Hydroxypropyl methylcellulose (hpmc)ndi ma cellulose a celluuse ndi mawonekedwe abwino opanga mafilimu, adheion, kukula ndi kuwongolera katundu, ndipo amagwiritsidwa ntchito kwambiri m'mafashoni. Monga mankhwala ophatikizira, mademencence ®hpmc angagwiritsidwe ntchito m'mapiritsi, makapisozi, kukonzekera kokhazikika, kukonzekera kwa ophthalmic ndi njira zoperekera mankhwala osokoneza bongo.
1..
HPMC ndi gawo lopanga polymer lomwe limapezeka ndi methylaing ndi hydroxypropyypypypypyprose cellulose, ndi solubility yamadzi abwino. Kusungunuka kwake sikukhudzidwa ndi kutentha ndi mtengo wa pH, ndipo kumatha kutukwana m'madzi kuti mupange mawonekedwe a viscous, omwe amathandizira kumasulidwa kwa mankhwalawa. Malinga ndi mafayilo, hpmc imatha kugawidwa m'magulu atatu: mamasukidwe otsika (5-100 MPPIC), sing'anga ma virus (4000-100000), omwe ali oyenera Zofunikira Zosiyanasiyana.
2. Kugwiritsa ntchito hpmc mu mankhwala opanga mankhwala
2.1 Kugwiritsa ntchito mapiritsi
HPMC itha kugwiritsidwa ntchito ngati binder, zojambula zokhala ndi zojambula, komanso zowongolera zowongolera m'mapiritsi.
Baner:HPMC imatha kugwiritsidwa ntchito ngati chomangira cha gytsated kapena kukoma kowuma kuti pakhale mphamvu ya tinthu, kukhazikika kwa mapiritsi ndi kukhazikika kwamakina a mankhwala osokoneza bongo.
Disvinrantrant:Kutsitsa kotsika kwa HPMC kumatha kugwiritsidwa ntchito ngati kusokonekera kulimbikitsa piritsi la piriji ndikuwonjezera kuchuluka kwa mankhwala osokoneza bongo atatupa chifukwa cha mayamwidwe amadzi.
Zokumba:HPMC ndi imodzi mwazinthu zazikulu za piritsi, zomwe zimatha kusintha mawonekedwe a mankhwala, kuphimba kukoma koyipa kwa mankhwala, ndipo itha kugwiritsidwa ntchito ngati mavidiyo kapena filimu yolumikizira mafakiti.
Zinthu zoyendetsedwa: Kutulutsidwa Kwambiri: Kutulutsa Kwakukulu kwa HPMC kumatha kugwiritsidwa ntchito ngati chipongwe cha skeleton kuti muchepetse kugwiritsa ntchito mankhwalawa ndikukwaniritsa kapena kulamulidwa. Mwachitsanzo, HPMC K4M K15m ndi HPMC K100M nthawi zambiri imagwiritsidwa ntchito kukonzekera mapiritsi otulutsidwa.
2.2 Kugwiritsa ntchito Kukonzekera kwa Castule
HPMC itha kugwiritsidwa ntchito kupanga makapisozi opangidwa ndi chomera kuti abwezeretse makapisozi a gelatin, omwe ali oyenera kwa osamba ndi anthu omwe sagwirizana ndi makapisozi omwe ali ndi nyama. Kuphatikiza apo, hpmc imatha kugwiritsidwa ntchito kudzaza mapiko amtundu kapena semisololid kuti azitha kusintha mapangidwe ndi kumasulira mankhwala.
2.3 Kufunsira Kukonzekera kwa Ophthalmic
Hpmc, monga gawo lalikulu la misozi yopanda zojambula, imatha kuwonjezera mawisi amaso, ndikuwonjezera nthawi yogwira ntchito mankhwala osokoneza bongo pamtunda, ndikusintha bioavailabilobility. Kuphatikiza apo, HPMC imatha kugwiritsidwanso ntchito kukonza ma gels, mafilimu amaso, etc., kukonza kumasulidwa kwa mankhwalawa.
2.4 Kugwiritsa ntchito pa Anucal Kukonzekera Kukonzekera
HUNGNVENCNCNC®hpm ili ndi katundu wabwino wamakanema ndi ma biocompotturict, ndipo itha kugwiritsidwa ntchito pokonza zigamba, ma gels ndi mafuta. Mwachitsanzo, mumankhwala ogulitsa mankhwala osokoneza bongo, hpmc imatha kugwiritsidwa ntchito ngati zinthu za matrix kuti muwonjezere kuchuluka kwa mankhwalawa ndikuwonjezera kutalika kwa zochita.
2.5 Kugwiritsa Ntchito Mumkamwa ndi Kuyimitsidwa
HPMC itha kugwiritsidwa ntchito ngati thickir ndi stebilizer kusintha minyewa ya pakamwa ndi kuyimitsidwa kwakamwa, kuletsa tinthu tokhazikika kuti tisasunthike, ndikusintha mafano ndi kukhazikika kwa mankhwala.
2.6 Kugwiritsa ntchito Kukonzekera kwa Kukonzekera
HPMC imatha kugwiritsidwa ntchito ngati chonyamulira cha ma infar owuma (dpis) kuti muwonjezere madzi ndi kuchuluka kwa mankhwala osokoneza bongo, onjezerani kuchuluka kwa mankhwalawa, ndikuwonjezera njira zochiritsira.
3. Ubwino wa HPMC mu kukonzekera kotulutsidwa
HPMC ili ndi izi ngati zotayidwa -
Kusungunuka kwa madzi:Imatha kutupa mwachangu m'madzi kuti apange chotchinga gel osakaniza ndikuwongolera kuchuluka kwa mankhwalawa.
Ubwino wazovomerezeka:Osakhala oopsa komanso osakwiya, osatengeka ndi thupi la munthu, ndipo ali ndi njira yodziwikiratu.
Kusintha kwamphamvu:Oyenera mitundu yosiyanasiyana ya mankhwala osokoneza bongo, kuphatikiza mankhwala osungunuka ndi madzi ndi hydrophobic.
Njira yosavuta:Zoyenera kusintha njira zosiyanasiyana zokonzekera monga field mwachindunji ndi kutulutsa kwadongosolo.
Monga mankhwala ofunika a mankhwala,HpmcZimagwiritsidwa ntchito kwambiri m'minda yambiri monga mapiritsi, makapisozi, kukonzekera kwa ophthalmic, kukonzekera kwapa zambiri, ndi zina zambiri, makamaka pakukonzekera kusungizidwa. M'tsogolomu, ndikukula mosalekeza kwa matekinoloje opangira mankhwala opangira mankhwala, ntchito yomwe imagwira ntchito ya Herncentl®hptc idzakulitsidwanso, kupereka mankhwala opangira mankhwala ndi zinthu zabwino kwambiri komanso zotetezeka.
Post Nthawi: Feb-08-2025