Kāwai: rauemi whakakikorua; rauemi membrane; Ko nga rauemi polymer tere-whakahaere mo nga whakaritenga tuku puhoi; Kaitohu whakau; He awhina whakatara, whakapiri papa; He kaihoko adhesion whakakaha.
1. Hua whakataki
KO TE HUA TENEI HUA KO TE IONIC CELLULOSE ETHER, ka kitea i waho he paura ma, he hongi me te kore reka, he wairewa i roto i te wai me te nuinga o nga whakarewa pararopi polar, e pupuhi ana i te wai matao ki te whakamotitia, ki te wairewa colloidal paku noa ranei. Ko te wairewa wai he mahi mata, he tino marama me te mahi pumau. Kei a HPMC te taonga o te kiri wera. Whai muri i te whakamahana, ka hangaia e te wairewa wai te wai o te wai o te hua i te rerenga wai, ka rewa i muri i te whakamatao. He rereke te pāmahana reera o nga whakaritenga rereke. Ko nga huringa o te wairewa me te viscosity, te iti o te viscosity zhao, ko te nui ake o te whakarewatanga, he rereke nga whakaritenga o nga taonga HPMC, ko te HPMC kua rewa ki te wai kaore e pa ki te uara pH.
Ko te pāmahana ngingiha mahorahora, te kiato wewete, te kiato pono me te pāmahana whakawhiti karaihe ko 360 ℃, 0.341g/cm3, 1.326g/cm3 me 170 ~ 180 ℃, ia. I muri i te whakamahana, ka huri parauri ki te 190 ~ 200 ° C ka wera ki te 225 ~ 230 ° C.
Ko te HPMC he tata kore e rewa i roto i te chloroform, te ewaro (95%), me te diethyl ether, ka rewa ki roto i te ranunga o te ewaro me te methylene chloride, te ranunga o te methanol me te methylene chloride, me te ranunga o te wai me te waihano. Ko etahi o nga taumata o te HPMC ka whakarewahia i roto i nga ranunga o te acetone, methylene chloride, me te 2-propanol, me etahi atu whakarewa pararopi.
Ripanga 1: Tohu Hangarau
kaupapa
mehua,
60 gd (2910).
65GD(2906)
75GD(2208)
Methoxy %
28.0-32.0
27.0-30.0
19.0-24.0
Hydroxypropoxy %
7.0-12.0
4.0-7.5
4.0-12.0
Paemahana kiri ℃
56-64.
62.0-68.0
70.0-90.0
Viscosity mpa s.
3,5,6,15,50,4000
50400 0
100400 0150 00100 000
mate taimaha maroke %
5.0 iti iho ranei
Te toenga tahu %
1.5 iti iho ranei
pH
4.0-8.0
Te whakarewa taumaha
20 iti iho ranei
arsenic
2.0 iti iho ranei
2. Nga ahuatanga hua
2.1 Ka rewa te Hydroxypropyl methylcellulose ki te wai matao hei hanga i te wairewa colloidal viscous. I te mea ka taapirihia ki te wai matao me te whakaoho paku, ka taea te rewa ki te otinga marama. Engari, karekau e rewa i roto i te wai wera i runga ake i te 60 ℃ ka pupuhi noa. I roto i te whakaritenga o te wairewa wai hydroxypropyl methicellulose, he pai ake te taapiri i tetahi waahanga o te hydroxypropyl methicellulose ki roto i te nui o te wai, kia kaha te whakaoho, kia wera ki te 80 ~ 90 ℃, katahi ka taapirihia te toenga hydroxypropyl methicellulose, ka mutu te whakamahi i te wai matao hei taapiri. ki te nui e hiahiatia ana.
2.2 Ko te Hydroxypropyl methylcellulose he ether cellulose kore-ionic, kaore tana otinga e kawe i te utu katote, kaore e pahekoheko ki nga tote whakarewa, ki nga pūhui waro katote ranei, kia kore ai te HPMC e tauhohe me etahi atu rauemi mata me nga taapiri i roto i te tukanga o te whakarite. hangahanga.
