HPMC (hydroxypypyl methylcellulose) ndi yotsitsimutsa ndipo kusungunuka nthawi zambiri amagwiritsidwa ntchito pomanga, zokutira, mankhwala opangira mankhwala ndi zakudya. HPMC 15 CPS imatanthawuza kuti ma viscction ndi 15 muyeso, womwe ndi kalasi yotsika.
1. Kuchulukitsa HPMC ndende
Njira yotsogola komanso yothandiza kwambiri kuti iwonjezere mawonekedwe a HPMC ndikuwonjezera ndende yake. Mlingo wambiri wa HPMC umawonjezeka, mafayilo a yankho adzachulukanso. Pakati pa njirayi ndikuti hpmc imawonjezera mafayilo a yankho popanga ma netiweki atatu. Pamene chiwerengero cha mamolekyulu a HPMC pakuthetsera chiwonjezere, kachulukidwe ndi mphamvu za ma network zikuwonjezekanso, potero, onjezani mafayilo. Komabe, pali malire pokulitsa kuchuluka kwa ndende. Kuchuluka kwambiri kwa HPMC kumapangitsa kuti madzi a muthetsedwe, ndipo amathanso kukhudza magwiridwe ake mu magwiridwe antchito, monga kugwiritsidwa ntchito ndi kubitana.
2. Sinthani kutentha kwa yankho
Kutentha kumakhala ndi mphamvu kwambiri pa solubility ndi mafayilo a HPMC. Pamadzi ochepa, mafano a HPMC yankho ndi kupitilira; Mukamatentha kwambiri, mafayilo a HPMC yankho limachepa. Chifukwa chake, kuchepetsa kutentha kwa yankho moyenera mukamagwiritsidwa ntchito kumatha kuwonjezera mafayilo a HPMC. Tiyenera kudziwa kuti kusungunuka kwa HPMC mu njirayi ndi kosiyana ndi kutentha kosiyanasiyana. Nthawi zambiri zimakhala zosavuta kufalikira m'madzi ozizira, koma zimatenga nthawi yayitali kuti isungunuke kwathunthu. Imasungunuka mwachangu m'madzi ofunda, koma mamasukidwe amakhala otsika.
3. Sinthani mtengo wa pH ya zosungunulira
Makulidwe a HPMC amakhudzidwanso ndi mtengo wa pH ya yankho. Pansi pa kusalowerera ndale kapena kulowerera kwa HPMC yankho la HPMC ndiye yapamwamba kwambiri. Ngati mtengo wa yankho lazolowera kusiya kusalowerera ndale, ma virus amachepetsa. Chifukwa chake, mawidwe a njira ya HPMC ikhoza kuchuluka ndikusintha bwino kabwino ka yankho (mwachitsanzo, powonjezera buffer kapena a asidi a asidi). Komabe, pakuchita zenizeni, kusintha kwa mtengo wamtengo wapatali kuyenera kukhala kosamala kwambiri, chifukwa kusintha kwakukulu kumatha kuyambitsa kuchepa kwa HPMC kapena kuwonongeka kwa magwiridwe antchito.
4. Sankhani zosungunulira zoyenera
Kusungunuka ndi mawonekedwe a HPMC m'machitidwe osiyanasiyana osungunuka ndi osiyana. Ngakhale HPMC imagwiritsidwa ntchito makamaka pamankhwala am'madzi, kuphatikiza kwa ena okhazikika (monga Ethanol, isopropanol, etc.) kapena mchere wosiyanasiyana umatha kusintha magwiridwe antchito. Mwachitsanzo, zochepa zosungunulira zimatha kuchepetsa ma molekyulu amadzi pa HPMC, potero kuwonjezereka mafayilo a yankho. Mwa ntchito zenizeni, ndikofunikira kusankha malo oyenera okhazikika malinga ndi pulogalamuyo.
