HPMC (hydroxypropyl methylcellulose) ndi zinthu zosungunuka m'madzi zomwe zimagwiritsidwa ntchito pomanga, mankhwala, chakudya ndi mankhwala a tsiku ndi tsiku. Ili ndi makulidwe abwino, emulsification, kupanga filimu, zoteteza colloid ndi zina. Mu kachitidwe emulsion, HPMC akhoza kulamulira mamasukidwe akayendedwe a emulsion m'njira zosiyanasiyana.
1. Mapangidwe a maselo a HPMC
Kukhuthala kwa HPMC kumakhudzidwa makamaka ndi kulemera kwake kwa maselo ndi kuchuluka kwake m'malo. Kulemera kwa maselo, kumapangitsanso kukhuthala kwa yankho; ndi mlingo wa m'malo (ndiko kuti, mlingo wa m'malo hydroxypropyl ndi methoxy magulu) zimakhudza solubility ndi mamasukidwe akayendedwe katundu wa HPMC. Mwachindunji, kuchuluka kwa kulowetsedwa m'malo kumapangitsa kuti madzi asungunuke bwino a HPMC, komanso kukhuthala kumawonjezeka moyenerera. Opanga nthawi zambiri amapereka zinthu za HPMC zokhala ndi masikelo osiyanasiyana a mamolekyu ndi magawo olowa m'malo kuti akwaniritse zosowa zamapulogalamu osiyanasiyana.
2. Gwiritsani ntchito maganizo
Kuchuluka kwa HPMC mu njira yamadzimadzi ndi chimodzi mwazinthu zazikulu zomwe zimakhudza kukhuthala. Nthawi zambiri, kuchuluka kwa HPMC kumapangitsanso kukhuthala kwa yankho. Komabe, mamasukidwe akayendedwe a mitundu yosiyanasiyana ya HPMC pa ndende yomweyo akhoza zosiyanasiyana kwambiri. Chifukwa chake, pazogwiritsa ntchito, ndikofunikira kusankha njira yoyenera ya HPMC malinga ndi zofunikira za viscosity. Mwachitsanzo, muzomangamanga, kuchuluka kwa HPMC nthawi zambiri kumayendetsedwa pakati pa 0.1% ndi 1% kuti apereke mamasukidwe oyenera ogwirira ntchito komanso ntchito yomanga.
3. Njira yothetsera
Kuwonongeka kwa HPMC kumakhudzanso kukhuthala komaliza. HPMC n'zosavuta kumwazikana m'madzi ozizira, koma mlingo kuvunda ndi wodekha; imasungunuka mofulumira m'madzi otentha, koma ndi yosavuta kugwirizanitsa. Pofuna kupewa agglomeration, njira yowonjezera pang'onopang'ono ingagwiritsidwe ntchito, ndiko kuti, choyamba kuwonjezera pang'onopang'ono HPMC kumadzi ozizira kuti mubalalitse, ndiyeno kutentha ndi kusonkhezera mpaka kusungunuka kwathunthu. Kuphatikiza apo, HPMC imathanso kusakanikirana ndi ufa wina wowuma ndikuwonjezeredwa kumadzi kuti isungunuke kuti isungunuke bwino komanso kukhazikika kwamakamaka.
4. Kutentha
Kutentha kumakhudza kwambiri kukhuthala kwa mayankho a HPMC. Ambiri, mamasukidwe akayendedwe a HPMC njira amachepetsa pamene kutentha ukuwonjezeka. Izi ndichifukwa choti kukwera kwa kutentha kumafooketsa mgwirizano wa haidrojeni pakati pa mamolekyu, ndikupangitsa kuti tcheni cha HPMC chizitha kuyenda mosavuta, potero kuchepetsa kukhuthala kwa yankho. Choncho, m'mapulogalamu omwe amafunikira kukhuthala kwakukulu, mayankho a HPMC amagwiritsidwa ntchito pa kutentha kochepa. Mwachitsanzo, muzogwiritsira ntchito mankhwala, njira za HPMC zimagwiritsidwa ntchito nthawi zambiri kutentha kutentha kuti zitsimikizire kukhazikika ndi mphamvu ya mankhwalawa.
5. pH mtengo
Kukhuthala kwa njira ya HPMC kumakhudzidwanso ndi mtengo wa pH. HPMC ali ndi mamasukidwe apamwamba kwambiri pansi ndale ndi ofooka acidic zinthu, pamene mamasukidwe akayendedwe adzachepa kwambiri pansi amphamvu acidic kapena zamchere zinthu. Izi ndichifukwa choti ma pH owopsa amawononga mamolekyu a HPMC ndikufooketsa mphamvu yake yokulirapo. Choncho, muzogwiritsira ntchito, pH mtengo wa yankho uyenera kuyendetsedwa ndikusungidwa mkati mwa HPMC (nthawi zambiri pH 3-11) kuti iwonetsetse kuti ikukula. Mwachitsanzo, muzakudya, HPMC imagwiritsidwa ntchito nthawi zambiri muzakudya za acidic monga yogurt ndi madzi, ndipo kukhuthala koyenera kungapezeke posintha mtengo wa pH.
6. Zina zowonjezera
Mu kachitidwe emulsion, ndi mamasukidwe akayendedwe a HPMC akhoza kusinthidwa ndi kuwonjezera thickeners ena kapena solvents. Mwachitsanzo, kuwonjezera kuchuluka koyenera kwa mchere wachilengedwe (monga sodium kolorayidi) kumatha kuwonjezera kukhuthala kwa njira ya HPMC; pamene kuwonjezera zosungunulira organic monga Mowa akhoza kuchepetsa mamasukidwe akayendedwe ake. Kuonjezera apo, akagwiritsidwa ntchito pamodzi ndi zowonjezera zina (monga xanthan chingamu, carbomer, etc.), kukhuthala ndi kukhazikika kwa emulsion kungathenso kusintha kwambiri. Chifukwa chake, pamapangidwe enieni a chilinganizo, zowonjezera zoyenera zitha kusankhidwa ngati pakufunika kukhathamiritsa mamasukidwe akayendedwe ndi magwiridwe antchito a emulsion.
HPMC akhoza kukwaniritsa kulamulira yeniyeni emulsion mamasukidwe akayendedwe mwa dongosolo maselo, ndende ntchito, njira kuvunda, kutentha, pH mtengo ndi zina. Pakugwiritsa ntchito, zinthuzi ziyenera kuganiziridwa mozama kuti musankhe mtundu woyenera wa HPMC ndi momwe mungagwiritsire ntchito kuti mukwaniritse kukhuthala koyenera. Kupyolera mukupanga ma formula asayansi ndi kuwongolera njira, HPMC imatha kutenga gawo lofunikira pantchito yomanga, zamankhwala, chakudya ndi mankhwala atsiku ndi tsiku, kupereka magwiridwe antchito komanso luso la ogwiritsa ntchito.
Nthawi yotumiza: Jul-17-2024