Hydroxypropyl methylcellulose (HPMC), yomwe imadziwikanso kuti hypromellose, ndi polima yosunthika yomwe imagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala. Ndi semi-synthetic, inert, viscoelastic polima yochokera ku cellulose, polysaccharide yachilengedwe. HPMC ndi yamtengo wapatali chifukwa cha kusungunuka kwake m'madzi, chikhalidwe chosakhala ndi poizoni, komanso kuthekera kwake kupanga mafilimu ndi ma gels.
1. Binder mu Tablet Formulations
Chimodzi mwazofunikira kwambiri za HPMC pazamankhwala ndi monga chomangira pamapangidwe a mapiritsi. HPMC imagwiritsidwa ntchito kuwonetsetsa kuti zosakaniza zomwe zili mu piritsi zimagwirizana ndikukhalabe okhazikika mpaka zitalowetsedwa. Kumangirira kwake kumapangitsa kuti mapiritsi azikhala ndi mphamvu zamakina, zomwe zimapangitsa kuti asamaphwanyike kapena kusweka panthawi yolongedza, kuyendetsa, ndikugwira. Kuonjezera apo, chikhalidwe cha HPMC chosakhala cha ionic chimatsimikizira kuti sichigwirizana ndi zosakaniza zina, kusunga bata ndi mphamvu ya zosakaniza zogwiritsira ntchito mankhwala (APIs).
2. Kutulutsidwa kwa Matrix
HPMC ndiyofunikira pakupanga kumasulidwa kolamulidwa (CR) ndi kumasulidwa kosasunthika (SR). Mankhwalawa amapangidwa kuti amasule mankhwalawa pamlingo wodziwikiratu, kukhalabe ndi milingo yokhazikika yamankhwala m'magazi kwa nthawi yayitali. Kuthekera kopanga gel osakaniza kwa HPMC kukakumana ndi madzi am'mimba kumapangitsa kuti izi zitheke. Amapanga mawonekedwe a gel osakaniza kuzungulira piritsi, kuwongolera kufalikira kwa mankhwalawa. Khalidweli limapindulitsa makamaka kwa mankhwala omwe ali ndi index yopapatiza yochizira, chifukwa imathandizira kusunga ndende ya plasma yomwe mukufuna, potero kumawonjezera mphamvu komanso kuchepetsa zotsatira zoyipa.
3. Kuphimba Mafilimu
Kugwiritsa ntchito kwina kofunikira kwa HPMC ndikupaka filimu pamapiritsi ndi makapisozi. Zovala zokhala ndi HPMC zimateteza piritsi kuzinthu zachilengedwe monga chinyezi, kuwala, ndi mpweya, zomwe zimatha kusokoneza zinthu zomwe zimagwira ntchito. Kupaka filimu kumapangitsanso kukongola kwa piritsi, kumapangitsanso kukoma kokoma, ndipo kungagwiritsidwe ntchito kupereka chitetezo cha matumbo, kuonetsetsa kuti mankhwalawa amatulutsidwa m'madera ena a m'mimba. Kuphatikiza apo, zokutira za HPMC zitha kupangidwa kuti zisinthe mawonekedwe a mankhwalawa, ndikuthandizira njira zoperekera zomwe akutsata.
4. Thickening Agent
HPMC akutumikira monga ogwira thickening wothandizila mu madzi formulations monga syrups ndi suspensions. Kutha kuonjezera mamasukidwe akayendedwe popanda kwambiri kusintha zina katundu wa chiphunzitso n'kopindulitsa kuonetsetsa yunifolomu kugawa mankhwala mkati mwa madzi, kupewa sedimentation ya inaimitsidwa particles, ndi kupereka zofunika mouthfeel. Katunduyu ndi wofunikira kwambiri pamapangidwe a ana ndi akulu, pomwe kuwongolera kumakhala kofunika kwambiri.
