Zofananira zofananira kunyumba ndi kunja kokonzekera mankhwala ophatikizira hydrocyllulose (kukonzekera kwamadzi) Biodhesies. Chifukwa cha kusiyana pakati pa kulemera kwa HPMC, ili ndi mawonekedwe ndikugwiritsa ntchito mawu a emulsization, kutsatsa, kukulitsa, kukweza, kuyika mafilimu. Amagwiritsidwa ntchito kwambiri kukonzekera mankhwala ndipo amatenga gawo lalikulu pantchito yokonzekera. Ndi kuphunzira kwamtundu wake komanso kusintha kwaukadaulo wake komanso kusintha kwaukadaulo, hpmc kudzagwiritsidwa ntchito kwambiri pakufufuza mitundu yatsopano ya mankhwala ndi njira zatsopano za mankhwala osokoneza bongo, potero amalimbikitsa kupitilizanso kufalikira kwa mapangidwe ake.
hydroxypypyl methylcellulose; Kukonzekera kwa mankhwala; Zosangalatsa za mankhwala.
Zosangalatsa za mankhwala sizokha pokhapokha popanga mapangidwe ophika mankhwala osokoneza bongo, komanso mtundu wamankhwala osokoneza bongo, chitetezo, njira yomasulira, komanso njira yatsopano yopangira makonzedwe atsopano ndi njira zatsopano zoyendetsera. zogwirizana kwambiri. Kutuluka kwa zokomera zatsopano zamankhwala nthawi zambiri kumalimbikitsa kusintha kwa ntchito ndi kukonza mitundu yatsopano. Hydroxypypyl methylcellulose (hpmc) ndi imodzi mwazomwe zimadziwika kwambiri zamankhwala kunyumba ndi kunja. Chifukwa cha kulemera kwake kosiyana ndi mafakisoni, imakhala ndi ntchito za ersiven, kumanga, kukulitsa, kukulitsa, kuyimitsa, kuyimitsa, ndikupindika. Mawonekedwe ndi kugwiritsa ntchito monga kuphatikiza mafilimu ndi makanema ogwiritsira ntchito matendawa amagwiritsidwa ntchito kwambiri muukadaulo wamankhwala. Nkhaniyi imakhudzanso kugwiritsa ntchito hydroxypropyl methylcellulose (hpmc) popanga zaka zaposachedwa.
1.Zoyambira za HPMC
Hydroxypropyl me cellulose (hpmc), mawonekedwe a ma c8h15o8- (C10 H18o6) Itha kupangidwa munjira ziwiri: chimodzi ndichakuti kupezeka kwa methyl kwa kalasi yoyenera kumathandizidwa ndi Naoh kenako adagwiranso ntchito ma prowyne ozizira kwambiri. Nthawi yochita iyenera kukhala yokhazikika kuti ilole methyl ndi hydroxypyl kuti mupange mphete ya aniegluose yolumikizidwa ndi mpheta ya cellulose mu cellulose, ndipo imatha kufika digiri yofunikira; Wina ndi kuchitira thonje lotchinga kapena chotchinga cha nkhuni ndi sopo soda, kenako nkuchita ndi chlorinated methane ndi ma propylene okwana. , ataphwanyidwa mu ufa wabwino ndi yunifolomu.
Mtundu wa izi ndi zoyera kuti mkaka woyera, wopanda fungo komanso wopanda pake, ndipo mawonekedwewo ndi a granolar kapena ufa wosakhalitsa. Izi zitha kusungunuka m'madzi kuti apange momveka bwino kuti mkaka wabwino wa colloidal ndi mamasukidwe. The Sol-gel okhazikika pass Phenomenon imatha kuchitika chifukwa cha kutentha kusintha kwa yankho ndi ndende inayake.
