Hydroxypylth methylcellulose (hpmc) Ndi zopanga zopangidwa, zomwe zimapangitsa kuti polity polity achokera ku cellulose, polysaride wachilengedwe. HPMC imakhala yofunika kususuka kwake m'madzi, osagwirizana ndi poizoni, komanso kuthekera kwake kupanga mafilimu ndi ma gels.
1. Conder mu piritsi
Chimodzi mwazinthu zoyambirira za HPMC mu mankhwala ali mu mankhwala ali ngati binder mu piritsi. HPMC imagwiritsidwa ntchito kuti zitsimikizire kuti zosakaniza za piritsi zimagwirizana pamodzi ndikukhazikika. Malo ake omanga akusintha mphamvu yamakina mapiritsi, kuwapangitsa kuti azikhala osadukiza kapena kuthyola panthawi ya madamu, mayendedwe, ndi kusamalira. Kuphatikiza apo, chilengedwe cha HPMC sichimawoneka ngati zosakaniza ndi zosakaniza zina, zomwe zikugwirizana ndi kukhazikika komanso kufunikira kwa mankhwala opangira mankhwala (apis).
2. Kutulutsa matrix
HPMC imafunikira kwambiri pakupanga kumasulidwa (CR) ndi kumasulidwa kwake (sr). Mapangidwe awa adapangidwa kuti atulutse mankhwalawo pamlingo wokonzedweratu, kusunga mankhwala osokoneza bongo pamagazi nthawi yayitali. Kutha kwa gel opanga ndi galoni pakukhudzana ndi miyala yam'mimba kumapangitsa kuti ikhale yabwino pazolinga izi. Imapanga mawonekedwe a sycaus gel mozungulira piritsi, ndikuwongolera mawonekedwe a mankhwalawa. Khalidwe ili limapindulitsa makamaka mankhwala osokoneza bongo okhala ndi njira yochepetsera, chifukwa imathandizanso kusunga plasma yofunikira, potero imathandizira bwino komanso kuchepetsa mavuto.
3.. Filimu yophimba
Kanema wina wofunika kwambiri wa HPMC ali mu kanema wokutidwa mapiritsi ndi makapisozi. Zovala za HPMC zimateteza piritsi ku chilengedwe monga chinyezi, kuwala, ndi mpweya, zomwe zimapangitsa kusokoneza zosagwira. Kuphimba kwamafilimu kumathandiziranso kukoma kwa piritsi, kumathandizanso kukoma, ndikuwonetsetsa kuti atetezedwe, kuonetsetsa mankhwalawa amasulidwa kumadera achipongwe. Kuphatikiza apo, zokutira za HPMC zitha kupangidwa kuti zisinthe mawonekedwe a mankhwalawa, pothandizira kuti muchepetse.
4. Wothandizila kukula
HPMC imagwira ntchito yothandiza kwambiri mu madzi amadzimadzi monga syrups ndi kuyimilira. Kutha kwake kukulitsa mamasukidwe osasintha zinthu zina za kapangidwe kake ndi kopindulitsa pakuwonetsetsa kuti mugawidwe kachulukidwe ka mankhwala, ndikupereka pakamwa. Katunduyu ndi wofunikira kwambiri mu ma prodric komanso ma geriatric ma geriatric, pomwe nthawi yoyang'anira ndiyofunika.
5. Stabilizer pamapangidwe apamwamba
M'mapanga apamwamba ngati mafuta, ma gels, ndi mafuta, hpmc amachita ngati chokhazikika komanso emulsifier. Zimathandizira kusasinthika komanso kukhazikika kwa kapangidwe kake, kuonetsetsa kuti zosagwira ntchito zimagawidwa. HPMC imaperekanso mawonekedwe osalala, kukulitsa njira ndi mayamwidwe pazogulitsa pakhungu. Makhalidwe ake osakwiya amapangitsa kuti ikhale yoyenera kugwiritsa ntchito khungu lakhungu.
6. Kukonzekera kwa oputhalmic
HPMC imagwiritsidwa ntchito kwambiri kukonzekera kwa ophthalmic, monga misozi yopanda zojambula ndi ma lens. Katundu wake wa ma viscoelastic amatsatira filimu ya chilengedwe, kupereka mafuta ndi chinyezi m'maso. Maso a HPMC amatsitsidwa makamaka kwa anthu omwe ali ndi matenda owuma, kupereka mpumulo ku mkwiyo komanso kusapeza bwino. Kuphatikiza apo, hpmc imagwiritsidwa ntchito mu njira zobweretsera mankhwala ocular, komwe zimathandizira nthawi yolumikizana ndi mankhwalawa ndi ocrur pamtunda, zimathandizira kuchira.
7. Kupanga kapasole
HPMC imagwiritsidwanso ntchito popanga makapisozi olimba ndi ofewa. Ili ndi njira ina ku gelatin, kupereka njira yatsamba kwa zipolopolo za mapisozi. Makapisozi a HPMC amasankhidwa chifukwa cha chinyontho chawo chachinyontho, chomwe ndichabwino kwa mankhwala onyowa. Amathandizanso mokhazikika mu chilengedwe ndipo sangakhale ndi ulalo wolumikizana, vuto lodziwika ndi makapisozi omwe amatha kusokoneza mapangidwe omasulidwa mankhwala.
8. Kupititsa patsogolo bioagality
Mu mapangidwe ena, hpmc amatha kukulitsa bioaavailability ya mankhwala osungunuka bwino. Popanga matrix a gel, hpmc amatha kuwonjezera kufooka kwa mankhwala m'mimba, kuthandizira mayamwidwe abwino. Izi ndizofunikira makamaka pamankhwala osungunuka madzi osungunuka, monga kuwonongeka kwabwino kumatha kukhumudwitsa kwambiri mankhwala ochizira.
9. MaChodum Mapulogalamu
HPMC imawonetsa katundu, ndikupanga kukhala koyenera kwa ma sccal ndi matenda osokoneza bongo. Makina awa amafunikira mankhwalawa kutsatira ma nembanemba a mucous, amatulutsa nthawi yayitali komanso magazi molunjika m'magazi, kudutsa kagayidwe koyamba. Njirayi ndi yopindulitsa mankhwala omwe amawononga mu chilengedwe cham'mimba kapena kukhala ndi bioavailaty pano.
Kuthera kwa hydroxypropyl methylcellulose (hpmc) mu mankhwala opanga mankhwala sangafapo kanthu. Ntchito zake zimakhala zochokera ku piritsi zomangika ndikuwombera kuti zitheke ndi kukhazikika mumitundu yosiyanasiyana. Kutha kwa HPMC kusinthitsa mafayilo omasulira, kuwonjezera pa bioaavality, ndikuwapatsanso makina ofunika kwambiri pakukula kwa madongosolo anthawi yayitali. Makampani ogulitsa mankhwala akupitiliza kusinthika, ntchito ya HPMC idzakula, yoyendetsedwa ndi kuyeserera kwanthawi yomwe mukufuna kukhazikitsa pokonza mankhwala othandizira ndi opirira.
Post Nthawi: Jun-05-2024