Hydroxypropyl methylcellulose (HPMC)Kei te whakamahia hei tetahi o nga rongoa rongoa nui rawa atu i te kaainga me o waho. Ka taea te whakamahi i te HPMC hei kaihoko hanga kiriata, hei whakapiri, hei kaikawe tuku toimau, hei kaikawe whakatara, hei whakaemulsifier, hei whakangao, aha atu.
Ko nga rongoa rongoa he waahanga nui o nga whakaritenga rongoa, a ko ta raatau mahi ko te whakarite kia haria nga raau taero ki nga kopa i runga i tetahi huarahi me tetahi tikanga, kia tukuna nga raau taero ki roto i te tinana i tetahi tere me te waa. Na reira, ko te kowhiringa o nga taapiri e tika ana ko tetahi o nga mea nui mo te hua rongoa o nga whakaritenga rongoa.
1 Nga ahuatanga o HPMC
He maha nga ahuatanga o te HPMC kaore i etahi atu taapiri. He tino pai te wairewa i roto i te wai matao. I te mea ka whakauruhia ki roto i te wai matao me te whakaoho paku, ka memeha ki roto i te otinga marama. I te anga ke, he waiwai tarewa i roto i te wai wera i runga ake i te 60E ka taea anake te memeha. Ko te Etera cellulose kore-katote, e kore e tona otinga i tiaki katote, me te tai whakarewa ranei pūhui organic katote, kia rite ki te whakarite kia kore e HPMC tauhohe ki ētahi atu rauemi mata i roto i te tukanga production faaineineraa. Ma te kaha anti-sensitivity, me te piki ake o te hanganga ngota o te tohu o te whakakapinga, ka whakanuia ano te anti-sensitivity, ma te whakamahi i te HPMC hei raau awhina, e pa ana ki te whakamahi i etahi atu taapiri tawhito (starch, dextrin, huka paura) raau taero, ko te kounga o te waa whai hua ka pumau. He inertia metabolic. Ka rite ki te rauemi awhina ho'oraa, e kore e taea te metabolized reira whenumi ranei, no reira e kore e whakarato Calories i roto i te rongoa me te kai. He whai tikanga motuhake mo te uara pukoro iti, te tote-kore me te rongoa mate-kore me te kai e hiahiatia ana e te hunga mate huka. He kaha ake te HPMC ki te waikawa me te kawakore, engari ki te nui ake te pH2 ~ 11 ka tukuna ki te pāmahana teitei ake, ka roa ake ranei te wa rokiroki, ka heke te pokey. Ko te wairewa wai e whakarato ana i te mahi mata me te whakaatu i te ahua o te mata me nga uara o te mahanga atanga. He emulsification whai hua i roto i te pūnaha rua-wahanga, me te taea te whakamahi hei stabilizer whai hua me te colloid tiaki. He pai rawa te hanga kiriata wairewa wai, he mea whakakikorua pai mo nga papa me nga pire. Ko te kiriata i hangaia e ia he kore tae, he uaua. Ka taea hoki te whakanui ake i tana kirihou ma te taapiri i te glycerol.
2.Application o HPMC i roto i te hanga papa
2.1 Whakapai ake i te whakakorenga
Ma te whakamahi i te otinga ethanol HPMC, i te wairewa wai ranei hei kaihoko makuku mo te granulation, mo te whakapai ake i te whakakorenga o nga papa, he mea whakamiharo te paanga, ka pehia ki roto i te kiriata pakeke he pai ake, he maeneene te ahua. Te wairewa o te papa Renimodipine: ko te whakarewatanga o te whakapiri ko te 17.34% me te 28.84% i te wa e 40% te waihano te whakapiri, 5% polyvinylpyrrolidone (40%) wairewa waihano, 1% konutai dodecyl sulfate (40%) wairewa ewaro, 3% HPMC kua memeha ki roto. 10% māngaro penupenu, 3% otinga HPMC, 5% HPMC otinga, ia. 30.84%, 75.46%, 84.5%, 88%. Ko te tere o te whakakore i nga papa waikawa piperic: i te mea ko te whakapiri he 12% te waihano, 1% HPMC(40%) wairewa wairewa, 2% HPMC(40%) wairewa wairewa, 3% HPMC(40%) wairewa wairewa, 80.94% te reiti whakamere , 86.23%, 90.45%, 99.88%, ia. Ko te tere o te whakakorenga o nga papa Cimetidine: i te mea ko te whakapiri ko te 10% te slurry starch me te 3% HPMC(40%) wairewa wairewa, ko te reiti whakamere ko 76.2% me te 97.54%, ia.
Mai i nga korero o runga ake nei, ka kitea ko TE wairewa waiwaro me te wairewa wai o te HPMC he painga ki te whakapai ake i te whakakorenga o nga raau taero, ko te nuinga o te hua o te whakatārewatanga me te mahi mata o HPMC, ka whakaheke i te awangawanga mata i waenga i te otinga me te raau taero totoka, te whakanui ake i te makuku, e pai ana ki te whakakore i nga raau taero.
2.2 Whakapai ake i te kounga o te paninga
HPMC rite te kiriata hanga rauemi, whakaritea ki ētahi atu kiriata hanga rauemi (kapia kiriaku, polyethylene pyrrolidone), te painga nui ko tona wairewa wai, e kore e hiahia whakarewa organic, mahi haumaru, watea. NaHPMChe momo o nga tohu pokey, kowhiringa e tika ana, whakakikoruatia te kounga o te kiriata, he pai ake te ahua i era atu rauemi. Ko nga papa Ciprofloxacin hydrochloride he papa maama me nga reta taha-rua. Ko enei pire mo te paninga kiriata angiangi he uaua, na roto i te whakamatautau, ka kowhiri i te pokey o te 50 mpa # s o te plasticizer wairewa-wai, ka taea te whakaiti i te ahotea o roto o te kiriata angiangi, te paninga papa kaore he piriti / werawera 0, 0, 0, 0 / karaka hinu tihorea, 0 / kapiti, penei i te raru o te kounga, te whakakikorua i te hanga kiriata wai, te piri pai, me te kawe mai i te pito o te kupu kaore he turuturu, ka taea te panui, Kotahi – taha kanapa, ataahua. Ka whakatauritea ki te wai whakakikorua tuku iho, he maamaa, he whaitake hoki tenei whakahaunga, a ka tino heke te utu.
Wā tuku: Apr-25-2024