Hydroxypropyl methylcellulose (hpmc)imagwiritsidwa ntchito ngati imodzi mwazinthu zazikulu kwambiri zopitilira munyumba ndi kunja. HPMC itha kugwiritsidwa ntchito ngati othandizira makanema, zomatira, omasulira, osuta, omuyimira, allsifier, osiyidwa, enc.
Zosangalatsa za mankhwala ndi gawo lofunikira pakukonzekera mankhwala, ndi udindo wawo ndikuwonetsetsa kuti mankhwalawa amasankhidwa mwanjira inayake, kotero mankhwalawa amasulidwa m'thupi lina komanso nthawi ina. Chifukwa chake, kusankhidwa kwa zokongoletsa zoyenera ndi chimodzi mwazinthu zofunika kwambiri kwa achire zotsatira za kukonzekera kwa mankhwala.
1 katundu wa hpmc
HPMC ili ndi mikhalidwe yambiri yomwe zokolola zina sizikhala nazo. Ili ndi madzi abwino amadzi ozizira m'madzi ozizira. Malingana ngati ikuwonjezeredwa m'madzi ozizira ndikukulimbikitsani pang'ono, imatha kusungunuka mu yankho lowonekera. M'malo mwake, zimakhala zopanda mphamvu m'madzi otentha pamwamba 60e ndipo imangosungunuka. Ndi ma ether osavomerezeka, yankho lake silikhala ndi Ionic Sertic, ndi mchere wachitsulo kapena ionic zopangidwa ndi ma ionic, kuti zitsimikizire kuti HPMC siyikukonzekera. Ndi luso lamphamvu lamphamvu, ndipo ndi kuchuluka kwa kuchuluka kwa kuchuluka kwa kuchuluka kwa malo osokoneza bongo, kugwiritsidwa ntchito kwa HPMC ngati mankhwala ena achikhalidwe (ophatikizika) mankhwala, mtundu wa nthawi yolimba imakhala yokhazikika. Ili ndi metabolic sirtia. Monga mankhwala ochitira mankhwala ogulitsa, sizingapangidwe kapena kulowetsedwa, motero sizikupereka zopatsa mphamvu mu mankhwala ndi chakudya. Ili ndi ntchito yapadera ya mtengo wotsika mtengo, mchere wopanda mchere komanso chakudya chomwe sichikufunika kwa anthu ashuga. HPMC imakhala yokhazikika kwa asidi ndi alkali, koma ngati imapitilira PH2 ~ 11 ndipo imasungidwa kutentha kwambiri kapena nthawi yosungirako ndiyotalikirapo, mafayilo amachepetsedwa. Madzi am'madzi amapereka zochitika zapadziko lapansi ndipo zimapereka mavuto osokoneza bongo komanso zikhalidwe zosiyanasiyana. Imakhala ndi emullsization mu dongosolo la magawo awiri ndipo lingagwiritsidwe ntchito ngati ribidi yothandiza komanso yoteteza. Madzi am'madzi ali ndi mawonekedwe abwino a filimu ndipo ndi zinthu zabwino za mapiritsi ndi mapiritsi. Kanema wopangidwa ndi iwo ndi wopanda utoto komanso wolimba. Ma pulasitiki ake amathanso kuwonjezeka ndi kuwonjezera gallcerol.
2.Pasppances ya hpmc mu piritsi
2.1 Sinthani Kutha
Kugwiritsa ntchito HPMC ethanol kapena njira yothetsera yonyowa chifukwa Wonyowa, chifukwa chosintha kusungunuka kwa mapiritsi, zotsatira zake ndizodabwitsa, ndikukakamira mumitundu ya kanema ndiyabwino, mawonekedwe osalala. Kusungunuka kwa piritsi ya Renimodipine: Kusungunuka kwa Abitive kunali 17.34% ndi 28.84% pomwe omata a ethanol, 3% Hopmc Pulp, 3% HPMC yankho, 5% hpmc yankho, motsatana. 30.84%, 75.46%, 84.5%, 88%. Kuchuluka kwa Piperric acid mapiritsi a acid: Pamene otsatsa ndi 12% Ethanol (40% hpmc (40% hpmc (40%) ethanol yankho, 90.23%, 99.88%, motere, motsatana. Dissolution rate of Cimetidine tablets: when the adhesive was 10% starch slurry and 3% HPMC(40%) ethanol solution, the dissolution rate was 76.2% and 97.54%, respectively.
Kuchokera pamwambapa, zitha kuwoneka kuti ethanol yankho la hpmc ndi zotsatira za kuyimitsidwa kwa mankhwalawa ndi ntchito yolimba, yomwe imakulitsa kuwonongeka kwa mankhwala.
2.2 Sinthani mtundu wa zokutira
HPMC ngati nkhani yopanga filimu, poyerekeza ndi zida zina za filimu (ma acrylic ston, polyethylene pirjisone), ubwino waukulu ndi madzi osinthika, osafunikira. NdiHpmcIli ndi mitundu yosiyanasiyana ya mafayilo, kusankha koyenera, kuphimba filimu, mawonekedwe ake ndi abwino kuposa zinthu zina. Mapiritsi a CIProfloxacin a hydrochloride ndi mapiritsi oyera oyera okhala ndi zilembo ziwiri. Mapiritsi awa ojambula owonda ndi ovuta, kudzera mukuyesera, amasankha mafayilo a 50 MOPA Poyerekeza ndi madzi ofunda achikhalidwe, mankhwalawa ndi osavuta komanso oganiza bwino, ndipo mtengo wake umachepetsedwa kwambiri.
Post Nthawi: Apr-25-2024