Hydroxypropyl methylcellulose (HPMC) ndi polima yosungunuka m'madzi yomwe imagwiritsidwa ntchito kwambiri, yomwe imagwiritsidwa ntchito kwambiri muzamankhwala, zodzoladzola, chakudya ndi mafakitale, makamaka pokonza ma gels. Mawonekedwe ake akuthupi ndi machitidwe osungunuka amakhudza kwambiri magwiridwe antchito osiyanasiyana. Kutentha kwa gelation kwa gel osakaniza a HPMC ndi chimodzi mwazinthu zake zazikulu zakuthupi, zomwe zimakhudza mwachindunji ntchito yake pokonzekera zosiyanasiyana, monga kumasulidwa kolamulidwa, kupanga filimu, kukhazikika, etc.
1. Kapangidwe ndi katundu wa HPMC
HPMC ndi polima osungunuka m'madzi omwe amapezeka poyambitsa zolowa ziwiri, hydroxypropyl ndi methyl, mu cellulose cell skeleton. Kapangidwe kake ka maselo kumakhala ndi mitundu iwiri ya zolowa m'malo: hydroxypropyl (-CH2CHOHCH3) ndi methyl (-CH3). Zinthu monga zamitundu yosiyanasiyana ya hydroxypropyl, digiri ya methylation, ndi digiri ya polymerization zikhudza kwambiri kusungunuka, khalidwe la gelling, ndi makina a HPMC.
Mu njira zamadzimadzi, AnxinCel®HPMC imapanga njira zokhazikika za colloidal popanga zomangira za haidrojeni ndi mamolekyu amadzi ndi kuyanjana ndi mafupa ake opangidwa ndi cellulose. Pamene chilengedwe chakunja (monga kutentha, mphamvu ya ionic, ndi zina zotero) chikusintha, kuyanjana pakati pa mamolekyu a HPMC kudzasintha, zomwe zimapangitsa kuti gelation.
2. Tanthauzo ndi zomwe zimakhudza kutentha kwa gelation
Kutentha kwa Gelation (Gelation Temperature, T_gel) kumatanthauza kutentha komwe njira ya HPMC imayamba kusintha kuchokera kumadzi kupita ku olimba pamene kutentha kwa yankho kumakwera kufika pamlingo wina. Pa kutentha uku, kuyenda kwa HPMC unyolo wa maselo adzakhala oletsedwa, kupanga mawonekedwe atatu azithunzithunzi maukonde, kuchititsa gel osakaniza mankhwala.
Kutentha kwa gelation kwa HPMC kumakhudzidwa ndi zinthu zambiri, chimodzi mwazinthu zofunika kwambiri ndizomwe zili ndi hydroxypropyl. Kuphatikiza pa zomwe zili ndi hydroxypropyl, zinthu zina zomwe zimakhudza kutentha kwa gel osakaniza ndi kulemera kwa maselo, ndende ya yankho, pH mtengo, mtundu wa zosungunulira, mphamvu ya ionic, etc.
3. Zotsatira za hydroxypropyl pa kutentha kwa gel osakaniza a HPMC
3.1 Kuwonjezeka kwa hydroxypropyl kumabweretsa kuwonjezeka kwa kutentha kwa gel
Kutentha kwa gelation kwa HPMC kumagwirizana kwambiri ndi kuchuluka kwa hydroxypropyl m'malo mwa molekyulu yake. Pamene zomwe zili mu hydroxypropyl zikuchulukirachulukira, kuchuluka kwa ma hydrophilic m'malo mwa mamolekyu a HPMC kumawonjezeka, zomwe zimapangitsa kuti pakhale mgwirizano pakati pa molekyulu ndi madzi. Kugwirizana kumeneku kumapangitsa kuti maunyolo a maselo azitha kutambasula kwambiri, motero amachepetsa mphamvu ya mgwirizano pakati pa maunyolo a maselo. M'kati mwazinthu zina, kuwonjezereka kwa hydroxypropyl kumathandiza kupititsa patsogolo kuchuluka kwa hydration ndikulimbikitsa mgwirizano wamagulu a maselo, kotero kuti dongosolo la intaneti likhoza kupangidwa pa kutentha kwakukulu. Chifukwa chake, kutentha kwa gelation nthawi zambiri kumawonjezeka ndi hydroxypropyl ikukwera ndikuwonjezeka.