2.3 Hydroxypropyl methylcellulose he kaha anti-sensitivity, me te pikinga o te tohu whakakapinga i roto i te hanganga ngota, ka whakareihia ano te anti-sensitivity. Ko nga raau taero e whakamahi ana i te HPMC hei awhina he pai ake te kounga i roto i te waa whai hua atu i nga raau taero e whakamahi ana i etahi atu rongoa tuku iho (te maaka, te dextrin, te paura huka).
2.4 Ko te Hydroxypropyl methylcellulose he mokowhiti. I te mea he rongoa rongoa, kaore i te whakakorikorihia, i te ngongo ranei, na reira kaore i te wera i roto i nga raau taero me nga kai. He mea motuhake ki te uara pukoro iti, te tote-kore, nga raau taero kore-allergenic me te kai mo te hunga mate huka.
Ko te 2.5HPMC he tino pumau ki nga waikawa me nga turanga, engari ki te nui ake te pH ki te 2 ~ 11 ka pa ki te teitei ake o te pāmahana, te roa ake ranei o te waa rokiroki, ka whakaitihia te tohu o te maoa.
2.6 Ka taea e te wairewa wairewa Hydroxypropyl methylcellulose te whakakorikori i te mata, e whakaatu ana i nga uara o te mata ngawari me nga uara riipene atanga. He emulsification whai hua i roto i te pūnaha rua-wahanga, me te taea te whakamahi hei stabilizer whai hua me te colloid tiaki.
2.7 Hydroxypropyl methylcellulose wairewa wai he pai rawa nga ahuatanga hanga kiriata, a he mea whakakikorua pai mo nga papa me nga pire. Ko te membrane i hangaia e ia he kore tae, he uaua. Mena ka taapirihia te glycerol, ka taea te whakanui ake i te kirihou. I muri i te maimoatanga o te mata, ka marara te hua i roto i te wai makariri, a ka taea te whakahaere i te tere o te whakakore ma te huri i te taiao pH. Ka whakamahia i roto i nga whakaritenga tuku puhoi me nga whakaritenga kua pania ki te enteric.
3. Tono hua
3.1. Ka whakamahia hei kaapiri me te maataki pakaru
Ka whakamahia te HPMC ki te whakatairanga i te whakakorenga tarukino me te tohu o nga tono tuku, ka taea te rewa tika i roto i te whakarewa hei whakapiri, te iti o te pokey o te HPMC kua rewa i roto i te wai ki te hanga marama ki te rei riipi otinga colloid, papa, pire, granules i runga i te whakapiri me te pakaru. kaihoko, me te pokey teitei mo te kāpia, whakamahia anake na te momo rereke me nga whakaritenga rereke, ko te whanui ko te 2% ~ 5%.
Wairewa wai HPMC me tetahi kukū o te waihā hei hanga i te herenga hiato; Hei tauira: 2%HPMC wairewa wai i konatunatua ki te 55% wairewa waihano i whakamahia mo te pelleting o te amoxicillin capsules, kia piki ake te rewa toharite o nga kapene amoxicillin mai i te 38% ki te 90% kaore he HPMC.
Ka taea te hanga HPMC ki te whakapiri hiato me te kukū rereke o te slurry māngaro i muri i te whakakorenga; Ko te whakakorenga o nga papa erythromycin enteric-coated i piki mai i te 38.26% ki te 97.38% i te wa i whakakotahihia te 2% HPMC me te 8% starch.
2.2. Hangaia he mea paninga kiriata me nga mea hanga kiriata
Ko te HPMC hei rauemi whakakikorua wai-wairewa he ahuatanga e whai ake nei: te pokey otinga ngawari; He ngawari te tukanga whakakikorua; He taonga hanga kiriata pai; Ka taea te pupuri i te ahua o te waahanga, te tuhi; Ka taea te makuku; Ka taea te tae, te kakara whakatika. HE WHAKAMAHI TENEI HUA HEI KAUPAPA KAUPAPA KAUPAPA KAUPAPA KAUPAPA MO NGA TAPU ME NGA PIRE KAUPAPA KAUPAPA KAUPAPA, MO TE KAUPAPA KAUPAPA KAUPAPA KAUPAPA KAUPAPA KAUPAPA, KO TE WHAKAMAHI KAUPAPA KO TE 2%-5%.
