1. Chikhalidwe choyambirira cha HPMC
HyPromellose, Chingerezi dzina la hydroxpyl methylcellulose, Alias HPMC. Njira yake ya molecular ndi C8H15o8- (C10hl8o6) N-C8hl5o8, ndipo kulemera kwa thupi ndi pafupifupi 86,000. Izi ndi zopangidwa ndi semi, zomwe ndi gawo la gulu la methyl ndi gawo la polyhydropyl ether of cellulose. Itha kupangidwa ndi njira ziwiri: chimodzi ndikuchita bwino kwambiri celyl ya digiri yoyenera ndi Naoh, kenako ndikuchita ndi ma propyle oxide otentha kwambiri komanso opanikizika kwambiri. Nthawi yochita kuti ikhale yokhazikika kuti ilole magulu a methyl ndi hydroxypyl kuti mugwirizane ndi ether. Mawonekedwe a mphete ya anilrogluose ya cellulose, ndipo amatha kufikira digiri yofunikira; Wina ndi kuchitira thonje lolemba kapena kuphika nkhuni ndi soda, kenako ndikupeza ndi chlorinated methane ndi ma proplene oxide okwana, ndikupanga ufa wabwino ndi yunifolomu. HPMC ndi mitundu yosiyanasiyana ya cellulose, ndipo ndichinthu chabwino kwambiri cha mankhwala, omwe ali ndi gwero lalikulu. Pakadali pano, imagwiritsidwa ntchito padziko lonse lapansi ndi kunja, ndipo ndi chimodzi mwazomwe zimathandizira kuchuluka kwa mankhwala omwe ali ndi vuto lamwambo.
Mtundu wa izi ndi zoyera kuti mkaka woyera, wosakhala wopanda mphamvu komanso wopanda pake, ndipo ndi ufa wamafuta kapena ufa wosavuta. Imakhazikika moyang'aniridwa ndi kuwonetsedwa ndi chinyezi. Amatupa m'madzi ozizira kuti apange yankho loyera loyera la colloidal ndi mawonekedwe ena. Sol-gel yolumikizana ndi sonomenon imatha kuchitika chifukwa cha kutentha kwa kutentha kwa njira inayake. Ndikosavuta kusungunuka mu 70% mowa kapena kemthyl kekene, ndipo osasungunuka mu mowa wambiri, chloroform kapena ethoxythane.
HyPromellose ali ndi bata bwino pomwe PH ili pakati pa 4.0 ndi 8.0, ndipo imatha kukhalapo pakati pa 3.0 ndi 11.0. Pambuyo pa kusunga kwa masiku 10 pa kutentha kwa 20 ° C ndi chinyezi cha 80%, chinyezi cholumikizira cha HPMC ndi 6.2%.
Chifukwa cha kusiyana pakati pa zomwe zili m'malo awiriwo pogwiritsa ntchito HyPromellose, methoxy ndi hydroxypropyl, mitundu yosiyanasiyana ya zinthu zopangidwa zidawonekera. Mu ndende inayake, mitundu yosiyanasiyana ya zinthu zikuwoneka bwino komanso kutentha kwa kutentha kwa mafuta, chifukwa chake, imakhala ndi zida zosiyanasiyana ndipo zitha kugwiritsidwa ntchito pazifukwa zosiyanasiyana. Mankhwala a mayiko osiyanasiyana ali ndi mitundu yosiyanasiyana ndi mawu osiyanasiyana: European Europe Memackopoe imakhazikika pamakampani osiyanasiyana ndi madigiri osiyanasiyana ammisika pamsika. Amafotokozedwa ndi kalasi kuphatikiza nambala. Unit ndi MPA • s. Pambuyo kuwonjezera manambala 4 posonyeza zomwe zili ndi mpweya uliwonse wa HyPromellose, ma birpomellose 2208, manambala awiri oyamba akuyimira kuchuluka kwa methoxypropyl matelo.
2. Njira Yosungunuka HPMC m'madzi
Njira Yamadzi Yamadzi
Popeza HyPromellose sasungunuka m'madzi otentha, imatha kukhala yobalalika m'madzi otentha nthawi yoyamba, kenako ikakhazikika, njira ziwiri zomwe zimafotokozedwa motere:
(1) Ikani madzi otentha omwe ali mumtsuko ndikutenthetsa pafupifupi 70 ℃. Pang'onopang'ono onjezani malonda omwe ali pansi pang'onopang'ono. Poyamba, malonda amayandama pamadzi, kenako pang'onopang'ono amapanga molumala. Ozizira pansi.
. Kumadzi otentha owotcha mu slurry, ozizira osakaniza pambuyo poyambitsa.