Chifukwa cha kusiyana kwa zomwe zili m'malo awiri awa pogwiritsa ntchito methoxy ndi hydroxypyll, mitundu yosiyanasiyana ya zinthu zapangidwa. M'malingaliro ena, mitundu yosiyanasiyana ya zinthu zimakhala ndi mawonekedwe. Maonekedwe a Kutentha kwa kutentha kwa mafuta, chifukwa chake ali ndi malo osiyanasiyana ndipo angagwiritsidwe ntchito pazifukwa zosiyanasiyana. Pharmacopoeia ya mayiko osiyanasiyana ali ndi malamulo osiyanasiyana komanso mawonekedwe owonetsera pa mtundu: European Europe Magemu osiyanasiyana ogulitsidwa ndi manambala, ndipo unit S ". Mu US Parmacopoeiaa, manambala 4 amawonjezeredwa pambuyo pa dzina la mtundu wa hydroxypyulose, manambala awiri oyamba akuyimira mgulu la methoxy. Kuchuluka, manambala awiri omaliza akuimira kuchuluka kwa hydroxypyl.
Ma hydroxypypylmmyl methylcellulose ali ndi mndandanda 3 mndandanda, ndi EQUE EQUA, F Jertiction ndi K Ndete, mndandanda uliwonse umakhala ndi mitundu yosiyanasiyana yosankha. E Lembani zimagwiritsidwa ntchito ngati zokutira filimu, zomwe zimagwiritsidwa ntchito piritsi zokutidwa, piritsi lotsekedwa; E, f mndandanda amagwiritsidwa ntchito ngati ma viscosiers ndikumasula obwezeretsa osintha ma ophthalmic kukonzekera kwa ophthalmic, osiyitsa, mabatani ndi ma granules; Maka oyitanitsa amagwiritsidwa ntchito kwambiri monga kumasulidwa kolepheretsa ndi zinthu za hydrophilic gel.
Opanga zapakhomo amaphatikizapo a Fuzhou. 2 Fakitala yamafuta 2, huzhou ya mankhwala opangira mankhwala ahugaina etc.
2.Ubwino wa HPMC
HPMC yakhala imodzi mwazomwe zimagwiritsidwa ntchito kwambiri pamtunda kunyumba ndi kunja, chifukwa HPMC ili ndi maubwino omwe osapeza ena alibe.
2.1 Madzi Ozizira Kusungunuka
Sungunuka m'madzi ozizira pansi pa 40 ℃ kapena 70% Ethanol, yopanda malire m'madzi otentha kuposa 60 ℃, koma imatha kugwa.
2.2 mwanjira ina
HPMC ndi mtundu wa ether celluse ether ether, yankho lake lilibe Ionic Store ndipo sagwirizana ndi mchere wachitsulo kapena ionic zopangidwa ndi ionic, motero zokolola zina sizimakonzekera kukonzekera.
2.3 Kukhazikika
Imakhala yokhazikika kwa acid ndi alkali, ndipo imasungidwa kwa nthawi yayitali pakati pa PH 3 ndi 11 popanda kusintha kwambiri pakuwoneka. Madzi am'madzi a hpmc ali ndi anti-brodew zotsatira ndikusunga mawonekedwe abwino pakusungidwa kwakanthawi. Zosangalatsa za mankhwala ogwiritsa ntchito hpmc zimakhala ndi zabwino kuposa zomwe zimagwiritsa ntchito zikhalidwe (monga dextrin, wowuma, etc.).
2.4 Kusintha kwa Mavicconce
Mawonekedwe osiyanasiyana a hpmc amatha kusakanikirana m'njira zosiyanasiyana, ndipo maonedwe ake atha kusinthidwa malinga ndi lamulo linalake, ndipo ali ndi ubale wabwino, kotero gawo lingasankhidwe molingana ndi zosowa.
2.5 kusamvana kwa metabolic
HPMC siimatengeka kapena yopangidwa mthupi, ndipo sapereka kutentha, kotero kukonzekera kwa mankhwala opezeka m'matumbo. 2.6 Chitetezo nthawi zambiri chimaganiziridwa kuti HPMC ndi zinthu zopanda pake komanso zosakhomera, mlingo wa makoswe ndi 5 K · Apg - 1. Mlingo wa tsiku ndi tsiku ndiwovulaza thupi la munthu.
