Hydroxypropyl methylcellulose (hpmc)Ndiogwiritsidwa ntchito kwambiri polymer polymer, amagwiritsidwa ntchito kwambiri pa mankhwala opangira mankhwala, chakudya, zodzola zodzola, zodzola komanso minda ina. HPMC ili ndi zosungunuka bwino komanso mawonekedwe a mafakisoni ndipo imatha kupanga yankho lokhazikika la colloidal, motero limakhala ndi gawo lofunikira pakugwiritsa ntchito. Pofuna kupereka seweroli lathunthu pakuchita kwa HPMC, njira yolondola yosinthira ndiyofunika kwambiri.
1. Kutentha kwabwinobwino kwamadzi
HPMC imatha kusungunuka m'madzi ozizira, koma nthawi zambiri maluso ena amafunikira kuti apewe kubula. Pofuna kukonza zochulukitsa, njira zotsatirazi zingagwiritsidwe ntchito:
Gawo 1: Onjezani HPMC ku Madzi
Kutentha koyambirira, koyamba kuwaza hpmc mokwanira pamadzi kuti muchepetse kutsanulira kwa hpmc m'madzi nthawi imodzi. Chifukwa HPMC ndi polymer contround, yowonjezera mwachindunji HPMC idzapangitsa kuti imeke madzi ndikutupa mwachangu m'madzi kuti apange zinthu zowoneka bwino.
Gawo 2: Woyambitsa
Pambuyo kuwonjezera hpmc, pitilizani kulimbikira ngakhale. Chifukwa HPMC ili ndi tinthu tabwino, imatupa pambuyo potenga madzi kuti apange zinthu zowoneka bwino. Kusangalatsa kumathandiza kupewa hpmc kuchokera ku zowombera.
Gawo 3: Imani ndikuyambitsa
Ngati HPMC siikusungunuka kwathunthu, yankho limatha kusiyidwa kuti liyime kwakanthawi kenako ndikupitilizabe kusokoneza. Nthawi zambiri imasungunuka kwathunthu mkati mwa maola ochepa.
Njirayi ndiyoyenera nthawi yopumira siyofunikira, koma zimatenga nthawi yayitali kuti HPMC imasungunuka kwathunthu.
2. Njira Yotentha Yokhumudwitsa
HPMC imasungunuka mwachangu m'madzi ofunda, motero kuthirira kutentha kwa madzi kumatha kugwira ntchito kwambiri kuti zisungunuke. Kutenthetsera kwamadzi komwe kumagwiritsidwa ntchito kutentha kwa 50-70 ℃, koma kuchuluka kwambiri kutentha (monga kupitirira 80 ℃) kungayambitse HPMC kuwonongeka, kotero kutentha kumayenera kulamuliridwa.
Gawo 1: Madzi
Tenthetsani madziwo mpaka 50 ℃ ndikusunga nthawi zonse.
Gawo 2: Onjezani HPMC
Kuwaza HPMC pang'onopang'ono m'madzi otentha. Chifukwa cha kutentha kwambiri kwamadzi, hpmc kumasungunuka mosavuta, kuchepetsa kuvuta.
Gawo 3: Woyambitsa
Pambuyo kuwonjezera hpmc, pitilizani kuyambitsa yankho la madzi. Kuphatikiza kwa kutentha ndi kusangalatsa kumatha kulimbikitsa kusungunuka mwachangu kwa HPMC.
Gawo 4: Sungani kutentha ndi kupitiriza kusuntha
Mutha kukhalabe ndi kutentha kwina ndikupitiliza kusangalatsa mpaka HPMC yasungunuka kwathunthu.
3. Njira yoledzera
HPMC imatha kusungunuka osati m'madzi okha, komanso nthawi zina mowa (monga ethanol). Ubwino waukulu wa moledzera njira yoledzera ndikuti zitha kusintha kusungunuka ndi kukana kwa hpmc, makamaka kwa machitidwe omwe ali ndi madzi ambiri.
Gawo 1: Sankhani zosungunulira zoyenera
Kumwa mowa kwa Ethanol ndi isoppanol nthawi zambiri kumagwiritsidwa ntchito kusungunula hpmc. Nthawi zambiri, 70-90% ethanol njira imathandizira kusungunula hpmc.
