Hydroxypropyl methylcellulose (HPMC)ndi polima yosungunuka m'madzi, yomwe imagwiritsidwa ntchito kwambiri muzamankhwala, chakudya, zomangira, zodzoladzola ndi zina. HPMC ali ndi solubility wabwino ndi mamasukidwe akayendedwe makhalidwe ndipo akhoza kupanga khola njira colloidal, choncho imagwira ntchito yofunika kwambiri ntchito zambiri. Kuti mupereke sewero lathunthu pakuchita kwa HPMC, njira yoyenera yothetsera ndiyofunikira kwambiri.
1. Njira yachibadwa ya kutentha kwa madzi kutentha
HPMC ikhoza kusungunuka m'madzi ozizira, koma nthawi zambiri maluso ena amafunika kupewa kuphatikizika kwake. Kuti muwonjezere mphamvu ya dissolution, njira zotsatirazi zingagwiritsidwe ntchito:
Gawo 1: Onjezani HPMC m'madzi
Pa kutentha kwa chipinda, choyamba kuwaza HPMC mofanana pamadzi kuti musathire kuchuluka kwa HPMC m'madzi nthawi imodzi. Chifukwa HPMC ndi polima pawiri, kuwonjezera mwachindunji kuchuluka kwa HPMC kungachititse kuti kuyamwa madzi ndi kutupa mofulumira m'madzi kupanga gel osakaniza mankhwala.
Gawo 2: Kuyambitsa
Mukawonjezera HPMC, pitirizani kuyambitsa mofanana. Chifukwa HPMC ili ndi tinthu tating'onoting'ono, imatupa pambuyo poyamwa madzi ndikupanga chinthu chonga gel. Kukondoweza kumathandiza kupewa HPMC kuti isagwirizane kukhala clumps.
Gawo 3: Imani ndikuyambitsanso
Ngati HPMC si kwathunthu kusungunuka, yankho akhoza kusiyidwa kuima kwa kanthawi kenako kupitiriza kusonkhezera. Nthawi zambiri imasungunuka mkati mwa maola angapo.
Njirayi ndi yoyenera nthawi zomwe kutentha sikofunikira, koma zimatenga nthawi yayitali kuti HPMC isungunuke.
2. Njira yothetsera madzi otentha
HPMC imasungunuka mwachangu m'madzi ofunda, kotero kutentha kwa madzi kumatha kufulumizitsa kwambiri kusungunuka. Kutentha kwamadzi komwe kumagwiritsidwa ntchito nthawi zambiri ndi 50-70 ℃, koma kutentha kwambiri (monga kupitirira 80 ℃) kungayambitse HPMC kutsika, kotero kutentha kumafunika kuwongoleredwa.
Gawo 1: Kutenthetsa madzi
Kutenthetsa madzi pafupifupi 50 ℃ ndi kusunga mosasinthasintha.
Gawo 2: Onjezani HPMC
Kuwaza HPMC pang'onopang'ono m'madzi otentha. Chifukwa cha kutentha kwambiri kwa madzi, HPMC idzasungunuka mosavuta, kuchepetsa agglomeration.
Gawo 3: Kuyambitsa
Pambuyo powonjezera HPMC, pitirizani kuyambitsa njira yamadzimadzi. Kuphatikiza kwa kutentha ndi kusonkhezera kumatha kulimbikitsa kutha msanga kwa HPMC.
Khwerero 4: Sungani kutentha ndikupitiriza kuyambitsa
Mukhoza kusunga kutentha kwina ndikupitirizabe kugwedeza mpaka HPMC itasungunuka kwathunthu.
3. Njira Yothetsera Mowa
HPMC ikhoza kusungunuka osati m'madzi okha, komanso m'madzi ena osungunulira mowa (monga ethanol). Ubwino waukulu wa njira yothetsera mowa ndikuti ukhoza kusintha kusungunuka ndi kusungunuka kwa HPMC, makamaka kwa machitidwe omwe ali ndi madzi ambiri.
1: Sankhani chosungunulira mowa choyenera
Mowa zosungunulira monga Mowa ndi isopropanol zambiri ntchito kupasuka HPMC. Nthawi zambiri, 70-90% ethanol yankho imakhala ndi zotsatira zabwino pakutha kwa HPMC.
Gawo 2: Kutha
Pang'onopang'ono kuwaza HPMC mu zosungunulira mowa, oyambitsa pamene kuwonjezera kuonetsetsa kuti HPMC omwazika kwathunthu.
