Zosangalatsa za mankhwala ndizosangalatsa komanso zoyendera zomwe zimagwiritsidwa ntchito popanga mankhwala ndi mankhwala opangira, ndipo ndi gawo lofunikira pakukonzekera kwa mankhwala. Monga chilengedwe cha polymer yochokera ku ether, cellulose ether ali ndi mawonekedwe a biodegradation, osadandaula, komanso mtengo wotsika, monga cellulose, hydroxypropyl cellouse,Cellulose earsMonga hydroxethyl cellulose ndi ethyl cellulose imakhala ndi phindu lofunikira muzomwe zimapatsa mankhwala. Pakadali pano, zopangidwa ndi ma etherpulic ethermic ma cellulose zimagwiritsidwa ntchito makamaka m'minda yapakati ndi yotsika kwambiri ya mafakitale, ndipo mtengo wowonjezereka siwokwezeka. Makampaniwa amafunikira kusintha ndikukweza ndikusintha mapulogalamu omaliza a zinthu.
Zofunikira za mankhwala opangira zimatenga gawo lofunikira pakupanga ndi kupanga. Mwachitsanzo, kukhazikitsidwa-kutukwana, zida zomasulira monga cellulose zimagwiritsidwa ntchito ngati mankhwala osokoneza bongo omasulidwa, mafilimu okhazikika, omasulidwa, amasulidwa - mankhwala osokoneza bongo. Kukonzekera ndi kukonzekera kwamadzi kokhazikika kwagwiritsidwa ntchito kwambiri. M'dongosolo lino, ma polima monga cellulose amagwiritsidwa ntchito ngati onyamula mankhwala osokoneza bongo m'thupi la munthu, ndiye kuti, amafunikira kuti atulutsidwe pang'onopang'ono mthupi mwa nthawi ina kuti akwaniritse cholinga cha chithandizo chothandiza.
Malinga ndi ziwerengero za kufunsana ndi Dipatimenti Yofufuzira, pali mitundu pafupifupi 500 yamisika m'dziko langa, koma poyerekeza ndi maboma oposa 3000), mitundu yoposa 3000 idali yaying'ono. Dziko langa lopanga zophatikizira zomwe zingakhale bwino pamsika ndi waukulu. Zimamveka kuti zotengera khumi zapamwamba mu msika wa dziko langa ndi makapisozi a gelatin, wokutira, ma pvmc, hydroxyplulose (hpmc), ndi ulusi wa Microcrystalline. Zasamba, hpc, lactose.
"Etherus wa cellulose ndi mawu ambiri opanga ma cellulose omwe amapangidwa ndi ma celluluse omwe ali ndi magulu a macroleum, zopangira, chakudya, mankhwala tsiku lililonse. M'magawo onse, malo ogulitsa ma garmaceutical amakhala m'malo okwanira komanso apamwamba kwambiri. Chifukwa cha kuchuluka kwa ma celluucial-celly Thickener kuti apangitse mapiritsi okhala ndi matrix, malo osungunuka osungunuka, osungunuka, amasulidwa, amasulidwa, zomwe zimasulidwa, zida zopangidwa ndi mankhwala osokoneza bongo, etc.
Sodium Carboxymethmethmethmethmethyl cellulose (cmc-na) ndi ethel ether ether ndi zotupa zazikulu kwambiri komanso zakumwa zakunyumba ndi kunja. Ndi cellulose ya ionic ether yopangidwa ndi thonje ndi nkhuni kudzera mu alkirization ndi kumasuka ndi chlorooceic asidi. CMC-na ndi yogwiritsidwa ntchito kawirikawiri. Nthawi zambiri imagwiritsidwa ntchito ngati chomangira kukonzekera molimba komanso ngati kukulira, kukulira ndi kuyimitsa wothandizira ku kukonzekera kwamadzi. Itha kugwiritsidwanso ntchito ngati malo osungunuka matrix ndi mafilimu. Nthawi zambiri imagwiritsidwa ntchito ngati chinthu chodziletsa komanso chokhazikika pa piritsi la matrix kukhazikika (kulamulidwa) kumasulidwa.
Kuphatikiza pa sodium carboxymethyl cellose cellulose monga sodium, croscarmarmemeose imatha kugwiritsidwanso ntchito ngati zothandizira mankhwala. Carboxymethylyl cellulose sodium (ccmc-n Womenzera wokhotakhota akhoza kukhala Pronsol Glycol, SucCinic Testic, Mwamuna Wauldride, Alupiki Anhydride, ndi zina. Solcarmembalase Sodium imagwiritsidwa ntchito ngati chosowa mapiritsi, makapisozi ndi ma granules pokonzekera pakamwa. Imadalira pa capillary ndi kutupa kuti athe kusokonezedwa. Ili ndi kusiyana pakati pakokha komanso kusokonekera kwamphamvu. Kafukufuku wasonyeza kuti kutupira kwa croscarmemelase m'madzi ndizambiri kuposa kuperewera kwa ma carboxyl carboxyl ndi ma cellstalline cellose.
