Nkà na ụzụ okpomọkụ nke hydroxypropyl methylcellulose (HPMC)

Hydroxypropyl Methyl Cellulose (HPMC) bụ ihe na-abụghị ionic cellulose ether nke a na-ejikarị eme ihe na-ewu, ọgwụ, nri, mkpuchi na ụlọ ọrụ ndị ọzọ. Njirimara anụ ahụ na kemịkal pụrụ iche na-enye ya nkwụsi ike dị mma na arụ ọrụ na gburugburu ebe okpomọkụ dị elu. Site na mmụba na-arịwanye elu maka ngwa okpomọkụ dị elu, nnukwu nguzogide okpomọkụ na teknụzụ mgbanwe nke HPMC ejirila nwayọọ nwayọọ ghọọ ebe nyocha.

1. Ihe ndị bụ isi nke HPMC

HPMC nwere mma mmiri solubility, ndim, ihe nkiri-akpụ, emulsifying, kwụsie ike na biocompatibility. N'okpuru ọnọdụ okpomọkụ dị elu, a ga-emetụta solubility, omume gelation na rheological Njirimara nke HPMC, ya mere njikarịcha nkà na ụzụ dị elu dị mkpa maka ngwa ya.

2. Isi njirimara nke HPMC n'okpuru ọnọdụ okpomọkụ dị elu

Thermal gelation

HPMC na-egosipụta ihe pụrụ iche na-ekpo ọkụ na gburugburu ebe okpomọkụ dị elu. Mgbe okpomọkụ na-ebili n'ókè ụfọdụ, viscosity nke ngwọta HPMC ga-ebelata na gelation ga-eme na ụfọdụ okpomọkụ. Njirimara a dị mkpa karịsịa n'ihe eji arụ ụlọ (dịka ngwa ngwa ciment, ngwa ngwa na-edozi onwe ya) na ụlọ ọrụ nri. Dịka ọmụmaatụ, na gburugburu ebe okpomọkụ dị elu, HPMC nwere ike inye njide mmiri ka mma ma weghachite mmiri mmiri mgbe ọ jụrụ.

Nkwụsi ike dị elu nke okpomọkụ

HPMC nwere ezigbo nkwụsi ike nke okpomọkụ na ọ dịghị mfe ire ere ma ọ bụ denature na okpomọkụ dị elu. N'ikwu okwu n'ozuzu, nkwụsi ike okpomọkụ ya metụtara ogo ngbanwe na ogo nke polymerization. Site na mgbanwe kemịkalụ kpọmkwem ma ọ bụ njikarịcha nhazi, enwere ike imeziwanye nguzogide okpomọkụ ya ka o wee nwee ike ịnọgide na-enwe ezigbo akụrụngwa rheological na arụ ọrụ na gburugburu okpomọkụ dị elu.

Nguzogide nnu na nguzogide alkali

Na elu okpomọkụ gburugburu, HPMC nwere ezi ndidi acid, alkalis na electrolytes, karịsịa ike alkali eguzogide, nke na-enyere ya n'ụzọ dị irè melite ewu arụmọrụ na ciment dabeere ihe na-anọgide na-adịgide adịgide n'oge ogologo oge ojiji.

Njide mmiri

Igwe mmiri ọkụ dị elu nke HPMC bụ ihe dị mkpa maka ngwa ngwa ya na ụlọ ọrụ ihe owuwu. Na elu okpomọkụ ma ọ bụ akọrọ gburugburu, HPMC nwere ike n'ụzọ dị irè ibelata mmiri evaporation, na-egbu oge simenti hydration mmeghachi omume, ma melite operability, si otú ibelata ọgbọ nke cracks na imeziwanye àgwà nke ikpeazụ ngwaahịa.

Ọrụ elu na mgbasa

N'okpuru elu okpomọkụ gburugburu ebe obibi, HPMC ka nwere ike ịnọgide na-enwe ezi emulsification na dispersibility, stabilize usoro, na-ọtụtụ-eji na coatings, ágbá, ụlọ ihe, nri na ndị ọzọ ubi.

