Zotsatira za hydroxypropyl pa kutentha kwa HPMC gel

Hydroxypropyl methylcellulose (hpmc) ndi polymer yogwiritsidwa ntchito polymer, zodzola zodzola zambiri, chakudya ndi mafakitale, makamaka pokonza ma gels. Mphamvu zake zakuthupi ndi zofatsa zimakhudza kwambiri ntchito zosiyanasiyana. Kutentha kwa HPMC Gel ndi imodzi mwazinthu zoyambirira zathupi, zomwe zimakhudza mwachindunji magwiridwe ake pakukonzekera kosiyanasiyana, monga kumasulidwa kwa mavidiyo, mafilimu, kukhazikika, etc.

1. Kapangidwe ndi katundu wa HPMC

HPMC ndi polymer osungunuka osungunuka omwe amapezeka poyambitsa magalamu awiri, hydroxypropyl ndi methyl, mu cellulose molecular mafupa. Kapangidwe kake kazithunzi kumakhala ndi mitundu iwiri ya magalamumu: hydroxypropyl (-ch2choch3) ndi methyl (-ch3). Zinthu monga njira zosiyana za hydroxypropyl, digiri ya methylation, ndipo kuchuluka kwa polymerization kumakhala ndi chofunikira kwambiri pa kusungunuka, machitidwe, komanso makina a HPMC.

M'matumba othetsera matendawa, madercence ®hptc amapanga zothetsera colloidal njira zothetsera ma hydrogen ndi mamolekyulu amadzi ndikuyanjana ndi mafupa ake okhazikika pa cellulose. Pamene malo akunja (monga kutentha, mphamvu ya Ionic, etc.) Kusintha, kulumikizana pakati pa mamolekyu a HPMC kudzasintha.

2. Tanthauzo ndi kukopa zinthu za kutentha kwa miyambo

Kutentha kwa kutentha (kutentha kutentha, T_Gel) kumatanthauza kutentha komwe HPMC imayamba kusintha kuchokera ku madzi mpaka kumapeto pomwe kutentha kwa njira kumawonekera pamlingo winawake. Kutentha kumeneku, kuyenda kwa ma unyolo kwa HPMC molecular kumangolekeredwe, ndikupanga mawonekedwe atatu-mawonekedwe, zomwe zimapangitsa gel osakaniza.

Kutentha kwa HPMC kumakhudzidwa ndi zinthu zambiri, chimodzi mwazinthu zofunikira kwambiri ndi ma hydroxypropyl zomwe zili. Kuphatikiza pa hydroxypropyl, zinthu zina zomwe zimakhudza kutentha kwa gel.

3. Mphamvu ya hydroxypropyl pa kutentha kwa HPMC gel

3.1 Kuchuluka kwa hydroxypropyl komwe kumabweretsa kuwonjezeka kwa kutentha kwa gel

Kutentha kwa HPMC kumagwirizana kwambiri ndi digiri ya hydroxypyl kulowetsa molekyulu yake. Monga momwe matenda a hydroxypyl amakulira, kuchuluka kwa hydrophilic miniti pamtunda wa HPMC Molecular kumawonjezeka, zomwe zimapangitsa kuyanjana pakati pa molekyulu ndi madzi. Kuchita izi kumapangitsa kuti maunyolo azowonjezera amatambasuka, potero kuchepetsa mphamvu ya kulumikizana pakati pa unyolo. Pakati pa mitundu ina, kuwonjezera ma hydroypropyl zomwe zimathandizira kukulitsa digiri ya hydration ndipo imalimbikitsa makonzedwe azomwe amakonzera ulure, kuti mawonekedwe a network amatha kupangidwa pamtunda wapamwamba kwambiri. Chifukwa chake, kutentha kwa kutentha kumakhala ndi hydroxypropyl kumakwera ndi zowonjezera.

HPMC yokhala ndi ma hydroxypyl (monga HPMC K15m) imakonda kuwonetsa kutentha komweko kuposa kuwunikira kwa Hydrokepyl ndi HPMC K4M). Izi ndichifukwa choti hydroxypyl yapamwamba imapangitsa kuti zikhale zovuta kwa mamolekyulu kuti azilumikizana komanso kupanga ma network otsika, ofunikira kutentha kwambiri kuti agonjetse machenjerero am'mimba ndikupanga mawonekedwe a mawonekedwe atatu. .

Ubwenzi wapakati pa hydroxypyl ndi yankho

Njira yothetsera vutoli ndinso chinthu chofunikira kwambiri chomwe chikukhudza kutentha kwa HPMC. Mu zothetsera zapamwamba za HPMC, njira zolumikizirana zimalimba, motero kutentha kwa minyewa kungakhale kokulirapo ngakhale ngati hydroxypyl zomwe zili m'munsi. Kukhazikika kochepa, kulumikizana pakati pa mamolekyu a HPMC ndi kufooka, ndipo yankho lake limakhala lodetsa kutsanulika.

Pamene hydroxypyl zomwe zimawonjezereka, ngakhale hydrophilicity imakwera, kutentha kwambiri kumafunikirabe kupanga gel. Makamaka pansi pamavuto otsika, kutentha kwa mikangano kumawonjezeka kwambiri. Izi zili choncho chifukwa HPMC yokhala ndi hydroxypyl yovuta kwambiri yovuta kwambiri pakati pamatumbo azosintha, ndipo minyewa imafuna mphamvu yowonjezera yothetsa matenda.

3.3 zotsatira za hydroxypropyl pamtundu waukulu

Pakatikati pa mitundu ina ya hydroxypyl, njira yankhondoyi imayendetsedwa ndi kulumikizana pakati pa ubweya wa hydration ndi manyolo. Pamene hydroxypyl molekyu ya HPMC imatsika, kugwiritsa ntchito mankhwalawa ndi yofooka, kulumikizana pakati pa mamolekyules kumakhala kolimba, ndipo kutentha kochepa kumatha kulimbikitsa mapangidwe a gel. Pamene hydroxpyl yomwe ili pamwamba, hydration imakulitsidwa kwambiri, kulumikizana pakati pa mambo kumayamba kufooka, ndipo kutentha kwa kutentha kumawonjezeka.

Zinthu zapamwamba za hydroxpyl zitha kubweretsanso kuwonjezeka kwa mafayilo a HPMC, kusintha komwe nthawi zina kumawonjezera kutentha kwa mitsinje.

Hydroxypyl ali ndi vuto lalikulu pamtunda waHpmc. Monga momwe matenda a hydroxypyl amakulira, hydrophilicity ya HPMC imawonjezeka ndi kulumikizana pakati pa unyolo matope amafooka, kotero kutentha kwake kwa miyala kumawonjezera, kotero kutentha kwake kutentha kumakhala kochuluka. Izi zitha kufotokozeredwa ndi kuphatikiza pakati pa kulumikizana pakati pa u hydration ndi ma unyolo. Posintha hydroxypyl zomwe zili mu HPMC, yeretsani kuwongolera kwa kutentha kwa HPMC itha kuchitika, pofuna kukonza magwiridwe antchito a HPMC mu mankhwala, chakudya ndi mapulogalamu ena a mafakitale.