2.2 Njira Yosakaniza
Ufa tinthu tating'onoting'ono ndi zinthu zina zophatikizika kapena zokulirapo zimabalalika mokwanira posakaniza kochepa, kenako madzi amawonjezeredwa kusungunuka. Pakadali pano, hypereyose amatha kusungunuka popanda kuchitika.
3. Ubwino wa HPMC
3.1 madzi ozizira
Imasungunuka m'madzi ozizira pansi pa 40 ° C kapena 70% ethanol. Zimakhala zopanda madzi m'madzi otentha kuposa 60 ° C, koma zimatha kupangidwa.
3.2 Kugwiritsa Ntchito Mankhwala
HyPromellose (HPMC) ndi mtundu wa ether ether ether. Njira yake ilibe nyumba ya Ionic ndipo samalankhula ndi mchere wachitsulo kapena ionic okonda. Chifukwa chake, ena osapeza sachita nawo panthawi yokonzekera.
3.3 Kukhazikika
Imakhala yokhazikika kwa acid ndi alkali, ndipo imasungidwa kwa nthawi yayitali pakati pa PH 3 mpaka 1l, ndipo ma viscy alibe kusintha koonekeratu. The kachilomboka yankho la hyPromellose (hpmc) ali ndi mphamvu yotsutsa ndipo imatha kukhalabe ndi mawonekedwe abwino pakusungidwa kwa nthawi yayitali. Zosangalatsa za mankhwala ogwiritsa ntchito hpmc zimakhala ndi zabwino kuposa zomwe zimagwiritsa ntchito zikhalidwe (monga dextrin, wowuma, etc.).
3.4 Kusintha kwa Masuki
Mawonekedwe osiyanasiyana otaya a HPMC akhoza kusakanizidwa m'njira zosiyanasiyana, ndipo maonedwe ake amatha kusintha malinga ndi lamulo linalake, ndipo ali ndi ubale wabwino, kotero ungasankhidwe molingana ndi zofunikira.
3.5 Metabolic Bartia
HPMC siimatengeka kapena yopangidwa mthupi, ndipo sakupereka zopatsa mphamvu, motero ndi kofunikira kuti mukonzekere mankhwala.
3.6 Chitetezo
Nthawi zambiri amakhulupirira kuti HPMC ndi zinthu zosafunikira komanso zosasangalatsa. Mlingo wa mbewa zam'madzi ndi 5g / kg, ndi mlingo wa makoswe a makoswe ndi 5.2g / kg. Mlingo wa tsiku ndi tsiku ndiwopanda vuto kwa thupi la munthu.
4. Kugwiritsa ntchito HPMC pakukonzekera
4.1 Zogwiritsidwa ntchito ngati kanema wokutira ndi mawonekedwe a makanema
HyPromellose (HPMC) imagwiritsidwa ntchito ngati piritsi lokhala ndi mafilimu. Poyerekeza mapiritsi okhala ndi zikhalidwe monga mapiritsi okutidwa ndi shuga, mapiritsi okhala ndi ziweto alibe zabwino zodziwika bwino pokoka kukoma ndi mawonekedwe ake, kuwonongeka kwawo, kuphatikizika kwa kulemera kwake ndi zina zabwinobwino. Kalasi yotsika kwambiri ya mankhwalawa imagwiritsidwa ntchito ngati mawonekedwe osungunuka filimu yamadzi ndi mapiritsi, ndipo kalasi yapamwamba kwambiri imagwiritsidwa ntchito ngati mawonekedwe a filimu ya machitidwe osinthika. Kugwiritsa ntchito ndende nthawi zambiri kumakhala 2.0% -20%.
4.2 Monga chomangira ndi kuwonongeka
Kalasi yotsika kwambiri ya mankhwalawa itha kugwiritsidwa ntchito ngati binder ndi kuwonongeka kwa mapiritsi, mapiritsi, ndi maganya, komanso kalasi yapamwamba kwambiri imangogwiritsidwa ntchito ngati binder. Mlingo umasiyanasiyana ndi mitundu yosiyanasiyana ndi zofunikira. Nthawi zambiri, kuchuluka kwa binder omwe amagwiritsidwa ntchito mapiritsi owuma ndi 5%, ndipo kuchuluka kwa bingar omwe amagwiritsidwa ntchito mapiritsi onyowa ndi 2%.
