Hec (hydroxyethyl cellulose)ndi polywed wamba polymer omwe amagwiritsidwa ntchito pokonzekera mankhwala. Ndizosatheka kwa cellulose, zomwe zimapezeka polemba Etharolamine (Ethylene oxide) ndi cellulose. Chifukwa cha kusakhazikika kwake, kukhazikika, kuthekera kwa ma viscrence, hec ali ndi mapulogalamu am'munda osiyanasiyana, makamaka mu chiyeso cha mapangidwe, mawonekedwe a mankhwala osokoneza bongo.
1. Zoyambira za Hec
Hec, monga cellulose yosinthidwa, ili ndi zinthu zotsatirazi:
Madzi osungunuka: Hullcence®hec amatha kupanga njira yothetsera m'madzi, ndipo kususuka kwake kumakhudzana ndi kutentha ndi Ph. Katunduyu amapangitsa kuti ikhale yogwiritsa ntchito mitundu yosiyanasiyana yamlomo monga pakamwa komanso zapamwamba.
Zoyenera: Hec siyopanda kupweteka komanso kusakwiya m'thupi la munthu ndipo amagwirizana ndi mankhwala ambiri. Chifukwa chake, imagwiritsidwa ntchito mwamphamvu mitundu yosungudwa ndi kusungidwa ndi makonzedwe amtundu wa mankhwala.
Kusinthika kwa Uku: Makutu a Hec amatha kusinthidwa ndikusintha kunenepa kapena kukhazikika kwa kuchuluka kwa mankhwala osokoneza bongo kapena kukonza bata la mankhwala.
2. Kugwiritsa ntchito hec mu zokonzekera zamankhwala
Monga kofunikira kokomera m'makonzedwe opanga mankhwala, hec imakhala ndi ntchito zingapo. Otsatirawa ndi madera ake ogwiritsa ntchito pokonzekera mankhwala.
2.1 Kugwiritsa ntchito pokonzekera pakamwa
M'mafomu amlomo, ngwazi nthawi zambiri amagwiritsidwa ntchito popanga mapiritsi, makapisozi ndi kukonzekera kwamadzi. Ntchito zake zazikulu zikuphatikiza:
Baner: m'mapiritsi ndi granules, hec imatha kugwiritsidwa ntchito ngati khola kuti imange bwino tinthu tambiri kapena ufa palimodzi kuti zitsimikizire kulimba ndi kukhazikika kwa mapiritsi.
Kusulidwa kwa kusungidwa: Hec kumatha kutulutsa mphamvu pakuwongolera kuchuluka kwa mankhwalawa. Pamene Hec imagwiritsidwa ntchito limodzi ndi zosakaniza zina (monga polyvinyl piryone, carboxymethyl cellulose, etc.), imatha kupitirira nthawi yomasulira mankhwalawa, ndi kukonza mogwirizana ndi mankhwala osokoneza bongo.
Thickener: Mu madzi amamwa pakamwa kukonzekera, kudana ndi nkhawa ngati kukulitsa kuwongolera kukoma kwa mankhwalawa komanso kukhazikika kwa mawonekedwe a mlingo.
2.2 Kukonzekera Pamba Zapamwamba
Hec amagwiritsidwa ntchito kwambiri m'mafuta apamwamba, mafuta, ma gels, zodzola ndi kukonzekera kwina, kusewera maudindo angapo:
Gel Unix: Nthawi zambiri hec nthawi zambiri imagwiritsidwa ntchito ngati matrix a ma gels, makamaka potumiza mankhwala osokoneza bongo. Itha kupereka ndalama moyenera ndikuwonjezera nthawi yokhalamo mankhwalawa pakhungu.
Maonekedwe ndi kukhazikika: Makutu a Hec amatha kukulitsa chitsamba cha kukonzekera kwapakhungu pakhungu ndikuletsa mankhwalawa kuti asagwere asanakwane chifukwa cha zovuta zakunja monga kukangana kapena kusambitsidwa. Kuphatikiza apo, hec imatha kukonza kukhazikika kwa mafuta ndi mafuta ndikupewa stratation kapena crystallization.
