Hydroxypypyl methylcellulose (hpmc) ndi polymer yosiyanasiyana yomwe imagwiritsidwa ntchito kwambiri popanga mankhwala monga chofunda, pakati pa ntchito zina. Ma Bandurs amatenga mbali yofunika pakupanga mapiritsi a mankhwala opangira mankhwala nthawi ya ufa mkati mwa mitundu yolimba yamitundu yolimba.
1. Makina Omanga:
HPMC imakhala ndi katundu wa hydrophilic ndi hydrophobic chifukwa cha kapangidwe kake, zomwe zimakhala ndi methyl ndi hydroxypyl magulu omwe amaphatikizidwa ndi msana wa cellulose. Pabulosi yopumira, hpmc imapanga filimu yomata, yosinthika pakuwonekera kwa madzi kapena njira zothetsera mchere, potero kumanga zitsulo zopangidwa limodzi. Izi zimapangitsa kuti chilengedwechi chimakhala kuchokera ku hydrogen kulumikizana kwa magulu a hydroxyl ku HPMC, zothandizirana ndi mamolekyulu ena.
2. Tinthu tating'onoting'ono:
Zothandizira za HPMC pakupanga ma oplomerates ndikupanga milatho pakati pa tinthu tating'onoting'ono. Pamene piritsi la magome limapanikizika, mamolekyulu a HPMC amawonjezera ndikusinthana pakati pa tinthu, kulimbikitsa zotsatsa tinthu tating'onoting'ono. Udzuwu umawonjezera mphamvu zamakina ndi umphumphu wa tebulo.
3. Kuwongolera kwa chiwerengero chofananira:
Makutu a HPMC yankho limakhudza kuchuluka kwa piritsi yopanda mankhwala komanso mankhwala osokoneza bongo. Posankha kalasi yoyenera ndi kukhazikika kwa HPMC, clamilators imatha kuwongolera mbiri yazitsulo kuti mukwaniritse mankhwala omwe amasiyidwa. Makonda apamwamba a HPMC nthawi zambiri amakhala ndi mitengo yofananira chifukwa cha kuchuluka kwa gel.
4. Kugawidwa yunifolomu:
Zogulitsa za HPMC mu kugawa yunifolomu yogwira zopanga (APIS) ndi zodziwikiratu pa piritsi la matrix. Kudzera mu ntchito yake yomanga, HPMC imathandizira kupewa tsankho, onetsetsani kuti amagawana ndi kugwiritsa ntchito mankhwala osokoneza bongo.
5. Kugwirizana ndi Zosakaniza:
HPMC imagwiritsa ntchito mosavuta komanso yogwirizana ndi zosakaniza zosiyanasiyana zam'madzi zomwe zimapangidwa, zomwe zimapangitsa kuti zikhale zoyenera kupanga mankhwala osiyanasiyana mankhwala. Sizitengera kapena kunyoza mankhwala ambiri, kusunga kukhazikika kwake ndi kukhazikika kwa alumali m'njira yonse ya magome.
6. Mapangidwe a fumbi:
Pabulosi kukanikiza, HPMC imatha kukhala ngati fumbi, yochepetsera m'badwo wa tinthu tating'onoting'ono. Katunduyu amawonjezera chitetezo chamankhwala ndikusunga malo oyeretsa.
7.
HPMC imawonetsa kuchuluka kwa ph-rodinader odalira, pomwe madzi ake okwera ndi a gel opangidwa ndi gel osakaniza amasiyanasiyana ndi pH. Khalidwe ili limatha kukhala labwino kwambiri pakupanga mitundu yovomerezeka-yotulutsidwa yomwe yapangidwa kuti itulutse mankhwalawa pamasamba enieni.
8. Kuvomerezedwa:
HPMC imavomerezedwa ndi mabungwe owongolera monga chakudya cha US chakudya ndi mankhwala osokoneza bongo (FDA) ndi Mankhwala a ku European Mankhwala a bungwe (EMA) kugwiritsidwa ntchito kwa mankhwala. Linalembedwa mu mankhwala osiyanasiyana phamucacias ndikugwirizana ndi miyezo yolimba kwambiri, ndikuonetsetsa chitetezo chambiri.
9. Kusinthasintha mu mawonekedwe:
HPMC imapereka kusinthasintha, chifukwa kungagwiritsidwe ntchito kokha kapena kuphatikiza ndi ena opanga, mafakitale, ndi kusokonekera kuti akwaniritse ndalama zomwe mukufuna. Kusintha kumeneku kumalola kuti opanga azikhala ndi mawonekedwe okhudzana ndi kukwaniritsa zofunikira zoperekera mankhwala.
10.
HPMC ndi kopanda chitetezo, osati poizoni, komanso osakhala odekha, ndikupanga kukhala koyenera kwa mitundu yamlomo. Zimakhala zotupa kwambiri m'matumbo popanda kuyambitsa kukwiya kapena zovuta, zomwe zimathandizira mbiri ya chitetezo cha mapiritsi a mankhwala.
Hydroxypylropyl imagwira ntchito ngati chomangira mapangidwe opangira mankhwala polimbikitsa tinthu tating'onoting'ono, ndikumawongolera kufala kosatha, ndikuwonetsa kusinthasintha kwa yunifolomu, ndikumatsatira molondola. Malo ake apadera amapangitsa kukhala chofunikira chofunikira pakupanga mapiritsi apamwamba kwambiri chifukwa cha pakamwa.
Post Nthawi: Meyi-25-2024