(1) Chiyambi cha HPMC
Hydroxypropyl Methylcellulose (HPMC) ndi yofunika ya nonionic cellulose ether yomwe imagwiritsidwa ntchito kwambiri mu zotsukira, zomangira, chakudya, mankhwala ndi zina. Mu chotsukira zovala, HPMC imagwiritsidwa ntchito ngati chokhuthala kuti ipereke kukhazikika kwa kuyimitsidwa ndi kusungunuka, kukulitsa kumamatira ndi kutsuka kwa chotsukira zovala. Komabe, kuti mukwaniritse kukhuthala koyenera kwa HPMC mu chotsukira zovala, zinthu zingapo ziyenera kuganiziridwa, kuphatikiza mtundu, mlingo, zikhalidwe za kusungunuka, kutsatizana kowonjezera, ndi zina zambiri za HPMC.
(2) Zinthu zomwe zimakhudza kukhuthala kwa HPMC
1. Mitundu ndi zitsanzo za HPMC
Kulemera kwa maselo ndi digiri ya m'malo (methoxy ndi hydroxypropyl substitution) ya HPMC imakhudza mwachindunji kukhuthala kwake ndi kusungunuka kwake. Mitundu yosiyanasiyana ya HPMC ili ndi ma viscosity osiyanasiyana. Kusankha mtundu wa HPMC womwe umagwirizana ndi zomwe mukufuna kupanga zotsukira zovala ndizofunikira. Nthawi zambiri, HPMCs yolemera kwambiri ya ma molekyulu imapereka ma viscosity apamwamba, pomwe ma HPMC otsika kwambiri amathandizira ma viscosity otsika.
2. Mlingo wa HPMC
Kuchuluka kwa HPMC kumakhudza kwambiri kukhuthala. Nthawi zambiri, HPMC imawonjezeredwa pakati pa 0.5% ndi 2% mu zotsukira zovala. Mlingo womwe uli wochepa kwambiri sudzakwaniritsa zofuna za thickening, pamene mlingo womwe uli wochuluka kwambiri ukhoza kubweretsa mavuto monga kuvutika kwa kusungunuka ndi kusakaniza kosagwirizana. Choncho, mlingo wa HPMC uyenera kusinthidwa malinga ndi zosowa zapadera ndi zotsatira zoyesera kuti akwaniritse kukhuthala koyenera.
3. Kuwonongeka kwa zinthu
Kusungunuka kwa HPMC (kutentha, pH mtengo, kuthamanga kwamphamvu, ndi zina zotero) kumakhudza kwambiri kukhuthala kwake:
Kutentha: HPMC imasungunuka pang'onopang'ono pa kutentha kochepa koma imatha kupereka ma viscosities apamwamba. Amasungunuka mofulumira pa kutentha kwakukulu koma ali ndi kukhuthala kochepa. Ndibwino kuti musungunule HPMC pakati pa 20-40 ° C kuti mutsimikizire kukhazikika kwake ndi kukhuthala kwake.
pH: HPMC imagwira bwino ntchito muzandale. Makhalidwe apamwamba a pH (okhala acidic kwambiri kapena amchere kwambiri) amatha kuwononga kapangidwe ka HPMC ndikuchepetsa kukhuthala kwake. Chifukwa chake, kuwongolera mtengo wa pH wa makina ochapira zovala pakati pa 6-8 kumathandizira kukhazikika komanso kukhuthala kwa HPMC.
Kuthamanga kothamanga: Kuthamanga koyenera kungathe kulimbikitsa kusungunuka kwa HPMC, koma kugwedezeka kwakukulu kungayambitse thovu ndikukhudza kufanana kwa yankho. Nthawi zambiri tikulimbikitsidwa kugwiritsa ntchito kuthamanga pang'onopang'ono komanso ngakhale kusuntha kuti musungunule HPMC.
4. Onjezani dongosolo
HPMC imapanga ma agglomerates mosavuta mu njira, zomwe zimakhudza kuwonongeka kwake ndi kukhuthala kwake. Chifukwa chake, dongosolo lomwe HPMC liwonjezedwa ndilofunika:
Kusakaniza koyambirira: Sakanizani HPMC ndi ufa wina wowuma mofanana ndikuwonjezera pang'onopang'ono m'madzi, zomwe zingalepheretse kupangika kwa clumps ndikuthandizira kusungunuka mofanana.