Methyl cellulose (MC) ndi cellulose yopanda ionic monoether yopangidwa ndi thonje ndi nkhuni kudzera pa alkalization ndi methyl chloride. Methyl cellulose imakhala ndi madzi abwino kwambiri osungunuka ndipo imakhazikika mu pH ya 2,0 mpaka 13.0. Amagwiritsidwa ntchito kwambiri m'magulu ogulitsa mankhwala, ndipo amagwiritsidwa ntchito mapiritsi apanyumba, kukonzekera kwa mafirusmic, makapisozi apakamwa, mapiritsi a pakamwa ndi kukonzekera pakamwa ndi kukonzekera pakamwa ndi kukonzekera pakamwa. Kuphatikiza apo, mumasulidwa-kumasulidwa, MC imatha kugwiritsidwa ntchito ngati mawonekedwe a hydrophilic matrix.
Hydroxypropyll methylcellulose (hpmc) ndi ma cellulose osakanikirana opangidwa ndi thonje ndi nkhuni kudzera mu ma prown oxide ndi methyl chleride. Ndiwopanda fungo, wopanda pake, wopanda poizoni, sungunuka m'madzi ozizira, ndi ma gels m'madzi otentha. Hydroxypropyl nothcellulose ndi ma cellulose osakanizika mitundu yomwe ikuwonjezeka mofulumira pakupanga, kudya ndi mtundu pazaka 15 zapitazi. Ilinso ndi imodzi mwazinthu zazikulu kwambiri zomwe zimagwiritsidwa ntchito kunyumba ndi kunja. Yakhala ikugwiritsidwa ntchito ngati mankhwala osokoneza bongo pafupifupi zaka 50. Zaka zingapo. Pakadali pano, kugwiritsa ntchito HPMC kumawonetsedwa makamaka muzinthu zisanu zotsatirazi:
Limodzi ndi lonyowa komanso wopanda pake. HPMC Monga Chingwe chingapangitse mankhwalawa kukhala osavuta kunyowa, ndipo imatha kukulitsa nthawi mazana angapo atatha kuyamwa madzi, kotero amatha kusintha chisungunuka kapena kumasula piritsi. HPMC ili ndi mafayilo olimba, ndipo imatha kukulitsa chidwi cha tinthu tambiri ndikusintha zosokoneza zomwe zili ndi zida zomera kapena zolimba. HPMC yokhala ndi mafayilo otsika imatha kugwiritsidwa ntchito ngati binder ndi kuwonongeka kwa hpmc, ndipo hpmc yokhala ndi mafayilo apamwamba imatha kugwiritsidwa ntchito ngati binder.
Kachiwiri, imagwiritsidwa ntchito ngati zinthu zomasulidwa komanso zowongolera pazokonzekera pakamwa. HPMC ndi nkhani yogwiritsidwa ntchito pokonzekera matrix pakukonzekera kokhazikika. HPMC ya kalasi yotsika yotsika (5 ~ 50mmsa ~ itha kugwiritsidwa ntchito ngati mapiritsi a mapiri a mapiri a mapiri a mapiri a mapiri osakhazikika. HPMC imasungunuka m'mimba, ili ndi mwayi wosiyana ndi zinthu zabwino, madzi abwino opangira mphamvu ndi mankhwala omasulira omwe sanakhudzidwe ndi Ph. Ndi nkhani yofunika kwambiri ya hydrophilic kwambiri mu njira zopangira magetsi ndipo nthawi zambiri imagwiritsidwa ntchito ngati matchesi a matrix ndi kuyamwa kwa matlekitiro omasulira, ndikugwiritsa ntchito kukonzekera kwam'mimba ndikukonzanso mankhwala a membrane othandiza.
Wachitatu ali ngati wothandizira makanema.Hpmcali ndi mawonekedwe abwino opanga mafilimu. Kanema wopangidwa ndi iwo ndi yunifolomu, wowonekera, komanso wolimba, ndipo sizophweka kutsatira pakupanga. Makamaka mankhwala omwe ndi osavuta kuyamwa ndi osakhazikika, pogwiritsa ntchito ngati mawonekedwe osungunuka amatha kusintha kwambiri kukhazikika kwa mankhwalawa ndikuletsa filimuyo imasintha mtundu. HPMC ili ndi mafayilo osiyanasiyana. Ngati mwasankhidwa moyenera, mawonekedwe ndi mawonekedwe a mapiritsi okutidwa ndi abwino kuposa zinthu zina, ndipo ndende yake yodziwika ndi 2% mpaka 10%.
