Hydroxypropyl methyl cellulose dị ka ihe mgbakwunye ọgwụ

Hydroxypropyl methyl cellulose (HPMC)bụ a vasatail pharmaceutical excipient ọtụtụ ebe na-eji dị iche iche onunu ogwu ụdị n'ihi na ya pụrụ iche Njirimara. Mwepụta cellulose a sitere na cellulose, polymer na-emekarị nke a na-ahụ na osisi, ma gbanwee site na mmeghachi omume kemịkal iji nweta àgwà ndị a chọrọ. N'ime usoro ọgwụ, HPMC na-arụ ọtụtụ ọrụ, gụnyere ihe nrụnye, ihe nkiri mbụ, thickener, stabilizer, na onye na-ahapụ ya. Ngwa ya zuru ebe niile yana mkpa dị na ụlọ ọrụ ọgwụ na-enye ikike nghọta zuru oke nke akụrụngwa, ngwa na uru ya.

Ngwongwo solubility na viscosity HPMC na-eme ka ọ bụrụ nhọrọ magburu onwe ya maka ịchịkwa mwepụta ọgwụ n'ụdị usoro onunu siri ike. Ọ na-etolite matrix gel n'elu hydration, nke nwere ike ịkwụsị ịhapụ ọgwụ site na mgbasa site na oyi akwa gel fụrụ akpụ. Viscosity nke gel na-adabere n'ihe ndị dị ka ịdị arọ molekụla, ogo ngbanwe, na ntinye nke HPMC na nhazi. Site n'ịgbanwe paramita ndị a, ndị ọkà mmụta sayensị na-emepụta ọgwụ nwere ike ịhazi profaịlụ ntọhapụ ọgwụ iji nweta nsonaazụ ọgwụgwọ achọrọ, dị ka ntọhapụ ozugbo, ntọhapụ na-adịgide adịgide, ma ọ bụ ntọhapụ a na-achịkwa.

A na-ejikarị HPMC eme ihe dị ka ihe nchikota n'ụdị mbadamba iji nye ịdị n'otu ma melite ike ọrụ nke mbadamba nkume. Dị ka ihe na-ekekọta, ọ na-akwalite nchikota urughuru na nhazi granule n'oge usoro mkpakọ mbadamba, na-ebute mbadamba nkume nwere otu ọdịnaya ọgwụ na profaịlụ mgbasa ozi na-agbanwe agbanwe. Ọzọkwa, ihe ndị na-emepụta ihe nkiri HPMC na-eme ka ọ dị mma maka mbadamba mkpuchi mkpuchi, nke na-eje ozi dị iche iche dịka nkpuchi uto, nchebe mmiri, na ntọhapụ ọgwụ gbanwere.

Na mgbakwunye na ụdị ọgwụgwọ ọnụ siri ike, HPMC na-achọta ngwa na usoro ọgwụ ndị ọzọ, gụnyere ngwọta anya, gels topical, patches transdermal, na injectables na-achịkwa. Na ngwọta anya, HPMC na-arụ ọrụ dị ka onye na-eme ka viscosity dịkwuo mma, na-eme ka oge obibi nke nhazi ahụ dị n'elu anya ma na-eme ka mmịpụta ọgwụ dịkwuo mma. N'ime gels dị n'elu, ọ na-enye njikwa rheological, na-enye ohere maka ngwa ngwa dị mfe na mmụba akpụkpọ anụ nke ihe ndị na-arụ ọrụ.

HPMCPatches transdermal dabeere na-enye usoro nnyefe ọgwụ dị mma na nke na-adịghị emerụ ahụ maka usoro ọgwụgwọ ma ọ bụ mpaghara mpaghara. Matrix polymer na-achịkwa mwepụta ọgwụ site na akpụkpọ ahụ ruo ogologo oge, na-ejigide ọkwa ọgwụgwọ ọgwụgwọ n'ime ọbara ma na-ebelata mgbanwe mgbanwe. Nke a bara uru karịsịa maka ọgwụ ndị nwere windo ọgwụgwọ dị warara ma ọ bụ ndị chọrọ nlekọta na-aga n'ihu.

Ihe ndakọrịta na enweghị ike nke HPMC na-eme ka ọ dabara maka ojiji na usoro parenteral dị ka onye na-akwụsịtụ ma ọ bụ ihe mgbanwe viscosity. N'ime injectables a na-ejikwa achịkwa, microspheres HPMC ma ọ bụ nanoparticles nwere ike itinye mkpụrụ ndụ ọgwụ, na-enye ntọhapụ na-adịgide adịgide ruo ogologo oge, si otú a na-ebelata ugboro ole dose na imeziwanye nnabata onye ọrịa.

HPMC na-egosipụta njirimara mucoadhesive, na-eme ka ọ baa uru na usoro emebere maka nnyefe ọgwụ mucosal, dị ka ihe nkiri buccal na imi imi. Site na ịrapagidesi ike na elu mucosal, HPMC na-agbatị oge obibi ọgwụ, na-enye ohere maka mmụba ọgwụ na bioavailability.

A na-amatakarị HPMC dị ka nchekwa (GRAS) site n'aka ndị na-ahụ maka nchịkwa dịka US Food and Drug Administration (FDA), na-eme ka ọ dabara maka ojiji na usoro ọgwụ echere maka oriri mmadụ. Ọdịdị biodegradability ya na ọdịdị na-adịghị egbu egbu na-enye aka na mmasị ya dị ka ihe na-emepụta ọgwụ.

Hydroxypropyl methyl cellulose (HPMC)bụ ihe pụrụ iche ọgwụ excipient nwere ngwa dị iche iche n'ofe dị iche iche usoro onunu ogwu. Ngwongwo ya pụrụ iche, gụnyere solubility, viscosity, ikike imepụta ihe nkiri, na ihe ndị dị ndụ, na-eme ka ọ bụrụ ihe dị mkpa na nhazi ọgwụ iji nweta ebumnuche ọgwụgwọ akọwapụtara. Ka nyocha ọgwụ na-aga n'ihu na-etolite, HPMC nwere ike ịnọgide na-abụ ihe mkpali na mmepe nke sistemụ nnyefe ọgwụ na usoro.