Hydroxypyl Methymerlil (Hpmc) bụ polymer dị iche iche na ọtụtụ ngwa ọrụ na ụlọ ọrụ dị iche iche gụnyere ọgwụ, nri, owuwu na ịchọ mma. Ihe eji eme ihe eji eme ihe eji eme ka HPMC bu cellose na proslene.
1. Celllose: Ndabere nke HPMC
1.1 Isi nke cellose
Cellulose bụ ihe mgbagwoju anya carbohydrate nke bụ ihe eji arụ ọrụ nke akụrụngwa nke osisi osisi akwụkwọ ndụ akwụkwọ ndụ. Ọ mejupụtara ụdọ glucose nke glucose jikọtara ọnụ site na bly-3,4-glycosidic. Otutu ndi otu hydroxy na cellulose na-eme ka ọ bụrụ ihe kwesịrị ekwesị maka njikọta nke mkpụrụ osisi cellulose dị iche iche, gụnyere HPMC.
1.2 cellulose
Enwere ike ịdapụta cellose site na ihe ọkụkụ dị iche iche, dị ka osisi pulp, akwa na-acha uhie uhie, ma ọ bụ ahịhịa ndị ọzọ. Osisi pulp bụ ihe na-eju anya n'ihi oke ya, ọnụ ahịa - arụmọrụ, na nkwado. Mmịpụta nke cellose na-agụnye na-agbada eriri ọkụ site na usoro nke usoro na kemịkal.
1.3 ịdị ọcha na njiri mara
Ogo na ịdị ọcha nke cellulose dị oke mkpa iji kpebie njirimara nke ngwaahịa HPMC. Mkpụrụ osisi mkpụrụ osisi dị elu na-enyere Hpmc na HPMC ya na ihe ndị na-agbanwe agbanwe dị ka viasse, sonyere na nkwụsi ike.
2.
2.1 Okwu Mmalite na Oxide
Proplene Oxide (poo) bụ usoro ihe eji eme ihe na kemịkal kemịkalụ c3h6o. Ọ bụ Epoxide, nke pụtara na ọ nwere ọ nwere oxygengengenge oxygen na atọm abụọ dị n'akụkụ carbon abụọ. Proplene oxide bụ igodo akụrụngwa maka njikọta nke hydroxyppppropyyl cellulose, nke bụ etiti maka mmepụta nke HPMC.
2.2 Hydroxypylation Usoro
Usoro hydroxypropotion na-emetụta mmeghachi omume nke cellose na proplene oxide iji iwebata ìgwè ndị na-eme nri na cellowpropy. Ihe mmeghachi omume a na-abụkarị ihe na-ahụ maka oke ihe. Otu dị iche iche na-enye nkwado dị mma na akụrụngwa ndị ọzọ dị mma na cellose, na-eduga na nguzobe nke celdropyyl cellulose.
3. Methylation: na-agbakwunye otu methy
3.1 methylation usoro
Mgbe hydroxypylation, usoro na-esote na HPMC Synthesis bụ methylation. Usoro ahụ gụnyere iwebata iche methyl dị n'otu sellulose barbone. Methyl chloride bụ ihe na-ejikarị resgents na-eji mmeghachi omume a. Ogo nke methylation na-emetụta akụrụngwa nke ngwaahịa HPMC ikpeazụ, gụnyere viscosity na omume gel ya.
Ole anya nke dochie anya
Obere ihe eji eme ihe (DS) bu oke ihe eji eme ka onu ogugu di iche iche (methyl na hydrolopsyl) kwa otu cellugluse. A na-achịkwa usoro na-arụpụta ihe iji nweta arụmọrụ achọrọ nke ngwaahịa HPMC.
4. Nnọkwa dị ọcha na njikwa ịdị mma
4.1 Iwepụ ngwaahịa
Nchịkọta nke HPMC nwere ike ibute usoro nke ndị dị ka nnu ma ọ bụ ndị na-adịghị agụ. A na-eji nzacha dị ọcha gụnyere ịsacha na nzacha iji wepu adịghị ọcha ndị a ma nwekwuo ịdị ọcha nke ngwaahịa ikpeazụ.
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A na-emejuputa usoro njikwa siri ike na usoro nrụpụta ọfụma iji hụ na nha anya na ịdị mma nke HPMC. A na-eji usoro nyocha dị ka ụdị ọhụụ, a na-eji chromatography na rhiology mee ihe ịtụle paramita dịka ogo molecular ibu, ogo nke dochie na viscosity.