3.Kugwiritsa ntchito HPMC mu mawonekedwe
3.1 Monga kanema wokutira ndi zinthu zopanga mafilimu
Kugwiritsa ntchito rpmc ngati piritsi yokulungidwa ndi mafilimu, piritsi lokutidwa silimapeza zabwino zodziwikiratu zokomera kukoma ndi mawonekedwe ophimbidwa ndi mapiritsi ake, chinyezi, digiri yam'madzi. , Kuchulukana Kuchepetsa Kulemera ndi zizindikiro zina zabwino zili bwino. Kalasi yotsika kwambiri ya mankhwalawa imagwiritsidwa ntchito ngati mawonekedwe osungunuka filimu yamadzi ndi mapiritsi, ndipo kalasi yapamwamba kwambiri imagwiritsidwa ntchito ngati mawonekedwe a filimu yosungunuka ya organic sols, nthawi zambiri.
Zhang Juming et al. Gwiritsani ntchito njira yothandizira kuti mukonzenso premix ndi hpmc pomwe kanema wokutira. Kutenga zojambulajambula zam'mayilo HPMC, kuchuluka kwa mowa wa polyvinyl ndi pulasitiki polcol glycol monga njira yolumikizirana, ndi mawonekedwe a filimuyo ndikuwonetsa mtundu wa masamu. Kugwiritsa kwake ntchito mobwerezabwereza ndi mafilimu a hydroxpyl methylcellulose (HPMCE5) 11.88 g, hireccyl polcol 13.1 Zhang Yuan adasintha njira yokonzekera, adagwiritsa ntchito HPMC ngati khola kuti asinthane ndi mapiritsi okhala ndi filimu kuti akonzekere kukonzekera kwake, mapiritsi ake, kuwonjezera pagome la piritsi. Njira zoyenera zoyeserera zidatsimikizika ndi zoyeserera za Orthogoner, zomwe zimachitika, nthawi yovuta kwambiri ya 2% ethanol yankho pakukula, ndipo nthawi yosangalatsa pamasamba inali mphindi 15. Zotsatirani za mapiritsi okutidwa ndi a Juua omwe adakonzedwa ndi njira yatsopano ndi mankhwala adakonzekereratu maonekedwe, nthawi yosiyanirana ndi omwe amapangidwa ndi mapiritsi ovomerezeka a mafilimu adasintha kwambiri. anafikira oposa 95%. Liang Meiyi, Lu Xiaohui, etc. Amagwiritsanso ntchito hydroxpyulluloliloulose monga momwe mafilimu amapangira piritsi, motsatana. kusokoneza kumasulidwa kwa mankhwala. Huang Yunran adakonza magazi a chinjoka cha chinjoka, ndikugwiritsa ntchito HPMC ku yankho la zokutira, ndipo chidutswa chake chinali 5%. Itha kuwoneka kuti HPMC imatha kugwiritsidwa ntchito kwambiri m'mankhwala operekera mankhwala.
Hydroxypropyll methylculose sikuti ndi zinthu zabwino kwambiri zokutira, komanso zitha kugwiritsidwanso ntchito ngati zinthu zopanga filimu mu filimu. Wang Tonhun etc. amakonzedwa kuti ndi mankhwala a licorice ndi aminolexanol mkamwa zopangidwa ndi ma pva.1 g ndi 6. filimuyo.
3.2 Monga womangika ndi kuwonongeka
Kalasi yotsika yowoneka bwino ya mankhwalawa itha kugwiritsidwa ntchito ngati binder ndi kuwonongeka kwa mapiritsi, mapiritsi ndi magalamu, ndi kalasi yapamwamba ija imangogwiritsidwa ntchito ngati bander. Mlingo umasiyanasiyana ndi mitundu yosiyanasiyana ndi zofunikira. Nthawi zambiri, mlingo wa mapiritsi owuma ma glanuration ndi 5%, ndipo mlingo wa binder ya mapiritsi onyowa granution ndi 2%.
