Sodium carboxymethmethmethmethmethyl cellulose (yemwe amadziwikanso kuti: sodium carboxymethyl cellose, carboxymethyl cellose,Cmc, Carboxymethyl, sodium wosungunuka, sodium mchere wa Caboxy Methyl cellulose) ndiye kuchuluka kwakukulu komanso kuchuluka kwakukulu komwe kumagwiritsidwa ntchito padziko lapansi masiku ano mitundu ya cellulose.
CMC-NA Mwachidule, ndi cellulose yochokera ku digiri ya galucesetion ya 100-2000, komanso kuchuluka kwa kuchuluka kwa 242.16. Oyera ang'ono kapena granlar ufa. Ower wopanda mafuta, wopanda chidwi, wopanda pake, hygroscopic, zopanda mphamvu m'malo okhazikika.
Katundu woyambira
1. Mapangidwe a molecular a sodium carboxymethylcelulose (cmc)
Iyo idapangidwa koyamba ndi Germany mu 1918, ndipo idatchulidwa mu 1921 ndipo idawonekera padziko lapansi. Kupanga malonda kwachitika ku Europe. Panthawiyo, zinali zongogulitsa zopanda pake, zomwe zimagwiritsidwa ntchito ngati colloid ndi binder. Kuyambira mu 1936 mpaka 1941, kafukufuku wogwiritsa ntchito mafakitale a sodium carboxylbyl anali achangu kwambiri, ndipo matiyere ambiri adapangidwa. Pa nkhondo yachiwiri yapadziko lonse, Germany ankagwiritsa ntchito sodium carboxymethylcelulose popanga zopanga zopanga. Hercules adapanga sodium carboxymethylcelilose kwa nthawi yoyamba ku United States mu 1943, ndipo amapanga carbon carbon carboxylluloseththylcelilose. Dziko langa linayamba kutengera mu 1970s, ndipo linagwiritsidwa ntchito kwambiri mu 1990s. Ndiogwiritsidwa ntchito kwambiri komanso kuchuluka kwa cellose padziko lapansi masiku ano.
Njira yojambulidwa: C6H7O2 (O) 2och2coona molecular formula, c8h11o7na
Izi ndi mchere wa sodium wa celloul carboxyme ether, fibernic
2. Maonekedwe a sodium carboxymethyl cellulose (CMC)
Izi ndi mchere wa sodium wa celloul carboxyl ether, ether ether ether, yoyera kapena yamkaka yoyera, yopanda fungo, yopanda matope. Ndiosavuta kubala m'madzi kuti ipange yankho la colloidal yowonekera, ndipo yopanda malire mu sopol monga ethanol [1]. PH of 1% yam'madzi ya 1 %.-8.5 STRS Kutentha, ma viscnce akukwera mwachangu pansipa 20 ° C, ndikusintha pang'onopang'ono pa 45 ° C. Kutentha kwa nthawi yayitali pamwamba pa 80 ° C kumatha kutsutsana ndi colloid ndikuchepetsa kwambiri. Imasungunuka mosavuta m'madzi, ndipo yankho lake limawonekera; Ndizokhazikika kwambiri mu njira ya alkaline, koma imakhazikika pomwe imakumana ndi asidi, ndipo idzatsogolera pomwe mtengo wa pH ndi 2-3, ndipo zimakhudzananso ndi mchere wa helyvale wa polyval.
Cholinga chachikulu
Amagwiritsidwa ntchito ngati thickier mu malonda azakudya, monga chonyamula mankhwala osokoneza bongo m'makampani opanga mankhwala, komanso monga wothandizira komanso wotsutsa-regation mu makampani amakampani tsiku lililonse. Mu kusindikiza ndi kupatsirana makampani, imagwiritsidwa ntchito ngati colloid colloid kuti agwiritse ntchito othandizira ndi kusindikiza pastes. M'makampani opanga ma peprochemical, itha kugwiritsidwa ntchito ngati gawo la mankhwala ochiritsira mafuta. [Chithunzi patsamba 2]
Kukhulupilika
Sodium Carboxymethmethmeusose ndi njira zamphamvu a acidi a acidin, mchere wamchere wa sungunuka, ndi zitsulo zina monga aluminiyamu, ndi zinc. Pamene pH ili yochepera 2, ndipo ikasakanikirana ndi 95% Mowa, mpweya umachitika.
Sodium Carboxymethyl cellulose imatha kupanga co-aglatin ndi pettin ndi pectin, ndipo amathanso kupanga ma hangin, omwe amatha kuwongolera mapuloteni ena abwino.
luso
CMC nthawi zambiri imakhala yophika poyipitsira ya inionic yokonzedwa ndi cellulose yokhala ndi caustic alkali ndi monochloroortic acid, ndi ma celecular olemera 6400 (± 1,000). Zopangidwa ndi zinthu zazikulu ndi sodium chloride ndi sodium glycolate. CMC ndi chikhalidwe cha cellulose. Bungwe la chakudya ndi zaulimi wa United Nations ndi World Health Organisation (ndani) mwatcha "cellulose yosinthidwa".
