Pakalipano, zopangira zokhwima za makapisozi a zomera ndi makamaka hydroxypropyl methylcellulose (HPMC) ndi pullulan, ndipo hydroxypropyl starch imagwiritsidwanso ntchito ngati zopangira.
Kuyambira chiyambi cha 2010s.Mtengo wa HPMCyakhala ikugwiritsidwa ntchito pamakampani opanga ma capsules aku China, ndipo kutengera magwiridwe ake abwino, makapisozi opanda kanthu a HPMC atenga malo pamsika wa makapisozi, kuwonetsa kufunikira kwakukulu muzaka khumi zapitazi.
Malinga ndi deta yamakampani, mu 2020, kuchuluka kwa malonda apanyumba a makapisozi olimba olimba adzakhala pafupifupi makapisozi 200 biliyoni (makampani opanga mankhwala ndi zaumoyo ataphatikizidwa), pomwe kuchuluka kwa makapisozi a HPMC kudzakhala makapisozi pafupifupi 11.3 biliyoni (kuphatikiza zotumiza kunja) , chiwonjezeko cha 4.2% kuposa 2019. %, chomwe chinali pafupifupi 5.5%. Makampani osapanga mankhwala amawerengera 93.0% ya makapisozi a HPMC ku China, ndipo kukula kwa makampani azachipatala kumayendetsa kugulitsa kwa makapisozi a HPMC.
Kuyambira 2020 mpaka 2025, CAGR ya makapisozi a HPMC okhala ndi ma gelling agents akuyembekezeka kukhala 6.7%, omwe ndi okwera kuposa kukula kwa 3.8% kwa makapisozi a gelatin. Kuphatikiza apo, kufunikira kwa makapisozi a HPMC m'makampani azachipatala am'nyumba ndikokwera kuposa komwe kumapangidwira m'makampani opanga mankhwala.Mtengo wa HPMCmakapisozi amatha kuthandiza kuthana ndi zovuta zomwe amapatsidwa komanso kutengera chikhalidwe ndi zakudya zomwe ogula padziko lonse lapansi amakonda. Ngakhale kufunikira kwa makapisozi a HPMC kwakadali kocheperako kuposa makapisozi a gelatin, kukula kwa kufunikira ndikwambiri kuposa makapisozi a gelatin.
1) Kupanga bwino komanso kukonza, popanda wothandizila gelling; imakhala ndi kusungunuka kwabwinoko, kusungunuka kosasinthasintha m'ma TV osiyanasiyana, osakhudzidwa ndi pH ndi mphamvu ya ionic, ndipo imakwaniritsa zofunikira za pharmacopoeia za mayiko akuluakulu ndi zigawo;
2) Pazakumwa zamchere zofooka, sinthani bioavailability ndikuwongolera mawonekedwe a mlingo;
3) Maonekedwe ndi okongola, ndipo zosankha zamtundu zimakhala zambiri.
Soft capsule ndi mankhwala opangidwa ndi kusindikiza mafuta kapena kuyimitsidwa kochokera ku mafuta mu chipolopolo cha kapisozi, ndipo mawonekedwe ake ndi ozungulira, ooneka ngati azitona, ang'onoang'ono oboola nsomba, owoneka ngati dontho, ndi zina zotero. mafuta, omwe ali ndi ntchito yofulumira komanso kupezeka kwapamwamba kuposa kupanga chogwiritsira ntchito chofanana ndi mapiritsi, ndipo amagwiritsidwa ntchito kwambiri pokonzekera mankhwala ndi mankhwala. Masiku ano, makapisozi ofewa okhala ndi mawonekedwe osiyanasiyana monga ophimbidwa ndi enteric, chewable, pampu ya osmotic, kumasulidwa kosalekeza, ndi ma suppositories ofewa ali kale pamsika. Chipolopolo chofewa cha capsule chimapangidwa ndi colloid ndi zowonjezera zowonjezera. Pakati pawo, colloids monga gelatin kapena chingamu chamasamba ndizo zigawo zikuluzikulu, ndipo khalidwe lawo limakhudza mwachindunji ntchito ya makapisozi ofewa. Mwachitsanzo, kutayikira kwa chipolopolo cha capsule, kumamatira, kusamuka kwa zinthu, kusungunuka pang'onopang'ono, ndi kusungunuka kwa makapisozi ofewa kumachitika panthawi yosungira Mavuto monga kusatsatira akugwirizana nazo.
Pakali pano, ambiri mwa zipangizo kapisozi ya makapisozi zofewa mankhwala m'dziko langa ndi nyama gelatin, koma ndi chitukuko mozama ndi ntchito gelatin makapisozi zofewa, zofooka zake ndi zofooka zakhala otchuka kwambiri, monga magwero zovuta za zipangizo, ndi zosavuta zolumikizirana zolumikizana ndi ma aldehyde compounds Mavuto abwino monga nthawi yochepa yosungirako ndi "zinyalala zitatu" zomwe zimapangidwa munjira yoyenga gelatin zimakhudza kwambiri chitetezo cha chilengedwe. Kuonjezera apo, palinso vuto la kuumitsa m'nyengo yozizira, yomwe imakhala ndi zotsatira zoipa pa khalidwe la kukonzekera. Ndipo makapisozi ofewa a chingamu samakhudza kwambiri chilengedwe. Chifukwa cha kufalikira kwa matenda opatsirana a zinyama padziko lonse lapansi, mayiko akuda nkhawa kwambiri ndi chitetezo cha zinyama. Poyerekeza ndi makapisozi a gelatin a nyama, makapisozi a zomera ali ndi maubwino apamwamba pakugwiritsa ntchito, chitetezo, kukhazikika, komanso kuteteza chilengedwe.
Onjezanihydroxypropyl methylcellulosekuthirira ndi kumwaza kupeza yankho A; onjezani gelling agent, coagulant, plasticizer, opacifier ndi colorant m'madzi ndikubalalitsa kuti mupeze yankho B; Sakanizani mayankho A ndi B, ndi kutentha mpaka 90 ~ 95 ° C, gwedezani ndi kutentha kwa 0,5 ~ 2h, kuziziritsa mpaka 55 ~ 70 ° C, tenthetsani ndikuyimirira kuti muwononge thovu kuti mutenge guluu;
Momwe mungatengere mwachangu madzi a glue, njira yayikulu ndikuwotcha pang'onopang'ono mu ketulo yochitirapo kanthu kwa nthawi yayitali,
Opanga ena amadutsa mwachangu pamphero ya colloid kudzera mu guluu wamankhwala
Nthawi yotumiza: Apr-25-2024