Hydroxypropyl cellulose, zophatikizira zophatikizira, zimagawidwa mu cellose yotsika (L-HPC) ndi Hoproxypropyll cellulose (HPC) malinga ndi zomwe zili m'malo ake a Hydroxypropoxy. L-HPC imatupa mu yankho la colloidal m'madzi, ili ndi katundu wazotsatira, mapangidwe a filimu, emulsization, etc., ndipo amagwiritsidwa ntchito ngati wothandizila ndi binder; Pomwe H-HPC imasungunuka m'madzi ndi osiyanasiyana okhazikika firiji, ndipo ili ndi thermoplascity yabwino. , zokhala ndi zithunzi ndi katundu wamavidiyo, filimu yopangidwa ndi yovuta, yonyezimira, komanso yotanuka, ndipo imagwiritsidwa ntchito ngati mawonekedwe a makanema komanso zokutira. Kugwiritsa ntchito kwa hydroxypyl cellulose pokonzekera bwino tsopano.
1. Monga kunyalanyaza kukonzekera molimba monga mapiritsi
Pamwamba pa Hydroxpyl yotsika kwambiri cellose tinthu tambiri ndi osasinthika, okhala ndi mwala wooneka ngati mwala wowoneka bwino. Mawonekedwe owoneka bwino awa samangopanga malo akuluakulu, komanso pomwe amakakamizidwa kukhala ndi mankhwala osokoneza bongo ndi zina zambiri, ma capillaries ambiri amapangidwa mu piritsi Mayamwidwe ndi mayamwidwe amadzi amawonjezera kutupa. OgwilizitsaL-hpcMonga zopatsa mphamvu zimatha kupanga piri mwachangu mwachangu kukhala yunifolomu, ndipo zimapangitsa kuti kulowetsedwa, kusungunuka ndi bioavailabilobility wa piritsi. Mwachitsanzo, kugwiritsa ntchito l-hpc kumatha kuthamanga mapiritsi a paracetamol, mapiritsi a aspirin mapiritsi, ndi chlorpheniramine, ndikusintha chilengedwe. Kusokonezeka ndi kusungunuka kwa mankhwala osungunuka bwino mapiritsi okhala ndi L-HPC ngati kusokoneza kwa PVPP, CRD-NMS-NAS-NAS-NAF ngati kusokoneza. Pogwiritsa ntchito l-hpc ngati kuwonongeka kwamkati kwa ma granules mu makapisozi kumakhala kopindulitsa pakuchotsa ma granules, kumawonjezera kusokonekera kwa mankhwalawa, kumalimbikitsa kusungunuka kwa mankhwalawa, ndikulimbikitsa bioavailability. Amasula kukonzekera motalika poyimiriridwa ndi kukonzekera kothamanga ndi kukonzekera molimba ndi kusungunuka kokhazikika, kusungunuka mwachangu, kuchepetsedwa kwa mankhwalawa, ndipo ndi yabwino kutenga ndipo khalani ndi kutsatira. ndi maubwino ena, okhala ndi udindo wofunikira m'munda wa mankhwala. L-HPC yakhala imodzi mwazosangalatsa kwambiri kuti musunge kukonzekera mwachangu chifukwa cha hydrophilicity yamphamvu, hysphopicity, nthawi yayifupi, madzi mwachangu kwa madzi kuthamanga, komanso madzi achangu Ndi njira yabwino yopezera mapiritsi a pakamwa. Paracetamol pakamwa mapiritsi adakonzedwa ndi L-HPC ngati kuwonongeka, ndipo magome adasanjidwa mwachangu mkati mwa 20s. L-HPC imagwiritsidwa ntchito ngati chosowa mapiritsi, ndipo Mlingo wake wa 2% mpaka 10%, makamaka 5%.
