Hydroxypropyl Methylcellulose (HPMC) bụ polymer vasatail nke a na-ejikarị eme ihe na ụlọ ọrụ sitere na ọgwụ na-ewu ụlọ n'ihi ihe pụrụ iche ya. Ọ bụ ihe sitere na cellulose, nke nwere otu hydroxyl nke methoxy na hydroxypropyl nọchiri anya ya, na-eme ka ike ya dị na mmiri na ụfọdụ ihe mgbaze.
Njirimara solubility nke HPMC
1. Mmiri Solubility
HPMC na-abụkarị mmiri-soluble. A na-emetụta solubility ya na mmiri site n'ọtụtụ ihe:
Okpomọkụ: HPMC na-agbaze na mmiri oyi ma ọ bụ nke ime ụlọ. N'elu ikpo ọkụ, HPMC nwere ike ịmepụta gel; na jụrụ oyi, gel na-agbaze ọzọ, na-eme ka ọ gbanwee. Gelation thermal a bara uru na ngwa dị ka mwepụta ọgwụ a na-achịkwa na ọgwụ.
Ntinye uche: Nleta dị ala (0.5-2%) na-agbaze ngwa ngwa. Ọnụ ọgụgụ dị elu (ruo 10%) nwere ike ịchọ mkpali na oge.
pH: HPMC ngwọta kwụsiri ike gafee a mbara pH nso (3-11), na-eme ka ha vasatail dị iche iche formulations.
2. Organic mgbaze
Ọ bụ ezie na isi mmiri soluble, HPMC nwekwara ike igbari na ụfọdụ organic mgbaze, karịsịa ndị nwere ụfọdụ larịị nke pola àgwà. Ndị a gụnyere:
Mmanya: HPMC na-egosi ezigbo solubility na obere mmanya dị ka methanol, ethanol, na isopropanol. Alcohols dị elu anaghị adị irè n'ihi ụdọ hydrophobic ha dị ogologo.
Glycols: Propylene glycol na polyethylene glycol (PEG) nwere ike igbari HPMC. A na-ejikarị ihe mgbaze ndị a na-ejikọta ya na mmiri ma ọ bụ mmanya na-eme ka ọ dịkwuo mma na nkwụsi ike ngwọta.
Ketones: Ụfọdụ ketone dị ka acetone na methyl ethyl ketone nwere ike igbari HPMC, ọkachasị mgbe agwakọtara ya na mmiri.
3. Ngwakọta
Enwere ike igbari HPMC na ngwakọta ihe mgbaze. Dịka ọmụmaatụ, ijikọta mmiri na mmanya ma ọ bụ glycols nwere ike ime ka ọ dịkwuo mfe. Mmekọrịta dị n'etiti ihe mgbaze nwere ike wedata mkpokọta achọrọ nke otu ihe mgbaze ọ bụla, na-ebuli mgbasa.
Usoro mgbasa
Mgbasa nke HPMC na ihe mgbaze na-agụnye imebi ike intermolecular n'etiti agbụ HPMC na ịmepụta mmekọrịta ọhụrụ na ụmụ irighiri ihe. Ihe na-emetụta usoro a gụnyere:
Hydrogen bonding: HPMC na-emepụta njikọ hydrogen na mmiri na ihe mgbaze ndị ọzọ, na-eme ka ọ dị mfe.
Mmekọrịta polymer-solvent: Ikike nke ụmụ irighiri ihe mgbaze ịbanye na imekọ ihe na agbụ HPMC na-emetụta nrụpụta mgbasa.
Mechanical Agitation: ịkpali na-enyere aka n'ịkwalite mkpokọta ma na-akwalite mgbasa otu.
Atụmatụ bara uru maka igbari HPMC
1. Usoro mgbasa
Maka mgbasa nke ọma, soro usoro ndị a:
Mgbakwunye nke nta nke nta: Jiri nwayọọ tinye HPMC na ihe mgbaze na-akpali akpali mgbe niile ka ịzenarị ịchịkọta.
Njikwa okpomọkụ: Gbasaa HPMC n'ime mmiri oyi iji zere gelation akabeghị aka. Maka ụfọdụ ihe mgbaze organic, obere ikpo ọkụ nwere ike inye aka.
Ngwakọta usoro: Jiri n'ibu stirrers ma ọ bụ homogenizers maka ịrụ ọrụ nke ọma Ịgwakọta, karịsịa na elu ịta.
