Gịnị bụ rheological Njirimara nke HPMC?

Gịnị bụ rheological Njirimara nkeHPMC?

Hydroxypropyl methylcellulose (HPMC) bụ polymer vasatail nke na-achọta ọtụtụ ọrụ na ụlọ ọrụ dị iche iche, gụnyere ọgwụ, ihe owuwu, nri, na ihe ịchọ mma, bụ isi n'ihi njirimara rheological ya pụrụ iche. Rheology bụ ọmụmụ ihe na-erugharị na nrụrụ ihe, na ịghọta rheological Njirimara nke HPMC dị oké mkpa maka ịkwalite arụmọrụ ya na ngwa dị iche iche.

Viscosity: HPMC na-egosiputa pseudoplastic ma ọ bụ omume na-akpachapụ anya, nke pụtara viscosity ya na-ebelata na ọnụ ọgụgụ shear na-abawanye. Ngwongwo a dị mkpa na ngwa dị ka usoro ọgwụ, ebe ọ na-enye ohere maka mgbapụta, ịgbasa na ngwa ngwa. Enwere ike ịhazi viscosity site n'ịgbanwe ogo nke nnọchi (DS) na ịdị arọ molekul nke HPMC.

Thixotropy: Thixotropy na-ezo aka na ntụgharị gel-sol na-agbanwe agbanwe nke ihe ụfọdụ gosipụtara n'okpuru nrụgide siri ike. gels HPMC emebere na izu ike nwere ike daa n'okpuru shii wee nwetaghachi usoro gel ha mgbe ewepụrụ nrụgide ahụ. Ngwongwo a bara uru na ngwa dị ka agba, ebe ọ na-egbochi sagging n'oge ngwa mana ọ na-eme ka mkpuchi kwesịrị ekwesị ozugbo etinyere ya.

Hydration: HPMC bụ hygroscopic ma nwee ike ịmịnye mmiri, na-eduga na ọzịza na ụbara viscosity. Ogo hydration na-adabere n'ihe ndị dị ka okpomọkụ, pH, na ike ionic nke usoro gburugburu. Hydration na-arụ ọrụ dị mkpa n'ịchịkwaa ntọhapụ nke ọgwụ sitere na usoro ọgwụ yana idobe ọdịnaya mmiri na ngwaahịa nri.

Mmetụta okpomọkụ:HPMCngwọta na-egosipụta viscosity dabere na ọnọdụ okpomọkụ, na viscosity na-ebelata ka okpomọkụ na-abawanye. Agbanyeghị, omume a nwere ike ịdịgasị iche dabere na ihe ndị dị ka mkpokọta polymer na pH ngwọta. Mmetụta okpomọkụ dị oke mkpa na ngwa dị ka ihe owuwu ụlọ, ebe ọ na-emetụta ọrụ na ịtọ oge.

Mmetụta Nnu: Ihe ngwọta HPMC nwere ike igosipụta mmetụta na nnu, yana ụfọdụ nnu na-eme ka viscosity kwalite yana ndị ọzọ na-ebute mbelata viscosity. A na-ekwu na ihe a bụ mmekọrịta dị n'etiti ụmụ irighiri ihe HPMC na ion na ngwọta. Mmetụta nnu dị mkpa na usoro ọgwụ na ngwaahịa nri ebe ọ dị mkpa iji nlezianya chịkwaa ọdịnaya nnu.

Ndabere ọnụ ahịa shear: Njirimara rheological nke ngwọta HPMC na-adabere nke ukwuu na ọnụego shiee etinyere. Na ọnụ ọgụgụ dị ala nke shea, viscosity dị elu n'ihi ụbara njikọ molekụla, ebe ọ bụ na ọnụ ọgụgụ dị elu nke shear, viscosity na-ebelata n'ihi ịkpụ ntutu. Ịghọta ịdabere na ọnụ ọgụgụ shear dị oke mkpa maka ịmepụta ọnọdụ nhazi na ngwa dị iche iche.

Nkwusioru urughuru: HPMC nwere ike rụọ ọrụ dị ka onye na-akwụsịtụ maka irighiri ihe dị na nhazi mmiri n'ihi ihe na-eme ka ọ sie ike na nkwụsi ike. Ọ na-enyere aka igbochi nhazi nke irighiri ihe siri ike, na-ahụ na nkesa otu na nkwekọ na ngwaahịa dị ka agba, nrapado, na nkwusioru ọgwụ.

Nhazi gel:HPMCnwere ike ịmepụta gels na oke elu ma ọ bụ n'ihu ndị na-eme ka ndị na-emekọrịta ihe dị ka divalent cations. Gel ndị a na-egosipụta njirimara viscoelastic ma jiri ya na ngwa ndị dị ka nnyefe ọgwụ na-achịkwa, ebe a chọrọ ntọhapụ na-adịgide adịgide nke ihe ndị na-arụ ọrụ.

rheological Njirimara nke HPMC, gụnyere viscosity, thixotropy, hydration, okpomọkụ na nnu uche, shiee ọnụego ịdabere, urughuru nkwusioru, na gel guzobe, na-arụ a dị oké mkpa ọrụ na-ekpebi ya arụmọrụ dị iche iche ulo oru ngwa. Ịghọta na ịchịkwa ihe ndị a dị mkpa maka ịkwalite nhazi na nhazi nke ngwaahịa ndị dabeere na HPMC.