Hydroxypropyl methylcellulose (HPMC)a na-eji dị ka otu n'ime ndị kasị ibu ọgwụ excipients n'ụlọ na ná mba ọzọ. Enwere ike iji HPMC dị ka onye na-emepụta ihe nkiri, ihe nrapado, onye ntọhapụ na-adịgide adịgide, onye nnọchi anya nkwusioru, emulsifier, onye na-emebi emebi, wdg.
Ihe ndị na-emepụta ọgwụ bụ akụkụ dị mkpa nke nkwadebe ọgwụ, ọrụ ha bụ ịhụ na a na-ahọrọ ọgwụ na-ebuga na anụ ahụ n'ụzọ ụfọdụ na usoro, nke mere na a na-ewepụta ọgwụ n'ime ahụ n'otu oge na oge. Ya mere, nhọrọ nke ihe mgbakwunye kwesịrị ekwesị bụ otu n'ime isi ihe maka mmetụta ọgwụgwọ nke nkwadebe ọgwụ.
1 Njirimara nke HPMC
HPMC nwere ọtụtụ njirimara nke ndị ọzọ excipients enweghị. Ọ nwere ezigbo mmiri solubility na mmiri oyi. Ọ bụrụhaala na a na-agbakwunye ya na mmiri oyi ma kpalie ya ntakịrị, ọ nwere ike igbari n'ime ngwọta na-egbuke egbuke. N'ụzọ megidere nke ahụ, ọ bụ isi ihe na-adịghị ike na mmiri ọkụ n'elu 60E ma nwee ike igbari. Bụ ihe na-abụghị ionic cellulose ether, ngwọta ya enweghị ionic ụgwọ, na metal salts ma ọ bụ ionic organic ogige, nke mere na HPMC adịghị emeghachi omume na ndị ọzọ akụrụngwa na nkwadebe mmepụta usoro. Na ike mgbochi uche, na na-abawanye nke molekụla Ọdịdị nke ogo nke nnọchi, mgbochi uche na-emeziwanye, na-eji HPMC dị ka adjuvant ọgwụ, ikwu na ojiji nke ndị ọzọ omenala adjuvants (starch, dextrin, sugar ntụ ntụ) ọgwụ. àgwà nke oge dị irè na-esikwu ike. Ọ nwere mmetụta metabolic inertia. Dị ka ihe enyemaka ọgwụ, ọ nweghị ike ịmegharị ma ọ bụ tinye uche ya, ya mere ọ naghị enye calorie na ọgwụ na nri. Ọ nwere ngwa pụrụ iche maka uru calorific dị ala, ọgwụ na-enweghị nnu na nke anaghị eri anụ na nri ndị nwere ọrịa shuga chọrọ. HPMC kwụsiri ike na acid na alkali, mana ọ bụrụ na ọ gafere pH2 ~ 11 ma tinye ya na okpomọkụ dị elu ma ọ bụ oge nchekwa dị ogologo, viscosity ga-ebelata. Aqueous ngwọta na-enye ọrụ elu ma na-egosi esemokwu elu na-agafeghị oke na ụkpụrụ esemokwu interfacial. Ọ nwere emulsification dị irè na usoro nke abụọ ma nwee ike iji ya dị ka stabilizer dị irè na colloid nchebe. Aqueous ngwọta nwere magburu onwe film akpụ Njirimara na bụ ezigbo mkpuchi ihe maka mbadamba nkume na ọgwụ. Ihe nkiri a na-emepụta site na ya enweghị agba ma sie ike. Enwere ike ịbawanye plasticity ya site na ịgbakwunye glycerol.
2.Ngwa nke HPMC na mmepụta mbadamba
2.1 Melite mgbasa
Iji HPMC ethanol ngwọta ma ọ bụ aqueous ngwọta dị ka wetting gị n'ụlọnga maka granulation, maka imeziwanye mgbasa nke mbadamba nkume, mmetụta dị ịrịba ama, na enwe n'ime film ekweghị ekwe ka mma, ọdịdị ire ụtọ. Solubility nke mbadamba nkume Renimodipine: solubility nke nrapado bụ 17.34% na 28.84% mgbe nrapado bụ 40% ethanol, 5% polyvinylpyrrolidone (40%) ethanol ngwọta, 1% sodium dodecyl sulfate (40%) ethanol ngwọta, 3% HPMC gbazere. 10% starch pulp, 3% HPMC ngwọta, 5% HPMC ngwọta, n'otu n'otu. 30.84%, 75.46%, 84.5%, 88%. Ọnụego mgbasa nke mbadamba nkume piperic acid: mgbe nrapado bụ 12% ethanol, 1% HPMC (40%) ethanol ngwọta, 2% HPMC (40%) ngwọta ethanol, 3% HPMC (40%) ethanol ngwọta, ọnụego mgbasa bụ 80.94% , 86.23%, 90.45%, 99.88%, otu. Ọnụego mgbasa nke mbadamba Cimetidine: mgbe nrapado bụ 10% starch slurry na 3% HPMC (40%) ethanol ngwọta, ọnụego mgbasa bụ 76.2% na 97.54%, n'otu n'otu.
Site n'elu data, ọ pụrụ hụrụ na THE ethanol ngwọta na aqueous ngwọta nke HPMC nwere mmetụta nke melite mgbasa nke ọgwụ ọjọọ eme ihe, nke bụ tumadi n'ihi nkwusioru na elu ọrụ nke HPMC, mbenata elu esemokwu n'etiti ngwọta na. ọgwụ siri ike, na-amụba mmiri mmiri, nke na-eme ka mgbasa nke ọgwụ.
2.2 Meziwanye mma mkpuchi
HPMC dị ka a film akpụ ihe, tụnyere ndị ọzọ film akpụ ihe (acrylic resin, polyethylene pyrrolidone), nnukwu uru bụ ya mmiri solubility, adịghị mkpa organic solvents, mma ọrụ, adaba. NaHPMCnwere nkọwa dị iche iche nke viscosity, nhọrọ kwesịrị ekwesị, mkpuchi mkpuchi ihe nkiri, ọdịdị dị mma karịa ihe ndị ọzọ. Mbadamba ụrọ Ciprofloxacin hydrochloride bụ mbadamba ọcha dị larịị nwere mkpụrụedemede nwere akụkụ abụọ. Ọgwụ ndị a maka mkpuchi ihe nkiri dị gịrịgịrị siri ike, site na nnwale ahụ, na-ahọrọ viscosity nke 50mpa # s nke plasticizer mmiri-soluble, nwere ike belata nrụgide nke ime ihe nkiri dị mkpa, mbadamba mkpuchi na-enweghị akwa / ọsụsọ 0, 0, 0, 0 / oroma. peel / permeability mmanụ, 0 / mgbape, dị ka àgwà nsogbu, mkpuchi mmiri mmiri film akpụ, ezi adhesion, na-eweta okwu ọnụ na-enweghị leakage, legible, Otu-akụkụ na-egbuke egbuke, mara mma. E jiri ya tụnyere mmiri mmiri mkpuchi ọdịnala, ndenye ọgwụ a dị mfe na ezi uche, na ọnụ ahịa na-ebelata nke ukwuu.
Oge nzipu: Eprel-25-2024