Hydroxypylththththththylcelllose (hpmc) bụ mmiri na-abụghị nke ikuku na-soluble na-enwetara site na ngbanwe kemịkal nke sellose eke. A na-ejikarị nri, ọgwụ, ihe ịchọ mma na ụlọ ọrụ na-ewu ihe, dị ka ihe nrapado, Trunelfier na igbochi ọrụ ọgwụ. N'ime usoro ntinye, njirimara viscosit nke HPMC ALL AL dị mkpa dị mkpa maka ịrụ ọrụ ya na mpaghara dị iche iche.
1. Ọdịdị na Njirimara nke Hydropyythylthylthyl
Usoro nke HPMC nwere otu ụzọ abụọ, hydroxyl (-Ch₂Krọk₃) na methyl (-Och)₃), nke na - eme ka ọ nwee ezigbo sọsọ na ike mgbanwe. Ahịhịa molecular nwere ụfọdụ usoro siri ike, mana ọ nwekwara ike ịkpụzi ntọala netwọdụ atọ n'ime ihe ọ bụla, na-ebute mmụba na viscosity. Ibu ya, ụdị nke njiri mara mma (ya bụ, ogo hydroxypylyl na methy nechibidoro nke ọ bụla) nwere mmetụta dị mkpa na viscosity nke ngwọta.
2
Njirimara viscosics nke HPMC os na-enwekarị njikọ chiri anya na ihe ịta, ogo molecular, okpomọkụ na uru mgbaze. N'ozuzu, viscosity nke HPMC os na-abawanye na mmụba nke itinye uche ya. Ọhụụ viscosis na-egosi omume rhite na-abụghị ndị ọhụrụ, ya bụ, ọnụego shon na-abawanye, viscosise nke ihe ngwọta nke nwayọọ na-ebelata, na-egosi ndị na-eme shieenon.
(1) mmetụta uche
Enwere ụfọdụ mmekọrịta dị n'etiti viscosity nke HPMC oque na ntinye ya. Dị ka ịta nke HPMC na-abawanye, mmekọrịta m na-eme ka ọ dịkwuo elu, na ntinye ya na ogidi na-abawanye, na-ebute mmụba nke viscosity nke ihe ngwọta. Na ala dị ala, viscosity nke HPMC A na-abawanye na mmụba nke ịta, mana na uto dị elu, uto visce nke ihe ngwọta na-aba uru dị larịị ma rute uru kwụ ọtọ.
(2) mmetụta nke oke molecular
Ibu molecular nke Hpmc na-emetụta viscosity nke ya. HPMC nwere oke molecular nwere ogologo molecular dị ogologo ma nwee ike ịmepụta ihe dị iche iche network atọ dị iche iche na-agbanwe agbanwe na ngwọta ala, nke na-ebute vicosise. N'ụzọ dị iche, HPMC nwere oke molecular dị ala nwere ihe owuwu netwọkụ na obere viscosity n'ihi ụdị m dị mkpụmkpụ. Ya mere, mgbe itinye akwụkwọ, ọ dị ezigbo mkpa ịhọrọ HPMC ya na ịdị mma molecular iji nweta nsonaazụ ọhụụ.
(3) mmetụta nke okpomọkụ
Ọnọdụ okpomọkụ bụ ihe dị mkpa na-emetụta viscosity nke HPMC onala. Ka ọnọdụ okpomọkụ na-abawanye, mmegharị nke moleculas mmiri na-esiwanye ike na viscosis nke ihe ngwọta na-ebelata. Nke a bụ n'ihi na mgbe ọnọdụ okpomọkụ na-eto, nnwere onwe nke ypmc diving na-abawanye na mmekọrịta dị n'etiti ụmụ irighiri ihe ngwọta. Agbanyeghị, nzaghachi HPMC site na batty dị iche iche ma ọ bụ ụdị dị iche iche nwekwara ike ịdị iche, n'ihi ya, ọ dị mkpa ka edozie ọnọdụ okpomọkụ dị ka ngwa achọrọ.
(4) mmetụta nke uru
HPMC n'onwe ya bụ ihe na-abụghị nke ionic, na viscosity nke ya bụ ihe na-emetụta mgbanwe na PH. Ọ bụ ezie na HPMC gosipụtara njirimara viscessistics dị iche iche na actic ma ọ bụ na-anọpụ iche na gburugburu acidic, solubsity ga-emetụta ya na gburugburu acidic ma ọ bụ gburugburu alkaline. Dịka ọmụmaatụ, n'okpuru acid siri ike ma ọ bụ ọnọdụ alkaline siri ike, nke HPMC Molecules nwere ike mebie, si otú a belata vict anticosit ya.
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Omume ọjọọ nke HPMC A na-egosikarị ihe na-abụghị ndị na-abụghị ndị ọhụrụ na-abụghị viscan nke Newtonis na-abụghị nsonaazụ uche na ịdị arọ molecular. N'ikwu okwu, na ọnụego Shear, HPMC Ashac dị elu na-egosi viscosity dị elu, ebe ọ bụ ezie na ọnụego shaar na-abawanye, na viscesese na-ebelata. A na-akpọ omume a "shieer finer" ma ọ bụ "shiee twoning" ma dịkwa mkpa n'ọtụtụ ngwa. Iji maa atụ, n'ọhịa nke mkpuchi, nkwadebe ọgwụ, nhazi nri, na-ejikọ ihe dị elu nke HPMC nwere ike ịgba mbọ hụ na ngwa dị ala, ọ nwere ike na-eruwanye mfe n'okpuru ọnọdụ shieer.
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(1) nsonaazụ nnu
Ihe mgbakwunye nnu (dịka sodium chloride) nwere ike iwelie viscosity nke HPMC EAL. Nke a bụ n'ihi na nnu nwere ike ịkwalite mmekọrịta dị n'etiti moleculs site na ịgbanwe ikike ionic site na nhazi netwọkụ ọzọ, si otú a na-ebute viscosity. Agbanyeghị, nsonaazụ nnu na ichebara ihe na viscosis ekwesighi ịgbanwe ya dabere n'ọnọdụ ụfọdụ.
(2) Mmetụta nke ndị ọzọ
Na-agbakwunye ihe mgbakwunye ndị ọzọ (dịka ndị na-eme ihe nkiri, polymers, wdg) na HPMC niile ga-emetụtakwa victisity. Dịka ọmụmaatụ, Surfants nwere ike belata viscosity nke HPMC, karịchaa mgbe ịta ụkwụ lekwasịrị anya dị elu. Na mgbakwunye, ụfọdụ polmers ma ọ bụ ụmụ irighiri ihe nwekwara ike iso HPMC ma gbanwee ihe ndị na - eme ihe ngwọta ya.
Njirimara viscosits nkehydroxypylthththththylcelllose Ọkpụkpụ ọrịa na-emetụta ọtụtụ ihe, gụnyere ịta, ọnọdụ moleucal na-egosipụtakarị ihe ndị na-abụghị ndị ọhụrụ, na-ejikwa ezigbo aka na mpaghara ụlọ ọrụ dị iche iche na ọgwụ. Nghọta na ịchịkọta njirimara ndị a na-ahụ anya ga-enyere aka iji aka HPMC na ngwa dị iche iche. N'ime ihe ndị dị mma, a ga-ahọrọ ụdị usoro nke HPMC kwesịrị ekwesị dabere na mkpa ụfọdụ iji nweta ezigbo viccosity Njirimara na ihe omimi.
Oge post: Mar-01-2025