Zizindikiro zazikulu kuti muyeze mtundu wa cmc ndi digiri ya zolowetsa (DS) ndi chiyero. Nthawi zambiri, zinthu za CMC ndizosiyana ngati DS ndi yosiyana; Kukweza kuchuluka kwa kulowetsa, kulimba, kususuka kuwonekera ndi kukhazikika kwa yankho. Malinga ndi malipoti, kuwonekera kwa cmc kuli bwino pomwe digiri ya mufilimu ndi 0,7-1.2, ndi mawonekedwe ake yankho lake ndi lalikulu pomwe mtengo wa PH ndi 6-9. Pofuna kuonetsetsa kuti, kuwonjezera pa kusankha kwa othandizira, zinthu zina zomwe zimakhudza kuchuluka kwa olowa m'malo mwa kuchuluka kwa kuchuluka kwa kuchuluka kwa kuchuluka kwa alkali, nthawi yolumikizidwa, madzi Njira, kutentha, PH yamtengo, yankho ndende ndi mchere etc.
zokhazikika
Pofuna kuthana ndi kusowa kwa zinthu zopangira (zoyenga zoyenga zopangidwa ndi thonje), m'zaka zaposachedwa, magawo ena a sayansi mdziko mu ndege kuti mugwiritse ntchito mabulogu kupanga masentimita bwino. Mtengo wopanga umachepa kwambiri, womwe umatsegula gwero latsopano la zopangira ma CMC ndikuzindikira kugwiritsidwa ntchito kwathunthu kwa zinthu. Kumbali ina, zopanga zopanga zimachepetsedwa, ndipo mbali inayo, cmc ikukula molondola. Kafukufukuyu ndi chitukuko cha cmc makamaka amayang'ana kwambiri zamatekinoloje omwe alipo kale komanso zatsopano za cmc zatsopano, monga njira yosinthira "3] Kwina ndipo wagwiritsidwa ntchito kwambiri. Mtundu watsopano wa cmc wosinthidwa ndi kukhazikika kwambiri kumapangidwa. Chifukwa cha kuchuluka kwa zolowa m'malo mwa magawidwe am'magawo, itha kugwiritsidwa ntchito popanga mafakitale ndi ntchito zovuta kugwiritsa ntchito zofunika kwambiri kuti akwaniritse zofunika kwambiri. Padziko lonse lapansi, mtundu watsopanowu wa cmc wosinthidwa amatchedwanso "paclionic cellulose (pac, penti anionic cellulose)".
chitetezo
Chitetezo kwambiri, Adi safunikira malamulo, ndipo miyezo yadziko yakonzedwa [4].
karata yanchito
Izi zimakhala ndi ntchito zomangiriza, ndikulimbitsa, kulimbikitsa, ndikusungunulira, kusungidwa kwamadzi komanso kuyimitsidwa.
Kugwiritsa ntchito cmc mu chakudya
Fao ndi amene anavomereza kugwiritsa ntchito CMC yoyera mu chakudya. Zinavomerezedwa pambuyo pochita masewera olimbitsa thupi komanso kuyesa koopsa komanso mayeso. Kudya koyenera (Adi) kwa Stavel Standard ndi 25mg / (kG · d), ndiye pafupifupi 1.5 g pa munthu aliyense. Zanenedwa kuti anthu ena alibe poizoni akakhala ndi makilogalamu 10. CMC siyongopanda kukhazikika kwa emulsifider ndikukula m'mapulogalamu azakudya, komanso kukhazikika kwabwino kwambiri komanso kusungunuka bwino komanso kusungunuka, ndipo kumatha kukonza zonunkhira, ndipo kumatha kukonza kununkhira kwa malonda ndikuthandizira nthawi yosungirako. Ndalama zomwe zimagwiritsidwa ntchito mkaka wa soya, ayisikilimu, ayisikilimu, zakudya, zakumwa, ndi zitini zili pafupifupi 1% mpaka 1.5%. CMC imatha kukhalanso ndi viniga okwanira okhala ndi viniga, soya msuzi, mafuta a masamba, msuzi wa zipatso, msuzi ndi 0,2% mpaka 0,5%. Makamaka. Chifukwa cha chitetezo ndi kudalirika, mlingo wake suli ndi chakudya chamagulu a Hagiene Standa. CMC yakhazikitsidwa mosalekeza mu gawo la chakudya, ndikufufuza pakugwiritsa ntchito sodium carboxymethylmethmeth
Kugwiritsa ntchito cmc mu mankhwala