Phukusi la mafuta: Hec ili ndi yonyowa katundu ndipo imatha kuthandiza pakhungu ndi kuwuma, momwemonso zimagwiritsidwanso ntchito pazinthu zina zosamalira khungu.
2.3 Kufunsira Kukonzekera kwa Ophthalmic
Kugwiritsa ntchito Hec mu kukonzekera kwa ophthalmic kumawonekera makamaka monga chomatira monga chomatira ndi mafuta:
Maudzu a ophthalmic ndi madontho amaso: Hec itha kugwiritsidwa ntchito ngati chomata za kukonzekera kwa ophthalmic kuti apitilize nthawi yolumikizana pakati pa mankhwala ndi diso ndikuwonetsetsa kuti akupitilizabe mankhwala. Nthawi yomweyo, ma viscy awo amathanso kuletsa diso kugwa chifukwa chotaya msanga ndikuwonjezera nthawi yosunga mankhwala.
Mafuta: Hec ali ndi hydration wabwino ndipo amatha kupereka mafuta osambirira mankhwala a ophthalmic matenda owuma monga diso lowuma, kuchepetsa nkhawa.
2.4 Kugwiritsa ntchito makanema okonzekera jakisoni
Hec itha kugwiritsidwanso ntchito pokonzekera jakisoni, makamaka pakukonzekera kwa nthawi yayitali komanso kukonzekera kumasulidwa. Ntchito zazikuluzikulu za hec mu kukonzekera izi zimaphatikizapo:
Thickener ndi Statefakurkurkurkurfarkeser: jakisoni,Hecimatha kuwonjezera mafayilo a yankho, pang'onopang'ono kuthamanga kwa mankhwalawa, ndikuwonjezera kukhazikika kwa mankhwalawa.
Kuwongolera mapangidwe osokoneza bongo: monga imodzi mwazinthu zomwe zimapangidwa ndi mankhwalawa, Hec imatha kuwongolera kutuwa kwa mankhwalawa popanga jelser, kuti akwaniritse cholinga cha chithandizo cha nthawi yayitali.
3. Udindo wa Hec mu Mankhwala Osiyanasiyana
Ndi chitukuko cha ukadaulo wamankhwala opangira mankhwala, HeC yagwiritsidwa ntchito kwambiri m'mankhwala osiyanasiyana otumizira mankhwala osokoneza bongo, makamaka m'minda ya nano-onyamula mankhwala, microsphere, ndi onyamula mankhwala osokoneza bongo. Hec imatha kuphatikizidwa ndi zida zosanyamula mankhwala kuti zipange zovuta zokhazikika kuti zitsimikizire kuti amasulidwe ndi kugwiritsa ntchito mankhwala osokoneza bongo.
Nano mankhwala onyamula mankhwala: Hec itha kugwiritsidwa ntchito ngati chosungira cha ma batala a nano onyamula mankhwala kuti apewe kuphatikizika kapena kuchuluka kwa tinthu tambiri ndikukulitsa bioavailability.
Microsscores ndi tinthu: Hec imatha kugwiritsidwa ntchito kukonza ma microsescy onyamula mankhwala kuti awonetsetse kuti amasulidwe pang'onopang'ono mankhwalawa m'thupi ndikusintha mphamvu mankhwala osokoneza bongo.
Monga mankhwala osokoneza bongo ophatikizira, kudandaula ®hec ali ndi chiyembekezo chothandiza pakukonzekera kwa mankhwala. Ndi chitukuko mosalekeza mwa ukadaulo wamankhwala opanga mankhwala, Hec amagwira ntchito yofunika kwambiri yomasulira mankhwala osokoneza bongo, makonzedwe am'deralo, amasulidwa kukonzekera kwa mankhwala ndi njira zatsopano zoperekera mankhwala. Kukhazikika kwake kwabwino, kusinthika kosinthika ndi kukhazikika kumapangitsa kuti zikhale zosatheka m'munda wa mankhwala. M'tsogolomu, pophunzira hec, ntchito yake yokonzekera mankhwala idzakhala yochulukirapo komanso yosiyanasiyana.
Post Nthawi: Desic-28-2024