2.3, hei māngai mātotoru me te kāpia tiaki colloidal
HPMC whakamahia rite māngai thickening ko 0.45% ~ 1.0%, ka taea te whakamahi rite pata kanohi me te māngai thickening roimata horihori; Ka whakamahia ki te whakanui ake i te pumau o te kapia hydrophobic, te aukati i te whakakotahitanga matūriki, te rerenga, te inenga o mua ko te 0.5% ~ 1.5%.
2.4, hei aukati, he mea tuku puhoi, he kaihoko tuku whakahaere me te kaihoko pore
Ka whakamahia te tauira pokey teitei o te HPMC ki te whakarite i nga kaitarai me nga apiha tuku whakahaere o nga papa tuku anga angiwi whakauru me nga papa tuku totika a te anga wai. Ko te tauira iti-pokey he kaihoko pore-inducing mo nga papa tuku-whakahaere, whakahaere-whakahaere ranei kia tere te whiwhi i te horopeta haumanu tuatahi o aua papa, ka whai muri i te tuku-a-te-whakahaere, te whakahaere-whakahaere ranei ki te pupuri i nga kohinga whai hua i roto i te toto.
2.5. Karepe me te matrix suppository
Ka taea te whakareri i nga whakangao wairere me nga whakaritenga whakapiri pekitiki ma te whakamahi i nga ahuatanga o te hanga hydrogel e whakamahia ana e te HPMC ki te wai.
2.6 Nga rauemi whakapiri koiora
I konatunatuahia te Metronidazole ki te HPMC me te polycarboxylethylene 934 i roto i te whakaranu hei hanga i nga papa tuku tuku koiora kei roto te 250mg. I whakaatuhia e te whakamatautau whakangao in vitro he tere te pupuhi o te whakareri i roto i te wai, a ko te tukunga o te raau taero i whakahaerehia e te whakamaarama me te whakangawari mekameka waro. I kitea e te whakatinanatanga kararehe ko te punaha tuku rongoa hou he nui nga ahuatanga o te piri koiora ki te mucosa sublingual bovine.
2.7, hei awhina whakatara
Ko te pokey HIGH o tenei hua he awhina whakatārewatanga pai mo te whakarite wai whakatārewatanga, ko tana inenga o mua ko te 0.5% ~ 1.5%.
4. Tauira tono
4.1 Te otinga whakakikorua Kiriata: HPMC 2kg, talc 2kg, hinu katorika 1000ml, Twain -80 1000ml, propylene glycol 1000ml, 95% ewaro 53000ml, wai 47000ml, poaka e tika ana. E rua nga huarahi hei hanga.
4.1.1 Te whakarite i te wai whakakikorua i nga kakahu whakakikorua i te waiu: Taapirihia te nui o te HPMC ki roto i te 95% te waihano, ka ruia mo te po, ka rewa tetahi atu vector pigment ki roto i te wai (tatari mehemea e tika ana), whakakotahi i nga wairewa e rua ka oho kia rite ki te hanga i tetahi otinga marama. . Whakaranuhia te 80% o te otinga (20% mo te whakakorikori) me te nui o te hinu castor, Tween-80, me te propylene glycol.
4.1.2 Te takahanga o te poaka karekau (pērā i te waikura rino) whakakikoruatia te wai HPMC i te 95% te waihā i te pō, ka tāpirihia te wai kia 2%HPMC te otinga maramara. Ko te 20% o tenei otinga i tangohia hei whakakorikori, a ko te toenga 80% o te wairewa me te waikura rino i mahia ma te tikanga huri wai, katahi ka taapirihia te nui o te whakahaunga o etahi atu waahanga me te whakaranu kia rite mo te whakamahi. Ko te tukanga whakakikorua o te wai whakakikorua: ringihia te pepa witi ki roto i te kohua paninga huka, i muri i te hurihanga, ka wera te hau wera ki te 45 ℃, ka taea e koe te pupuhi i te paninga kai, te whakahaere rere i roto i te 10 ~ 15ml / min, i muri i te pupuhi, ka maroke tonu. me te hau wera mo te 5 ~ 10min ka puta mai i te kohua, maka ki roto i te whakamaroke kia maroke mo te neke atu i te 8h.