Lihoutao et al adalemba chomangira cha tizitsulozozole mapiritsi. 8% Polyvinylylpriodrone (PVP-K30), 40% shupya, 2.0% hydroxypyulose k4 (hpmck4m), 50% Ethanol adasanthula mapiritsi a Tinidazole. Kukonzekera mapiritsi a tinidazole. Maonekedwe amasintha mapiritsi odziwika komanso atatha kufananizidwa, ndi kutopa, kuuma, nthawi yopanda tanthauzo la mapiritsi osiyanasiyana amayezedwa. Zimapangitsa mapiritsi omwe akukonzedwa ndi 2.0% hydroxpylls methylcellulose anali okongola, ndipo miyeso yolimbana ndi pompopompo, komanso yophimba zinthu, mawonekedwe a piritsi anali okwanira ndipo mawonekedwe ake anali abwino. Chifukwa chake, mapiritsi a Tinidazole adakonzedwa ndi 2.0% hpmc-k4 ndi 50% ethanol monga omanga adagwiritsidwa ntchito. Guan Shihai adaphunzira mapiritsi a mapiritsi, ndipo adayika 50% ethanol, 15% pvp ndi 50% mabhathancs, mosatekeseka, komanso kuwunika zizindikiro. , 5% cmc-na ndi 15% hpmc yankho (5 MPA s). Zimapangitsa mapepala okonzedwa ndi 50% ethanol, 15% pvp 50% ethanol yankho ndi ma cmc-9 komanso kuuma kotsika, komwe sikungakwaniritse zosowa zokutidwa; 15% HPMC yankho (5 MPPOPE) Chifukwa chake, HPMC (5 MPA s) idasankhidwa monga chomatira.
3.3 Monga kuyimilira
Kalasi yapamwamba kwambiri ya mankhwalawa imagwiritsidwa ntchito ngati malo oyimilira kuti akonzekere kuyimitsidwa. Ikuyimilira bwino, ndizosavuta kuyikanso kubwezeretsanso, sikumamatira kukhoma, ndipo zimakhala ndi tinthu tambiri tambiri. Mlingo wachizolowezi ndi 0,5% mpaka 1.5%. Nyimbo Tian et al. Kugwiritsa ntchito zida zomwe zimagwiritsidwa ntchito polymer kuyimitsidwa kouma. Kudzera muyezo wamasu-mawu osiyanasiyana, cholembera, ndi chizolowezi choyimitsidwa ndi ma viscology morphology omwe adawonedwa, ndipo kukhazikika kwa tinthu tating'onoting'ono tomwe timathamangitsidwa. Zotsatira zowuma ndi 2% hpmc monga kuyimilira kunali kovuta komanso kukhazikika kwabwino.
Poyerekeza ndi methyl cellulose, hydroxypropyl methyl cellulose ali ndi mawonekedwe opanga zinthu zowoneka bwino, ndipo ndi zochepa chabe zomwe sizikugwiritsa ntchito ngati kuyimitsidwa ngati kukonzekera kwa ophthalmic. Liu jie et al. gwiritsani ntchito hpmc, hydroxypropyl cellulose (hpc), carbomer 940, polyethylene glycol opthdal ophtharism (kukula), Kuimitsa Mtumiki. Zotsatirazi zikuwonetsa kuti ma acyclovir ophthalmic kuyimitsidwa ndi 0.05% ha ndi 0,05% hpmc monga 0,998, kukonzanso ndikwabwino, ndipo kukonzekera ndi kugonana kokhazikika kumawonjezeka.
3.4 Monga blocker, wodekha komanso wowongolera wotumidwa ndi wowongolera
Kalasi yapamwamba kwambiri ya mankhwalawa imagwiritsidwa ntchito pokonza mapiritsi a hydrophilic gel. Kukhazikika kwake ndi 10% mpaka 80%. Makalasi otsika otsika amagwiritsidwa ntchito ngati marogens omasulidwa kapena kumasulidwa-kutulutsidwa. Mlingo woyamba wofunikira pakuchiritsa matele oterowo amatha kufikiridwa mwachangu, kenako kumasulidwa kapena kutulutsa magazi kumachitika, ndipo mankhwala osokoneza magazi amasungidwa mthupi. . Hydroxypypyl methylcellulose ndi hydration kuti apange mafuta a gel. Limagwirira mankhwala osokoneza bongo ku matrix makamaka amaphatikizanso mawonekedwe a gel wosanjikiza wa gel wosanjikiza. Jung Bo shim el al adakonza mapiritsi a Cardulol osuta fodya ndi HPMC ngati zinthu zomasulidwa.
