Cellulose eders olamulidwa kutulutsidwa kwa mankhwala mu hydrophilic matrix kachitidwe

Cellulose etrars, makamakaHydroxypropyl methylcellulose (hpmc), amagwiritsidwa ntchito kwambiri pamtundu wa mankhwala opangira mankhwala omasulira mankhwala ku Hydrophilic matrix. Kutulutsidwa kwa mankhwalawa ndikofunikira kuti athetse zotsatira zochizira, kuchepetsa mavuto, ndikuwonetsa kutsatira wodwala. Umu ndi momwe ma cellulose amagwirira ntchito mu hydrophilic matrix kachitidwe ka mankhwala ovomerezeka:

1. Hydrophilic Matrix dongosolo:

• Tanthauzo: Mankhwala a hydrophilic matrix ndi njira yoperekera mankhwala omwe amagwira ntchito yopanga (api) amabalalitsidwa kapena kuphatikizidwa mu hydrophilic polymer matrix.
• Cholinga: Matrix amawongolera kumasulidwa kwa mankhwalawa pochotsa kusiyana kwake kudzera polymer.

2. Udindo wa cellulose et (mwachitsanzo, HPMC):

• Maonekedwe ndi mawonekedwe a gel osakaniza:
  • HPMC imadziwika chifukwa cha kuthekera kwake kupanga ma gels ndikuwonjezera mafayilo a mayankho am'madzi.
  • Mu matrix systems, hpmc imathandizira kupanga matrix a gelatinous.
• Chibadwa cha hydrophilic:
  • HPMC ndi hydrophilic kwambiri, kuthandizira kuyanjana ndi madzi m'mimba thirakiti.
• Kutupa kwa:
  • Mukakumana ndi gastric madzi, matyrophilic matrix amatuluka, ndikupanga gawo la gel kuzungulira tinthu ta mankhwala.
• Kusakanikirana Mankhwala:
  • Mankhwalawa ndi obalalika kapena okhazikika mkati mwa gel onrix.

3. Makina ovomerezeka:

• Kusakanikirana ndi kukokoloka:
  • Kutulutsidwa kolamulidwa kumachitika kudzera mu kuphatikiza kwa mayendedwe ndi kusintha kwa kukokoloka.
  • Madzi amalowa matrix, zomwe zimapangitsa kutupa, ndipo mankhwalawa amasokoneza pakati pa gel wosanjikiza.
• Kumasulidwa kwa Zero:
  • Mbiri yovomerezeka yovomerezeka nthawi zambiri imatsata zero-dongosolo loyitanitsa, kupereka kuchuluka kwa mankhwala osokoneza bongo komanso owonetsera bwino pakapita nthawi.

4. Zinthu zomwe zimapangitsa kuti musulidwe mankhwala:

• Polymer ndende:
  • Kukhazikika kwa hpmc mu matrix kumapangitsa kuchuluka kwa mankhwala osokoneza bongo.
• Kulemera kwa HPMC:
  • Magawo osiyanasiyana a hpmc okhala ndi zolemera zosiyanasiyana amatha kusankhidwa kuti agwirizane ndi mamasulidwe.
• Kusungunulira Mankhwala:
  • Kusungunuka kwa mankhwala mu matrix kumakhudza mawonekedwe ake.
• Matrix Dyclence:
  • Mulingo wa kutupa kwa gel ndi matrix omwe amayambitsa mankhwala amasokoneza.

5. Ubwino wa cellulose etrase mu matrix:

• Mabizinesi: cellulose yokhazikika nthawi zambiri imakhala yovomerezeka komanso yolekika m'mimba thirakiti.
• Kusiyanitsa: Magawo osiyanasiyana a cellulose eder amatha kusankhidwa kuti akwaniritse mbiri yomwe mukufuna.
• Kukhazikika: cellulose yokhazikika imapereka bata ku matrix system, ndikuwonetsetsa kuti kugwiritsa ntchito mankhwalawa nthawi yayitali.

6. Ntchito:

• Kutumiza kwa Pamlomo: Hydrophilic matrix Makina omwe nthawi zambiri amagwiritsidwa ntchito ngati pakamwa mankhwala, amathandizira kumasulidwa.
• Zinthu Zachikhalidwe: Zothandiza pakugwiritsa ntchito mankhwala ogwiritsidwa ntchito munthawi zambiri momwe zimamasulira mankhwala osokoneza bongo amathandiza.

7. Maganizo:

• Kutha kwa mapangidwe: Kupanga kuyenera kukhazikitsidwa kuti mukwaniritse mbiri yopanga mankhwala osokoneza bongo ogwiritsa ntchito mankhwala othandiza mankhwalawa.
• Kutsatira kwa Cellatotory Kugwiritsa ntchito mankhwala ogulitsa amayenera kutsatira mfundo zothandiza.

Kugwiritsa ntchito cellulose etral mu hydrophilic mayrix machitidwe a hydrophilic kumatsimikizira tanthauzo lawo pakupanga mankhwala, kupereka njira yosiyanasiyana komanso njira yothanirana ndi mankhwala osokoneza bongo.