2. Ntinye uche na viscosity
Ntinye uche nke HPMC na-emetụta viscosity nke ngwọta:
Ntụkwasị obi dị ala: Nsonaazụ na ngwọta viscosity dị ala, dabara maka ngwa dị ka mkpuchi ma ọ bụ ihe nkedo.
Ntụkwasị obi dị elu: Na-emepụta ngwọta viscosity dị elu ma ọ bụ gel, bara uru na usoro ọgwụ maka ntọhapụ a na-achịkwa.
3. Ndakọrịta
Mgbe ị na-eji HPMC na usoro, hụ na ndakọrịta na ihe ndị ọzọ:
PH Stability: Nyochaa na akụrụngwa ndị ọzọ anaghị agbanwe pH gafere oke kwụsiri ike maka HPMC.
Mmetụta okpomọkụ: Tụlee akụrụngwa gelation thermal mgbe ị na-emepụta usoro metụtara mgbanwe okpomọkụ.
Ngwa nke HPMC Solutions
A na-eji ngwọta HPMC arụ ọrụ n'ofe ụlọ ọrụ dị iche iche n'ihi ihe ha pụrụ iche:
1. Ọgwụ ọgwụ
HPMC na-arụ ọrụ dị ka onye na-ekekọta, ihe nkiri mbụ, yana onye nnọchite ntọhapụ a na-achịkwa:
Mbadamba ụrọ na Capsules: Ihe ngwọta HPMC na-enyere aka n'ijikọta ihe ndị na-emepụta ihe na ịmepụta ihe nkiri maka mwepụta ọgwụ a na-achịkwa.
Gels: A na-eji ya eme ihe n'ụdị usoro maka ịgbatị ya na ihe na-eme ka ọ dị ike.
2. Ụlọ ọrụ nri
Dị ka ihe mgbakwunye nri, a na-eji HPMC eme ka ọ kwụsie ike na ihe emulsifying:
Thickers: Na-akwalite udidi na nkwụsi ike na sauces na uwe.
Nhazi ihe nkiri: Na-emepụta ihe nkiri oriri maka mkpuchi na mkpuchi.
3. Mwube
Ihe ngwọta HPMC na-akwalite njirimara nke ihe owuwu:
Simenti na Mortar: A na-eji ya dị ka ihe na-agbapụta mmiri na ihe na-ejigide mmiri na ngwaahịa ndị sitere na ciment.
Agba na mkpuchi: Na-enye njikwa rheological na nkwụsi ike na agba.
Usoro mgbasa ozi dị elu
1. Ultrasonication
Iji ultrasonic ebili mmiri na igbari HPMC nwere ike welie mgbasa ọnụego na arụmọrụ site n'ịkụda irighiri ihe na-akwalite edo dispersion.
2. Akwa-Shear Ịgwakọta
Ndị na-agwakọta ihe dị elu na-enye ngwakọta kpụ ọkụ n'ọnụ, na-ebelata oge mgbasa ma na-eme ka homogeneity dịkwuo mma, karịsịa na nhazi viscosity dị elu.
Ihe gbasara gburugburu na nchekwa
1. Biodegradable
HPMC bụ ihe na-emebi emebi, na-eme ka ọ bụrụ enyi na gburugburu ebe obibi. Ọ na-agbada n'ime ihe okike, na-ebelata mmetụta gburugburu ebe obibi.
2. Nchekwa
HPMC anaghị egbu egbu ma dịkwa mma maka ojiji na nri, ọgwụ na ihe ntecha. Agbanyeghị, ekwesịrị inyocha mpempe akwụkwọ nchekwa nchekwa (SDS) maka njikwa na ntuziaka nchekwa.
Ịgbasa HPMC nke ọma chọrọ ịghọta njirimara solubility ya yana mmekọrịta ya na ihe mgbaze dị iche iche. Mmiri ka bụ isi ihe mgbaze, ebe alcohols, glycols, na ihe mgbaze na-enye ihe ngwọta ọzọ maka ngwa ngwa. Usoro kwesịrị ekwesị na nleba anya na-eme ka mgbasa nke ọma, na-eme ka ojiji HPMC na-eme ihe n'ofe ụlọ ọrụ.
Oge nzipu: Jun-14-2024