Kusungidwa kwamadzi ndi chinthu chofunikira kwa mafakitale ambiri omwe amagwiritsa ntchito mankhwala a hydrophilic monga cellolic etrase. Hydroxypropylmethylcellulose (hpmc) ndi imodzi mwa cellulose etter ndi malo osungirako madzi ambiri. HPMC ndi poldemer polymer yopangidwa kuchokera ku cellulose ndipo nthawi zambiri amagwiritsidwa ntchito pamapulogalamu osiyanasiyana pantchito yomanga, mafakitale am'madzi.
HPMC imagwiritsidwa ntchito kwambiri ngati thicker, okhazikika ndi emulsifier m'malonda osiyanasiyana monga ayisikilimu, sosecessi ndi mavalidwe kuti azithamangitsa mawonekedwe, kusinthika ndi moyo wa alumali. HPMC imagwiritsidwanso ntchito popanga mankhwala ogulitsa mankhwala monga chofunda, kusinthitsa filimu ndi makanema. Amagwiritsidwanso ntchito ngati wothandizira madzi opanga madzi pomanga, makamaka mu simenti ndi matope.
Kusungidwa kwamadzi ndi chinthu chofunikira pomanga chifukwa kumathandizira kuti pakhale simenti yatsopano ndi matope kuti isauma. Kuyanika kumatha kuyambitsa shrinkage ndi kuwonongeka, zomwe zimapangitsa kuti mumitundu yofooka komanso yosakhazikika. HPMC imathandizira kuti zikhale zodzaza ndi simenti ndi matope mwa kuyamwa mamolekyulu amadzi ndipo pang'onopang'ono kumasula matope, kulola zida zomangira kuti zichiritse komanso kuumitsa.
Mfundo yosungiramo madzi ya HPMC imakhazikitsidwa ndi hydrophilicity. Chifukwa cha magulu a ma hydroxyl (-Oh) muzopanga zake, HPMC ili ndi ubale wokwera wamadzi. Magulu a hydroxyl amalumikizana ndi mamolekyulu amadzi kuti apange zomangira za haidrojeni, zomwe zimapangitsa kupangidwa kwa chipolopolo cha hydration kuzungulira unyolo wa polymer. Chipolopolo chotchinga chimalola maunyolo a polymer kuti awonjezere, kuwonjezera kuchuluka kwa HPMC.
Kutupa kwa HPMC ndi njira yamphamvu yomwe imatengera zinthu zosiyanasiyana monga kuchuluka kwa zolowa m'malo mwake (DS), kukula kwa tinthu, kutentha ndi Ph. Mlingo wa cholowa m'malo mwake amatanthauza kuchuluka kwa ma hydroxyl magulu a borydroglucose mu unyolo wapanjala. Mtengo wapamwamba wa DS, wokwera hydrophilicity komanso bwino magwiridwe antchito. Tinthu tating'onoting'ono tokhala ndi tinthu tomwe timathandiziranso kusungidwa kwamadzi, monga tinthu tating'onoting'ono timakhala ndi gawo lalikulu pa unit misa, zomwe zimapangitsa mayamwidwe amadzi ambiri. Kutentha ndi mtengo wa pH kumakhudza kuchuluka kwa zotupa ndi kusungunuka kwamadzi, komanso kutentha kwambiri komanso mtengo wotsika wa pH.
Njira yosungira kwa madzi aku Hpmc imaphatikizapo njira ziwiri: mayamwidwe komanso kutuluka. Pa mayamwa, hpmc imayamwa mamolekyulu amadzi kuchokera kumalo ozungulira, ndikupanga chipolopolo cha hydration kuzungulira unyolo wa polymer. Chipolopolo cha hydrate chimalepheretsa maunyolo a polymer kuchokera kugwa ndikuwasunga kupatukana, kutsogolera kutupa kwa HPMC. Mamolekyulu amadzi amapangidwa maulendo a hydrogen ndi magulu a hydroxyl ku HPMC, kukulitsa magwiridwe antchito a madzi.
Nthawi yanthawi zonse, hpmc imatulutsa mamolekyu amadzi, kulola kuti nyumbayo muchiritsidwe moyenera. Kutulutsa pang'onopang'ono kwa mamolekyu amadzi kumatsimikizira kuti simenti ndi matope amakhalabe ndi hydd, chifukwa chokhazikika komanso cholimba. Kutulutsa pang'onopang'ono kwa mamolekyulu amadzi kumaperekanso madzi osalekeza ku simenti ndi matope, kukulitsa njira yochiritsa ndikuwonjezera mphamvu ndi kukhazikika kwa chinthu chomaliza.
Mwachidule, kusungidwa kwamadzi ndi chinthu chofunikira kwa mafakitale ambiri omwe amagwiritsa ntchito mankhwala a hydrophilic monga cellolic etrase. HPMC ndi imodzi mwa cellulose etter yokhala ndi madzi osungirako madzi ambiri ndipo imagwiritsidwa ntchito kwambiri pomanga, mafakitale opangira mankhwala. Kuphatikiza kwamadzi kwa HPMC kumakhazikika pa hydrophilicity yake, yomwe imapangitsa kuti ichotse mamolekyulu amadzi kuchokera kumalo ozungulira, ndikupanga chipolopolo cha hydration kuzungulira unyolo wa polymer. Chigoba chotchinga chimayambitsa hpmc kuti chitupa cha HPMC, ndipo pang'onopang'ono mamolekyulu amadzi amatsimikizira kuti nyumbayo imakhalabe yokhazikika komanso yokhazikika komanso yolimba.
Post Nthawi: Aug-24-2023