Hydroxypylrosell imagwiritsidwanso ntchito kwambiri m'mapiritsi a matrix a matrix, ndipo ambiri mwazomwe amagwira, magawo othandiza komanso kukonzekera kamodzi kwachikhalidwe chachi China. Liu wen et al. Gwiritsani ntchito 15% hydroxypypyl monga matrix, 1% lacrose ndi 5% microcrystalline cellose celsiction mapiritsi a matrix. Chitsanzo ndi Ikulu ya Hiruchi. Njira yosinthira mawonekedwe ndi yosavuta, kukonzekera ndikosavuta, ndipo kumasulidwa ndikokhazikika, komwe kumakwaniritsa zofunikira za DemaCopoeia. Tang Guanguang et al. Gwiritsani ntchito zotupa zonse za Astragalus monga mankhwala achitsanzo, okonzeka mapiritsi a HPMC matrix, ndikufufuza zinthu zomwe zikukhudza mankhwala osokoneza bongo a mankhwala achi China mu HPMC ma mapiritsi a HPMC matrix. Zotsatira za kuchuluka kwa HPMC kunachulukirachulukira, kutulutsidwa kwa Astragaloside kunachepa, ndipo kumasulidwa kwa mankhwalawa kunali paubwenzi wapakati pa matrix. Mu hyPromelweose hpmc matrix matrix, pali ubale wina pakati pa kutulutsidwa kwa gawo lothandiza la chilengedwe chachi China komanso mlingo wa hpmc, ndipo kumasulidwa kwa Monomer Someror ndikofanana ndi iyo. Hydroxypropyll methylcellulose sioyenera ma hydrophilic mankhwala, komanso chifukwa cha hydrophilic zinthu. Liu Guhia adagwiritsa ntchito 17% hydroxpyl meth methylcellulose (hpmck1m) monga ma matrix xuel mapiritsi okhala ndi matrix omwe ali ndi mawonekedwe. Mphamvu yosungidwa inali yodziwikiratu, ndipo njira yokonzekera inali yokhazikika komanso yotheka.
Hydroxypylropyl samangogwiritsidwa ntchito pa mapiritsi a matrix a matrix a zinthu zogwira ntchito ndi mbali zothandiza zamankhwala achi China, komanso zochulukirapo pamankhwala omwe amagwiritsidwa ntchito pazithunzi zachikhalidwe. Wu Huichao et al. Gwiritsani ntchito 20% hydroxypypyl mealoul (hpmck4m) monga matrix, ndikugwiritsa ntchito mawonekedwe a matrix kuti akonzekere mankhwalawa mosalekeza. Saponin RG1, Ginsenoside RB1 ndi Panax Nogining Spoonan R1 adagwiritsidwa ntchito ngati zizindikiro zopezera mamasulidwe mu vitro, ndipo mankhwala omasulira mankhwalawa adayenera kuphunzira magwiridwe omasulidwa. Zimapangitsa kuti makina omasulira mankhwala opangidwa ndi ziro ndi quitger-pefas equations, pomwe mphezi zitatuzo zidatulutsidwa ndi kusana kwa Panax Nooginese adamasulidwa ndi kukokoloka kwa mafupa.
3.5 Kuteteza guluu woteteza ngati Thicker ndi Colloid
Izi zikagwiritsidwa ntchito ngati thicker, kugwiritsidwa ntchito kwanthawi yayitali kwa 0,45% mpaka 1.0%. Zimathandizanso kukhazikika kwa guluu Hydrophobic, ndikupanga cololoid colloid, kupewa tinthu tokhala ndi coalesting ndi kubuma, potero kulepheretsa mapangidwe a utoto. Kukhazikika kwake kwa kuchuluka kwake ndi 0,5% mpaka 1.5%.
