọdụ shiee, viscosity nke HPMC ga-ebelata, mana mgbe Shear na-akwụsị, vist na-akwụsị. Maka usoro chọrọ viscosity dị ukwuu, a ga-eme ka a nwee ike belata ya, ma ọ bụ enwere ike rụọ ya n'okpuru ọnọdụ sheile ka ọ nọgide na-enwe viscosity.
9. Họrọ oke molecular
Ibu molecular nke hpmc na-emetụta viscosise ya. HPMC nwere oke molecular na-etolite nnukwu netwọki na ihe ngwọta ahụ, na-ebute viacosity dị elu. Ọ bụrụ na ịchọrọ ịbawanye viscosity nke HPMC, ị nwere ike ịhọrọ ngwaahịa HPMC na oke molecular dị elu. Ọ bụ ezie na HPMC 15 CPS bụ ngwaahịa dị ala, enwere ike ịbawanye ụba site na ịhọrọ otu molecular dị arọ nke otu ngwaahịa.
10. Tụlee ihe ndị metụtara gburugburu
Ihe gburugburu gburugburu ebe obibi dị ka iru mmiri na nrụgide nwekwara ike ime ka ụfọdụ mmetụta na viscosity nke viscy ngwọta. N'ụdị obibi elu iru mmiri, Hpmc nwere ike ịnabata mmiri site na ikuku, na-eme ka ọhụụ ya belata. Iji zere nke a, ọnọdụ gburugburu ebe obibi nke nrụpụta ma ọ bụ jiri saịtị e ji rụọ ọrụ nke ọma iji mee ka gburugburu ahụ kpọọ nkụ na arụ ọrụ kwesịrị ekwesị iji nọgide na-enwe viscosity nke HPMC.
Enwere ọtụtụ ụzọ iji bulie viscosity nke HPMC 15 CPS, gụnyere ịbawanye itinye uche, na-achịkwa phy, na-eji usoro dị mma, na-ahọrọ usoro a kapịrị ọnụ dabere na ngwa ahụ ihe nkiri na usoro achọrọ. Na ọrụ n'ezie, ọ na-adịkarị mkpa iji tụlee ọtụtụ ihe na ndozi ezi uche na ịchachasị mma iji hụ na arụmọrụ kachasị mma nke HPMC Ngwọta na ngwa.
Oge Post: Ọkt-16-2024