Mayi wina amagwiritsidwa ntchito ngati zinthu za kapisozi. M'zaka zaposachedwa, kufalikira pafupipafupi kwa zilonda za nyama zapadziko lonse, poyerekeza ndi makapisozi a gelatin, makapisozi azomera asandulika Darling watsopano wa mafakitale a mankhwala ndi chakudya. Pfizer wakwanitsa kuthana ndi HPMC kuchokera ku mbewu zachilengedwe ndikukonzekera masamba a VCAPMM. Poyerekeza ndi zipilala za Gelatin Holow, makapisozi amaputa zamasamba ali ndi maubwino osinthika, osakhala pachiwopsezo cholumikizirana, komanso kukhazikika kwambiri. Mlingo wopangidwa ndi mankhwalawo ndi wokhazikika, ndipo kusiyana kwako ndikochepa. Pambuyo kusokonekera m'thupi la munthu, sichimayamwa ndipo chimatha kuchonderela. Kuchotsedwa m'thupi. Pankhani yosungirako zinthu zosungirako, pambuyo pamayeso ambiri, sizikhala zopanda chinyezi pansi pa chinyezi chotsika, ndipo katundu wa kapisozi amakhala wokhazikika pansi pa chinyezi chambiri, ndipo zotsatsira zosiyanasiyana za kapisozi zomera sizikhudzidwa. Ndi kumvetsetsa kwa anthu kwa makapisozi ndi kusintha kwa malingaliro a anthu kunyumba ndi kunja, kufunikira kwa msika kumera makapisozi kumakula mwachangu.
Wachisanu ali ngati womangirira. Kukonzekera kwamadzimadzi kukonzekera kwa mankhwala omwe nthawi zambiri amagwiritsidwa ntchito ndi makonda omwe amasungunuka komwe sikusungunuka komwe sikunathere mankhwala obalalitsidwa. Kukhazikika kwa dongosololi kumatsimikizira mtundu wa kuyimitsidwa kwamadzi. HPMC Colloidal yankho la HPMC imatha kuchepetsa mavuto okhazikika, kuchepetsa mphamvu yaulere ya tinthu tokha, ndikukhazikitsa chizolowezi chobalalitsa. Ndi woyimba bwino. HPMC imagwiritsidwa ntchito ngati thickener ya madontho amaso, yokhala ndi 0,45% mpaka 1.0%.
Hydroxypropyl cellulose (hpc) ndi cellulose yopanda ionic monoether yopangidwa ndi thonje ndi nkhuni kudzera mu alkalization ndi ma proplene oxide. HPC nthawi zambiri imasungunuka m'madzi pansi pa 40 ° C ndi kuchuluka kwa polant, ndipo ntchito yake imakhudzana ndi zomwe zili hydroxypyl ndi kuchuluka kwa polymerization. HPC ikhoza kukhala yogwirizana ndi mankhwala osiyanasiyana ndipo imakhala ndi mawonekedwe abwino.
Makina otsika otsika a hydroxpyl cellulose(L-hpc)imagwiritsidwa ntchito ngati piritsi yopanga ndi binder. Makhalidwe ake ndi awa: zosavuta kukanikiza, kugwiritsa ntchito mwamphamvu, makamaka mapiritsi a piritsi komanso kunyezimira kwa piritsi, ndikusintha njira.
Mkulu woyang'anira hydroxypropyl cellulose (H-HPC) itha kugwiritsidwa ntchito ngati wothandizira mapiritsi, ma granules ndi granules abwino mu gawo la pharmaceutical. H-HPC ili ndi katundu wabwino kwambiri wamakanema, ndipo kanemayo ndi wolimba komanso wotanuka, womwe ungafanane ndi mafayilo. Mwa kusakanikirana ndi othandizira ena oletsa, mafilimuwo amatha kukhalanso patsogolo, ndipo nthawi zambiri amagwiritsidwa ntchito ngati zokutira kanema mapiritsi. H-HPC imatha kugwiritsidwanso ntchito ngati chidziwitso cha matrix kuti akonzekere mapiritsi osuta matrix, ma pellets osuta fodya ndi mapiritsi osungulumwa kawiri.
Hydroxyethyl cellulose (hec) ndi cellulose yopanda ionic monoether yopangidwa ndi thonje ndi nkhuni kudzera mu alkalization ndi ethylee oxide. Hec imagwiritsidwa ntchito ngati thicker, othandizira othandizira colloidal, okonda okondana, obalira, kuyimitsa wothandizira, omwe amamuimitsa pang'onopang'ono ndikumasulidwa pang'onopang'ono pamankhwala. Itha kugwiritsidwa ntchito kwa emulsions, mafuta, ndi madontho amaso a mankhwala apadera. Madzi apakamwa, mapiritsi olimba, makapisozi ndi mitundu ina ya mankhwala. Hydroxyathyl cellulose yaphatikizidwa mu US PRIVCOMEAMIA / US National Challalale ndi Europe la Meyi ku Europecacopoeia.
