Hydroxypropyl methylcellulose (hpmc)ndi ma celluuse osungunuka, osungunuka madzi osakaniza. Maonekedwe ake ndi oyera a ufa wachikasu kapena wakuda, wopanda mphamvu, wopanda mphamvu, wopanda poizoni, ndikusungunuka m'madzi kuti apange yankho losalala, lowoneka bwino komanso la viscous. Chimodzi mwazinthu zofunikira kwambiri za hydroxpyl meth methylcellulose ogwiritsa ntchito ndikuti zimawonjezera mafayilo amadzimadzi. Kukula kwa kukula kumadalira kuchuluka kwa polymerization (dp) ya mankhwalawo, kuchuluka kwa cellulose ether mu madzi am'madzi, ndiye kutentha. Ndi zinthu zina.
01
Mtundu wa madzimadzi a HPMC Aquaous yankho
Mwambiri, kupsinjika kwamadzi komwe kumadzimadzi kumatha kufotokozedwa ngati ntchito yongogwira ntchito ƒ (γ), bola sizili nthawi. Kutengera mawonekedwe a ƒ (γ), madzimadzi amatha kugawidwa m'mitundu yosiyanasiyana,:
Cellulose etres amagawidwa m'magulu awiri: imodzi siinac cellulose ether ndipo inayo ndi ionic cellulose ether ether. Kwa chiwerewere cha mitundu iwiri iyi ya cellulose et. Sc Naik et al. Anaphunziranso mofananira ndi mwatsatanetsatane pa hydroxyethyl cellulose ndi sodium carboxymethyl cellulose mayankho. Zotsatira zake zidawonetsa kuti ma ethee oyenera a celluose ndi ionic cellulose ether ethersose anali ndi ma preeudoplastic. Kuyenda, mwachitsanzo, kutuluka kwa NewTtonian, kumangofikira zakumwa zatsopano zokhazokha pokha. Pseudoplastity ya hydroxypropyl me methylcellulose yankho limagwira gawo lofunikira pakugwiritsa ntchito. Mwachitsanzo, kupakidwa zokutira, chifukwa cha misozi yopendekera, mawonekedwe a njirayi amachepetsa ndikuwonjezeka kwa chimbudzi, komanso kumawonjezera madzi okutira . Zotsatira zake ndi zazikulu kwambiri; Pomwe mukupuma, mawonekedwe a yankholi ndi yayikulu, yomwe imalepheretsa kuyika kwa tinthu tating'onoting'ono.
02
Njira ya HPMC
Chizindikiro chofunikira kuyeza kukula kwa hydroxypropyl methylcellulose ndiye mawonekedwe akuwoneka kuti akuwoneka bwino. Njira zoyezera njira zomwe zikuwoneka ngati njira yamapiko a Capillary, njira yosinthitsira ma visa yosinthira ndikugwa njira ya mpira.
kuti: Kodi mafakisoniwo akuwoneka kuti, MPA S; K ndiye woyenda nthawi zonse; D ndi kachulukidwe ka yankho ndi 20/10 ° C; T ndi nthawi yoti yankho lidutse kumtunda kwa wotchireyo mpaka kumapeto kwa Marko; Nthawi yomwe mafuta a muyezo amayenda kudzera mu wotchiyo amayeza.
Komabe, njira yoyezera ndi woyenda pa capillary ndiyovuta kwambiri. Ma viscosties a ambiricellulose earsndizovuta kusanthula pogwiritsa ntchito mapiritsi a capillary chifukwa njira izi zimakhala ndi zokhumba zomwe zimapezeka zokhazokha zomwe zimapezeka zokha pamene woyendayenda wapezeka. Chifukwa chake, opanga ambiri amagwiritsa ntchito mapulusa ozungulira kuti athetse mtundu wa hydroxypropyl methylcelulose. Osoweka aku Brookfield nthawi zambiri amagwiritsidwa ntchito m'maiko akunja, ndipo otuwa a NDJ amagwiritsidwa ntchito ku China.
03
Kukopa Zinthu Za HPMC
3.1 ubale ndi kuchuluka kwa kuphatikiza
Pamene magawo ena amakhala osasinthika, mamasukidwe a hydroxypropyl soluse ndi yolingana ndi kuchuluka kwa polymerization (kutalika) kapena kutalika kwa ma polymerization wa polymerization wa polymerization. Izi zimatchulidwa kwambiri pankhani ya polymerization yochepa kwambiri kuposa polymerization.