Gawo 2: Kusungunuka
Pang'onopang'ono, mumawaza HPMC mu zosungunuka zoledzera, zolimbikitsa pomwe zimawonjezera kuti HPMC imabalalika kwathunthu.
Gawo 3: Kuyimirira ndikuyambitsa
Njira ya kuledzera kwa HPMC imathamanga, ndipo nthawi zambiri imatenga mphindi zochepa kuti mukwaniritse zosintha zathunthu.
Njira yoledzera imagwiritsidwa ntchito nthawi zambiri yomwe imagwiritsidwa ntchito mu kafukufuku yemwe amafunikira kusungunuka mwachangu komanso madzi ochepa.
4. Madzi osungunuka madzi osakanikirana
Nthawi zina HPMC idasungunuka mu gawo lina la madzi ndi zosungunulira. Njirayi ndi yoyenera makamaka pamikhalidwe yomwe imakupatsirani chidwi kapena kusungunuka kwa chilengedwe kuyenera kusintha. Maso wamba amaphatikizapo acetone, ethanol, etc.
Gawo 1: Konzani yankho
Sankhani chiwerengero choyenera cha zosungunulira ndi madzi (mwachitsanzo, madzi 50%, 50% solven) ndi kutentha mpaka kutentha koyenera.
Gawo 2: Onjezani HPMC
Ngakhale oyambitsa, onjezani HPMC kuti muwonetsetse kuti ziphuphu.
Gawo 3: Kusintha kwina
Pofunika, kuchuluka kwa madzi kapena kusungunuka kungachuluke kuti asinthe solubility ndi mafayilo a HPMC.
Njirayi ndiyoyenera nthawi yomwe madokotala oyipitsira amawonjezeredwa kuti athetseretu kuti asinthane kapena kusintha katundu wa yankho.
5. Akupanga - Kuthandizira Kukhumudwitsa Njira
Pogwiritsa ntchito osquiceration Osquillation Escilicy of Ultrasound, njira yofalitsidwayo imathandizira kuti hpmc ithe. Njirayi ndi yoyenera makamaka kwa HPMC yambiri ikufunika kusungunuka mwachangu, ndipo imatha kuchepetsa vuto la chibwibwi lomwe lingachitike pakakhwima.
Gawo 1: Konzani yankho
Onjezani hpmc ku madzi oyenera kapena njira yothetsera madzi osokoneza bongo.
Gawo 2: Akupanga Chithandizo
Gwiritsani ntchito zotsuka kapena zosungunulira zomwe akupanga ndikuzichitira molingana ndi mphamvu ndi nthawi. Zotsatira za oscillation za ultrasound zimatha kufutula kwambiri njira yosungunulira ya HPMC.
Gawo 3: Onani zotsatira zosinthika
Pambuyo popanga mankhwala, onani ngati yankho lasungunuka kwathunthu. Ngati pali gawo losagwirizana, akupanga chithandizo chimatha kuchitidwa kachiwiri.
Njirayi ndiyoyenera kugwiritsa ntchito zomwe zimafunikira kuthekera komanso kosavuta.
6. Kudzitukumula musanasungunule
Pofuna kupewaHpmcKuphatikizika kapena zovuta pakusungunuka, njira zina zokongoletsera zitha kugwiritsidwa ntchito, monga kusakaniza HPMC yokhala ndi ma sodires ena (monga glycerol), kuyanika kaye, kapena kunyowetsa HPMC musanawonjezere zosungunulira. Njira zopangira zokopa izi zimatha kusintha kusungunuka kwa HPMC.
Pali njira zambiri zosungunulira hpmc. Kusankha njira yoyenera yofalitsira kungasinthe kwambiri kusinthika kwachuma komanso mtundu. Njira yotentha yosungiramo chipinda ndizoyenera malo odyetsera bwino, njira yozizira yokhumudwitsa imatha kufulumira kusungunuka, komanso njira yosungunulira yoletsedwa komanso njira yosinthira madzi osinthika ndioyenera kuwonongedwa ndi zosowa zapadera. The akupanga - njira yofatsa yophweka ndi njira yothandiza kuti ithetse kusungunuka mwachangu kwa HPMC yayikulu. Malinga ndi zofunikira zina zomwe mungagwiritse ntchito, kusankha njira yosinthika yotsimikizika yovomerezeka kumatha kuonetsetsa kuti hpmc mosiyanasiyana.
Post Nthawi: Dis-19-2024