2. Monga chomangira pokonzekera monga mapiritsi ndi granules
Mapangidwe owopsa a L-HPC amathandizanso kukhala ndi mafupa azosangalatsa ndi mankhwala osokoneza bongo komanso tinthu tambiri, zomwe zimawonjezera kuchuluka kwa coutheon, ndipo kumakhala ndi magwiridwe antchito osokoneza bongo. Atakanikizidwa m'mapale, zimawonetsa kuumitsidwa komanso gloss, motero kumasintha mawonekedwe a piritsi. Makamaka mapiritsi omwe siophweka kupanga, omasuka kapena osavuta kuvumbulutsa, kuwonjezera l-hpc kumatha kusintha zotsatira zake. Piritsi la Ciprofloxcacin limadziwika bwino, zosavuta kugawanika komanso zomata, ndipo ndizosavuta kupanga zikamagetsi, ndi mawonekedwe okongola, ndi zofunikira zofananira. Pambuyo kuwonjezera l-hpc mu piritsi yomwazika, mawonekedwe ake, maluwa, kubalalika yunifolomuty ndi zinthu zina zimayenda bwino kwambiri ndikusintha. Pambuyo wowuma mu mankhwala oyambirirawo adasinthidwa ndi L-HPC, kuuma kwa mapiritsi ocheperako kunawonjezeredwa, kugundana kunasinthidwa, komanso zovuta zomwe zimasowa m'mbali mwa piritsi zoyambirira zidathetsedwa. L-HPC imagwiritsidwa ntchito ngati chofunda mapiritsi, ndipo kuchuluka kwa kuchuluka kwa 5% mpaka 20%; Pomwe H-HPC imagwiritsidwa ntchito ngati chofunda mapiritsi, magalamu, ndi zina zambiri, ndipo Mlingo waukulu ndi 1% mpaka 5% yokonzekera.
3. Kugwiritsa ntchito kanema wokutidwa ndi kukhazikika komanso kuwongolera kumasulira
Pakadali pano, zida zosungunulira madzi nthawi zambiri zimagwiritsidwa ntchito mufilimu kuphatikiza hydroxypropylmethy, hydroxypropyllulose (ma hydroxypropyllulose, peg). Hydroxypyl cellulose nthawi zambiri imagwiritsidwa ntchito ngati wothandizira makanema mufilimu yolumikizana ndi zinthu zovuta zambiri chifukwa cha filimu yake yolimba, yokongola komanso yokongola. Ngati Hydroxypyl cellulose imasakanikirana ndi othandizira ena ophatikizika, magwiridwe antchito ake amatha kusinthanso.
Kugwiritsa ntchito njira zoyenera mapiritsi a matrix, mapiritsi oyandama, mapiritsi ophatikizika, mapiritsi a mafuta osachedwa, ndikuwonjezera kuchuluka kwa mankhwala osokoneza bongo komanso kukhazikika Mankhwala m'magazi. Kuzindikira, kuchepetsa mavuto, sinthani kuchuluka kwa mankhwala, ndipo yesetsani kukulitsa concitive zotsatira ndi mlingo wocheperako, ndipo muchepetse zovuta zina. Hydroxypyl cellulose ndi imodzi mwazomwe zimakonda kukonzekera koteroko. Kuwonongeka kwa mapiritsi a diclofenac a diclofenac a sodium kumayang'aniridwa pogwiritsa ntchito hydroxypropyl cellulose ndi ethyl cellulose ngati zinthu zolumikizira ndi mafupa. Pambuyo m`kamwa Kudzera mu kusungunuka kwa gel osakaniza mamolekyutala osokoneza bongo mu gel osakaniza, cholinga chomasulidwa kwa mamolekyulu a mankhwala amakwaniritsidwa. Hydroxypropyl cellulose imagwiritsidwa ntchito ngati matrix owongoletsedwa, pomwe zomwe zili mu cellose ethyl cellulose ndizomwe zimasungidwa mwachindunji, ndipo mankhwalawa ndi zochulukirapo ya hydroxypyl cellulose imachedwa. Ma pellets okhalamo adakonzedwa pogwiritsa ntchitoL-hpcNdipo gawo lina la HPMC ngati njira yolumikizira yokutidwa ngati yotupa, komanso monga yoletsedwa-yoletsedwa yokutidwa ndi ethyl celluuse yofalitsa. Mlingo wotupa ndi mankhwalawa atakhazikika, powongolera makulidwe otulutsidwa, ma pellets ovomerezeka amatha kumasulidwa nthawi zosiyanasiyana. Mitundu ingapo ya ma pellets ophatikizika ndi kulemera kwina kwa kuchuluka kwa malo ogulitsira omwe amasakanikirana ndi kusakanikirana kwa Shuxiong kukhazikitsidwa-kumasulidwa. Mu zosungunulira zosungunulira, ma pellets osiyanasiyana amatha kumasulidwa mankhwala motsatizana nthawi zosiyanasiyana, kotero kuti zigawozo zomwe zimapangidwa ndi mapangidwe osiyanasiyana ndi mankhwala zimatheka nthawi yomweyo monga kutulutsidwa kwakanthawi
Post Nthawi: Apr-25-2024