Wange zhen et al. Kugwiritsa ntchito njira yoyesera ya L9 Njira zabwino zomwe zimakhala zomaliza za mankhwala omaliza a Carbon Elemarthyl celkrose ndi 2.0% methoxyl, ma hydroxypropupose, njira zomwe zimathandizira kuti zithandizire kukhazikika kwa mankhwala kaboni. Zhang Zhiqang et al. Anakulitsa levofloxacin hydrochloride ophthaburtic okonzeka kusinthana, pogwiritsa ntchito carbopol ngati gelropol ngati meth methylcelulose. Poyesedwa moyenera poyesa, pamapeto pake imalandira mankhwala oyenera ndi levofloxacin hydrochloride 0.1 g, carbopol (945 g, phosphorol hyphagen 0.35 g, phosphorol hyphagen 0.35 g, phosphorn Sodium chloride, 0.03 g wa ethyl paraben, ndipo madzi adawonjezedwa kuti apange 100 ml. Poyesedwa, wolemba adalemba ma hydroxypropyl methylcellulose mndandanda wa kampani yosiyanasiyana (k4m, e15 lv, e15 lv, e15 lv, e15 lv, e15 lv, e15 lv, e15 lv, e15 lv, e15 lv. Thickener ya PH-Strive Levofloxacin hydrochloride idfs.
3.6 Monga kapisozi
Nthawi zambiri, zida za makapisozi za makapisozi ndizo gelatin. Kupanga zipolopolo za kapisozi ndikosavuta, koma pali zovuta zina komanso zojambulajambula zosayenera pa mankhwala onyowa komanso ochepetsa mankhwala, ndikuchepetsa kuwonongeka kwa kapisozi panthawi yosungirako. Chifukwa chake, hydroxypropyl methylcellulose imagwiritsidwa ntchito ngati cholowa m'malo mwa mapiritsi a gelatin pokonzekera makapisozi, zomwe zimapangitsa kuti chipilala chopanga chipisozi, ndipo chimakhala cholimbikitsidwa kunyumba ndi kunja.
Kugwiritsa ntchito theophylline ngati mankhwala owongolera, podczeck et al. anapeza kuti mankhwala osokoneza bongo a makapisozi ndi hydroxypropyl chipolopolo chinali chokulirapo kuposa mapiritsi a gelatiin. Chifukwa chowunikira ndikuti kusokonekera kwa HPMC ndiko kusokonekera kwa kapisozi yonse nthawi yomweyo, pomwe kusokonekera kwa kapisozi kachulukidwe kakang'ono, kenako kusokonekera kwa kapisozi ka nthula kwa mapiko omasulidwa mwachangu. Chiwele et al. Komanso zinazindikiranso fanizo lofananalo ndipo adafanizira kuwonongeka kwa a Glatin, Gelatin / Polyethylene Glycol ndi HPMC. Zotsatira zake zinawonetsa kuti zipolopolo za HPMC zidasungunuka mwachangu pansi pa pH Tang Yue et al. Wolemba mtundu watsopano wa capsule chipolopolo cha mankhwala otsika otsika owuma ufa wonyamula ma invaler. Poyerekeza ndi chipolopolo cha hydroxypypyulluloull ndi chipolopolo cha gelatin, kukhazikika kwa chipolopolo cha gelasole ndi katundu wa ufa mu chipolopolo. Zotsatira zikuwonetsa kuti poyerekeza ndi mapiritsi a gelatin, hpmc kapisozi bwino mokhazikika komanso kutetezedwa kwa ufa, ndipo khalani ndi chipolopolo champhamvu kwambiri kuposa mapiritsi a ufa wowuma ufa.
