Hydroxypylmethylcelllose (HPMC) bụ ndị otu mbanye na-ejikarị ụlọ ọrụ ọgwụ. Ọ bụ nke cellulose ụdị ma na-enweta site na okike cellulose. HPMC bụ Synchazed site na ịgwọ ọrịa cellose na propylene oxide na methyl chloride, nke na-ebute ngwakọta na njikwa ndị ọzọ dị mma. A na-eji ọgwụ ogwu eme ihe n'ọtụtụ ebe na mmepe nke usoro onunu ogwu, gụnyere mbadamba, capsules, usoro ophthaltic na usoro nnyefe ọgwụ na-achịkwa ọgwụ.
Okwu Mmalite na Hydropyylthylthylthylthyllose:
Ọmụma kemịkal na akụrụngwa:
Hydroxypyl Methylcellose bụ semi-synhetic, internet, polymen-soluble. Ihe owuwu kemịkal ya gụnyere hydroxypyl na otu methoxy sonided na ballose backbone. Ntinye nke ndi eji eme ihe nwere ike ịdị iche, na-ebute akara mmụta dị iche iche nke HPMC na Njirimara dị iche iche. Ihe eji eme ihe na-emetụta paramita dịka viscosity, solubity na Njirimara Gel.
Usoro imeputa:
Mmepụta HPMC na-emetụta ogo nke cellulose na proplene oxide na methyl chloride. Enwere ike ịchịkwa otu ihe eji eme ihe na Methoxyyl na Methoxy, na-ekwe ka ịhazi ihe Njirimara ọgwụ ọgwụ akọwapụtara.
Ngwa na ụlọ ọrụ ọgwụ:
Ndị na-emekọ ihe na mbadamba ụrọ:
A na-eji HPMC mee ihe dị ka ihe mgbochi na usoro ọkwa mbadamba. Enyemaka ya na-emekọrịta ihe na-agbakọta ntụ ntụ ahụ na mbadamba ahụ siri ike. Enwere ike ị nweta mwepụta nke ọgwụ na-arụ ọrụ (APIS) site na iji akara akara ụfọdụ nke HPMC na ọkwa dị mma na ọkwa dị mma.
Ihe nkiri na-akwụ ụgwọ:
A na-eji HPMC dị ka ihe nkiri na-akwụ ụgwọ maka mbadamba maka mbadamba na granules. Ọ na - enye mkpuchi eji echekwa edo na - eme ka ọdịdị dị mma, ise masking na nkwụsi ike nke usoro onunu ogwu. Ọzọkwa, mkpuchi mkpuchi HPMC nwere ike imegharị profaịlụ ọgwụ.
Ntọhapụ na-achịkwa:
Ọdịdị hydrophilic nke polymer a na-eme ka ọ dị mma maka iji ya na nhazi nke na-achịkwa ya. HPMC matrix na-enye ohere ịtọhapụ ọgwụ a na-achịkwa ogologo oge, na-eme ka onye ọrịa ma na-ebelata ugboro ole.
Nkwadebe Ophthalmic:
Na usoro Ophthalmic, a na-eji HPMC iji bulie viscosise nke anya mmiri, si otú a na-eweta oge obibi dị ogologo na elu elu. Nke a na - eme ka bioioapality nke ọgwụ na nrụpụta ọgwụgwọ.
Ibu agha:
A na-eji HPMC mee ihe dị ka nke na-adaba na mmiri mmiri na ọkara-ike siri ike dịka gels, ude na nkwụsị. Ọ na-enye viscosis na ụdị ndị a ma na-eme ka ihe ha na-eme ka ihe ha dị mma.
Ihe njiri mara nke HPMC:
Solubality:
HPMC na-agbanye mmiri na mmiri ma mee ka usoro doro anya. Ọnụego nke mgbasa na-emetụta ogo nke nbanye na ọkwa viscosis.
Viscosity:
Nleta visc nke HPMC Ngwọta dị oke mkpa n'ikpebi arụmọrụ ha na ngwa dị iche iche. Uzo di iche di iche di iche iche di iche iche, na-enye ohere ka mmachi nke ihe nmehie nke udi.
Igwe ọkụ na-ahụ:
Gradesfọdụ akara ule HPMC gosipụtara akụrụngwa ọkụ, na-akpụ gels na oke okpomọkụ. A na-eji ala a rụpụta usoro iwe iwe.
Ntụkọrịta:
HPMC dakọtara na ụdị ọgwụ na-akpata ọgwụ na APIS, na-eme ka ọ bụrụ nhọrọ mbụ maka ndị na-akpụ akpụ. Ọ naghị emeghachi omume ma ọ bụ mebie ihe ndị kachasị arụ ọrụ.
Ihe ịma aka na echiche:
Hygroscopity:
HPMC bụ hygroscopic, nke pụtara na ọ na-ekekọta mmiri na gburugburu ebe obibi. Nke a na - emetụta nkwụsi ike na ọdịdị nke usoro ahụ, yabụ achọrọ nchekwa nchekwa kwesịrị ekwesị.
Ndakọrịta na ndị ọzọ enweghị atụ:
Ọ bụ ezie na ọ bụ ezie na ọ dị mkpa, ndị na-arụ ọrụ kwesịrị ịtụle ndakọrịta nke HPMC ya na ndị ọzọ enweghị atụ iji zere inwe mmekọrịta dị na ya nwere ike imetụta usoro ọmụmụ.
Mmetụta na mpaghara:
Nhọrọ nke ọkwa HPMC nwere ike imetụta profaịlụ profaịlụ nke ọgwụ. Onye na-ahụ maka akwụkwọ ahụ ga-eji nlezianya họrọ ọkwa kwesịrị ekwesị iji mezuo njirimara ndị a chọrọ.
Ntughari uche:
A nabatara HPMC nabatara dị ka ihe ịtụnanya na-adịghị mma ma na-arụ ọrụ. Ọ na-ezute ụkpụrụ nchịkwa dị iche iche ma tinye ya na plamashipopuias gburugburu ụwa. Ndị na-emepụta ihe ga-agbarịrị ezigbo ihe omume (GMP) iji hụ na ịdị mma na ịdịgide nke ngwaahịa ọgwụ na-eme ọgwụ nwere HPMC.
na ngwụcha:
Hydroxypylmethylcelllose (HPMC), dị ka onye maara nke ọma ma jiri ọrụ dị mkpa na ụlọ ọrụ ọgwụ. Ngwongwo pụrụ iche ya na-eme ka ọ dị mma maka iji ụdị usoro onunu ogwu, gụnyere mbadamba, capsules na nkwadebe Ophthalmic. Ndị mejupụtara na-erite uru site na inwe ike ịhazi Njirimara nke HPMC iji mezuo usoro usoro akọwapụtara, dị ka ntọhapụ na nkwụsi ike na-adịgide adịgide. N'agbanyeghị ụfọdụ ihe ịma aka, HPMC na-abụ ihe dị mkpa na mmepe nke ngwaahịa ọgwụ dị elu, na-enye aka na nchekwa na arụmọrụ nke ọtụtụ ọgwụ ọgwụ.
Oge post: Dec-15-2023