HPMC (Hydroxypropyl Methylcellulose) bụ nonionic cellulose ether nke a na-ejikarị na ọgwụ, nri, ihe owuwu na ihe ịchọ mma. A na-ekewa ọkwa dị iche iche nke HPMC dịka usoro kemịkalụ ha si dị, akụrụngwa anụ ahụ, viscosity, ogo nnọchi na ojiji dị iche iche.
1. Chemical Ọdịdị na ogo nke nnọchi
Usoro ihe omimi nke HPMC nwere otu hydroxyl na agbụ cellulose nke methoxy na otu hydroxypropoxy nọchiri anya ya. Njirimara anụ ahụ na kemịkal nke HPMC dịgasị iche dabere na ogo nnọchi nke methoxy na otu hydroxypropoxy. Ogo nke nnọchi na-emetụta solubility, nkwụsi ike ọkụ na ọrụ elu nke HPMC. Kpọmkwem:
HPMC nwere ọdịnaya methoxy dị elu na-achọ igosipụta okpomoku gelation dị elu, nke na-eme ka ọ dabara adaba maka ngwa nwere mmetụta okpomọkụ dị ka nkwadebe ọgwụ na-achịkwa.
HPMC nwere nnukwu hydroxypropoxy ọdịnaya nwere mma mmiri solubility, na mgbasa ya usoro adịghị emetụta okpomọkụ, na-eme ka ọ dị mma maka ojiji na gburugburu oyi.
2. ọkwa viscosity
Viscosity bụ otu n'ime ihe ngosi dị mkpa maka ọkwa HPMC. HPMC nwere viscosities dịgasị iche iche, site na centipoise ole na ole ruo iri puku kwuru iri puku centipoise. Ogo viscosity na-emetụta ojiji ya na ngwa dị iche iche:
Low viscosity HPMC (dị ka 10-100 centipoise): Nke a na ọkwa nke HPMC na-akasị ji na ngwa na-achọ ala viscosity na elu fluidity, dị ka film mkpuchi, mbadamba adhesives, wdg Ọ nwere ike inye a ụfọdụ ogo nke bonding ike na-enweghị emetụta. mmiri mmiri nke nkwadebe.
Ọkara viscosity HPMC (dị ka 100-1000 centipoise): A na-ejikarị eme ihe na nri, ihe ịchọ mma na ụfọdụ nkwadebe ọgwụ, ọ nwere ike rụọ ọrụ dị ka ihe na-esi ísì ụtọ ma melite udidi na nkwụsi ike nke ngwaahịa ahụ.
HPMC viscosity dị elu (dị ka n'elu 1000 centipoise): A na-ejikarị ọkwa HPMC na ngwa chọrọ viscosity dị elu, dị ka gluu, nrapado na ihe ụlọ. Ha na-enye ike ịgbatị na nkwusioru nke ọma.
3. Njirimara anụ ahụ
Njirimara anụ ahụ nke HPMC, dị ka solubility, gelation okpomọkụ, na ike mmịnye mmiri, dịkwa iche na ọkwa ya:
Solubility: Ọtụtụ HPMC nwere ezigbo solubility na mmiri oyi, mana solubility na-ebelata ka ọdịnaya methoxy na-abawanye. Ụfọdụ pụrụ iche akara ule nke HPMC nwekwara ike-etisasịwo na organic solvents maka kpọmkwem ulo oru ngwa.
Gelation okpomọkụ: The gelation okpomọkụ nke HPMC na aqueous ngwọta dịgasị iche iche na ụdị na ọdịnaya nke nnọchi. N'ikwu okwu n'ozuzu, HPMC nwere ọdịnaya methoxy dị elu na-eme ka ọ bụrụ gels na okpomọkụ dị elu, ebe HPMC nwere ọdịnaya hydroxypropoxy dị elu na-egosipụta okpomọkụ gelation dị ala.
Hygroscopicity: HPMC nwere hygroscopicity dị ala, ọkachasị akara ule edochiri anya dị elu. Nke a na-eme ka ọ mara mma na gburugburu ebe chọrọ mgbochi mmiri.
