Hydroxypropylmethmethcellulose (hpmc) ndi polimme yosiyanasiyana yomwe imagwiritsidwa ntchito kwambiri m'mafakitale osiyanasiyana chifukwa chazinthu zake zapadera. Patsamba ili ndikuchokera ku cellulose, polymer yachilengedwe imapezeka mu khoma la maselo. Kaphatikizidwe ka HPMC kumaphatikizapo kuchitira cellulose ndi ma propely oxide kuti ayambitse magulu a hydroxypyl ndipo ndi methyl chloride kuyambitsa magulu a meya. Polymer akuwonetsa kuti ndi zinthu zingapo zakuthupi komanso zamankhwala, zomwe zimapangitsa kuti zigwiritsidwe ntchito mu mankhwala ogulitsa, zomanga, chakudya ndi mafakitale ena.
Kupanga ndi kapangidwe kake:
Hydroxypropyl methylcellulose ndi polymer polymer yokhala ndi mawonekedwe ovuta mankhwala. Matuluke kumbuyo kwa polymer amakhala ndi cellulose, mamona a mzere wa shuga wolumikizidwa ndi β-1,4-glycosiidic. Gulu la hydroxypropyl limayambitsidwa ndi gulu la hydroxyl (-Oh) ndi gulu la Propyl, ndipo gulu la methyl limayambitsidwa chimodzimodzi. Mlingo wa zolowetsa (DS) akuyimira chiwerengero cha hydroxypyl ndi meth
2. Solubility:
Chimodzi mwazinthu zosiyanitsa ndi HPMC ndi njira yake yosasinthika. Imasungunuka m'madzi onse ozizira komanso otentha, kupereka zabwino zapadera zogwiritsidwa ntchito zosiyanasiyana. Solubility imatha kusinthidwa ndikusintha kuchuluka kwa zolowa m'malo mwazolemera kwa polymer. Katunduyu amapangitsa kuti akhale woyenera kuyesedwa bwino kwambiri polemba mankhwala osokoneza bongo, pomwe kusungidwa kwa mankhwalawa kumachita mbali yofunika kwambiri pomasulira ma kinetics.
3. Makutu:
Hydroxypropyll methylclulose milingo ya mafayilo osiyanasiyana, kutengera zinthu monga kulemera kwa ma celecular, digiri ya kulowetsedwa. Makutu a HPMC mayankho a HPMC amawalola kugwiritsidwa ntchito mu mafakitale ambiri, kuphatikizapo zamafuta ambiri, monga otsatsa mu madzi a mankhwalawa, komanso mawonekedwe opanga mafilimu.
4. Magwiridwe antchito afilimu:
Kutha kwa mafilimu ndikofunikira pakugwiritsa ntchito monga zokutira mankhwala, komwe kumagwiritsidwa ntchito kupereka chosakanizira choteteza mankhwala osokoneza bongo, kuwongolera kugwiritsa ntchito mankhwala, ndikusintha. Makanema a HPMC ndiomveka komanso osinthika, ndipo katundu wawo amatha kupangidwa ndi kusintha kwa polymer ndende, kutukwana masentimita ndi miyala yapulidi.
5. Ntchito yamafuta:
Hydroxypropyll methylcelulose imawonetsa kukhazikika kwa matenthedwe mkati mwa kutentha kwina. Zomera zimakhudzidwa ndi zinthu monga kuchuluka kwa kulowetsa, kunenepa kwambiri, komanso kupezeka kwa maphikidwe. Izi zimapangitsa kuti hpmc zizigwiritsa ntchito ntchito pomwe kukhazikika kwa marrmal ndikofunikira, monga kukonzekera ma ptraceceumical.
6 ..
M'minda ya mankhwala ndi biomedacal minda, zopanda pake ndi zofunika kuganizira zinthu zomwe zimagwiritsidwa ntchito m'mankhwala omasulira mankhwala. Hydroxypropyl methylcellulose nthawi zambiri amawoneka otetezeka ndipo ali ndi chitetezo chamtengo wapatali. Amagwiritsidwa ntchito kwambiri pakupanga mitundu yamlomo ya milomo, ma ophthalmic njira ndi makina operekera mankhwala osokoneza bongo.
7. Kusungidwa kwamadzi komanso katundu wa thicking:
Kutha kwa HPMC kuti musunge madzi ndi kukula kwa maliseche kumapangitsa kuti ikhale yofunika pakupanga zomanga monga zinthu zochokera kumenta. Mu mapulogalamu awa, hpmc amachita ngati wothandizira madzi, kusintha kusinthasintha ndikuletsa kuyanika koyambirira kwa zinthuzo. Kukula kwazinthu kumagwiritsidwanso ntchito pazogulitsa zosiyanasiyana za chakudya kuti zithandizire kapangidwe kake komanso kamwa.
8. Kutumiza mankhwala osokoneza bongo:
Chimodzi mwazofunikira za hydroxypropyl methylcellulose ndikupanga njira zoyendetsera mankhwala osokoneza bongo. Kusungunuka kwa polymer, chidwi cha polima, ndi katundu wopanga makanema omwe amathandizira kumasulidwa kwa mankhwala osokoneza bongo, zomwe zimathandizira kusungidwa ndi kukhazikika. Izi ndizopindulitsa kwambiri kuti zithandizire odwala odwala komanso kuchepetsa zovuta zomwe zimagwirizana ndi mankhwala osokoneza bongo.
9. Kukhazikika pansi pa b m'malo osiyanasiyana:
HPMC imawonetsa kukhazikika pamasamba ambiri, ndikupangitsa kukhala koyenera kwa mapangidwe omwe amafuna kukhazikika pansi pa acidic kapena alkalinine. Katunduyu ndiwopindulitsa mu mankhwala opangira mankhwala chifukwa mapangidwe osokoneza bongo amatha kukumana ndi masinthidwe osiyanasiyana m'mimba.
10. Zovala zankhanza:
Khalidwe la Rhelogical la mayankho a HPMC ndizofunikira pazogwiritsa ntchito komwe kuchepa kwa katundu ndikofunikira, zomatira ndi ma gels. Zomera zazomera zimatha kupangidwa ndi kusintha kwa kuchuluka kwa kuchuluka kwa HPMC kuti mukwaniritse zotuluka zomwe zimafunikira pakuwongolera.
Hydroxypropyll methllulose yakhala polymer yofunika kwambiri m'mafakitale osiyanasiyana chifukwa cha kuphatikiza kwake kwa kusungunuka, mafayilo, luso lopanga mafilimu komanso zopanda pake. Kusintha kwake kumapangitsa kukhala koyenera kugwiritsa ntchito mitundu yosiyanasiyana ya mankhwala, kuchokera ku mankhwala othandizira komanso zinthu zomanga chakudya ndi zodzoladzola. Monga ofufuza akupitilizira kufufuza zatsopano, zomwe zimagwiritsidwa ntchito kwa hydroxpyl mosakayikira zimathandiza kuti zipitirize kupezeka pa sayansi ndi makampani.
Post Nthawi: Jan-10-2024