3.7 Monga biohedive
Tekinoloje biohethethion imagwiritsa ntchito zokomera ndi ma polimatu. Potsatira zachilengedwe mucoloological mucosa, zimawonjezera kupitiriza ndi kulimba kwa kulumikizana pakati pa kukonzekera ndi mucosa, kuti mankhwalawa amasulidwe pang'onopang'ono ndikulowetsedwa ndi mucosa kuti akwaniritse cholinga cha chithandizo. Amagwiritsidwa ntchito nthawi zambiri. Kuchiza matenda am'mimba thirakiti, nyini, mucosa wam'kamwa ndi mbali zina.
Technology yama biohedeya ion ndi njira yatsopano yoperekera mankhwala yomwe idayamba posachedwa. Sikuti amangotaya nthawi yokonzekera mankhwala kum'mimba thirakiti, komanso amathandizanso kulumikizana pakati pa maselo a mayamwidwe, ndipo amasintha madzi a cell a cell. Wei keda et al. Wolemba piritsi yochokera ku HPMCK4m ndi Carbomer 940 monga momwe kafukufuku wambiri, ndipo adagwiritsa ntchito chida chodzipangira pa piritsi ndi mtundu wa madzi mu thumba la pulasitiki. , ndipo pomaliza sanayankhe zomwe zili mu HPMck40 ndi Carbomer 940 kuti mukhale 15 ndi 27.5 mg mu gawo loyenerera la NCAEEBTTLOSE) limatha kuwonetsa kuti ma piodet a Ncaebygyl (monga hydroxyprose (monga hydroxyprose)
Kukonzekera kwa pakamwa ndi mtundu watsopano wa dongosolo loperekera mankhwala omwe aphunziridwa kwambiri m'zaka zaposachedwa. Kukonzekera kwa pakamwa kumatha kutsatsa mankhwalawa ku gawo la vuto la mkamwa, lomwe silimangokulitsa nthawi yokhazikika ya mankhwalawa mkamwa, komanso amateteza mucosa wam'kamwa. Zabwino achire komanso kusintha mankhwala bioavailability. Xue xiayan et al. Mapiritsi a insulin mikamwa ya insulin, pogwiritsa ntchito apulo Pectin, Chitosan, carbomer 934p, hydroxyprose ngati zida za m'matumbo, ndikuwuma kuti mukonzekere pakamwa. Zomata zomata ziwiri. Piritsi lokonzekereratu la insulin limakhala ngati kapangidwe kake ngati katatu, komwe kumadziwika kwa insulin, ndipo ali ndi osanjikiza a Hydrophobic, omwe angawonetsetse kumasulidwa kwa mankhwalawa ndikupewa kuwonongeka kwa mankhwalawa. Hao jifu et al. Komanso anakonzanso mikanda ya Blue-yachikasu pakamwa pogwiritsa ntchito guluu wa Baji, HPMC ndi Carbomer monga zida za bioidheture.
M'makina a mankhwala osokoneza bongo a mankhwala, ukadaulo wa biohetheth ugwiritsidwanso ntchito kwambiri. Zhut yt et al. Gwiritsani ntchito carbomer (CP) ndi HPMC monga zomatira ndi matrix osunthika kuti akonzekere matebulo a kununkhira ndi magwiridwe ake, nthawi yotsatsa ndi kuchuluka kwa madzi ojambula. , chodziwika bwino chomwe chidasinthidwa kuti CP-HPMC1: 1, pepala lomata linali ndi machitidwe abwino otsatsa, ndipo njirayi inali yosavuta komanso yotheka.
3.8 Monga gel osakaniza
Monga kukonzekera kosangalatsa, gel imakhala ndi zabwino monga chitetezo, kukongola, kuyeretsa kosavuta, mtengo wotsika mtengo, njira yokonzekera bwino, komanso kulingana bwino ndi mankhwala. Kuwongolera chitukuko. Mwachitsanzo, zofalitsa zodziwika bwino ndi mtundu watsopano womwe waphunziridwa kwambiri m'zaka zaposachedwa. Sizingangopewa kuwonongedwa kwa mankhwalawa m'mimba ndikuchepetsa kusintha kwa magazi osokoneza bongo, komanso wakhalanso imodzi mwazinthu zomasulira mankhwala kuti zithetse mavuto a mankhwala osokoneza bongo. .
