Hydroxypropy Cellulose (HPC) bụ ihe siri ike na ọgwụ na-emepụta ọgwụ na ọtụtụ ọrụ ọrụ. A na-ejikarị ya na nkwadebe siri ike dịka mbadamba na capsules. Dị ka otu akụkụ contivative, a na-ewebata Hydyyl dị iche iche n'ime usoro celdrose molecular, nke na-enye ya ezigbo solul, adhesion na ihe nkiri na-akpụ akpụ.
1. Ndị dị egwu na ndị na-eme
HPC, dị ka onye na-eto eto na ihe mkpuchi, nwere ike inyere aka mejupụtara akụkụ na mpempe akwụkwọ n'oge mmiri mmiri nke mbadamba ụrọ. O nwere adhesion siri ike ma nwee ike ịgbaso ntụ ntụ mejupụtara na-eto eto site na mmiri mmiri iji mepụta ụmụ irighiri ihe na ezigbo ọfụma na ebumnuche. Ihe ndị a dị mfe iji mepụta ma nwee ezigbo njirimarapụta n'oge tableting, na-ebute mbadamba mbadamba. Na usoro nkwadebe nke mbadamba, mgbakwunye nke bindres nwere ike hụ na ike siri ike, guzogide ike ịzọpịa ala mbadamba nkume ndị ahụ.
2. Ndị ọrụ na-achịkwa ya
Mmetụta nraranye na-achịkwa nke HPC na mbadamba mbadamba bụ otu n'ime ngwa ya kachasị mkpa. N'ihi ihe ọzịza ya na ọdịiche ya na mmiri, HPC nwere ike itolite ihe nkiri hydration n'elu mbadamba, na-egbochi ọnụego ọgwụ, na-egbochi nsonaazụ ịtọhapụ ọgwụ ọgwụ. Na mbadamba idepụta ya, HPC nwere ike idozi ọnụego ịtọhapụ ọgwụ ọgwụ site na idozi ogo molecular ya, weghaara ugboro ole nchịkwa ọgwụ, na imeziwanye nnabata onye ọrịa. Ya hydration n'elu nke na - eji nwayọọ nwayọọ nwayọọ na - agbaghasị oge, na ọnụego mwepụta ọgwụ na - adịkarị mfe, na - eme ya ka ọ bụrụ ezigbo usoro na mbadamba akwụkwọ.
3. Ndị na-eme ihe nkiri
Ngwongwo HPC nke HPC na-eme ka a na-eme ya n'ọtụtụ ebe, ọkachasị ihe mkpuchi mmiri. Izobe alaka elu ahụ na ihe nkiri HPC nwere ike imepụta oyi akwa na akwa mkpuchi na-ekpuchi ilu nke ọgwụ ahụ ma mekwaa ọgwụ ahụ ma mee ka ị kwụsie ike ma mee ka ị kwụsie ike. N'ihi na HPC nwere nghọta dị mma, ihe nkiri ọ dị n'ụdị dị larịị, ma ọ nweghị mmetụta na ọdịdị nke mbadamba ahụ. Na mgbakwunye, ihe nkiri HPC nwere ezigbo sogbulity na eriri afọ na agaghịkwa emetụta ajọ omume na bioavailability nke ọgwụ.
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Mmebi nchebe nke HPC dịkwa ezigbo mkpa na ntinye mbadamba, ọkachasị maka ọgwụ ndị ahụ na-emetụta ìhè na iru mmiri. HPC nwere ike ịpụkwa mmetụta nke ikuku na mmiri, ma gbochie ọgwụ na-emebi emebi ma ọ bụ na-enweghị atụ n'ihi mmiri. Karịsịa mgbe a kwadebere mkpuchi mbadamba ahụ na ụlọ ntukwa mmiri, nkwụsi ike na kemịkalụ nke hpc na-egbochi ya imeghachi ọgwụ na-arụ ọrụ na ndụ ọgwụ ike.