5. Njirimara nke Hydropyl Methylcellose (HPMC)
5.1 Njirimara anụ ahụ
HPMC bụ ọcha na-acha ọcha, ntụ ntụ na-enweghị isi na ezigbo ihe nkiri na-akpụ akpụ. Ọ bụ hygroscopic ma ọ dị mfe iche gel nke transpere mgbe mmiri. Nkwelite nke HPMC dabere na ogo nke dochie ma metụta ihe ndị dị ka okpomọkụ na PH.
5.2 Chemical
Ihe owuwu kemịkal nke Hpmc mejupụtara ihe ballonose ballese na hydroxypyl na methyl na methyl. Atutu nke ndi ozo, gosipụtara n'usoro nke dochie anya, na-ekpebi ihe owuwu kemịkalụ ma si otú a na-ahụ maka HPMC.
5.3 viscosity na ihe omimi
HPMC dị na akara ule dị iche iche nwere ụdị viscosity dịgasị iche iche. Nleta visc nke HPMC bụ ihe dị mkpa na ngwa ndị dị ka ọgwụ, ebe ọ na-emetụta profaịlụ nke ngwa agha na nke ogige.
5.4 fim-na-akpụ akpụ na ihe ndị dị omimi
A na-eji HPMC mee ihe dị ka ihe nkiri mbụ na-eme ọgwụ na-egbu egbu ma dị ka onye na-ahụ maka iche iche. Casabalities na-eme ihe nkiri na-eme ka ọ baa uru na mmepe nke sistemụ ọgwụ ọgwụ na-achịkwa, ebe ya na-eme ka udiri na nkwụsi ike nke ọtụtụ ngwaahịa.
6. Ngwa nke hydropyylthylthylcelllose
6.1 Omuma ahia ahia
N'ime ụlọ ọrụ ọgwụ, a na-eji HPMC mee ihe iji gosipụta usoro dosage dị ka mbadamba na capsules. A na-ejikarị ya dị ka ihe mgbochi, na-eme ihe nkiri na ihe nkiri na-akwụ ụgwọ. Ngwongwo ndị a na-achịkwa nke HPMC na-eme ka ngwa ya na -echebe ya.
6.2 ụlọ ọrụ owuwu
N'ebe a na-ewu ihe owuwu, a na-eji HPMC mee ihe dị ka mmiri na-ejigide onye na-eche nche, bụ isi na nrapado na ngwaahịa ciment. Ọ na - eme ka ọrụ nke ngwa agha ahụ, na - egbochi ịkacha ngwa na ngwa, ma na - eme ka arụmọrụ nke ụlọ ahụ.
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A na-eji HPMC mee ihe na ụlọ ọrụ nri dị ka nke ukwu, mmachi na emififier. Ikike ya iji mepụta mkpụrụ osisi na mpekere dị ala na-eme ka ọ dị mma maka ọtụtụ ngwa, gụnyere sauces, akwa na ihe ụtọ.
6.4 Nchọpụta ihe na ngwaahịa nlekọta onwe ya
Na Ngwaahịa Nlekọta nkeonwe na ngwaahịa HPMC n'ọtụtụ usoro gụnyere ude, mma lotions na shampoos. Ọ na - enyere aka mee ka ederede, nkwụsi ike na arụmọrụ nke ngwaahịa ndị a.
6.5 ndị ọzọ
Vafatitydị nke HPMC na-agbasa ụlọ ọrụ ndị ọzọ, gụnyere agwakọta agwa, ebe enwere ike iji ya mee ihe dị ka onye na-ahụ maka oge na-agagharị na Trimener.
7. Mmechi
Hydroxypylmethylcelllose bụ polymer dị ukwuu na ọtụtụ ngwa. Nchịkọta ya na-eji cellulose na proslene oxide dị ka ihe bụ isi akụrụngwa, na celllose na-agbanwe site na usoro hydrolose na methylation. Njikwa akụrụngwa ndị a na ọnọdụ mmeghachi omume ndị a nwere ike iwepụta HPMC yana Njirimara Usoro iji gboo mkpa ụlọ ọrụ mmepụta akọwapụtara. Ya mere, HPMC na-arụ ọrụ dị mkpa na imezi arụmọrụ na arụmọrụ nke ngwaahịa ndị dị na ọrụ. Nyochaa ngwa ọhụrụ na ndozi nke usoro na-arụ ọrụ na-enyere HPMC aka na-arụ ọrụ dị mkpa na ahịa ụwa niile.
Oge post: Dec-28-2023