4.2α-interferon kanohi membrane 50μg o α-interferon i rewa i roto i te 10ml0.01ml waikawa pūmāota, i konatunatua ki te 90ml te waihā me te 0.5GHPMC, kua tohua, kua pania ki runga i te rakau karaihe hurihuri, kua whakamarokehia i te 60 ℃ ka maroke i te hau. Ka hangaia tenei hua hei taonga kiriata.
4.3 Papa Cotrimoxazole (0.4g±0.08g) SMZ (80 mata) 40kg, māngaro (120 mata) 8kg, 3%HPMC wairewa wai 18-20kg, konupora stearate 0.3kg, TMP (80 mata) 8kg, te tikanga whakarite ko te ki uruhia te SMZ me te TMP, katahi ka tapirihia te maaka ka uru mo te 5min. Ki te wairewa wai 3%HPMC kua oti te hanga, he mea ngohengohe, me te 16 mesh mata granulation, whakamaroke, a ka ki 14 mata mata witi katoa, tāpiri konupora stearate ranunga, ki te 12mm a tawhio noa ki te kupu (SMZco) papa takahi. Ko te nuinga o tenei hua ka whakamahia hei here. Ko te rewa o nga papa he 96%/20min.
4.4 Piperate papa (0.25g) piperate 80 mata 25kg, māngaro (120 mata) 2.1kg, konupora stearate te rahinga tika. Ko tana tikanga whakaputa ko te whakaranu i te waikawa pipeoperic, te maaka, te HPMC kia rite, me te 20% te waihano mea ngohengohe, 16 mata mata granulate, maroke, a ka 14 mata mata witi katoa, me te vector konupora stearate, me te 100mm kupu whitiki porohita (PPA0.25 ) nga papa takai. Ki te māngaro hei kaihoko whakakore, ko te tere rewa o tenei papa kaua e iti iho i te 80%/2min, he teitei ake i nga hua rite i Hapani.
4.5 Haehae horihori HPMC-4000, HPMC-4500 or HPMC-5000 0.3g, konutai pūhaumāota 0.45g, pāhare pāporo pūhaumāota 0.37g, borax 0.19g, 10% haukinia chlorbenzylammonium otinga 0.02ml, wai tāpiri ki te 10ml. Ko tana tikanga whakaputa ko te HPMC ka whakanohoia ki roto i te wai 15ml, i te 80 ~ 90 ℃ te wai ki tonu i te wai, taapirihia te 35ml wai, katahi ka mau nga toenga o te 40ml wairewa wai i konatunatua kia rite, taapirihia te wai ki te nui tonu, ka konatunatua kia rite, ka tu mo te po. , ringihia atahia te filtration, filtrate ki roto i te ipu kua hiritia, kua whakahoroa ki te 98 ~ 100 ℃ mo te 30min, ara, Ko te pH mai i 8.4 ° C ki te 8.6 ° C. HE WHAKAMAHI TENEI HUA MO TE TAHUA ROIMATA, HE WHAKAARO pai mo te roimata, ka whakamahia mo te microscopy ruma o mua, ka taea te whakanui tika i te horopeta o tenei hua, 0.7% ~ 1.5% he tika.
4.6 Meththorphan mana tuku papa meththorphan resin tote 187.5mg, lactose 40.0mg, PVP70.0mg, vapor silica 10mg, 40.0 mGHPMC-603, 40.0mg ~ microcrystalline cellulose phthalate-102.5mg stearate. Ka whakaritea hei papa ma te tikanga noa. Ka whakamahia tenei hua hei rauemi tuku whakahaere.