4.3 Monga Wogulitsa
Kuimitsa Mtumiki ndi chinthu chowoneka bwino ndi hydrophilicity. Kugwiritsa ntchito kuyimilira kwa kuyimilira kumachepetsa liwiro la tinthu tambiri, ndipo chitha kulumikizidwa pamwamba pa tinthu tating'onoting'ono kuti tilepheretse tinthu tating'onoting'ono komanso kukhazikika. Kusuma kwa malo ofunikira pakupanga kuyimitsidwa. Hpmc ndi mitundu yabwino yopumira. Njira yothetsera colloidal idasungunuka kuti ithetse mawonekedwe a mawonekedwe okwanira madzi ndi mphamvu yaulere pa tinthu tating'onoting'ono tomwe timayambitsa matenda a heruogeneous. Izi ndizomwe zimayimitsa madzi ambiri kukonzekera madzi kukonzekera ngati kuyimilira. Ili ndi kuyimitsidwa bwino, kosavuta kubwezeretsanso, osaphika, komanso tinthu tabwino. Kuchuluka kwa chizolowezi ndi 0,5% mpaka 1.5%.
4.4 Wogwiritsidwa ntchito ngati blocker, wodekha komanso wowongolera wotumidwa ndi wopanga
Kalasi yapamwamba kwambiri ya mankhwalawa imagwiritsidwa ntchito kukonza mapiritsi a hydrophilic gelrix. Zimakhala ndi zotsatira zochedwetsa mankhwala osokoneza bongo. Kugwiritsa ntchito mwamphamvu kwa 10% ~ 80% (W / W). Kalasi yotsika isccess imagwiritsidwa ntchito ngati yopanga pore-pored yopanga kapena kulamulidwa. Mlingo woyamba wofunikira pakuchiritsa kwa piritsi yamtunduwu ikhoza kufikiridwa mwachangu, kenako ndikumasulidwa kapena kulamulidwa ndi magazi kumayendetsedwa, ndipo mankhwala osokoneza bongo amasungidwa mthupi. HyPromellose ma hydrate kuti apange mawonekedwe a gel osakaniza pomwe amakumana ndi madzi. Limagwirira mankhwala osokoneza bongo a matrix makamaka makamaka amasanjikiza wa gel osanjikira khungu.
4.5 Chitani chikho chazotchinjiriza monga thickener ndi colloid
Izi zikagwiritsidwa ntchito ngati thickener, chidwi chokhazikika ndi 0,45% ~ 1.0%. Izi zitha kuwonjezera kukhazikika kwa guluu Hydrophobic, ndikupanga colloid yoteteza, kulepheretsa tinthu tating'onoting'ono komanso kuvuta, potero ndikulepheretsa mapangidwe a utoto. Kuyang'aniridwa kwake mwachizolowezi ndi 0,5% ~ 1.5%.
4.6 wogwiritsidwa ntchito ngati mtengo wa kapisozi
Nthawi zambiri, chipolopolo cha kapisozi cha kapisozi makamaka gelatin. Kupanga kopanga zipolopolo za kapisozi ndikosavuta, koma pali zovuta zina komanso zosokoneza bongo monga kutetezedwa ndi mankhwala osokoneza bongo, komanso kuchepetsedwa kusokonekera kwa kapisozi panthawi yosungirako. Chifukwa chake, HyPromellose imagwiritsidwa ntchito ngati cholowa m'malo mwa kapisozi pokonzekera makapisozi, omwe amasintha kuwumbidwa ndi kugwiritsa ntchito kapisozi, ndipo amalimbikitsidwa kunyumba ndi kunja.
4.7 Monga biohedive
Tekinoloje ya Biodive Chithandizo. Imagwiritsidwa ntchito kwambiri tsopano imagwiritsidwa ntchito pochiza matenda a m'mphuno ndi mucosa pakamwa. Technology ya m'mimba ya m'mimba ndi mtundu watsopano wa dongosolo loperekera mankhwala omwe adakwaniritsidwa m'zaka zaposachedwa. Sikuti amangotaya nthawi yokonzekera mankhwala kum'mimba thirakiti, komanso amathandizanso kulumikizana ndi mankhwalawa ndi cell nembanemba ya mavalidwe a cell nembane. Mphamvu yolowera ya mankhwalawa maselo a epithelial a matumba ang'onoang'ono amalimbikitsidwa, potero kukonza bioavailability wa mankhwala.
4.8 Monga gel osakaniza
Monga kukonzekera kosangalatsa kwa khungu, gel ali ndi zabwino monga chitetezo, kukongola, kuyeretsa kosavuta, mtengo wotsika mtengo, njira yabwino yokonzekera mankhwala. M'zaka zaposachedwa, yalandila chidwi kwambiri ndipo yakhala ikukonzekera khungu lakunja. malangizo.
4.9 Monga mpweya woletsa ku Emulsifices
Post Nthawi: Disembala 16-2021