3.2 Ubwenzi wapakati pa Masukini
Makulidwe a hydroxypropyll methylcelulose imachulukana ndikuwonjezeka kwa kuchuluka kwa chinthucho mu njira yothetsera matenda am'madzi. Ngakhale kusintha pang'ono kwa ndende kumayambitsa kusintha kwakukulu kwa ufa. Ndi mamasukidwe mwadzinal wa hydroxypropyl wa methylcelulose zotsatira za kusintha kwa mawonekedwe akuwoneka kuti ndi yodziwikiratu.
3.3 Ubale pakati pa mamasukidwe ndi kumeta ubweya
Hydroxypropyll methylcellulose yankho ili ndi nyumba yowonda. Hydroxypropyll methyllulose yosiyanasiyana imakonzedwa mu 2% ya madzi am'madzi, komanso chidwi chake pamitengo yosiyanasiyana ya shear imayeza motero. Zotsatira zake ndizotsatira monga zikuwonekera. Pa mtengo wotsika wa shear, mamasukidwe a hydroxypropyl methylcellulose yankho sanasinthe kwambiri. Ndi kuwonjezeka kwa chimbudzi, mamasukidwe a hydroxypropyl sose yothetsera vutoli adachepa, pomwe njira yothetsera vuto lotsika silinachepe.
Ubwenzi wapakati pa ma vinya ndi kutentha
Makutu a hydroxypropyll methylcellulose yankho limakhudzidwa kwambiri ndi kutentha. Kutentha kumawonjezeka, mawidwe a yankho amachepa. Monga momwe chithunzichi chikusonyezera, limakonzedwa mu madzi am'madzi ndi kuchuluka kwa 2%, ndikusintha kwa mafano ndi kuwonjezeka kwa kutentha kumayesedwa.
3.5 zinthu zina zokopa
Maonekedwe a mankhwala a mankhwala a hydroxypypyll methylcelluse amakhudzidwanso ndi zowonjezera mu yankho, mtengo wamtengo wapatali wa yankho, komanso kuchepa kwa microbial. Nthawi zambiri, kuti athe kupeza bwino magwiridwe antchito, ndikofunikira kuwonjezera zosintha, monga dongo, dongo losalala, ku matenda am'mimba a hydroxygyulose. , ndi ma electrolyte monga chloride, a bromide, phosophate, nitrate, etc. amathanso kuwonjezeredwa ndi yankho la madzi. Izi zowonjezera sizimangokhudza ma vinction mbozi zothetsera njira yamadzi am'madzi, komanso zimakhudzanso ntchito zina za hydroxpyupyl. , kukana sag, etc.
Makutu am'madzi am'madzi a hydroxypylpyl satha kukhudzidwa ndi asidi ndi alkali, ndipo nthawi zambiri amakhala ofooka m'magulu a 3 mpaka 11. Phosphoric acid , Boric acid, citric acid, etc. Komabe, acid acid adzachepetsa mafayilo. Koma caustic soda, potaziyamu hydroxide, madzi a laimu, etc. samalimbikitsa pang'ono. Poyerekeza ndi cellulose ina,hydroxypypyl methylcelluloseMadzi am'madzi ali ndi vuto lokhazikika, chifukwa chachikulu ndikuti hydroxypyllulose ali ndi magulu olepheretsa kwambiri komanso osasunthika Pakuwonongeka kwa cellulose ether mamolekyulu ndi chinyalala. Magwiridwe ake ndi omwe akuwoneka kuti akuwoneka kuti akuwoneka kuti yankho la madzi amachepa. Ngati kuli kofunikira kusungitsa yankho la matenda a hydroxypropyl wa nthawi yayitali, tikulimbikitsidwa kuwonjezera pa antifungal wothandizira antifungal kuti mamasulidwe sasintha kwambiri. Posankha othandizira anti-Fungal, oteteza kapena fungicides, muyenera kusamala ndi chitetezo, ndikusankha zinthu zomwe sizikuletsa thupi, monga ma bankhuni am'madzi, malo osungira mafuta ogulitsa mafuta ndi zinthu zina. amatha kusewera gawo lolingana.
Post Nthawi: Apr-282024