5. Nchịkọta
Ọ bụ ezie na a na-eji HPC bụ ihe dị ka onye na-achịkwa akwụkwọ mwepụta na-achịkwa, enwere ike iji ya dị ka ihe na-ekpo ọkụ n'akụkụ mbadamba ihe ụfọdụ. HPC dị ala nwere ike igba ngwa ngwa ma zaa, na-ebute ngwa ngwa ịkpọtụrụ mbadamba ahụ, si otú a na-akwalite mgbasa na eriri afọ. Ngwa a dabara adaba maka ọgwụ ụfọdụ kwesịrị ịrụ ngwa ngwa ngwa. HPC nwere ike imepụta njirimara dị iche iche dị iche iche na usoro usoro dị iche iche site na ịhazigharị molecular ya, ego na ego ndị ọzọ.
6. Ngwa dị na mbadamba ụrọ
Mmiri solus na viscosity nke HPC na-egosi ezi mmetụta na mbadamba ụrọ (ODT). Na mbadamba ihe a, HPC nwere ike ịkwalite ọnụ ọgụgụ ọnụego nke mbadamba ụrọ ahụ na oghere a na-ahụ maka oghere ọnụ, na-eme ka ọ dịrị ndị ọrịa mfe, karịchaa ndị agadi ma ọ bụ ụmụaka, ka ha loro. Mmiri solubility hpc na-enyere ya aka igbari ma kpoo ya na obere oge, ebe ya na-eme ka ike nke mbadamba ma na-egbochi ya imebi n'oge mmepụta na nchekwa.
7. Synergy na ndị ọzọ na-eme
HPC nwekwara ezigbo ọkọlọtọ na usoro mbadamba ma nwee ike ịkpa ike na ndị ọzọ na-eme ihe ike (dịka microcrystalline nwere cellulose, celloxythythythylythylylylythylylylylylylylylylylylylyylythylTylTylTylTylTylTylTylTylTylTyltylyylylTolose na celloset, wdg) iji mee ka arụmọrụ nke mbadamba ụrọ. Dịka ọmụmaatụ, mgbe ejiri ya na microcrystalline Celllose, HPC nwere ike ime ka ndị na-agbanwe mmiri na ịdị n'otu nke mbadamba ahụ mgbe ị na-agbasi mbọ ike nke mbadamba ahụ. Mgbe ejiri ya na ngwakọta ndị ọzọ, ọ nwere ike ịkwalite nrapado nke mbadamba ahụ, melite ogo nke granations na mmetụta mkparịta ụka.
8. Na-emetụta ihe na oke
Ọ bụ ezie na HPC nwere ọtụtụ uru na mbadamba ihe ndị ọzọ, dịka oke ihe, dị ka molecular ibu, iru mmiri dị elu, na ike ikike ijikwa ọnụ ọgụgụ ọgwụ ọjọọ; N'otu oge ahụ, iru mmiri gburugburu ebe obibi nwere ike ime ka mbadamba ahụ nwee mmiri, na-emetụta nkwụsi ike ya. Ya mere, mgbe ọ na-eji HPC, ọ dị mkpa iji mata nke ọma ịhọrọ paramita kwesịrị ekwesị iji hụ na mmetụta kachasị mma na usoro ụwa.
Mkpụrụ osisi hydroxypypy nwere ọtụtụ ọrụ na mbadamba usoro mbadamba, gụnyere nnukwu, ihe nkiri, mmachi, nke nwere ike ime ka ogo mbadamba ọgwụ na arụmọrụ ọgwụ. Dabere na akụrụngwa ọgwụ a kapịrị ọnụ na usoro usoro a kapịrị ọnụ, oke molecular nwere ike ịgbanwe ọkwa dị iche iche, na-eme ka ọ nwee uru dị mkpa na ụlọ ọrụ ọgwụ.
Oge Post: Nove-04-2024