M'makampani opanga mankhwala, itha kugwiritsidwa ntchito ngati emulsion filebilizer ya jakisoni, chofunda ndi othandizira mapiritsi. Anthu ena atsimikizira kuti masentimita ndionyamula mankhwala otetezeka komanso odalirika a kuyesa koyambirira ndi nyama. Pogwiritsa ntchito CMC monga ma membrane, njira yosinthidwa ya chinenerochi ku China yangyin shengjin ufa, yangyen shengji membrane, itha kugwiritsidwa ntchito kwa mabala a Dermabrasion a Dermabrasion ndi mabala owopsa. Kafukufuku wotsatsa nyama awonetsa kuti kanemayo amateteza matenda a bala ndipo alibe kusiyana kwakukulu kuchokera ku zovala za gauze. Potengera kuwongolera matenda osokoneza bongo am'madzi komanso kuchiritsa kwa bala lambiri, filimuyi ndiyabwino kwambiri kuposa zovala za gauze, ndipo zimathandiza kuchepetsa edema. Kukonzekera kwamakanema kopangidwa ndi mowa wa polyvinyl: sodium carboxymethyl cellulose: polycaxothyene pamlingo wa 3: 6: 1 ndiye mankhwalawa onsewo amawonjezeka. Kutsatira kwa kukonzekera, nthawi yokhazikika yokonzekera mkamwa mwamwambo komanso momwe mankhwala omwe amakakonzekera onse amathandizidwa kwambiri. Bupivicaine ndi zokongoletsa zamphamvu, koma nthawi zina zimatha kupanga zovuta zazikuluzikulu zikaipizi. Chifukwa chake, pomwe bupivaine umagwiritsidwa ntchito kwambiri m'cipatala, kafukufuku wotha kupewa komanso kuchiza matenda ake poizoni nthawi zonse amakhudzidwa kwambiri. Kafukufuku wamankhwala a pharmacological asonyeza kuti anthu ngati chuma chokhazikitsidwa ndi Bupivacaine yankho limatha kuchepetsa mavuto. Mu opaleshoni ya Prk, kugwiritsa ntchito tetracaine wotsika kwambiri komanso mankhwala osagwirizana ndi kutupa omwe amaphatikizidwa ndi CMC kumatha kuthandizidwa kwambiri. Kupewa kuphatikizika kwa zomata za post peritonaal peritonal ndi kuchepetsa kwa matumba otsetsereka ndichimodzi mwazinthu zovuta kwambiri pakuchita opaleshoni zamankhwala. Kafukufuku wawonetsa kuti masentimita ndiabwino kwambiri kuposa sodium hyoluronite pochepetsa kutengera kuchuluka kwa zomata za peritolative peritolaal. CMC imagwiritsidwa ntchito ku Catheter Hepatic arteritial kulowetsedwa kwa khansa ya anti-khansa yogwiritsa ntchito khansa ya anti-khansa yothetsera ma anti-anti-chotupa, ndikuwongolera mphamvu yochizira. Mu mankhwala, cmc nawonso ali ndi ntchito zosiyanasiyana. Zalembedwa [5] kuti intrapersoneal insulution ya 1% cmc cmc yankho la abulu limakhala lothandiza poletsa dystoocia ndi m'mimba pambuyo polera thiramu.
CMC mu mafakitale ena
Kuwonongeka, CMC itha kugwiritsidwa ntchito ngati gawo lotsutsa-dothi, makamaka kwa nsalu ya hydrophobic, yomwe ili bwino kwambiri kuposa nthito ya carboxymethyl.
CMC itha kugwiritsidwa ntchito kuteteza zitsime za mafuta ngati matope okhazikika ndi madzi osungira madzi atabowola mafuta. Mlingo wa mafuta aliwonse bwino ndi 2.3t kwa zitsime zosaya ndi 5.6T zitsime zakuya;
M'makampani opanga malembawo, amagwiritsidwa ntchito ngati muyeso wogwirizira, wokutira wosindikiza ndi kupaka utoto ndi kusindikiza kwapakati. Mukamagwiritsa ntchito ngati wogwirizira, pamatha kusintha kusungunuka ndi mafakisoni, ndipo nkosavuta kusankha; Monga wothandizila wothandizila, mlingo wake ndi woposa 95%; Mukamagwiritsa ntchito ngati wogwirizira, mphamvu ndi kusinthasintha kwa kanema kwazikulitsa; Ndi silika wokhazikika wa fibroin ma nembanemba opangidwa ndi carboxymethyl cellulose ya oxidase, ndipo feluose ya glucose yopangidwa ndi chidwi kwambiri komanso kukhazikika. Kafukufuku wawonetsa kuti silika gel homogenate umakonzedwa ndi cmc yankho la ma cmc ndi cholumikizira cha 1% (w / v), ma plamatraphic magwiridwe antchito ophika ndi abwino kwambiri. Nthawi yomweyo, mbale yotsekemera yomwe inakutidwa ndi mikhalidwe yabwino ili ndi mphamvu zoyenera, zoyenera kugwiritsa ntchito njira zosiyanasiyana zitsanzo, zosavuta kugwira ntchito. CMC imatsatira ulusi wambiri ndipo zimatha kukonza mgwirizano pakati pa ulusi. Kukhazikika kwa ma viscnce kumatha kuonetsetsa kuti kugwirizanitsidwa, potero kumathandizira kuchita bwino kwa kuluka. Itha kugwiritsidwanso ntchito ngati wothandizila womaliza malembawo, makamaka anti-khwinking okhazikika, omwe amabweretsa kusintha kokhazikika ku nsalu.