Moisturizing: Musanawonjezere HPMC ku chotsukira chochapa zovala, mutha kunyowetsa kaye ndi madzi ozizira pang'ono, ndikuwonjezera madzi otentha kuti musungunuke. Izi zitha kusintha kuwonongeka kwachangu komanso kukhuthala kwa HPMC.
(3) Njira zowonjezeretsa kukhuthala kwa HPMC
1. Mapangidwe a chilinganizo
Sankhani mtundu woyenera wa HPMC ndi mlingo kutengera kugwiritsa ntchito komaliza ndi zofunikira za chotsukira zovala. Zotsukira zochapa zotsuka bwino kwambiri zingafunike kukhuthala kwamphamvu kwa HPMC, pomwe zinthu zotsuka zitha kusankha HPMC yapakatikati mpaka yotsika.
2. Kuyesa kuyesa
Chitani mayeso ang'onoang'ono mu labotale kuti muwone momwe zimakhudzira kukhuthala kwa chotsukira zovala posintha mlingo, zikhalidwe zakutha, dongosolo lowonjezera, ndi zina zambiri za HPMC. Lembani magawo ndi zotsatira za kuyesa kulikonse kuti mudziwe kuphatikiza kwabwino.
3. Kusintha kwa ndondomeko
Ikani maphikidwe abwino kwambiri a labotale ndi momwe mungapangire zinthu pamzere wopangira ndikusintha kuti apange zazikulu. Onetsetsani kugawa yunifolomu ndi kutha kwa HPMC panthawi yopangira kuti mupewe mavuto monga ma clumps ndi kuwonongeka koyipa.
4. Kuwongolera khalidwe
Kupyolera mu njira zoyesera zabwino, monga kuyeza kwa viscometer, kusanthula kukula kwa tinthu, ndi zina zotero, magwiridwe antchito a HPMC mu chotsukira zovala amawunikidwa kuti awonetsetse kuti akukwaniritsa kukhuthala komwe kumayembekezeredwa ndikugwiritsa ntchito. Chitani kuyendera kwaubwino wanthawi zonse ndikusintha mwachangu njira ndi ma formula ngati mavuto apezeka.
(4) Mafunso ndi mayankho omwe amafunsidwa kawirikawiri
1. Kuwonongeka koyipa kwa HPMC
Zifukwa: Kutentha kosayenera kwa kusungunuka, kuthamanga kwambiri kapena pang'onopang'ono, kuthamanga kosayenera, ndi zina zotero.
Yankho: Sinthani kutentha kwa kutentha kufika 20-40 ° C, gwiritsani ntchito pang'onopang'ono komanso mofulumizitsa liwiro, ndikuwonjezera kutsatizana kowonjezera.
2. HPMC mamasukidwe akayendedwe si kwa muyezo
Zifukwa: Mtundu wa HPMC ndi wosayenera, mlingo wake ndi wosakwanira, mtengo wa pH ndiwokwera kwambiri kapena wotsika kwambiri, etc.
Yankho: Sankhani mtundu woyenera wa HPMC ndi mlingo, ndikuwongolera mtengo wa pH wa makina ochapira zovala pakati pa 6-8.
3. HPMC clump mapangidwe
Chifukwa: HPMC adawonjezedwa mwachindunji mu yankho, zosayenera Kusungunuka zinthu, etc.
Yankho: Gwiritsani ntchito njira yosakaniza isanayambe, choyamba sakanizani HPMC ndi ufa wina wouma, ndikuwonjezera pang'onopang'ono m'madzi kuti musungunuke.
Kuti mukwaniritse kukhuthala koyenera kwa HPMC mu zotsukira zovala, zinthu monga mtundu, mulingo, mikhalidwe ya kusungunuka, ndi dongosolo la kuwonjezera kwa HPMC ziyenera kuganiziridwa mozama. Kupyolera mu kapangidwe ka fomula yasayansi, kuyezetsa koyeserera ndikusintha njira, magwiridwe antchito a viscosity a HPMC amatha kukhathamiritsa bwino, potero kuwongolera magwiridwe antchito komanso kupikisana pamsika kwa zotsukira zovala.
Nthawi yotumiza: Jul-08-2024