3. HPMC teknụzụ mgbanwe okpomọkụ dị elu

Na nzaghachi mkpa ngwa okpomọkụ dị elu, ndị nchọpụta na ụlọ ọrụ emepụtala teknụzụ mgbanwe HPMC dị iche iche iji meziwanye nguzogide okpomọkụ ya na nkwụsi ike ọrụ. Nke kachasị gụnyere:

Na-abawanye ogo nke nnọchi

Ogo nke nnọchi (DS) na molar nnọchi (MS) nke HPMC nwere mmetụta dị ukwuu na nguzogide okpomọkụ ya. Site n'ịbawanye ogo nke nnọchi nke hydroxypropyl ma ọ bụ methoxy, enwere ike ibelata okpomọkụ ya nke ọma na nkwụsi ike okpomọkụ ya dị elu.

Mgbanwe nke copolymerization

Copolymerization na ndị ọzọ polymers, dị ka compounding ma ọ bụ ngwakọta na polyvinyl mmanya (PVA), polyacrylic acid (PAA), wdg, nwere ike melite okpomọkụ iguzogide HPMC na-ezi ọrụ Njirimara n'okpuru elu okpomọkụ gburugburu.

Mgbanwe na-ejikọta ọnụ

Enwere ike imeziwanye nkwụsi ike nke okpomọkụ nke HPMC site na njikọ njikọ kemikal ma ọ bụ njikọ anụ ahụ, na-eme ka arụmọrụ ya kwụsie ike n'okpuru ọnọdụ okpomọkụ dị elu. Dị ka ọmụmaatụ, iji silicone ma ọ bụ polyurethane mgbanwe nwere ike melite okpomọkụ iguzogide na n'ibu ike nke HPMC.

Mgbanwe Nanocomposite

N'afọ ndị na-adịbeghị anya, mgbakwunye nanomaterials, dị ka nano-silicon dioxide (SiO₂) na nano-cellulose, nwere ike n'ụzọ dị irè welie okpomọkụ iguzogide na n'ibu Njirimara nke HPMC, nke mere na ọ ka nwere ike ịnọgide na-enwe ezi rheological Njirimara n'okpuru elu okpomọkụ gburugburu ebe obibi.

4. HPMC elu okpomọkụ ngwa ubi

Ihe owuwu ụlọ

N'ime ihe owuwu ụlọ dị ka ngwa ngwa akọrọ, ihe ntanye tile, ntụ ntụ putty, na usoro mkpuchi mgbidi dị n'èzí, HPMC nwere ike imeziwanye arụmọrụ ihe owuwu n'okpuru ọnọdụ okpomọkụ dị elu, belata mgbawa, ma melite njide mmiri.

Ụlọ ọrụ nri

Dị ka ihe mgbakwunye nri, enwere ike iji HPMC mee ihe na nri ndị nwere okpomọkụ dị elu iji melite njide mmiri na nkwụsi ike nke ihe oriri, belata mmiri na-efunahụ, ma melite uto.

Ngalaba ahụike

N'ime ụlọ ọrụ na-emepụta ọgwụ, a na-eji HPMC dịka mkpuchi mbadamba na ihe ntọhapụ na-adịgide adịgide iji melite nkwụsi ike nke ọgwụ, igbu oge ntọhapụ ọgwụ, ma melite bioavailability.

Ịkụpụta mmanụ

Enwere ike iji HPMC mee ihe dị ka ihe mgbakwunye maka mmiri mmiri na-egwupụta mmanụ iji melite nkwụsi ike dị elu nke mmiri mmiri na-egwupụta ihe, gbochie mgbidi mgbidi nke ọma, ma melite ịrụ ọrụ nke ọma.

HPMC nwere gelation thermal pụrụ iche, nkwụsi ike dị elu, nguzogide alkali na njigide mmiri n'okpuru ọnọdụ okpomọkụ dị elu. Enwere ike imeziwanye nguzogide okpomọkụ ya site na mgbanwe kemịkalụ, mgbanwe copolymerization, mgbanwe njikọ njikọ na mgbanwe nano-composite. A na-eji ya n'ọtụtụ ụlọ ọrụ dịka ihe owuwu, nri, ọgwụ na mmanụ ala, na-egosi nnukwu ahịa ahịa na atụmanya ngwa. N'ọdịnihu, site na nyocha na mmepe nke ngwaahịa HPMC dị elu, a ga-agbasawanye ngwa ngwa na mpaghara okpomọkụ dị elu.