Hydroxylopyopyochin (hpmc) ndi polymer yogwiritsidwa ntchito poyipitsa kwambiri m'makampani opanga mankhwala ndipo ndi njira yofunika kwambiri. Amagwiritsidwa ntchito makamaka ngati zomatira mogwirizana ndi mlingo wolimba (monga mapiritsi, makapisozi, ndi ma tinthu), mafayilo akumwamba ndi kuwola.
Pokonzekera mankhwala, kusungunuka kwa zosakaniza ndikofunikira kuti alowetse ndikupanga mankhwala. Komabe, kusuta kwa ntchito yogwira ntchito kumalepheretsedwa ndi formula. Chifukwa chake, ndikofunikira kumvetsetsa kusungunuka kwa hpmc mu kilogalamu ya mankhwala chifukwa zimakhudza momwe mankhwalawa amagwirira ntchito.
Njira Yokhumudwitsa ya HPMC
USP Demacy (USP) yasintha njira yoyesera kusungunulira hpmc. Njirayi nthawi zambiri imaphatikizapo kugwiritsa ntchito zida zosungunulira, zomwe zimakhazikika ndikuyesa kusungunuka kwa mtundu wa mankhwalawa. Kuyesedwa kumakhudzanso kuyika mlingo mudenga kapena paddle, ndipo dengu kapena kunyamula kuzungulira chidebe chomwe chili ndi sing'anga wosungunuka.
Sitima yapamwamba iyenera kusankhidwa malinga ndi momwe amafunira kwa mlingo (monga m'mimba kapena matumbo osungunuka). Consemolmol soubility ya HPMC imaphatikizapo madzi, buffete buffer yankho ndi masinthidwe am'mimba (sgf) kapena analog matumbo (sif).
Kuti muwonetsetse kubwereza komanso kulondola, kuyeza magawo kuyenera kukhala koyenera, monga kuthamanga kwa kuzungulira, kutentha, ndi kusungunuka, ndi kusungunuka kwa sing'anga. Kenako gwiritsani ntchito njira yoyenera kusanthula zitsanzo zomwe zimaperekedwa ndi nthawi yosiyanasiyana kuti mudziwe kuchuluka kwa zisudzo za HPMC.
Njira zopewera mukamachita mayeso a HPMC
1. Kusankhidwa kwa ndalama zakuthambo: Kusankha kusungunuka kwapakatikati kumadalira momwe amafunira. Kusankha sing'anga yovomerezeka ndikofunikira kwambiri chifukwa chidzakhudza mayendedwe a HPMC.
2. Kutsimikizira molondola njira: kutsimikizira njira yosungunulira kuti muwonetsetse kuti ndizoyenera ndipo ndikofunikira kukwaniritsa zofunikira za bungwe la Appreotry. Chitsimikizo chikuyenera kuphatikizira ndi kubwereza kwa muyeso.
3. Chifukwa chake, magawo awa ayenera kukhala oyenera kuti awonetsetse kuwunikira komanso kusanthula kolondola.
4. Chitsanzo: Chitsanzo chosasamala ndichofunika kupeza zitsanzo zoimira kuti zisasungunule sing'anga. Samalani ndi nthawi yowerengera ndi zitsanzo kuti muwonetsetse kuti sampuli imasonkhanitsidwa mogwirizana.
5. Njira Yosanthula: Sankhani njira yowunikira kuti mupendeke zitsimikizidwe, ndipo ziyenera kukhala ndi chidwi choyenera, kusankha ndi kulondola.
Mwachidule, kuyesedwa kwa HPMC ndi chida chofunikira pakupanga mankhwala ndi njira yamankhwala. Labotale yowongolera imachitika pafupipafupi kuti iwonetsetse kumasulidwa koyenera kwa zosakaniza, ndipo mankhwalawa ndi otetezeka komanso ogwira mtima. Zolakwika munjira yoyeserera zingayambitse kusamvana komanso mawu abodza pa zomwe zimachitika mu mankhwala osokoneza bongo. Chifukwa chake, ndikofunikira kutsatira miyezo ndi njira zopewera panthawi yofatsa yofananira.
Post Nthawi: Jun-29-2023