Ubwino wahydroxypropyl methylcellulose (HPMC)ikhoza kuyesedwa pogwiritsa ntchito zizindikiro zingapo. HPMC ndi chochokera ku cellulose chomwe chimagwiritsidwa ntchito kwambiri pomanga, mankhwala, chakudya ndi zodzoladzola mafakitale, ndipo khalidwe lake limakhudza mwachindunji ntchito ya mankhwala.
1. Maonekedwe ndi kukula kwa tinthu
Maonekedwe a HPMC ayenera kukhala oyera kapena oyera amorphous ufa. Ufa wapamwamba wa HPMC uyenera kukhala ndi tinthu tating'ono, osaphatikizana, komanso zonyansa zakunja. Kukula ndi kufanana kwa tinthu tating'onoting'ono kumakhudza kusungunuka kwake ndi kufalikira. HPMC ndi lalikulu kwambiri kapena agglomerated particles osati kumakhudza solubility, komanso zingachititse m'njira kubalalitsidwa zotsatira kwenikweni ntchito. Chifukwa chake, kukula kwa tinthu ting'onoting'ono ndiye maziko owunikira mtundu wake.
2. Kusungunuka kwamadzi ndi kusungunuka kwamadzi
Kusungunuka kwamadzi kwa HPMC ndi chimodzi mwazizindikiro zake zofunika kwambiri. HPMC yapamwamba imasungunuka mofulumira m'madzi, ndipo yankho losungunuka liyenera kukhala lowonekera komanso lofanana. Kuyesa kusungunuka kwamadzi kumatha kuweruzidwa powonjezera kuchuluka kwa HPMC m'madzi ndikuwona ngati imatha kusungunuka mwachangu ndikupanga yankho lokhazikika. Kusungunuka kwapang'onopang'ono kapena njira yosagwirizana kungatanthauze kuti mtundu wa mankhwalawo sukumana ndi muyezo.
3. Makhalidwe a viscosity
The mamasukidwe akayendedwe a HPMC ndi imodzi mwamagawo ofunikira pakuwunika mtundu wake. Kukhuthala kwake m'madzi nthawi zambiri kumawonjezeka ndi kuchuluka kwa kulemera kwake. Njira yodziwika bwino yoyezetsa viscosity ndikugwiritsa ntchito viscometer yozungulira kapena viscometer kuyeza mayendedwe amakayendedwe osiyanasiyana. Nthawi zambiri, HPMC yapamwamba iyenera kukhala ndi mamasukidwe okhazikika, ndipo kusintha kwa mamasukidwe akuchulukirachulukira kuyenera kugwirizana ndi lamulo linalake. Ngati mamasukidwe akayendedwe ndi osakhazikika kapena pansi muyezo osiyanasiyana, zingatanthauze kuti maselo ake ndi wosakhazikika kapena ali ndi zosafunika.
4. Chinyezi
Chinyezi mu HPMC chidzakhudzanso ubwino wake. Kuchuluka kwa chinyezi kungapangitse kuti iwumbe kapena kuwonongeka ikasungidwa. Muyezo wa chinyezi uyenera kuyendetsedwa mkati mwa 5%. Njira zoyesera monga njira yowumitsa kapena njira ya Karl Fischer zitha kugwiritsidwa ntchito kudziwa kuchuluka kwa chinyezi. HPMC yapamwamba imakhala ndi chinyezi chochepa ndipo imakhala yowuma komanso yokhazikika.
5. pH mtengo wa yankho
Mtengo wa pH wa yankho la HPMC ukhoza kuwonetsanso mtundu wake. Nthawi zambiri, mtengo wa pH wa yankho la HPMC uyenera kukhala pakati pa 6.5 ndi 8.5. Mayankho a acidic mochulukira kapena amchere amatha kuwonetsa kuti chinthucho chili ndi zinthu zodetsedwa kapena chasinthidwa molakwika panthawi yopanga. Kupyolera mu kuyesa pH, mutha kumvetsetsa bwino ngati mtundu wa HPMC ukukwaniritsa zofunikira.
6. Zonyansa
Zonyansa za HPMC zimakhudza mwachindunji ntchito yake, makamaka pazamankhwala ndi chakudya, pomwe zonyansa zosayenera zimatha kubweretsa zinthu zosatetezeka kapena zovuta. Zonyansa nthawi zambiri zimakhala ndi zinthu zosakwanira bwino, mankhwala ena, kapena zonyansa zomwe zimapangidwa panthawi yopanga. Zomwe zili mu HPMC zitha kuzindikirika ndi njira monga high-performance liquid chromatography (HPLC) kapena gas chromatography (GC). HPMC yapamwamba kwambiri iyenera kuwonetsetsa kuti zili ndi zonyansa zochepa ndikukwaniritsa zofunikira.
