HPMC mbali ndi ntchito

Hydroxypropyl methylcellulose (HPMC) ndi polima multifunctional ndi ntchito lonse m'mafakitale osiyanasiyana monga mankhwala, zomangamanga, chakudya, zodzoladzola, etc. katundu wake zosiyanasiyana ndi ntchito zimapangitsa kukhala chofunika pophika mankhwala ambiri. Nayi kufufuza mozama kwa HPMC:

1. Makhalidwe a HPMC:

Kapangidwe ka Mankhwala: HPMC imachokera ku cellulose, polima wachilengedwe wopezeka muzomera. Amapangidwa ndi kusintha kwa cellulose ndi propylene oxide ndi methyl chloride. Mlingo wolowa m'malo mwa magulu a hydroxypropyl ndi methoxy amatsimikizira katundu wake.

Kusungunuka: HPMC imasungunuka m'madzi pa kutentha kwakukulu. Solubility zimadalira mlingo wa m'malo ndi maselo kulemera kwa polima. Kukwera m'malo kumabweretsa kusungunuka kwamadzi.

Viscosity: HPMC imawonetsa pseudoplastic kapena kumeta ubweya wa ubweya, kutanthauza kuti mamasukidwe ake amachepa chifukwa cha kumeta ubweya. The mamasukidwe akayendedwe a HPMC mayankho akhoza kusinthidwa ndi kusintha magawo monga molecular kulemera, mlingo wa m'malo, ndi ndende.

Kupanga Makanema: HPMC imapanga makanema omveka bwino komanso osinthika akataya yankho. Mafilimu amatha kusinthidwa ndikusintha ndende ya polima komanso kukhalapo kwa mapulasitiki.

Kukhazikika kwamafuta: HPMC ili ndi kukhazikika kwamafuta abwino, ndi kutentha kwapang'onopang'ono nthawi zambiri kupitilira 200 ° C. Izi zimapangitsa kukhala oyenera njira zosiyanasiyana processing, kuphatikizapo otentha Sungunulani extrusion ndi jekeseni akamaumba.

Hydrophilicity: Chifukwa cha chikhalidwe chake cha hydrophilic, HPMC imatha kuyamwa ndikusunga madzi ochulukirapo. Katunduyu ndi wopindulitsa pakugwiritsa ntchito monga kutulutsa mankhwala oyendetsedwa ndi kumasulidwa komanso ngati chowonjezera mumayendedwe amadzi.

Kugwirizana: HPMC imagwirizana ndi zida zina zosiyanasiyana, kuphatikiza ma polima ena, mapulasitiki, ndi zosakaniza zogwira ntchito zamankhwala (APIs). Kugwirizana kumeneku kumapangitsa kuti machitidwe ovuta apangidwe ndi mawonekedwe osinthika.

Zinthu Zopanda Ionic: HPMC ndi polima yopanda ionic, zomwe zikutanthauza kuti ilibe magetsi. Katunduyu amachepetsa kuyanjana ndi mitundu yoyipitsidwa mukupanga ndikuwonjezera kukhazikika kwake mu yankho.

2.HPMC ntchito:

Zomangira: Pamipangidwe yamapiritsi, HPMC imagwira ntchito ngati chomangira, kulimbikitsa kulumikizana pakati pa tinthu tating'onoting'ono ndikuwonjezera mphamvu zamakina a piritsi. Zimathandizanso kuti mapiritsiwo awonongeke akameza.

Kupaka Mafilimu: HPMC imagwiritsidwa ntchito kwambiri ngati chopangira filimu chamapiritsi ndi makapisozi. Zimapanga yunifolomu, zokutira zotetezera zomwe zimabisala kukoma ndi fungo la mankhwala, zimawonjezera kukhazikika, ndikuthandizira kumeza.

Kutulutsidwa kokhazikika: HPMC ikhoza kugwiritsidwa ntchito kuwongolera kuchuluka kwa mankhwala omwe amatulutsidwa kuchokera kumitundu yamankhwala. Mwa hydrating kupanga gel wosanjikiza, HPMC imatha kuchedwetsa kutulutsidwa kwa mankhwala ndikupereka chithandizo chokhazikika.

Viscosity Modifier: M'makina amadzimadzi, HPMC imagwira ntchito ngati viscosity modifier kapena thickener. Amapereka machitidwe a pseudoplastic otaya, kupititsa patsogolo kukhazikika ndi kagwiritsidwe ntchito ka mapangidwe monga zonona, mafuta odzola ndi ma gels.

Suspending wothandizira: HPMC ntchito kukhazikika suspensions wa insoluble particles mu madzi formulations. Kumalepheretsa okhazikika ndi kuonjezera mamasukidwe akayendedwe a mosalekeza gawo ndi utithandize tinthu kubalalitsidwa.

Emulsifier: Mu emulsion formulations, HPMC imakhazikitsa mawonekedwe pakati pa magawo a mafuta ndi madzi, kuteteza kupatukana kwa gawo ndi emulsification. Imawongolera kukhazikika komanso moyo wa alumali wamafuta odzola muzinthu monga zonona, mafuta odzola ndi odzola.

Mapangidwe a Hydrogel: HPMC imatha kupanga ma hydrogel ikathiridwa madzi, kupangitsa kuti ikhale yothandiza pamavalidwe a bala, ma lens olumikizana, ndi machitidwe operekera mankhwala. Ma hydrogel awa amapereka malo achinyezi ochiritsira mabala ndipo amatha kudzazidwa ndi mankhwala operekera kwanuko.

Thickening Agent: HPMC imagwiritsidwa ntchito kwambiri ngati chowonjezera pazakudya monga sosi, mavalidwe ndi zokometsera. Zimapangitsa kuti zikhale zosalala komanso zimawonjezera kukoma popanda kusintha kakomedwe kapena zakudya.

Zowonjezera Zomangamanga: M'makampani omanga, HPMC imagwiritsidwa ntchito ngati chosungira madzi mumatope opangidwa ndi simenti ndi pulasitala. Imawongolera magwiridwe antchito, kumamatira, ndikuchepetsa kusweka pochepetsa kutuluka kwa madzi.

Surface Modifier: HPMC imatha kusintha mawonekedwe apamwamba a magawo olimba monga mapepala, nsalu ndi zoumba. Imawongolera kusindikizidwa, kumamatira ndi zotchinga za zokutira ndi mafilimu.

Hydroxypropylmethylcellulose (HPMC) ndi polima wosunthika wokhala ndi katundu ndi ntchito zosiyanasiyana. Kusungunuka kwake, kukhuthala kwake, luso lopanga mafilimu komanso kuyanjana kwake kumapangitsa kuti ikhale yofunika kwambiri pamagwiritsidwe ambiri m'mafakitale. Kuchokera ku mankhwala mpaka kumanga, chakudya kupita ku zodzoladzola, HPMC ikupitiriza kugwira ntchito yofunika kwambiri popititsa patsogolo ntchito ndi khalidwe lazogulitsa. Pamene kafukufuku ndi luso lamakono likupita patsogolo, kusinthasintha ndi kugwiritsidwa ntchito kwa HPMC kungathe kukulirakulira, ndikuyendetsa luso lamakono pakupanga mapangidwe ndi chitukuko cha mankhwala.