HPMC yokhala ndi ma hydroxypropyl apamwamba (monga HPMC K15M) imakonda kuwonetsa kutentha kwa gelation pamlingo womwewo kuposa AnxinCel®HPMC yokhala ndi hydroxypropyl yotsika (monga HPMC K4M). Izi ndichifukwa choti kuchuluka kwa ma hydroxypropyl kumapangitsa kuti zikhale zovuta kuti mamolekyu azilumikizana ndikupanga maukonde pazitentha zotsika, zomwe zimafuna kutentha kwambiri kuti zigonjetse hydration ndikulimbikitsa kuyanjana kwapakati kuti apange maukonde amitundu itatu. .
3.2 Ubale pakati pa hydroxypropyl zomwe zili ndi mayankho
Kuyika kwa mayankho ndi chinthu chofunikira chomwe chimakhudza kutentha kwa gelation kwa HPMC. M'mayankho apamwamba a HPMC, kuyanjana kwa intermolecular kumakhala kolimba, kotero kutentha kwa gelation kungakhale kwakukulu ngakhale kuti hydroxypropyl imakhala yochepa. Pazochepa kwambiri, kuyanjana pakati pa mamolekyu a HPMC kumakhala kofooka, ndipo njira yothetsera vutoli imakhala yotentha kwambiri.
Pamene hydroxypropyl okhutira ikuwonjezeka, ngakhale hydrophilicity ukuwonjezeka, kutentha apamwamba akadali chofunika kupanga gel osakaniza. Makamaka pansi pazikhalidwe zochepa, kutentha kwa gelation kumawonjezeka kwambiri. Izi ndichifukwa choti HPMC yokhala ndi ma hydroxypropyl ambiri ndizovuta kwambiri kuyambitsa kuyanjana pakati pa unyolo wa maselo kudzera pakusintha kwa kutentha, ndipo njira ya gelation imafuna mphamvu yowonjezera yowonjezera kuti igonjetse mphamvu ya hydration.
3.3 Zotsatira za hydroxypropyl pakupanga gelation
Mkati mwazinthu zina za hydroxypropyl, njira ya gelation imayendetsedwa ndi kuyanjana pakati pa hydration ndi unyolo wa maselo. Pamene hydroxypropyl zili mu molekyulu HPMC ndi otsika, ndi hydration ndi ofooka, kugwirizana pakati mamolekyu ndi wamphamvu, ndi kutentha m'munsi akhoza kulimbikitsa mapangidwe gel osakaniza. Pamene okhutira hydroxypropyl ndi apamwamba, ndi hydration kwambiri kumatheka, kugwirizana pakati pa maselo unyolo amakhala wofooka, ndi gelation kutentha kumawonjezeka.
Zomwe zili pamwamba pa hydroxypropyl zingapangitsenso kuwonjezeka kwa kukhuthala kwa njira ya HPMC, kusintha komwe nthawi zina kumawonjezera kutentha kwa gelation.
Zomwe zili mu Hydroxypropyl zimakhudza kwambiri kutentha kwa gelationMtengo wa HPMC. Pamene hydroxypropyl okhutira ikuwonjezeka, ndi hydrophilicity wa HPMC kuwonjezeka ndi kugwirizana pakati pa maselo unyolo amafooka, kotero ake gelation kutentha nthawi zambiri kumawonjezeka. Chodabwitsa ichi chitha kufotokozedwa ndi njira yolumikizirana pakati pa hydration ndi unyolo wa maselo. Mwa kusintha zomwe zili mu hydroxypropyl za HPMC, kuwongolera molondola kwa kutentha kwa gelation kumatha kutheka, potero kukulitsa magwiridwe antchito a HPMC muzamankhwala, chakudya ndi ntchito zina zamafakitale.
Nthawi yotumiza: Jan-04-2025