Gawo 3: Kuyimirira ndikugwedeza
Njira ya mowa zosungunulira Kutha HPMC ndi mofulumira, ndipo nthawi zambiri amatenga mphindi zingapo kukwaniritsa Kutha wathunthu.
Njira yothetsera mowa nthawi zambiri imagwiritsidwa ntchito pazochitika zomwe zimafuna kusungunuka msanga komanso kuchepa kwa madzi.
4. Njira yosungunulira-madzi osakanikirana
Nthawi zina HPMC imasungunuka mu chisakanizo cha gawo lina la madzi ndi zosungunulira. Njirayi ndiyoyenera makamaka pamikhalidwe yomwe kukhuthala kwa yankho kapena kuchuluka kwa kusungunuka kumayenera kusinthidwa. Zosungunulira zodziwika bwino zimaphatikizapo acetone, ethanol, etc.
1: Konzani yankho
Sankhani chiŵerengero choyenera cha zosungunulira ndi madzi (monga 50% madzi, 50% zosungunulira) ndi kutentha kwa kutentha koyenera.
Gawo 2: Onjezani HPMC
Pamene mukuyambitsa, onjezerani pang'onopang'ono HPMC kuti muwonetsetse kusungunuka kofanana.
3: Kusintha kwina
Ngati pakufunika, kuchuluka kwa madzi kapena zosungunulira akhoza ziwonjezeke kusintha solubility ndi mamasukidwe akayendedwe a HPMC.
Njirayi ndi yoyenera nthawi zomwe zosungunulira za organic zimawonjezeredwa ku njira zamadzimadzi kuti ziwongolere kuchuluka kwa kusungunuka kapena kusintha mawonekedwe a yankho.
5. Akupanga-anathandizidwa kuvunda njira
Kugwiritsa ntchito kwambiri pafupipafupi oscillation zotsatira za ultrasound, ndi akupanga-anathandiza kuvunda njira akhoza imathandizira ndi kuvunda ndondomeko ya HPMC. Njirayi ndiyoyenera makamaka pazambiri za HPMC zomwe zimayenera kusungunuka mwachangu, ndipo zimatha kuchepetsa vuto la agglomeration lomwe lingachitike panthawi yachisangalalo chachikhalidwe.
1: Konzani yankho
Onjezani HPMC pamlingo woyenera wamadzi kapena madzi osungunulira osakaniza.
Gawo 2: Akupanga mankhwala
Gwiritsani ntchito akupanga zotsukira kapena akupanga dissolver ndi kuchiza izo molingana ndi mphamvu anapereka ndi nthawi. The oscillation zotsatira za ultrasound akhoza kwambiri imathandizira ndi kuvunda ndondomeko ya HPMC.
Khwerero 3: Yang'anani zotsatira za kusungunuka
Pambuyo akupanga mankhwala, fufuzani ngati yankho kwathunthu kusungunuka. Ngati pali undissolved mbali, akupanga mankhwala akhoza kuchitidwa kachiwiri.
Njirayi ndi yoyenera kugwiritsira ntchito zomwe zimafuna kusungunuka bwino komanso mofulumira.
6. Pretreatment pamaso kutha
Pofuna kupewaMtengo wa HPMCagglomeration kapena zovuta kusungunula, njira zina pretreatment angagwiritsidwe ntchito, monga kusakaniza HPMC ndi zochepa zosungunulira zina (monga glycerol), kuyanika izo poyamba, kapena kunyowetsa HPMC pamaso kuwonjezera zosungunulira. Njira zopangiratu izi zitha kukonza bwino kusungunuka kwa HPMC.
Pali njira zambiri zothetsera HPMC. Kusankha njira yoyenera yosungunulira kumatha kupititsa patsogolo kwambiri kuwonongeka kwazinthu komanso mtundu wazinthu. Njira yothetsera kutentha kwa chipinda ndi yoyenera ku malo ochepetsetsa, njira yowonongeka kwa madzi otentha imatha kufulumizitsa njira yowonongeka, ndipo njira yothetsera mowa ndi njira yothetsera madzi osakanikirana ndi zosungunulira ndizoyenera kusungunuka ndi zosowa zapadera. The akupanga-anathandiza kuvunda njira ndi njira yothetsera mofulumira kuvunda kwa kuchuluka kwa HPMC. Malinga ndi zofunikira zenizeni zogwiritsira ntchito, kusankha kosinthika kwa njira yoyenera yosungunula kungawonetsetse kuti HPMC ikugwira ntchito bwino m'magawo osiyanasiyana.
Nthawi yotumiza: Dec-19-2024