5. Gwiritsani ntchito Eduning Edzi
Nthawi zina, zotsatsa zina zokula zimatha kuwonjezeredwa ku hpmc kuti mukwaniritse mphamvu zakuwonjezereka. Zowonjezera zotukuka zimaphatikizapo chingamu, Guar chingamu, carbomer, etc. Mwachitsanzo, Xanthan chingamu ndi polysaride wachilengedwe wokhala ndi mphamvu yolimba. Mukamagwiritsa ntchito ndi hpmc, awiriwo amatha kupanga synergist moderger komanso kuwonjezera mamasukidwe a dongosololi.
6. Sinthani kuchuluka kwa zomwe zili mu HPMC
Makulidwe a HPMC amakhudzananso ndi digiri ya kulowetsedwa kwa methoxy ndi hydroxyprophongo m'magulu. Mulingo wazolowa zomwe zimakhudza kusungunuka kwake ndikuwoneka bwino kwa yankho. Posankha HPMC yokhala ndi madigiri osiyanasiyana, mafayilo a yankho amatha kusintha. Ngati ma viscc okwera hpmc amafunikira, chinthu chomwe chili ndi methoxy chokwera cha methoxy chitha kusankhidwa, chifukwa chambiri cha methoxy, cholimba cha hydrophobicity ya HPMC, ndikuwoneka bwino pambuyo pake.
7. Tsatirani nthawi yopuma
Nthawi yomwe maforo a HPMC imathandiziranso kusokoneza ma viscty. Ngati HPMC siikusungunuka kwathunthu, mafayilo a yankho sakufika patsogolo. Chifukwa chake, kukonza nthawi yofatsa ya HPMC m'madzi kuti muwonetsetse kuti HPMC yatha chifukwa dzalani moyenera yankho la yankho lake. Makamaka posungunuka pamatenthedwe otsika, kusintha kwa HPMC kungakhale kochezeka, ndipo nthawi yake ndi yofunikira.
8.. Sinthani zigawo
Makulidwe a HPMC amakhudzananso ndi gulu lankhondo lomwe limachitidwa. Pansi pa zingwe zazitali, kukweza kwa HPMC kutsika kwakanthawi, koma pamene ma shear aima, ma virus adzachira. Kwa njira zomwe zimafunikira kuwonjezereka, gulu lankhondo lomwe yankho limayankhidwa limatha kuchepetsedwa, kapena limatha kugwira ntchito pansi pa malo owoneka bwino kuti mukhale ndi mamasukidwe apamwamba.
9. Sankhani kulemera koyenera
Kulemera kwa HPMC kumakhudza mwachindunji. HPMC yokhala ndi kulemera kokulirapo kumapangitsa kuti pakhale malo ochulukirapo pa intaneti, zomwe zimapangitsa kuti mafakizedwe apamwamba. Ngati mukufuna kuwonjezera mafayilo a HPMC, mutha kusankha zinthu za HPMC ndi kulemera kwakukulu. Ngakhale HPMC 15 CPS ndi chinthu chotsika kwambiri, mafayilo amatha kuchuluka posankha kusiyanasiyana kwa thupi kwambiri.
10. Ganizirani zinthu zachilengedwe
Zinthu zachilengedwe monga chinyezi komanso kukakamizidwa kumathandizanso pakukweza kwa HPMC. Mu chinyezi chambiri, hpmc chimatha kuyamwa chinyezi kuchokera mlengalenga, ndikupangitsa kuti ma vionelo ake akuchepa. Kuti mupewe izi, zochitika zachilengedwe zopangidwa kapena malo zitha kulamulidwa bwino kuti chilengedwe chizikhala chouma komanso kukhalabe oyenera kusunga mamasukidwe a HPMC.
Pali njira zambiri zowonjezera mawonekedwe a HPMC 15 CPS, kuphatikizapo kuchuluka kwa masinthidwe, kusintha kwa ph, njira yochepetsera, etc. Zochitika ndi Zofunikira. Mukuchita opareshoni zenizeni, nthawi zambiri zimakhala zofunikira kuganizira zinthu zingapo ndikusinthasintha ndi makonzedwe osintha kuti muwonetsetse bwino magwiridwe antchito a HPMC pakugwiritsa ntchito.
Post Nthawi: Oct-16-2024