M'makampani opanga mankhwala, hypromellose (Mtengo wa HPMC, METHOCEL ™) itha kugwiritsidwa ntchito ngati zodzaza, zomangira, zopaka polima zamapiritsi komanso chothandizira chofunikira kuti muchepetse kutulutsidwa kwa mankhwala. Hypromellose yakhala ikugwiritsidwa ntchito m'mapiritsi kwazaka zopitilira 60 ndipo ndi gawo lofunikira lomwe limagwiritsidwa ntchito kwambiri pamapiritsi a hydrophilic gel matrix.
Makampani ambiri opanga mankhwala amagwiritsa ntchito hypromellose potulutsa mankhwala olamulidwa, makamaka pakupanga mapiritsi a hydrophilic gel matrix. Zikafika pazinthu za hypromellose, mutha kukhala mukuganiza momwe mungasankhire - makamaka ngati mukuyang'ana china chake chosavuta komanso chokhazikika kuti mugulitse makasitomala anu. Mu bukhuli, tikambirana zinthu zazikulu zomwe muyenera kudziwa za hypromellose.
Kodi hypromellose ndi chiyani?
Hypromellose, yomwe imadziwikanso kutihydroxypropyl methylcellulose (HPMC), ndi polima wogwiritsidwa ntchito ngati wothandizira mankhwala kuti athetse kutulutsidwa kwa mankhwala kuchokera ku mapiritsi a oral hydrophilic gel matrix.
Hypromellose ndi semi-synthetic material yochokera ku cellulose, polima wochuluka kwambiri m'chilengedwe. Zina mwazodziwika bwino ndi izi:
. sungunuka m'madzi ozizira
. osasungunuka m'madzi otentha
. Nonionic
. Kusankha sungunuka mu organic solvents
. Reversibility, matenthedwe gel osakaniza katundu
. Hydration ndi viscosity popanda pH
. Wokwera pamwamba
. zopanda poizoni
. Kukoma ndi fungo ndizofatsa
. Kukana kwa enzyme
. pH (2-13) kukhazikika kwamitundu
. Itha kugwiritsidwa ntchito ngati thickener, emulsifier, binder, rate regulator, filimu yakale
Kodi Hydrophilic Gel Matrix Tablet ndi chiyani?
Hydrophilic gel matrix piritsi ndi mawonekedwe a mlingo omwe amatha kuwongolera kutulutsidwa kwa mankhwalawa kuchokera papiritsi kwa nthawi yayitali.
Kukonzekera kwa piritsi la Hydrophilic gel matrix:
. zosavuta
. Pamafunika muyezo piritsi psinjika zida
. Pewani kutaya mankhwala
. Osakhudzidwa ndi kuuma kwa piritsi kapena kukakamiza
. Kutulutsidwa kwa mankhwala kumatha kusinthidwa molingana ndi kuchuluka kwa othandizira ndi ma polima
Kugwiritsiridwa ntchito kwa hypromellose pamapiritsi a hydrophilic gel-matrix kwalandira kuvomerezedwa kwakukulu koyang'anira, ndipo hypromellose ndiyosavuta kugwiritsa ntchito ndipo ili ndi mbiri yabwino yachitetezo, yomwe yasonyezedwa ndi maphunziro ambiri. Hypromellose yakhala chisankho chabwino kwambiri kwa makampani opanga mankhwala kupanga ndi kupanga mapiritsi otulutsidwa mosalekeza.
Zomwe Zimakhudza Kutulutsidwa kwa Mankhwala Ochokera ku Matrix Tablets:
Popanga piritsi lotulutsa nthawi yayitali, pali zinthu ziwiri zofunika kuziganizira: kupanga ndi kukonza. Palinso zinthu zing'onozing'ono zomwe ziyenera kuganiziridwa podziwa kupanga ndi kutulutsa mbiri ya mankhwala omaliza.
Fomula:
Mfundo zazikuluzikulu zomwe muyenera kuziganizira pakukula koyambirira:
1. Polima (m'malo mtundu, mamasukidwe akayendedwe, kuchuluka ndi tinthu kukula)
2. Mankhwala (kukula kwa tinthu ndi kusungunuka)
3. Bulking agents (kusungunuka ndi mlingo)
4. Zowonjezera zina (ma stabilizer ndi mabafa)
Luso:
Izi zikugwirizana ndi momwe mankhwalawa amapangidwira:
1. Njira zopangira
2. Kukula kwa piritsi ndi mawonekedwe
3. Mphamvu ya piritsi
4. pH chilengedwe
5. Kuphimba mafilimu
Momwe ma skeleton chips amagwirira ntchito:
Mapiritsi a hydrophilic gel masanjidwewo amatha kuwongolera kutulutsidwa kwa mankhwala kudzera mugawo la gel osakaniza, kuphatikiza njira ziwiri zophatikizira (zosakaniza zosungunuka) ndi kukokoloka (zosakaniza zosasungunuka), kotero kukhuthala kwa polima kumakhudza kwambiri mbiri yotulutsidwa. Pogwiritsa ntchito hypromellose, makampani opanga mankhwala angagwiritse ntchito teknoloji ya piritsi ya hydrophilic gel matrix kuti asinthe mawonekedwe otulutsidwa a mankhwalawa, kupereka mlingo wokwanira komanso kutsata bwino kwa odwala, potero kuchepetsa kulemetsa kwa mankhwala kwa odwala. Njira yogwiritsira ntchito mankhwala kamodzi patsiku ndi yabwino kuposa kumwa mapiritsi angapo kangapo patsiku.
Nthawi yotumiza: Apr-25-2024