M'munda wamankhwala, sodium carboxymethylcellulose (CMC) ndi hydroxypropyl methylcellulose (HPMC) ndi awiri omwe amagwiritsidwa ntchito kwambiri popanga mankhwala okhala ndi mankhwala osiyanasiyana komanso ntchito.
Kapangidwe ka mankhwala ndi katundu
CMC ndi chochokera m'madzi chosungunuka cha cellulose chomwe chimapezedwa posintha gawo lamagulu a hydroxyl a cellulose kukhala magulu a carboxymethyl. Kusungunuka kwamadzi ndi kukhuthala kwa CMC kumadalira kuchuluka kwake kwa kusintha ndi kulemera kwa maselo, ndipo nthawi zambiri imakhala ngati chowonjezera chabwino komanso choyimitsa.
HPMC imapezeka posintha gawo lamagulu a hydroxyl a cellulose ndi magulu a methyl ndi hydroxypropyl. Poyerekeza ndi CMC, HPMC ili ndi kusungunuka kwakukulu, imatha kusungunuka m'madzi ozizira ndi otentha, ndikuwonetsa kukhuthala kokhazikika pamitundu yosiyanasiyana ya pH. HPMC nthawi zambiri amagwiritsidwa ntchito ngati filimu wakale, zomatira, thickener ndi ankalamulira kumasulidwa wothandizila mu mankhwala.
Malo ogwiritsira ntchito
Mapiritsi
Popanga mapiritsi, CMC imagwiritsidwa ntchito kwambiri ngati disntegrant ndi zomatira. Monga disintegrant, CMC imatha kuyamwa madzi ndikutupa, potero kulimbikitsa kupasuka kwa mapiritsi ndikuwonjezera kuchuluka kwa mankhwala. Monga chomangira, CMC imatha kupititsa patsogolo mphamvu zamakina zamapiritsi.
HPMC imagwiritsidwa ntchito kwambiri ngati filimu yakale komanso yowongolera yotulutsa m'mapiritsi. Kanema wopangidwa ndi HPMC ali ndi mphamvu zamakina komanso kukana kuvala, zomwe zimatha kuteteza mankhwalawa ku chikoka cha chilengedwe chakunja. Nthawi yomweyo, zinthu zopanga filimu za HPMC zitha kugwiritsidwanso ntchito kuwongolera kuchuluka kwa mankhwalawa. Mwa kusintha mtundu ndi mlingo wa HPMC, kumasulidwa kosalekeza kapena kumasulidwa kolamulirika kungathe kupezedwa.
Makapisozi
Pokonzekera kapisozi, CMC sagwiritsidwa ntchito pang'ono, pamene HPMC imagwiritsidwa ntchito kwambiri, makamaka popanga makapisozi a zamasamba. Zipolopolo zachikhalidwe za kapisozi nthawi zambiri zimapangidwa ndi gelatin, koma chifukwa cha vuto la nyama, HPMC yakhala njira ina yabwino. Chipolopolo cha kapisozi chopangidwa ndi HPMC sichingokhala ndi biocompatibility yabwino, komanso chimakwaniritsa zosowa za anthu odya zamasamba.
Kukonzekera kwamadzimadzi
Chifukwa cha makulidwe ake abwino kwambiri komanso kuyimitsidwa, CMC imagwiritsidwa ntchito kwambiri pokonzekera zamadzimadzi monga mayankho apakamwa, madontho am'maso ndikukonzekera pamutu. CMC kuonjezera mamasukidwe akayendedwe a madzi Kukonzekera, potero kuwongolera kuyimitsidwa ndi bata la mankhwala ndi kupewa mankhwala sedimentation.
Kugwiritsiridwa ntchito kwa HPMC mu kukonzekera kwamadzimadzi kumakhazikika kwambiri mu thickeners ndi emulsifiers. HPMC imatha kukhala yokhazikika pamitundu yambiri ya pH ndipo imatha kukhala yogwirizana ndi mitundu yosiyanasiyana yamankhwala popanda kusokoneza mphamvu ya mankhwalawa. Kuonjezera apo, mafilimu opanga mafilimu a HPMC amagwiritsidwanso ntchito pokonzekera zam'mwamba, monga filimu yopanga mafilimu otetezera m'maso.
Kukonzekera kumasulidwa koyendetsedwa
Pokonzekera kumasulidwa kolamulidwa, kugwiritsa ntchito HPMC kumakhala kodziwika kwambiri. HPMC amatha kupanga gel osakaniza maukonde, ndi kumasulidwa mlingo wa mankhwala akhoza lizilamulira ndi kusintha ndende ndi dongosolo HPMC. Katunduyu wakhala akugwiritsidwa ntchito kwambiri m'mapiritsi ndi ma implants otulutsa pakamwa. Mosiyana ndi izi, CMC simagwiritsidwa ntchito pang'onopang'ono pokonzekera kumasulidwa, makamaka chifukwa mawonekedwe a gel omwe amapanga siwokhazikika monga HPMC.
Kukhazikika ndi kuyanjana
CMC imakhala yosakhazikika pamitundu yosiyanasiyana ya pH ndipo imakhudzidwa mosavuta ndi malo okhala ndi acid. Kuphatikiza apo, CMC imagwirizana bwino ndi zinthu zina za mankhwala, zomwe zingayambitse kugwa kwa mankhwala kapena kulephera.
HPMC imasonyeza kukhazikika bwino pamitundu yambiri ya pH, sichimakhudzidwa mosavuta ndi acid-base, ndipo imakhala yogwirizana kwambiri. HPMC ikhoza kukhala yogwirizana ndi zosakaniza zambiri za mankhwala popanda kukhudza kukhazikika ndi mphamvu ya mankhwala.
Chitetezo ndi malamulo
Onse a CMC ndi HPMC amaonedwa kuti ndi othandiza pamankhwala otetezeka ndipo avomerezedwa kuti agwiritsidwe ntchito pokonzekera mankhwala ndi ma pharmacopoeias ndi mabungwe olamulira m'maiko osiyanasiyana. Komabe, mukamagwiritsa ntchito, CMC imatha kuyambitsa kusamvana kapena kusapeza bwino kwa m'mimba, pomwe HPMC simayambitsa zovuta zina.
CMC ndi HPMC ali ndi maubwino awo pazamankhwala. CMC ili ndi malo ofunikira pokonzekera zamadzimadzi chifukwa cha kukhuthala kwake komanso kuyimitsidwa, pomwe HPMC yakhala ikugwiritsidwa ntchito kwambiri m'mapiritsi, makapisozi ndikukonzekera kumasulidwa koyendetsedwa bwino chifukwa cha mawonekedwe ake abwino kwambiri opangira mafilimu komanso kutulutsa kowongolera. Kusankhidwa kwa mankhwala okonzekera mankhwala kuyenera kukhazikitsidwa pamtundu wa mankhwala ndi zofunikira zokonzekera, kuganizira mozama ubwino ndi kuipa kwa onse awiri, ndikusankha wothandizira woyenera kwambiri.
Nthawi yotumiza: Jul-19-2024