Zochita zamankhwala mu nayonso mphamvu ya hydroxypropyll methylcellulose

Hydroxypropyl methylcellulose (hpmc)Ndi gawo losungunulira lamadzi lomwe limagwiritsidwa ntchito m'makampani ambiri komanso zamankhwala, ndipo lili ndi mitundu yambiri yogwirizira, monga kumasulidwa kwa mankhwala, kukonza zakudya ndi zida zomangira. Zomwe zimachitika mu mphamvu zake zimagwirizana makamaka ndi kuwonongeka ndi kusintha kwa cellulose ndi zochitika za kagayidwe ka tizilombo. Kuti mumvetsetse bwino zochita za hpmc mu mphamvu ya mphamvu, choyamba tiyenera kumvetsetsa kapangidwe kake ndi kuwonongeka kwa cellulose.

1. Kapangidwe ka koyambira ndi katundu wa hydroxypropyll methylcelulose

HPMC ndi yochokera mwa kusinthidwa kwa mankhwala a cellulose ya chilengedwe (cellulose). Botu la mtsinje wa ma molecular ndi ma molekyulu a glucose (C6H12o6) yolumikizidwa ndi β-1,4 glycosidic. Cellulose pakokha nkovuta kusungunuka m'madzi, koma poyambitsa methyl (-Och3) ndi hydroxypropyl (-Chnthooxypropyl (-Chnthooxypropyl (-Chnthooxypropyl (-Chnthooxypropyl (-Chnthooxypropyl (-Chkh3hnioh) maguluwo, kusungunuka kwamadzi kumatha kusintha polymer kuti apange polymer. Njira yosinthira HPMC nthawi zambiri imaphatikizapo zomwe zimachitika pa cellulose ndi methyl chloride (ch3cl) ndi ma prololine mowa (c3h6o) mwamphamvu, ndipo zotsatira zake zimakhala ndi hydrophilicity ndi kusandulika.

2. Zochita zamankhwala pa nayonso mphamvu

Njira yochitira mphamvu ya HPMC imatengera zomwe zimachitika mu tizilombo tating'ono, omwe amagwiritsa ntchito HPMC ngati gwero la kaboni komanso gwero la michere. Njira yofuula ya HPMC imaphatikizaponso magawo akulu otsatira:

2.1. Kuwonongeka kwa hpmc

Chuma chokha chimapangidwa ndi mayunitsi a glucose olumikizidwa, ndipo HPMC idzawonongedwa ndi tizilombo tating'onoting'ono, choyamba ndikuwola mu shuga (monga shuga, xylose, etc.). Njirayi nthawi zambiri imaphatikizapo kuchitapo kanthu kwa ma ennose ambiri. Kuwonongeka kwakukulu komwe kumaphatikizapo:

Cellulose hydrolysis chisanachitike: The-1-1,4 glycosidic mu mamolekyulu a celluulose adzasweka ndi ma celrouse, zokhala ndi ma endocellase), ma Diackaccharides, ndi zina zambiri). Izi sizimapangidwanso ndikugwiritsidwa ntchito ndi tizilombo tating'onoting'ono.

Hydrolysis ndi kuwonongeka kwa hpmc: methyl ndi hydroxypyl oyimira mu HPMC Moleklule imachotsedwa pang'onopang'ono ndi hydrolysis. Njira inayake ya hydrolysis yomwe sinamveke bwino, koma imatha kumvekedwa kuti munso mphamvu, ma hydrolysis angalandidwe ndi ma enzymed omwe amasungidwa ndi tizilombo tating'onoting'ono (monga hydroxyl esterase). Izi zimatsogolera ku chiwonongeko cha HPMC Molecular unyolo ndi kuchotsedwa kwa magulu ogwirira ntchito, pamapeto pake amapanga ma molekyulu ang'onoang'ono.

2.2. Ma microbial metabolic

Nthawi yomweyo HPMC imawonongeka m'matumbo a shuga, tizilombo tating'onoting'ono timatha kusintha shuga izi mphamvu kudzera mu enzymatic imachitika. Makamaka, tizilombo tating'onoting'ono timawola shuga mu ethanol, lactic acid kapena ma metabolites ena kudzera m'njira. Mankhwala osiyanasiyana amatha kuperewera mankhwala a HPMC kuwonongeka kudzera munjira zosiyanasiyana. Mitundu yodziwika bwino ya kagayidwe imaphatikizapo:

Njira ya Glycolysis: Glucose imawola mu ma enzymes ndikusinthidwa kukhala mphamvu (atp) ndi ma metabolites (monga Lactic acid, ethanol, etc.).

Mbadwo wa Fermentation: Pansi pa Anaerobic kapena hypoxic mikhalidwe, tizilombo tating'onoting'ono tomwe timayambitsa matenda a ethanol, ndi zina mwamphamvu, zomwe zimagwiritsidwa ntchito kwambiri mu njira zosiyanasiyana zamakisiri.

2.3. Makonzedwe a redox

Pa nthawi ya mphamvu ya hpmc, ena a tizilombo tating'onoting'ono amathanso kusinthitsa zinthu zapakatikati pazinthu zomwe zimachitika. Mwachitsanzo, kupanga kwa ethanol kumayenderana ndi redox kumachitika ozizira kuti atulutse pyrute, kenako pyrute amasinthidwa kukhala ethanol zosintha. Izi zimathandiza kuti zikhalebe ndi maselo a metabolic.

3..

Panthawi ya mphamvu ya HPMC, zachilengedwe zimakhala ndi zofunika pa zomwe zimachitika. Mwachitsanzo, PH, kutentha, kusungunuka kwa oxygen, Sourced Yopatsa chidwi, ndi zina zambiri. Makamaka kutentha ndi Ph, ntchito ya michere ya microbial imasiyana kwambiri pansi pa kutentha kosiyanasiyana ndi pH

Njira ya mphamvu yaHpmcImakhudzanso zovuta zamankhwala, kuphatikizapo hydrolysis of cellulose, kuwonongeka kwa HPMC, kagayidwe ka shuga, ndi m'badwo wa zotayira. Kuzindikira zomwe zimachitika sizimangothandiza kukonza njira ya hpmc, komanso imathandizira kwambiri thandizo la ma botiri okhudzana ndi ma botili. Ndi kuyang'ana kwa kafukufuku, njira zothandizira kwambiri komanso zothandiza komanso zachuma zitha kukhazikitsidwa mtsogolo kuti musinthe momwe mungawonongere HPMC ndi zokolola za malonda, ndikulimbikitsa kugwiritsa ntchito zachilengedwe ndi minda ina.