Ethyl cellulose (EC) ndi imodzi mwazomwe zimagwiritsidwa ntchito kwambiri pa cellulose. EC ndi yopanda mphamvu, yokhazikika, yokhazikika m'madzi, acid kapena njira za alkalinine, ndikusungunuka m'malo okhazikika monga Ethanol ndi methanol. Zosungunulira zogwiritsidwa ntchito kwambiri ndi zosungunulira zosakanikirana za Tonuene / Ethanol 4/1 (kulemera). EC yagwiritsa ntchito ambiri pakukonzekera kokhazikika, ndipo imagwiritsidwa ntchito kwambiri ngati chonyamula ndi microcapsules, zopanga mafilimu, zomata, zophatikizika, zimagwiritsidwa ntchito ngati zinthu zosungidwa bwino komanso Ma pellets omasulidwa, monga osinthika othandizira othandizira kuti akonzekere mic nyama yotulutsidwa; Itha kugwiritsidwanso ntchito ngati zinthu zonyamula zomwe zimagwiritsidwa ntchito kukonza mabala okhazikika; Itha kugwiritsidwa ntchito kwambiri mwaukadaulo wazopanga zopangira mankhwala ngati chinthu chopanga mafilimu komanso zokutira zoteteza, ndipo zitha kugwiritsidwanso ntchito ngati binder ndi filler. Monga zotetezera mapiritsi, zimachepetsa chidwi cha mapiritsiwo kuti muchepetse mankhwalawa kuti asapumidwe komanso kufesedwa ndi chinyontho; Itha kupanganso guluu wosungunuka pang'onopang'ono ndi ma microencapsterate polymer kuti amasule mankhwalawa.
Mwachidule, sodium-soduble sodium carboxymethylyl cellulose, methyl cellulose, hydroxypropyl cellose, ma hydroxyprose cellulose, Zosokoneza, zida zowongolera komanso zowongolera komanso zowongolera zokonzekera pakamwa, zokutira makanema opanga mafilimu, zida za kapisozi ndi kuyimitsa masitolo. Kuyang'ana dziko lapansi, makampani angapo akunja akunja (Shin-Emfa Japan, Dow Wolsu Japan, TUSNORT) Ndalama mkati mwa ntchito. Dow Wolff adalengeza kuti ziwonjezera chidwi chake pakupanga, zosakaniza ndi zosowa za msika waku China zam'madzi, ndipo kafukufuku wake amayesetsanso kuyandikira pafupi ndi msika. Cellulose Cellose Division of Mankhwala Mankhwala a United States adakhazikitsa kutulutsa kokhazikika padziko lonse lapansi. Ili ndi antchito oposa 1,200 m'mizinda 9, mabungwe 15 ndi 6 gmp. Akatswiri ofufuza amagwiritsa ntchito makasitomala m'maiko pafupifupi 160. Ashland ali ndi zokulirapo zopanga ku Beijing, Shanghai, nanzeng, angzhou, angshan ndi Jiangmen, ndipo wapereka malo ophunzitsira a ukadaulo mu Shanghai ndi nanjing.
Malinga ndi ziwerengero kuchokera patsamba la ku China cellulose mayanjano. Mu 2017, kuchuluka kwenikweni kwa IonicCmcanali matani 234,000, kuwonjezeka kwa chaka cha 18.61%, komanso kuchuluka kwa matani 126,000, kuwonjezeka kwa 8.2% chaka ndi chaka. Kuphatikiza pa HPMC (yomanga malo) Zogulitsa zopanda Ionic,Hpmc. Cellulose yapanyumba manja akhala akukula mwachangu kwa zaka zopitilira khumi, ndipo zotulukapo zakhala koyamba padziko lapansi. Komabe, ambiri mwa malonda a cellulose amagwiritsidwa ntchito makamaka kumapeto kwa mafakitale, ndipo phindu lowonjezeredwa silokwezeka.
Pakadali pano, ambiri am'madzi am'mphepete mwa ma celluse ali nthawi yovuta yosintha ndikukweza. Ayenera kupitiriza kuwonjezera kafukufuku wofufuza za mankhwala ndi chitukuko, kusinthasintha kwa China, msika waukulu kwambiri padziko lonse lapansi, ndikuwonjezera kuyesetsa kukulitsa misika yakunja kotero kuti mabizinesi akuwonjezereka posachedwa. Malizitsani kusintha ndikukweza, lowani kumapeto kwa mafakitale, ndipo mukwaniritse zaphokoso komanso zobiriwira.
Post Nthawi: Apr-25-2024