7. Kuwonekera ndi kukhazikika kwa yankho
Kutumiza kwa yankho la HPMC ndichizindikiro chomwe chimagwiritsidwa ntchito kwambiri. Njira yothetsera kuwonekera kwambiri komanso kukhazikika nthawi zambiri imatanthawuza kuti HPMC ndi yoyera kwambiri ndipo ili ndi zonyansa zochepa. Yankho lake liyenera kukhala lomveka bwino komanso lowonekera pakatha nthawi yayitali, popanda mvula kapena chipwirikiti. Ngati yankho la HPMC litsika kapena likhala chipwirikiti pakusungidwa, zikuwonetsa kuti litha kukhala ndi zinthu zina zomwe sizinachitike kapena zonyansa.
8. Kukhazikika kwa kutentha ndi kutentha kwa kutentha kwa kutentha
Kuyeza kwa kutentha kwa kutentha kumachitidwa ndi kusanthula kwa thermogravimetric (TGA). HPMC iyenera kukhala ndi kukhazikika kwabwino kwa kutentha ndipo sikuyenera kuwola pa kutentha koyenera. HPMC yokhala ndi kutentha kwapang'onopang'ono kowola imakumana ndi kuwonongeka kwa magwiridwe antchito pamatenthedwe apamwamba kwambiri, kotero kukhazikika kwamafuta abwino ndi gawo lofunikira la HPMC yapamwamba kwambiri.
9. Njira yothetsera vutoli ndi kupanikizika kwapamwamba
Kuvuta kwapamwamba kwa yankho la HPMC kumatha kukhudza magwiridwe antchito ake, makamaka pakuyala ndi zida zomangira. Apamwamba HPMC ali otsika padziko mavuto pambuyo kuvunda, amene amathandiza kusintha dispersibility ndi fluidity mu TV zosiyanasiyana. Kuthamanga kwake pamwamba kumatha kuyesedwa ndi mita yothamanga pamwamba. Njira yabwino ya HPMC iyenera kukhala yotsika komanso yokhazikika pamtunda.
10. Kukhazikika ndi kusunga
Kukhazikika kosungirako kwa HPMC kumatha kuwonetsanso mtundu wake. HPMC yapamwamba iyenera kusungidwa mokhazikika kwa nthawi yayitali popanda kuwonongeka kapena kuwonongeka kwa magwiridwe antchito. Pochita kuyendera kwaubwino, kukhazikika kwake kumatha kuyesedwa mwa kusunga zitsanzo kwa nthawi yayitali ndikuyesa magwiridwe antchito nthawi zonse. Makamaka m'madera omwe ali ndi chinyezi chachikulu kapena kusintha kwakukulu kwa kutentha, HPMC yapamwamba iyenera kukhala yokhazikika yakuthupi ndi mankhwala.
11. Kuyerekeza zotsatira zoyesera ndi miyezo yamakampani
Pomaliza, imodzi mwa njira zodziwikiratu za mtundu wa HPMC ndikufanizira ndi miyezo yamakampani. Kutengera gawo lofunsira (monga zomangamanga, mankhwala, chakudya, ndi zina zambiri), miyezo yapamwamba ya HPMC ndi yosiyana. Posankha HPMC, mutha kulozera ku miyezo yoyenera ndi njira zoyesera ndikuphatikiza zotsatira zoyeserera kuti muweruze momveka bwino mtundu wake.
Kuwunika kwa khalidwe laMtengo wa HPMCayenera kuganizira zinthu zingapo, kuphatikizapo maonekedwe, solubility, viscosity, zonyansa, pH mtengo, chinyezi, etc. Kupyolera mu mndandanda wa njira zoyesera zovomerezeka, ubwino wa HPMC ukhoza kuweruzidwa mwachidziwitso. Pazofuna za magawo osiyanasiyana ogwiritsira ntchito, zizindikiro zina zogwirira ntchito zingafunikirenso kuyang'aniridwa. Kusankha zinthu za HPMC zomwe zimakwaniritsa miyezo yoyenera kungathe kutsimikizira mtundu ndi kukhazikika kwa chinthu chomaliza.
Nthawi yotumiza: Dec-19-2024