4.7 Mo nga papa avantomycin ⅳ, 2149g avantomycin ⅳ monohydrate me te 1000ml te ranunga wai isopropyl o 15% (te kukū papatipu) eudragitL-100 (9: 1) i whakaohohia, i konatunatua, i te kirikiri, ka maroke i te 35 ℃. Ko nga granules maroke 575g me te 62.5g hydroxypropylocellulose E-50 i tino whakaranuhia, katahi ka taapirihia te 7.5g waikawa stearic me te 3.25g konupora stearate ki nga papa ki te tuku tonu i nga papa vanguard mycin ⅳ. Ka whakamahia tenei hua hei rauemi tuku puhoi.
4.8 Ko nga papura tuku totika a Nifedipine 1 wahanga nifedipine, e 3 nga wahanga hydroxypropyl methyl cellulose me nga wahanga ethyl cellulose e 3 i konatunatua ki te whakarewa whakauru (ewaro: methylene chloride = 1:1), a e 8 nga wahanga o te maaka kanga i tapirihia hei whakaputa i nga kowhatu ma te reo-wairewa. tikanga. Ko te tere o te tuku tarukino o nga papura kaore i pa ki te huringa o te pH taiao me te puhoi ake i tera o nga kirikiri e waatea ana ki te hokohoko. I muri i nga haora 12 o te whakahaere waha, ko te toto toto o te tangata ko 12mg / ml, a kaore he rereketanga o te tangata.
4.9 Propranhaol hydrochloride pūmau tuku pūmau Propranhaol hydrochloride 60kg, microcrystalline cellulose 40kg, tāpiri 50L wai ki te hanga granules. Ko te HPMC1kg me te EC 9kg i konatunatua ki te whakarewa whakauru (methylene chloride: methanol =1:1) 200L ki te hanga i te otinga whakakikorua, me te tere rere o te 750ml/min rehu i runga i nga matūriki porowhita hurihuri, matūriki pani i roto i te rahi o te pore o te 1.4 mm nga matūriki katoa, ka whakakiia ki roto i te kapene kohatu me te miihini whakakii kapi noa. Kei ia capsule 160mg o propranolol hydrochloride matūriki porohita.
4.10 Naprolol HCL skeleton tablets i whakaritea ma te ranu naprolol HCL :HPMC: CMC-NA i te tauwehenga o te 1:0.25:2.25. Ko te tere o te tuku tarukino i tata ki te kore ota i roto i te 12 haora.
Ko etahi atu raau taero ka taea ano te hanga mai i nga taonga koiwi whakauru, penei i te metoprolol: HPMC: CMC-NA kia rite ki: 1: 1.25: 1.25; Allylprolol :HPMC rite ki te 1:2.8:2.92 ōwehenga. Ko te tere o te tuku tarukino i tata ki te kore ota i roto i te 12 haora.
4.11 I whakaritea nga papa angaahi o nga mea whakauru o te ethylaminosine derivatives ma te whakamahi i te ranunga o te moroiti paura silica gel: CMC-NA :HPMC 1:0.7:4.4. Ka taea te tuku i te rongoa mo te 12h i roto i te vitro me te in vivo, a he pai te hononga o te tauira tuku raina. Ko nga hua o te whakamatautau pumau i runga i nga ture a te FDA e tohu ana ko te roanga o te rokiroki o tenei hua ki te 2 tau.
4.12 HPMC (50mPa·s) (5 ngā wāhanga), HPMC (4000 mPa·s) (3 ngā wāhanga) me HPC1 i rewa i roto i te 1000 ngā wāhanga wai, 60 ngā wāhanga acetaminophen me 6 ngā wāhanga silica gel i tāpirihia, i whakakorikoria ki te homogenizer, a rehu maroke. Kei roto i tenei hua te 80% o te rongoa matua.
4.13 I tatauhia nga papa anga anga Theophylline hydrophilic gel i runga i te taumaha o te papa katoa, 18%-35% theophylline, 7.5% -22.5% HPMC, 0.5% lactose, me te nui o te hinu hinu wai-wai-wai i te nuinga o te wa ka whakaritea ki nga papa tuku mana, ka taea pupuri i te kukū toto whai hua o te tinana tangata mo te 12h i muri i te whakahaere waha.
Wā tuku: Feb-05-2024