Hydroxypropyl methylcellulose (hpmc) ndi zopangidwa ndi polymer yopangidwa mwamphamvu zomwe zimagwiritsidwa ntchito kwambiri m'makampani ambiri, makamaka mu gawo la pharmaceutical. HPMC yakhala yovuta kwambiri pakukonzekera mankhwala opanga mankhwala chifukwa cha kusakhulupirika kwake, osadandaula komanso mozama komanso mankhwala.
(1) Makhalidwe oyambira a plarmaceutical hpmc
HPMC ndi ma cellulose osankhidwa ether okonzedwa ndi zomwe zimapangidwa ndi cellulose ndi ma propelyl oxide ndi methyl chloride pansi pa milkaline. Kapangidwe kake kosiyanasiyana kumapangitsa kusungunuka kwa HPMC kukhala koyenera, kukulira, mawonekedwe a filimu ndi emulsift zinthu. Otsatirawa ndi machitidwe ofunikira a HPMC:
Kusungunuka kwamadzi ndi kudalira kwa ph: hpmc kusungunuka m'madzi ozizira ndikupanga njira yowonekera yowonekera. Makutu a yankho lake amakhudzana ndi kuchuluka kwa chidwi ndi kuchuluka kwa matope, ndipo ali ndi mphamvu yolimba mpaka pH ndipo imatha kukhala yokhazikika m'mitundu yonse ya acidic ndi alkaline.
Thermogel katundu: hpmc imawonetsa katundu wapadera wa thermogel atatenthedwa. Itha kupanga gel pomwe pakutentha mpaka kutentha kwina ndikubwerera ku madzi mutazizira. Katunduyu ndi wofunikira kwambiri pokonzekera mankhwala osokoneza bongo.
Zogwirizana ndi zopanda pake: Popeza HPMC imachokera ku cellulose ndipo ilibe chindapusa ndipo sichingakuchitireni bwino, zimakhala ndi zinthu zina. Ndiwopanda tanthauzo.
(2) Kugwiritsa ntchito HPMC mu mankhwala
HPMC imagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala, kuphimba minda yambiri monga mankhwala amkamwa, apamwamba komanso jakisoni. Malangizo ake akulu ndi awa:
1. Zojambulajambula zamakanema pamapiritsi
HPMC imagwiritsidwa ntchito kwambiri mu mapiritsi a mapiritsi ngati chinthu chopanga mafilimu. Piritsi lophimba silingangoteteza mankhwala ku zinthu zakunja, monga chinyezi komanso kuwala, komanso kubisa fungo labwino komanso kukoma kwa mankhwala osokoneza bongo. Kanema wopangidwa ndi HPMC ali ndi madzi abwino ndi mphamvu, zomwe zimatha kukulitsa moyo wa alumali bwino.
Nthawi yomweyo, HPMC itha kugwiritsidwanso ntchito ngati gawo lalikulu la ma memberal olamulidwa chifukwa chopangidwa ndi mapiritsi omasulidwa. Katundu wake wa gel opatsa mafuta amalola mankhwala kuti atulutsidwe m'thupi pamalo omasulira, potero amapeza chithandizo chamankhwala chochuluka. Izi ndizofunikira kwambiri pochiritsa matenda osadalitsira, monga mankhwala otenga odwala omwe ali ndi matenda ashuga ndi matenda oopsa.
2. Monga wothandizira-kumasulidwa
HPMC imagwiritsidwa ntchito kwambiri ngati yomasulidwa pogwiritsa ntchito kukonzekera kwa pakamwa. Chifukwa imatha kupanga gel m'madzi ndi chimfine pang'onopang'ono monga momwe mankhwalawa amasulidwira, imatha kuyendetsa bwino mamasulidwe a mankhwalawa. Izi ndizofunikira kwambiri pamankhwala omwe amafunikira kumasulidwa kwa mankhwala osokoneza bongo, monga insulin, antidepressants, etc.
M'mimba malo okhala ndi gelsel wosanjikiza HPMC imatha kuwongolera kuchuluka kwa mankhwalawa, popewa kumasulidwa kwa mankhwalawa kwakanthawi, potengera zovuta komanso zolimbitsa thupi. Katundu womasulidwayu ndi woyenera makamaka pakuchiza mankhwala omwe amafunikira kuchuluka kwa magazi osokoneza bongo, monga maantibayotiki, anti-khunyu-khunyu.
3. Monga chomangira
HPMC imagwiritsidwa ntchito ngati chomangira mu piritsi. Powonjezera hpmc ku tinthu tating'onoting'ono kapena ufa, madzi ake komanso zotsatsa zimatha kusintha, potengera kusinthasintha kwa piritsi komanso nyonga ya piritsi. Kusasamala komanso kukhazikika kwa HPMC kumapangitsa kuti ikhale yomanga yabwino m'mapiritsi, magalamu ndi makapisozi.
4. Monga chofiyira ndi kukhazikika
Mu kukonzekera kwamadziku kumene, hpmc imagwiritsidwa ntchito kwambiri ngati thickiner ndi kukhazikika m'madzi amadzimadzi osiyanasiyana, madontho amaso ndi zozizwitsa zapamwamba. Katundu wake wambiri amatha kuwonjezera mafayilo amadzimadzi, pewani stratization kapena mpweya, ndikuwonetsetsa kuti amagawana ndi mankhwala osokoneza bongo. Nthawi yomweyo, mafuta komanso kuthira zinthu zothira hpmc zimathandizira kuchepetsa kusapeza bwino m'maso ndikuteteza maso kuti asakwiyitse kunja.
5. Zogwiritsidwa ntchito mu makapisozi
Monga cellulose yochokera ku celly, hpmc imakhala ndi zinthu zabwino, zimapangitsa kuti ikhale yofunika popanga makapisozi. Poyerekeza ndi mapiritsi a nyama za gelatin, makapisozi a HPMC ali ndi bassule bwino, makamaka kutentha kwambiri komanso chinyezi chambiri, ndipo sizophweka kuti tiletse kapena kusatha. Kuphatikiza apo, makapisozi a HPMC ndioyenera masamba ndi odwala omwe amadwala gelatin, kukulitsa mawonekedwe a mankhwala a kapisole.
(3) Mankhwala ena a HPMC
Kuphatikiza pa ntchito zamankhwala zomwe zili pamwambapa, hpmc zitha kugwiritsidwanso ntchito m'malo enaake. Mwachitsanzo, pambuyo pa opaleshoni ya ophthalmic, hpmc imagwiritsidwa ntchito m'madontho amaso ngati mafuta kuti muchepetse mikangano ya diso ndikuthandizira kuchira. Kuphatikiza apo, HPMC imatha kugwiritsidwanso ntchito mafuta ndi ma gels kulimbikitsa kuyamwa mankhwala osokoneza bongo komanso kusintha kwa mankhwala am'deralo.
Gawo la garraceutical HPMC limakhala ndi gawo lofunikira pakukonzekera mankhwala chifukwa cha thupi lake labwino komanso mankhwala. Monga mankhwala osokoneza bongo ophatikizira, hpmc sinathe kungosintha mankhwala osokoneza bongo ndikuwongolera kumasulidwa kwa mankhwala, komanso kusintha mankhwalawa omwe akutenga munthu wodwala. Ndi kupita patsogolo kosalekeza kwa ukadaulo wamankhwala opangira mankhwala, gawo lofunsira HPMC lidzakhala lochulukirapo komanso lothandiza kwambiri m'thupi la mankhwala.
Post Nthawi: Sep-19-2024