4. Mpaghara ngwa
N'ihi na akara ule dị iche iche nke HPMC nwere ihe anụ ahụ na kemịkal dị iche iche, ngwa ha na mpaghara dị iche iche dịkwa iche:
Ụlọ ọrụ na-emepụta ọgwụ: A na-ejikarị HPMC eme ihe na mkpuchi mbadamba, nkwado ntọhapụ, adhesives na thickeners. Pharmaceutical ọkwa HPMC kwesịrị izute kpọmkwem pharmacopoeia ụkpụrụ, dị ka United States Pharmacopoeia (USP), European Pharmacopoeia (EP), wdg Dị iche iche akara ule nke HPMC nwere ike iji gbanwee ntọhapụ ọnụego na kwụsie ike nke ọgwụ.
Ụlọ ọrụ nri: A na-eji HPMC eme ihe dị ka thickener, emulsifier, stabilizer na ihe nkiri mbụ. A na-achọkarị HPMC ọkwa nri ka ọ bụrụ nke na-adịghị egbu egbu, enweghị ụtọ, enweghị isi, yana mkpa ịgbaso ụkpụrụ mgbakwunye nri, dị ka nke US Food and Drug Administration (FDA) na European Food Safety Authority (EFSA).
Ụlọ ọrụ ihe owuwu: A na-eji HPMC ọkwa ihe owuwu a na-ejikarị eme ihe na ciment, ngwaahịa gypsum na mkpuchi iji mee ka ọ sie ike, na-ejigide mmiri, mmanye na ịkwalite. HPMC nke ọkwa viscosity dị iche iche nwere ike imetụta arụmọrụ nke ihe ụlọ na arụmọrụ nke ngwaahịa ikpeazụ.
5. Ogo ụkpụrụ na ụkpụrụ
Ọkwa HPMC dị iche iche na-edokwa ụkpụrụ na ụkpụrụ dị mma dị iche iche:
Pharmaceutical ọkwa HPMC: ga-egbo pharmacopoeia chọrọ, dị ka USP, EP, wdg Ya mmepụta usoro na àgwà akara chọrọ dị elu iji hụ na ya nchekwa na irè na ọgwụ nkwadebe.
HPMC-ọkwa nri: Ọ ga-agbasorịrị ụkpụrụ dị mkpa maka mgbakwunye nri iji hụ na nchekwa ya na nri. Mba na mpaghara dị iche iche nwere ike ịnwe nkọwapụta dị iche iche maka ọkwa nri HPMC.
HPMC nke ụlọ ọrụ mmepụta ihe: HPMC eji arụ ụlọ, mkpuchi na mpaghara ndị ọzọ anaghị adịkarị mkpa ịgbaso ụkpụrụ nri ma ọ bụ ọgwụ, mana ọ ka kwesịrị irubere ụkpụrụ ụlọ ọrụ kwekọrọ, dị ka ụkpụrụ ISO.
6. Nchekwa na nchekwa gburugburu ebe obibi
HPMC nke ọkwa dị iche iche dịkwa iche na nchekwa na nchekwa gburugburu ebe obibi. Ọkwa ọgwụ na ọkwa nri HPMC na-enwetakarị nyocha nchekwa siri ike iji hụ na ha adịghị emerụ ahụ mmadụ. N'aka nke ọzọ, HPMC nke ụlọ ọrụ mmepụta ihe, na-etinyekwu uche na nchedo gburugburu ebe obibi ya na mmebi mgbe a na-eji ya belata mmetụta na gburugburu ebe obibi.
Ọdịiche dị n'etiti ọkwa dị iche iche nke HPMC na-egosipụtakarị na nhazi kemịkalụ, viscosity, akụrụngwa anụ ahụ, mpaghara ngwa, ụkpụrụ ịdị mma na nchekwa. Dabere na ihe achọrọ ngwa ngwa, ịhọrọ ọkwa ziri ezi nke HPMC nwere ike melite arụmọrụ yana ogo ngwaahịa. Mgbe ị na-azụta HPMC, a ga-atụlerịrị ihe ndị a n'ụzọ zuru ezu iji hụ na ọ dabara na ịdị mma nke ngwaahịa ahụ.
Oge nzipu: Ọgọst-20-2024