Hydroxypylththththththylcelllose (hpmc)A na-eji ya dị ka otu n'ime ọgwụ na-akpata ọgwụ kachasị ukwuu n'ụlọ na mba ọzọ. Enwere ike iji HPMC mee ihe nkiri na-eme ka ihe nkiri, ihe ngbanwe, onye na-edebe ihe na-akwụ ụgwọ, onye nnọchi anya nkwụchi, na-ekewa gị, wdg.
Ihe omuma nke ogwu bu ihe di nkpa nke ọgwụ ọgwụ, yana ọrụ ha na-ebugharị ọgwụ n'ụkwụ n'ụzọ na usoro a na-ewepụta n'arụ na oge ụfọdụ. Ya mere, nhọrọ nke ihe kacha mma bụ otu n'ime ihe ndị bụ isi maka mmetụta ọgwụgwọ nke ọgwụ na-akwado ọgwụ.
1 Njirimara nke HPMC
HPMC nwere ọtụtụ njirimara ndị ọzọ na-enweghị atụ enweghị. Ọ nwere ezigbo mmiri na mmiri oyi. Ọ bụrụhaala na a na-agbakwunye ya n'ime mmiri oyi ma kpalie ntakịrị, ọ nwere ike igbari ngwọta. Kama nke ahụ, ọ bụ n'ụzọ na-egbochi mmiri ọkụ dị n'elu 60e ma nwee ike igbari. Ọ bụ nke na-abụghị ionic ewer, azịza ya enweghị ụgwọ ionic na-akwụ, ma ọ bụ ihe eji eme ihe, iji hụ na hpmc anaghị emeghachi omume ndị ọzọ na usoro nkwalite. Site na mgbochi siri ike, yana mmụba nke ogo nke ihe eji edochi anya, na-emekwa ka ọgwụ ndị ọzọ mee ka ọ bụrụ, na-eji HPMC, DEXTIN, ọgwụ ntụ), Ogo nke oge dị irè na-akwụsi ike karịa. O nwere metabolic intia. Dị ka ihe a na-eme ka ọgwụ inyeaka, ọ nweghị ike ịmịkọrọ ma ọ bụ na-etinye ya, yabụ na ọ naghị enye calorie na ọgwụ na nri. O nwere ngwa puru iche maka uru kalori di ala, nnu na nri nnu na nri achoghi nke ndi mmadu n'agbanyeghi. HPMC bụ ihe kwụsiri ike na acid na alkali, mana ọ ga-agafe ph2 ~ 11 ma oge nchekwa dị ogologo, a ga-ebe nchekwa viscosis. Ngwọta osisi na-enye ọrụ dị elu ma na-enye oke esemokwu na ọnọdụ nkwuwa okwu. Ọ nwere emulsification na usoro abụọ na usoro ihe abụọ ma nwee ike iji ya dị ka colroid dị irè. Ngwọta osisi nwere ezigbo ihe nkiri akpụ akpụ ma bụrụ ezigbo mkpuchi maka mbadamba ụrọ na ọgwụ. Ihe nkiri a na-acha odo odo na siri ike. Enwere ike ịbawanye plastimity ya site na ịgbakwunye Glyceol.
2.Application nke hpmc na emepụta mbadamba
2.1 Ka mma
Iji ngwọta othanol ethanol ma ọ bụ ihe ọ bụla dị ka ihe dị ka onye na-ahụ maka iwesasị, maka imezigharị mbadamba, ma gbanye n'ime ihe ndị ahụ dị mma, ma na-arị mma. Solubligine nke renimodipine: solubalition nke nrapado bụ 17.34% mgbe ihe ngwọta bụ 40% 10% Starch Pulp, 3% HPMC Ngwọta, 5% HPMC Ngwọta, n'otu n'otu. 30.84%, 75.46%, 84.5%, 88%. Afakwa ọnụego nke mbadamba ụrọ a na-agbada: Mgbe ihe nrapado bụ 12% ethanol, 1% hpmc (40% hpmc (40% hpmc (40% hpmc (40%) Ethanol (40%) , 86.23%, 90.45%, 99.88%, n'otu n'otu. Onu ogugu cimetidine: Mgbe ihe nrapado bu 10% starch slurry na 3%) Ethanol (40) Ngwọta bu 76.2% na 97.54%, n'otu n'otu.
Site na data dị n'elu, enwere ike ịhụ na ngwọta ethanol na ngwọta nke HPMC nwere mmetụta nke imezi ọgwụ nke ọgwụ, nke bụ nsonaazụ nke nkwusioru nke HPMC, belata esemokwu dị n'etiti ngwọta na Ọgwụ siri ike, na-abawanye mmiri, nke na-eme ka mgbasa nke ọgwụ ọjọọ.
2.2 Meziwanye ogo nke mkpuchi
HPMC dị ka ihe nkiri na-akpụ akpụ, ma e jiri ya tụnyere ihe nkiri ndị ọzọ (acrylic resin, polyethylene pyrrolidone), ọ dịghị uru ọfụma, ọ dịghị ọrụ na-emegharị ahụ, ọ ga-adị mma. NaHpmcnwere nkọwa dịgasị iche iche dị iche iche, nhọrọ kwesịrị ekwesị, mkpuchi dị mma karịa ihe ndị ọzọ. Ndị mbadamba cidrofloxloxacin hydrochloride bụ akwụkwọ ozi doro anya na mkpụrụedemede abụọ. Ọgwụ ndị a dị mkpa maka mkpuchi ihe nkiri siri ike, site na nnwale nke ihe nkiri 50, ọ ga-ebelata nrụgide nke mmiri / ọsụsọ 0, 0, oroma Bee / permeability mmanụ, 0 / mgbape, dị ka nnukwu nsogbu, ezigbo ngbasa mmiri, ma weta ya nke ọma, nke nwere ike, mara mma. E jiri ya tụnyere mmiri mkpuchi ọdịnala, ọgwụ a dị mfe ma nwee ezi uche, na-ebelata ego ahụ nke ukwuu.
Oge post: Apr-25-2024