Zhu Jingjie et al. Anaphunzira zotsatira za matrics osiyanasiyana pakutulutsidwa kwa scatellar gl ger colro, ndipo ophatikizidwa ndi carbomer (980nf) ndi hydroxyprosell (hpmrnf) ndi hydroxyprose (hpmroxyprose (hpmrnf) ndi ma matricllarllulose (hpmrock15m) monga Scritelrin yoyenera SCutellarin. Kuphatikizidwa kwa zidutswa za mowa. Zotsatira zoyesera zikuwonetsa kuti 1. 0% carbomer, 1. 5% carbomer, 1. 0% Carbomer + 1. Pakuyesera, zinapezeka kuti HPMC ikhoza kusintha njira zomasulira za carbomer gel matrix pokonza ma coid, ndi 1.0% hpmc ikhoza kusintha 1.0% carbomer matrix ndi 1.5% carbomer matrix. Cholinga chake chikhoza kukhala kuti HPMC ikukula mwachangu, ndipo kufulumira mwachangu koyambirira kwa kuyesa kwa kavale wa carbomer zinthu zazikulu. Zhao Wencui et al. Gwiritsani ntchito carbomer-934 ndi hydroxypropyl methylcelluloulose ngati onyamula ma Norloxacin gelshmic gel. Njira yokonzekera ndi yosavuta komanso yotheka, ndipo mtunduwo umagwirizana ndi gelthalmic gel "Memacopoeia" (2010 Edition) Zofunikira.
3.9
Njira zodzipangira mankhwala osokoneza bongo (madedds) ndi mtundu watsopano wa njira zoperekera mankhwala osokoneza bongo, omwe ndi osakanikirana, osakaniza ndi osakaniza ndi mafuta, emulsifier ndi nthumwi. Kuphatikizidwa kwa mankhwalawa ndikosavuta, ndipo chitetezo komanso kukhazikika kuli bwino. Kwa mankhwala osungunuka osakwanira, zida zam'madzi zam'madzi, monga hpmc, polyvinyllpriidneone (pvp), etc.
Peng xuan et al. Konzani silika wopepuka wodziletsa kugula mankhwala osokoneza bongo a mankhwala osokoneza bongo (S-Asds). Oxyathyylene hydrogenited castor mafuta (Cremophy RH40), 12% Capry Cacride glycol glycol gycelsier, ndi 50 hprocc. Kuonjezera HPMC ku Ssedds ikhoza kuperewera kwaulere sisibinin kuti isungunuke mu S-Adds ndipo amalepheretsa Sibibinin kuti asalowe. Poyerekeza ndi micromalsion yodzidalira, kuchuluka kwa zochulukitsa kumachitika nthawi zambiri kumawonjezeredwa popewa kusakwanira kwa mankhwala. Kuphatikiza kwa hpmc kumatha kusunga kusungunuka kwa sinibinin muyezo wosungunulira mosalekeza, kuchepetsa emulsization mu ma micromalsion. Mlingo wa wothandizira.
4.Concord
Itha kuwoneka kuti HPMC yagwiritsidwa ntchito kwambiri pokonzekera thupi lake mwakuthupi, mankhwala ndi kwachilengedwenso, koma hpmc imakhalanso ndi zophophonya zambiri pokonzekera, monga chiwonetsero chambiri. Methyl Methacrylate) kuti musinthe. Nthawi yomweyo, ofufuza ena adafufuza lingaliro la osmotic pokonzekera mapiritsi a Carbamazopine omasulidwa ndi mapiritsi a verapamil hydrochloride kuti aphunzire makina ake. Mu liwu, ofufuza ochulukirachulukira akugwira ntchito yambiri pakukonzekera kwa HPMC pokonzekera, ndipo pophunzira zinthu zina mwa njira zake ndi kusintha kwa ukadaulo watsopano, hpmc kugwiritsidwa ntchito kwambiri mumitundu yatsopano ndi mitundu yatsopano. Mu kafukufuku wa mankhwala opangira mankhwala, kenako kulimbikitsa kukulitsa mafidayi.
Post Nthawi: Oct-08-2022