Hydroxypropyl methylcellulose (HPMC)amagwiritsidwa ntchito ngati chimodzi mwazinthu zazikulu zothandizira mankhwala kunyumba ndi kunja. HPMC angagwiritsidwe ntchito ngati filimu kupanga wothandizila, zomatira, kupitiriza kumasulidwa wothandizila, kuyimitsidwa wothandizira, emulsifier, disintegrating wothandizira, etc.
Zothandizira mankhwala ndizofunikira kwambiri pokonzekera mankhwala, ndipo udindo wawo ndikuonetsetsa kuti mankhwalawa amatumizidwa ku minofu mwanjira inayake ndi ndondomeko, kotero kuti mankhwala amamasulidwa m'thupi pa liwiro linalake ndi nthawi. Choncho, kusankha koyenera kothandizira ndi chimodzi mwa zinthu zofunika kwambiri pa chithandizo chamankhwala chamankhwala okonzekera mankhwala.
1 Katundu wa HPMC
HPMC ili ndi mikhalidwe yambiri yomwe ma excipients ena alibe. Ili ndi kusungunuka kwabwino kwamadzi m'madzi ozizira. Malingana ngati awonjezeredwa m'madzi ozizira ndikugwedezeka pang'ono, amatha kusungunuka mu njira yowonekera. M'malo mwake, imakhala yosasungunuka m'madzi otentha pamwamba pa 60E ndipo imatha kusungunuka. Ndi non-ionic cellulose ether, yankho lake liribe ndalama za ionic, ndi mchere wachitsulo kapena mankhwala a ionic organic, kuti atsimikizire kuti HPMC sichichita ndi zipangizo zina pokonzekera kupanga. Ndi mphamvu zotsutsana ndi mphamvu, komanso kuwonjezeka kwa maselo a mlingo wa kulowetsedwa, anti-sensitivity imakulitsidwanso, pogwiritsa ntchito HPMC monga mankhwala adjuvant, poyerekeza ndi kugwiritsa ntchito mankhwala ena achikhalidwe (wowuma, dextrin, ufa wa shuga) mankhwala, ubwino wa nthawi yogwira ntchito ndi wokhazikika. Ali ndi vuto la metabolic. Monga mankhwala wothandiza zakuthupi, izo sizingakhoze zimapukusidwa kapena odzipereka, choncho sapereka zopatsa mphamvu mu mankhwala ndi chakudya. Imagwiritsidwa ntchito mwapadera pamtengo wotsika wa calorific, wopanda mchere komanso wopanda allergenic mankhwala ndi chakudya chofunikira kwa anthu odwala matenda ashuga. HPMC imakhala yolimba kwambiri ku asidi ndi zamchere, koma ngati idutsa pH2 ~ 11 ndipo imakhala ndi kutentha kwakukulu kapena nthawi yosungiramo nthawi yayitali, kukhuthala kumachepetsedwa. Njira yamadzimadzi imapereka zochitika zapamtunda ndikuwonetsa kugwedezeka kwapang'onopang'ono komanso kusamvana kwapakati. Iwo ali ogwira emulsification mu dongosolo magawo awiri ndipo angagwiritsidwe ntchito monga stabilizer ogwira ndi zoteteza colloid. Njira yamadzimadzi imakhala ndi mawonekedwe abwino kwambiri opangira mafilimu ndipo ndi yabwino yokutira mapiritsi ndi mapiritsi. Filimu yopangidwa ndi iyo ndi yopanda mtundu komanso yolimba. Mapulasitiki ake amathanso kuwonjezeredwa powonjezera glycerol.
2.Kugwiritsa ntchito HPMC pakupanga mapiritsi
2.1 Kupititsa patsogolo kusinthika
Kugwiritsa ntchito HPMC Mowa njira kapena njira amadzimadzi monga wetting wothandizila kwa granulation, chifukwa kuwongolera kuvunda kwa mapiritsi, zotsatira zake n'zochititsa chidwi, ndi mbamuikha mu filimu kuuma bwino, maonekedwe yosalala. Kusungunuka kwa piritsi la Renimodipine: kusungunuka kwa zomatira kunali 17.34% ndi 28.84% pamene zomatira zinali 40% ethanol, 5% polyvinylpyrrolidone (40%) ethanol solution, 1% sodium dodecyl sulfate (40%) ethanol solution, 3% HP solution 10% wowuma zamkati, 3% HPMC yankho, 5% HPMC yankho, motero. 30.84%, 75.46%, 84.5%, 88%. Kusungunuka kwa mapiritsi a piperic acid: pamene zomatira ndi 12% ethanol, 1% HPMC (40%) ethanol solution, 2% HPMC (40%) ethanol solution, 3% HPMC (40%) ethanol solution, kusungunuka ndi 80.94% , 86.23%, 90.45%, 99.88%, motero. Kusungunuka kwa mapiritsi a Cimetidine: pamene zomatira zinali 10% wowuma slurry ndi 3% HPMC (40%) yankho la ethanol, mlingo wa kusungunuka unali 76.2% ndi 97.54%, motero.
Kuchokera pamwamba deta, Tingaone kuti The Mowa njira ndi amadzimadzi njira ya HPMC ndi zotsatira za kusintha Kutha kwa mankhwala, amene makamaka chifukwa cha kuyimitsidwa ndi pamwamba ntchito ya HPMC, kuchepetsa mavuto padziko pakati pa yankho ndi. mankhwala olimba, kuonjezera chinyezi, chomwe chimapangitsa kuti mankhwala awonongeke.
2.2 Sinthani mtundu wa zokutira
HPMC monga filimu kupanga zakuthupi, poyerekeza ndi zipangizo zina filimu kupanga (akiliriki utomoni, polyethylene pyrrolidone), mwayi waukulu ndi solubility ake madzi, safuna zosungunulira organic, ntchito otetezeka, yabwino. NdipoMtengo wa HPMCali ndi mawonekedwe osiyanasiyana a viscosity, kusankha koyenera, kupaka filimu khalidwe, maonekedwe ndi abwino kuposa zipangizo zina. Mapiritsi a Ciprofloxacin hydrochloride ndi mapiritsi oyera oyera okhala ndi zilembo zambali ziwiri. Mapiritsi awa opaka filimu yopyapyala ndi ovuta, kudzera mukuyesera, amasankha kukhuthala kwa 50 mpa # s wa pulasitiki wosungunuka m'madzi, amatha kuchepetsa kupsinjika kwamkati kwa filimu yopyapyala, kupaka piritsi popanda mlatho / thukuta 0, 0, 0, 0 / lalanje. peel/permeability mafuta, 0 / crack, monga vuto lapamwamba, kupaka filimu yamadzimadzi kupanga, kumamatira bwino, ndi kubweretsa m'mphepete mwa mawu popanda kutayikira, zomveka, Mmodzi - mbali chowala, chokongola. Poyerekeza ndi madzi ophikira achikhalidwe, mankhwalawa ndi osavuta komanso omveka, ndipo mtengo wake umachepetsedwa kwambiri.
Nthawi yotumiza: Apr-25-2024