Hydroxypropyl methylcellulose (HPMC) ndi polima yosungunuka m'madzi, yopanda poizoni, yomwe imagwiritsidwa ntchito kwambiri m'mafakitale monga mankhwala, chakudya, zodzoladzola ndi zomangira. Ubale pakati pa kulemera kwake kwa maselo ndi kukhuthala kwake kumakhudza kwambiri ntchito zake zosiyanasiyana.
1. Kusungunuka ndi kupanga mafilimu
Kukhuthala kwa HPMC kumakhudza mwachindunji kusungunuka kwake m'madzi. HPMC ndi mamasukidwe m'munsi akhoza kupasuka m'madzi mofulumira ndi kupanga mandala ndi yunifolomu njira, amene ali oyenera ntchito zimene zimafuna kubalalitsidwa mofulumira, monga zakumwa yomweyo kapena mankhwala yomweyo. HPMC yokhala ndi mamasukidwe apamwamba amafunikira nthawi yayitali yosungunuka, koma imatha kupereka makulidwe abwino ndi mphamvu popanga filimu, kotero ndiyoyenera kuphimba piritsi, filimu yoteteza komanso ngati matrix pokonzekera kumasulidwa kosalekeza.
2. Kukhazikika ndi kumamatira
HPMC yokhala ndi mamasukidwe apamwamba nthawi zambiri imakhala yokhazikika komanso yomatira. Mwachitsanzo, ikagwiritsidwa ntchito ngati chowonjezera cha simenti kapena gypsum pazida zomangira, kukhuthala kwamphamvu kwa HPMC kumatha kupititsa patsogolo kusungirako madzi komanso kukana kwamadzi, kuthandizira kukulitsa nthawi yomanga ndikuchepetsa kusweka. M'makampani opanga mankhwala, HPMC yamphamvu kwambiri imagwiritsidwa ntchito kuwongolera kuchuluka kwa kutulutsa kwamankhwala. Kumamatira kwake kwakukulu kumapangitsa kuti mankhwalawa atulutsidwe pang'onopang'ono m'thupi ndikuwongolera bioavailability ya mankhwalawa.
3. Kuyimitsidwa ndi emulsification
Kusintha mamasukidwe akayendedwe zimakhudzanso kuyimitsidwa ndi emulsification zimatha HPMC. Chifukwa cha unyolo wake wamfupi wa maselo, HPMC yotsika kachulukidwe ndi yoyenera kugwiritsidwa ntchito ngati woyimitsa. Iwo akhoza bwino suspend insoluble zigawo zikuluzikulu mu madzi mankhwala ndi kupewa mpweya. HPMC ndi mamasukidwe akayendedwe mkulu akhoza kupanga amphamvu maukonde dongosolo mu yankho chifukwa yaitali maselo unyolo, choncho amachita bwino mu bata la emulsions ndi suspensions ndi kukhalabe yunifolomu kwa nthawi yaitali.
4. Rheology ndi ntchito katundu
The rheological katundu wa HPMC nawonso mbali yofunika kukhudzidwa ndi mamasukidwe akayendedwe. Mayankho a HPMC otsika mamasukidwe otsika amawonetsa madzi abwinoko, ndi osavuta kupopera ndikuyika, ndipo amagwiritsidwa ntchito popanga zosamalira khungu ndi utoto. Yankho lapamwamba la mamasukidwe amphamvu a HPMC limakhala ngati madzi osakhala a Newtonian ndipo lili ndi mawonekedwe ometa ubweya. Khalidwe limeneli limapangitsa mkulu-makamaka HPMC kupirira pansi mikhalidwe mkulu kukameta ubweya, pamene kusunga mamasukidwe akayendedwe mkulu pansi pa malo malo amodzi, potero kuwongolera filimu kupanga ndi bata la mankhwala.
5. Zitsanzo zogwiritsira ntchito
Pharmaceutical field: Low-viscosity HPMC (monga 50 cps) nthawi zambiri amagwiritsidwa ntchito popaka mapiritsi omwe amatulutsidwa nthawi yomweyo kuti azitha kutulutsa mwachangu mankhwala, pomwe HPMC yowoneka bwino kwambiri (monga 4000 cps) imagwiritsidwa ntchito pamapiritsi omasulidwa kuti asinthe mawonekedwe. kuchuluka kwa mankhwala.
Munda wazakudya: Muzakumwa pompopompo, HPMC yotsika kachulukidwe imatha kusungunuka mwachangu popanda kugwa; mu mankhwala ophikidwa, mkulu-makamaka HPMC akhoza kusintha madzi atagwira mphamvu mtanda ndi kumapangitsanso kukoma ndi moisturizing zimatha katundu wophika.
Munda womanga: Mu ma putty ndi zokutira, HPMC yocheperako imathandizira kumanga ndikuwongolera magwiridwe antchito; pamene mkulu-makamaka HPMC kumawonjezera makulidwe ndi sag kukana ❖ kuyanika.
Kukhuthala kwa HPMC ndi gawo lofunikira lomwe limatsimikizira momwe amagwirira ntchito. Low mamasukidwe akayendedwe HPMC ambiri ntchito kumene Kusungunuka mofulumira ndi flowability chofunika, pamene mkulu mamasukidwe akayendedwe HPMC ndi opindulitsa kwambiri ntchito amafuna mkulu adhesion, wabwino filimu mapangidwe ndi bata. Chifukwa chake, kusankha HPMC yokhala ndi mamasukidwe oyenera ndikofunikira kuti ikwaniritse ntchito zake m'magawo osiyanasiyana.
Nthawi yotumiza: Jul-08-2024