5. Stabilizer mu Topical Formulations
M'mapangidwe apamutu monga zonona, ma gels, ndi mafuta odzola, HPMC imakhala ngati stabilizer ndi emulsifier. Zimathandizira kukhazikika ndi kukhazikika kwa mapangidwewo, kuonetsetsa kuti zinthu zogwira ntchito zimagawidwa mofanana. HPMC imaperekanso mawonekedwe osalala, kupititsa patsogolo ntchito ndi kuyamwa kwa mankhwala pakhungu. Chikhalidwe chake chosakwiyitsa chimapangitsa kuti chigwiritsidwe ntchito popanga khungu lodziwika bwino.
6. Kukonzekera kwa Ophthalmic
HPMC imagwiritsidwa ntchito kwambiri pokonzekera maso, monga misozi yochita kupanga ndi njira zothetsera ma lens. Mawonekedwe ake a viscoelastic amatsanzira filimu yachilengedwe yamisozi, kupereka mafuta ndi chinyezi m'maso. Madontho a maso opangidwa ndi HPMC ndi opindulitsa makamaka kwa anthu omwe ali ndi vuto la diso lowuma, lomwe limapereka mpumulo ku mkwiyo komanso kusapeza bwino. Kuphatikiza apo, HPMC imagwiritsidwa ntchito m'machitidwe operekera mankhwala a ocular, komwe imathandizira kutalikitsa nthawi yolumikizana ndi mankhwalawo ndi mawonekedwe owoneka bwino, kumathandizira kuchiza.
7. Kupanga kapisozi
HPMC imagwiritsidwanso ntchito popanga makapisozi olimba komanso ofewa. Imakhala ngati m'malo mwa gelatin, ikupereka njira yamasamba ya zipolopolo za capsule. Makapisozi a HPMC amakondedwa chifukwa cha chinyezi chochepa, chomwe chimakhala chopindulitsa pamankhwala oletsa chinyezi. Amaperekanso kukhazikika kwabwinoko pamikhalidwe yosiyanasiyana ya chilengedwe ndipo samatha kulumikizana, nkhani yodziwika ndi makapisozi a gelatin omwe angakhudze mbiri yotulutsa mankhwala.
8. Kupititsa patsogolo kwa Bioavailability
M'mapangidwe ena, HPMC imatha kupititsa patsogolo kupezeka kwa mankhwala osasungunuka bwino. Mwa kupanga gel osakaniza masanjidwewo, HPMC akhoza kuonjezera Kusungunuka kwa mankhwala mu thirakiti m'mimba, kutsogolera mayamwidwe bwino. Izi ndizofunikira kwambiri pamankhwala omwe ali ndi kusungunuka kwamadzi otsika, chifukwa kusungunuka kwabwino kumatha kukhudza kwambiri machiritso a mankhwalawa.
9. Mucoadhesive Mapulogalamu
HPMC imasonyeza zinthu zomatira mucoadhesive, zomwe zimapangitsa kuti zikhale zoyenera kwa machitidwe a buccal ndi sublingual mankhwala operekera mankhwala. Machitidwewa amafuna mankhwala kumamatira mucous nembanemba, kupereka yaitali kumasulidwa ndi mayamwidwe mwachindunji m`magazi, kulambalala woyamba chiphaso kagayidwe. Njirayi ndi yopindulitsa kwa mankhwala omwe amawononga m'mimba acidic kapena kukhala ndi bioavailability wapakamwa.
Kusinthasintha kwa hydroxypropyl methylcellulose (HPMC) muzopanga zamankhwala sikunganenedwe mopambanitsa. Ntchito zake zimachokera ku zomangira mapiritsi ndi zokutira filimu kupita ku thickening ndi stabilizing agents mumitundu yosiyanasiyana. Kuthekera kwa HPMC kusintha mbiri yotulutsa mankhwala, kukulitsa kupezeka kwa bioavailability, komanso kupereka mucoadhesion kumatsimikiziranso kufunikira kwake pakupanga njira zapamwamba zoperekera mankhwala. Pamene makampani opanga mankhwala akupitilirabe, udindo wa HPMC ukhoza kukulirakulira, motsogozedwa ndi kafukufuku wopitilira ndi ntchito zachitukuko zomwe cholinga chake ndi kukhathamiritsa kaperekedwe ka mankhwala ndi zotsatira za odwala.
Nthawi yotumiza: Jun-05-2024