CMC itha kugwiritsidwa ntchito ngati othandizira othandizira, emulsifier, obalalitsa, othandizira, komanso amamatira chifukwa chofuula. Zimatha kupanga zomwe zili zolumikizira mofikira mofatsa mu zosungunulira, kuti zokuti zigawezo sizimamuletsa kwa nthawi yayitali. Amagwiritsidwanso ntchito kwambiri mu utoto. .
CMC ikagwiritsidwa ntchito ngati nyumba yoyendetsedwa, imakhala yothandiza kwambiri kuposa sodium gluconate pochotsa cacium ion. Mukamagwiritsa ntchito ngati ma cution kusinthana, kusinthitsa kwake kumatha kufikira 1.6 ml / g.
CMC imagwiritsidwa ntchito ngati wothandizila papepala pamapepala, omwe amatha kusintha mphamvu youma komanso mphamvu yonyowa, komanso kukana mafuta, inki imaza madzi.
CMC imagwiritsidwa ntchito ngati hydrosol mu zodzikongoletsera komanso ngati wokulirapo mu dzino la mano, ndipo Mlingo wake umakhala pafupifupi 5%.
CMC itha kugwiritsidwa ntchito ngati malo oyamwa, chelating, emulsifier, thiCerner, othandizira pamagetsi, zinthu zopangidwa ndi zikopa, zopindika, mano, tsiku ndi tsiku Mankhwala ndi minda ina, ndipo chifukwa cha ntchito yake yabwino kwambiri komanso kugwiritsa ntchito mitundu yambiri, imatsegulira magawo atsopano, ndipo chiyembekezo chamsika ndi chochuluka.
Kusamalitsa
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(2) Kudya kovomerezeka kwa izi ndi 0-25mg / kg · d.
Malangizo
Sakanizani cmc mwachindunji ndi madzi kuti apange guluu wa pabusa wa pakhomo. Pokhazikitsa guluu la CMC, koyambirira onjezani madzi oyeretsa mu thanki yopukutira, ndipo chipangizocho chikatsegulidwa mwachangu, mopitilira muyeso, kotero kuti masentimita ophatikizika kwathunthu Ndi madzi, masentimita amatha kusungunuka kwathunthu. Mukatha Kutha kwa CMC, chifukwa chake kuyenera kukodwa mwachangu ndikusunthidwa mosalekeza ndikuti "kupewa mavuto a kubzala, ndikuchepetsa kuchuluka kwa masentimita, ndikuwonjezera kuchuluka kwa masentimita. Nthawi yolimbikitsa siyofanana ndi nthawi ya masenti kuti isungunuke kwathunthu. Ndi malingaliro awiri. Nthawi zambiri, nthawi yoti munthu aziyambitsa ndiyofupikirapo kuposa nthawi ya masentimita kuti isungunuke kwathunthu. Nthawi yofunikira kuti awiriwa amatengera zochitika zina.
Maziko odziwitsa nthawi yosangalatsa ndi: pomweCmcNdiwobalalika mosafanana m'madzi ndipo palibe zotumphukira kwambiri, zosasangalatsa zitha kuyimitsidwa, kulola masentimita ndi madzi kuti alowe ndi kutentha wina ndi mnzake m'malo oyimirira.
Maziko a kuti adziwe nthawi yofunikira kwa masenti kuti asungunuke kwathunthu ndi motere:
(1) CMC ndi madzi ali omangidwa kwathunthu, ndipo palibe madzi olimba pakati pa awiriwa;
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. Kuyambira nthawi yomwe cmc imayikidwa mu thanki yokhotakhota ndikusakanizika ndi madzi nthawi yomwe masentimita amasungunuka kwathunthu, nthawi yofunikira ili pakati pa 10 mpaka 20 maola.
Post Nthawi: Apr-26-2024